Affiliation: Chungnam National University
Lee S, Koh W, Kim H, Kim C, Lee S. Cancer-upregulated gene 2 (CUG2) overexpression induces apoptosis in SKOV-3 cells. Cell Biochem Funct. 2010;28:461-8 pubmed publisher
..Apoptotic cell death was also observed during early development of zebrafish when CUG2 was overexpressed in zebrafish embryo. We propose that high expression of CUG2 induces apoptotic cell death. ..
Min H, Hong J, Cho I, Jang Y, Lee H, Kim D, et al
. TLR2-induced astrocyte MMP9 activation compromises the blood brain barrier and exacerbates intracerebral hemorrhage in animal models. Mol Brain. 2015;8:23 pubmed publisher
..TLR2 plays a detrimental role in ICH-induced brain damage by activating MMP9 in astrocytes, compromising BBB, and enhancing neutrophils infiltration and proinflammatory gene expression. ..
Koh W, Park B, Lee S. A new kinetochore component CENP-W interacts with the polycomb-group protein EZH2 to promote gene silencing. Biochem Biophys Res Commun. 2015;464:256-62 pubmed publisher
..Collectively, this study suggests CENP-W is a novel kinetochore component that may be involved in the EZH2-mediated silencing machinery. ..
Kim H, So J, Jung S, Ahn D, Koh W, Kim N, et al
. Cug2 is essential for normal mitotic control and CNS development in zebrafish. BMC Dev Biol. 2011;11:49 pubmed publisher
Lee S, Gang J, Jeon S, Choo S, Lee B, Kim Y, et al
. Molecular cloning and functional analysis of a novel oncogene, cancer-upregulated gene 2 (CUG2). Biochem Biophys Res Commun. 2007;360:633-9 pubmed
Kim H, Chun Y, Che L, Kim J, Lee S, Lee S. The new obesity-associated protein, neuronal growth regulator 1 (NEGR1), is implicated in Niemann-Pick disease Type C (NPC2)-mediated cholesterol trafficking. Biochem Biophys Res Commun. 2017;482:1367-1374 pubmed publisher
..These findings provide the first insight into the role of NEGR1 in intracellular cholesterol homeostasis, possibly explaining the missing link between NEGR1 with human obesity. ..