Genomes and Genes


Bon Seok Koo


Affiliation: Chungnam National University College of Medicine
Country: Korea


  1. Won H, Chang J, Kang Y, Kang J, Koo B. Optimal extent of lateral neck dissection for well-differentiated thyroid carcinoma with metastatic lateral neck lymph nodes: A systematic review and meta-analysis. Oral Oncol. 2018;87:117-125 pubmed publisher
    ..In conclusion, selective neck dissection may be considered in patients with well-differentiated thyroid carcinoma with lateral neck lymph node metastases without any other risk factors. ..
  2. Liu L, Jung S, Oh C, Lee K, Won H, Chang J, et al. LAMB3 is associated with disease progression and cisplatin cytotoxic sensitivity in head and neck squamous cell carcinoma. Eur J Surg Oncol. 2018;: pubmed publisher
    ..Our findings indicate that LAMB3 may be used as a prognostic biomarker in HNSCC and support that LAMB3 silencing could induce the sensitivity of anti-cancer drugs such as cisplatin. ..
  3. Joo J, Jin J, Seo S, Lim Y, Rha K, Koo B. Recurrence in regional lymph nodes after total thyroidectomy and neck dissection in patients with papillary thyroid cancer. Oral Oncol. 2015;51:164-9 pubmed publisher
    ..Patients with tumor size >1 cm or extrathyroidal extension were more likely to have tumor recur both within the previously dissected field as well as the un-dissected compartments. ..
  4. Seo S, Chang J, Jin J, Lim Y, Rha K, Koo B. Transient and permanent hypocalcemia after total thyroidectomy: Early predictive factors and long-term follow-up results. Surgery. 2015;158:1492-9 pubmed publisher
    ..Mean postoperative PTH level and the mean relative decline in PTH measured 1 hour postoperatively were the most reliable predictors of postoperative or permanent hypocalcemia. ..
  5. Liu L, Oh C, Heo J, Park H, Lee K, Chang J, et al. Clinical significance of extrathyroidal extension according to primary tumor size in papillary thyroid carcinoma. Eur J Surg Oncol. 2018;44:1754-1759 pubmed publisher
    ..05). Our data suggests that the presence and degree of ETE may be associated with PTC outcome based on primary tumor size. ..
  6. Chang J, Gwak S, Shim G, Liu L, Lim Y, Kim J, et al. EZH2 is associated with poor prognosis in head-and-neck squamous cell carcinoma via regulating the epithelial-to-mesenchymal transition and chemosensitivity. Oral Oncol. 2016;52:66-74 pubmed publisher
    ..Our results indicate that EZH2 may not be only a predictive and prognostic biomarker but also a potential personalized therapeutic target for the treatment of HNSCC. ..
  7. Jung S, Lim H, Liu L, Chang J, Lim Y, Rha K, et al. LAMB3 mediates metastatic tumor behavior in papillary thyroid cancer by regulating c-MET/Akt signals. Sci Rep. 2018;8:2718 pubmed publisher
    ..These results suggest that LAMB3 leads to tumor invasion via Akt activation induced by the HGF/c-MET axis in papillary thyroid cancer cells. Our findings reveal a novel mechanism of action for LAMB3 in papillary thyroid cancer cells. ..
  8. Lim Y, Liu L, Chang J, Koo B. Lateral lymph node recurrence after total thyroidectomy and central neck dissection in patients with papillary thyroid cancer without clinical evidence of lateral neck metastasis. Oral Oncol. 2016;62:109-113 pubmed publisher
    ..Close surveillance may be necessary for early detection of lateral LN recurrence in PTC patients with tumor size ?1cm, and central LN metastasis with extranodal extension. ..
  9. Liu L, Chang J, Jung S, Park H, Oh T, Lim Y, et al. Clinical implications of the extent of BRAFV600E alleles in patients with papillary thyroid carcinoma. Oral Oncol. 2016;62:72-77 pubmed publisher

More Information


  1. Park J, Chang J, Liu L, Jung S, Koo B. Clinical implications of microscopic extrathyroidal extension in patients with papillary thyroid carcinoma. Oral Oncol. 2017;72:183-187 pubmed publisher
    ..Patients with microscopic ETE have a poorer clinical outcome than those without ETE, but they showed a better outcome than patients with macroscopic ETE. ..
  2. Chang J, Park K, Heo J, Jung S, Liu L, Kim S, et al. Relationship Between 18F-fluorodeoxyglucose Accumulation and the BRAF V600E Mutation in Papillary Thyroid Cancer. World J Surg. 2018;42:114-122 pubmed publisher
    ..0%, area under the curve 0.929; P < 0.0001) according to ROC curve analysis. The BRAF V600E mutation is independently associated with high 18F-FDG uptake in PTC, especially in those with a tumor size >1 cm. ..
  3. Kang Y, Kim J, Jee S, Jo C, Koo B. Detection of voice changes due to aspiration via acoustic voice analysis. Auris Nasus Larynx. 2018;45:801-806 pubmed publisher
    ..Thus, acoustic voice analysis may be helpful in making a diagnosis of AR as a supplementary tool for standard swallowing study including VFSS or fiberoptic examination. ..