Young Ho Kim

Summary

Affiliation: Chungnam National University
Country: Korea

Publications

  1. ncbi request reprint Crinamine from Crinum asiaticum var. japonicum inhibits hypoxia inducible factor-1 activity but not activity of hypoxia inducible factor-2
    Young Ho Kim
    College of Pharmacy, Chungnam National University, Daejeon, Korea
    Biol Pharm Bull 29:2140-2. 2006
  2. doi request reprint Lupane-type triterpene glycosides from the leaves of Acanthopanax koreanum and their in vitro cytotoxicity
    Xuan Nhiem Nguyen
    College of Pharmacy, Chungnam National University, Daejeon, Korea
    Planta Med 76:189-94. 2010
  3. pmc Effect of KOB03, a polyherbal medicine, on ovalbumin-induced allergic rhinitis in guinea pigs
    Hyo Won Jung
    Oriental Medicine R and D Center, Dongguk University, Gyeongju, 780 714, Republic of Korea
    Chin Med 7:27. 2012
  4. pmc Anti-inflammatory components of the starfish Astropecten polyacanthus
    Nguyen Phuong Thao
    Institute of Marine Biochemistry, Vietnam Academy of Science and Technology VAST, 18 Hoang Quoc Viet, Nghiado, Caugiay, Hanoi 10000, Vietnam
    Mar Drugs 11:2917-26. 2013
  5. doi request reprint Isolation of nematicidal triterpenoid saponins from Pulsatilla koreana root and their activities against Meloidogyne incognita
    Wei Li
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    Molecules 18:5306-16. 2013
  6. doi request reprint A new C29-sterol with a cyclopropane ring at C-25 and 26 from the Vietnamese marine sponge lanthella sp
    Nguyen Huu Tung
    Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Nghiado, Caugiay, Hanoi, Vietnam
    Arch Pharm Res 32:1695-8. 2009
  7. ncbi request reprint Labdane-type diterpenoids from the rhizomes of Hedychium coronarium inhibit lipopolysaccharide-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells
    Phan Van Kiem
    Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam
    Chem Pharm Bull (Tokyo) 60:246-50. 2012
  8. doi request reprint Inhibitory effects of oleanane-type triterpenes and saponins from the stem bark of Kalopanax pictus on LPS-stimulated pro-inflammatory cytokine production in bone marrow-derived dendritic cells
    Tran Hong Quang
    College of Pharmacy, Chungnam National University, Daejeon, 305 764, Korea
    Arch Pharm Res 36:327-34. 2013
  9. ncbi request reprint Chemical constituents from the leaves of Manglietia phuthoensis and their effects on osteoblastic MC3T3-E1 cells
    Phan Van Kiem
    Institute of Natural Products Chemistry, Vietnamese Academy of Science and Technology, Viet, Nghiado, Caugiay, Hanoi, Vietnam
    Chem Pharm Bull (Tokyo) 56:1270-5. 2008
  10. doi request reprint Anti-inflammatory activity on LPS-stimulated dendritic cells of lupanetype triterpenoids from the leaves of Acanthopanax koreanum
    Nguyen Xuan Nhiem
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    Arch Pharm Res 34:1593-8. 2011

Collaborators

Detail Information

Publications148 found, 100 shown here

  1. ncbi request reprint Crinamine from Crinum asiaticum var. japonicum inhibits hypoxia inducible factor-1 activity but not activity of hypoxia inducible factor-2
    Young Ho Kim
    College of Pharmacy, Chungnam National University, Daejeon, Korea
    Biol Pharm Bull 29:2140-2. 2006
    ..japonicum together with lycorine (2), norgalanthamine (3) and epinorgalanthamine (4). The other components (2-4) showed no significant inhibition of HIF-1alpha induced transcriptional activity...
  2. doi request reprint Lupane-type triterpene glycosides from the leaves of Acanthopanax koreanum and their in vitro cytotoxicity
    Xuan Nhiem Nguyen
    College of Pharmacy, Chungnam National University, Daejeon, Korea
    Planta Med 76:189-94. 2010
    ..4, 36.5, 22.6, and 18.5 microM for 1; 6.8, 18.6, 23.1, and > 100 microM for 2; and 28.9, 21.8, 11.0, and 27.5 microM for 3, respectively...
  3. pmc Effect of KOB03, a polyherbal medicine, on ovalbumin-induced allergic rhinitis in guinea pigs
    Hyo Won Jung
    Oriental Medicine R and D Center, Dongguk University, Gyeongju, 780 714, Republic of Korea
    Chin Med 7:27. 2012
    ..abstract:..
  4. pmc Anti-inflammatory components of the starfish Astropecten polyacanthus
    Nguyen Phuong Thao
    Institute of Marine Biochemistry, Vietnam Academy of Science and Technology VAST, 18 Hoang Quoc Viet, Nghiado, Caugiay, Hanoi 10000, Vietnam
    Mar Drugs 11:2917-26. 2013
    ..05 ± 2.05 μM) exhibited moderate inhibitory effects on the production of IL-12 p40, whereas compounds 3 (IC50 = 22.80 ± 0.21 μM) and 4 (IC50 = 16.73 ± 0.25 μM) moderately inhibited the production of TNF-α and IL-6, respectively. ..
  5. doi request reprint Isolation of nematicidal triterpenoid saponins from Pulsatilla koreana root and their activities against Meloidogyne incognita
    Wei Li
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    Molecules 18:5306-16. 2013
    ..1 to 94.7 μg/mL after 48 h. These results suggest that triterpenoid saponins from P. koreana should be explored as potential natural nematicides for developing new agents to control root-knot nematode disease...
  6. doi request reprint A new C29-sterol with a cyclopropane ring at C-25 and 26 from the Vietnamese marine sponge lanthella sp
    Nguyen Huu Tung
    Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Nghiado, Caugiay, Hanoi, Vietnam
    Arch Pharm Res 32:1695-8. 2009
    ..Their structures were elucidated by extensive spectroscopic analyses. Both 1 and 2 showed moderate cytotoxic activity against MCF-7, SK-Hep-1, and HeLa cell lines with IC(50) in the range of 12.8-27.8 microM...
  7. ncbi request reprint Labdane-type diterpenoids from the rhizomes of Hedychium coronarium inhibit lipopolysaccharide-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells
    Phan Van Kiem
    Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam
    Chem Pharm Bull (Tokyo) 60:246-50. 2012
    ..0±1.3 and 12.7±0.3 μM. The remains of compounds showed inactivity. These results warrant further studies concerning the potential anti-inflammatory benefits of labdane-diterpenes from H. coronarium...
  8. doi request reprint Inhibitory effects of oleanane-type triterpenes and saponins from the stem bark of Kalopanax pictus on LPS-stimulated pro-inflammatory cytokine production in bone marrow-derived dendritic cells
    Tran Hong Quang
    College of Pharmacy, Chungnam National University, Daejeon, 305 764, Korea
    Arch Pharm Res 36:327-34. 2013
    ..pictus stem bark and its triterpene and saponin components in the inhibition of pro-inflammatory cytokine secretion, including IL-12 p40, IL-6, and TNF-α, and for prevention and treatment of inflammatory diseases...
  9. ncbi request reprint Chemical constituents from the leaves of Manglietia phuthoensis and their effects on osteoblastic MC3T3-E1 cells
    Phan Van Kiem
    Institute of Natural Products Chemistry, Vietnamese Academy of Science and Technology, Viet, Nghiado, Caugiay, Hanoi, Vietnam
    Chem Pharm Bull (Tokyo) 56:1270-5. 2008
    ..Among them, compounds 2 and 5 significantly (p<0.05) increased the growth and differentiation of osteoblastic MC3T3-E1 cells in vitro...
  10. doi request reprint Anti-inflammatory activity on LPS-stimulated dendritic cells of lupanetype triterpenoids from the leaves of Acanthopanax koreanum
    Nguyen Xuan Nhiem
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    Arch Pharm Res 34:1593-8. 2011
    ..0 to 84.5% at a concentration of 50 μM. These results warrant further studies concerning the potential anti-inflammatory benefits of medicinal foods containing the leaves of A. koreanum...
  11. doi request reprint Cytotoxic and PPARs transcriptional activities of sterols from the Vietnamese soft coral Lobophytum laevigatum
    Tran Hong Quang
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Republic of Korea
    Bioorg Med Chem Lett 21:2845-9. 2011
    ....
  12. ncbi request reprint Gymnasterkoreayne G, a new inhibitory polyacetylene against NFAT transcription factor from Gymnaster koraiensis
    Nguyen Tien Dat
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    Chem Pharm Bull (Tokyo) 53:1194-6. 2005
    ..44+/-0.59 microM). In term of the isomers, compound 1 (IC(50) 43.9+/-2.24 microM) with an erythro-configuration showed less inhibition than 2 (IC(50) 7.24+/-0.42 microM) with a threo-configuration...
  13. ncbi request reprint Steamed ginseng-leaf components enhance cytotoxic effects on human leukemia HL-60 cells
    Nguyen Huu Tung
    College of Pharmacy, Chungnam National University, Daejeon, Korea
    Chem Pharm Bull (Tokyo) 58:1111-5. 2010
    ..0, 9.0, 7.5, and 8.2 microM, respectively. This is the first report on chemical components of the steamed ginseng leaves...
  14. pmc Inhibition of nuclear transcription factor-κB and activation of peroxisome proliferator-activated receptors in HepG2 cells by cucurbitane-type triterpene glycosides from Momordica charantia
    Nguyen Xuan Nhiem
    College of Pharmacy, Chungnam National University, Daejeon, Korea
    J Med Food 15:369-77. 2012
    ..9 μM). Compounds 4, 6, and 8 also inhibited TNFα-induced expressions of inducible nitric oxide synthase and cyclooxygenase-2 mRNA. However, only compound 13 significantly increased PPARγ transactivation...
  15. doi request reprint Anti-inflammatory norditerpenoids from the soft coral Sinularia maxima
    Nguyen Phuong Thao
    Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Nghiado, Caugiay, Hanoi, Viet Nam
    Bioorg Med Chem Lett 23:228-31. 2013
    ..30 ± 0.21 and 13.12 ± 0.64 μM, respectively. Compound 1 exhibited moderate inhibitory activity against IL-12 and IL-6 production with IC(50) values of 23.52 ± 1.37 and 69.85 ± 4.11 μM, respectively...
  16. doi request reprint Anti-inflammatory asterosaponins from the starfish Astropecten monacanthus
    Nguyen Phuong Thao
    Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam
    J Nat Prod 76:1764-70. 2013
    ..Such potent anti-inflammatory activities render compounds 1, 5, and 6 important materials for further applications including complementary inflammation remedies and/or functional foods and nutraceuticals. ..
  17. ncbi request reprint Inhibition of interleukin-8 production in the human colonic epithelial cell line HT-29 by 18 beta-glycyrrhetinic acid
    Ok Hwa Kang
    Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, Jeonbuk, Korea
    Int J Mol Med 15:981-5. 2005
    ....
  18. ncbi request reprint Gymnasterkoreaynes A-F, cytotoxic polyacetylenes from Gymnaster koraiensis
    Hyun Ju Jung
    College of Pharmacy, Chungnam National University, Taejon 305 764, Korea
    J Nat Prod 65:897-901. 2002
    ..Of the compounds isolated, gymnasterkoreaynes B (2), C (3), F (6), and 1,9,16-heptadecatrien-4,6-diyn-3,8-diol (8) exhibited significant cytotoxicity against L1210 tumor cells with ED(50) values of 0.12-3.3 microg/mL...
  19. doi request reprint A new norlupane triterpene from the leaves of Acanthopanax koreanum increases the differentiation of osteoblastic MC3T3-e1 cells
    Sang Hyouk Park
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    Arch Pharm Res 33:75-80. 2010
    ..These results suggest that the compounds isolated from A. koreanum leaves have a direct stimulatory effect on bone formation in vitro and may contribute to the prevention for osteoporosis...
  20. doi request reprint Rhusonoside A, a new megastigmane glycoside from Rhus sylvestris, increases the function of osteoblastic MC3T3-E1 cells
    Yan Ding
    College of Pharmacy, Chungnam National University, Daejeon, Korea
    Planta Med 75:158-62. 2009
    ..39 %, 171.27 %, and 134.25 %, respectively, of the basal value at 10 muM ( P < 0.05). In addition, 0.1 muM of compound 1 significantly increased mineralization of MC3T3-E1 cells to 142.78 % ( P < 0.05) of the basal value...
  21. ncbi request reprint Phenolic compounds from Artemisia iwayomogi and their effects on osteoblastic MC3T3-E1 cells
    Yan Ding
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    Biol Pharm Bull 33:1448-53. 2010
    ..Compounds 3, 4, 7, and 9 showed potential in stimulating osteoblastic bone formation and may be useful for the prevention and/or treatment of osteoporosis...
  22. doi request reprint Diarylheptanoid glycosides from Tacca plantaginea and their effects on NF-κB activation and PPAR transcriptional activity
    Tran Hong Quang
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Republic of Korea Institute of Marine Biochemistry, Vietnam Academy of Science and Technology VAST, 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam
    Bioorg Med Chem Lett 22:6681-7. 2012
    ..0-30.1 μM. These data provide the rationale for using T. plantaginea and its components for the prevention and treatment of inflammatory and metabolic diseases...
  23. doi request reprint A new iridoid and effect on the rat aortic vascular smooth muscle cell proliferation of isolated compounds from Buddleja officinalis
    Bui Huu Tai
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Republic of Korea
    Bioorg Med Chem Lett 21:3462-6. 2011
    ..Among them, iridoids were the main active components and showed significant inhibitory effects on PDGF-BB-induced proliferation in rat aortic VSMCs...
  24. doi request reprint Chemical constituents of Acanthus ilicifolius L. and effect on osteoblastic MC3T3E1 cells
    Phan Van Kiem
    Institute of Natural Products Chemistry, Vietnamese Academy of Science and Technology, 18 Hoang Quoc Viet, Nghiado, Caugiay, Hanoi, Vietnam
    Arch Pharm Res 31:823-9. 2008
    ..Compounds 2, 3, and 5 (30 microM) increased the growth and differentiation of osteoblasts significantly (P<0.05), indicating that A. ilicifolius leaves may help prevent osteoporosis...
  25. doi request reprint An anti-influenza component of the bark of Alnus japonica
    Nguyen Huu Tung
    College of Pharmacy, Chungnam National University, Daejeon, 305 764, Korea
    Arch Pharm Res 33:363-7. 2010
    ..Betulinic aldehyde (3) exhibited a particularly strong anti-influenza effect against KBNP-0028 relative to a positive control...
  26. doi request reprint Effects of impressic acid from Acanthopanax koreanum on NF-κB and PPARγ activities
    Jeong Ah Kim
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    Arch Pharm Res 34:1347-51. 2011
    ..In this study, impressic acid was found to inhibit tumor necrosis factor (TNF)-α induced NF-κB activity and to up-regulate transcriptional activity of PPARγ...
  27. doi request reprint New monoterpene glycosides and phenolic compounds from Distylium racemosum and their inhibitory activity against ribonuclease H
    Jeong Ah Kim
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Republic of Korea
    Bioorg Med Chem Lett 21:2840-4. 2011
    ..Among them, 6″-O-galloylsalidroside (6) showed potent inhibitory effects with an IC(50) value of 3.5 μM on HIV-2, and 1.7 μM on human RNase H, respectively...
  28. doi request reprint Effect of triterpenes and triterpene saponins from the stem bark of Kalopanax pictus on the transactivational activities of three PPAR subtypes
    Tran Hong Quang
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Republic of Korea
    Carbohydr Res 346:2567-75. 2011
    ..7, 15.5, 14.8, 10.9, 17.1, and 16.3 μM, whereas compounds 8 and 10 significantly upregulated PPARβ(δ) transcriptional activity, with EC(50) values of 15.7 and 17.7 μM, respectively...
  29. doi request reprint Chemical components from the Vietnamese soft coral Lobophytum sp
    Huu Tung Nguyen
    Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Nghiado, Caugiay, Hanoi, Vietnam
    Arch Pharm Res 33:503-8. 2010
    ..Compounds 1 and 2 showed significant cytotoxic activities against lung (A549) and colon (HT-29) cell lines with IC(50) values of 8.2 and 5.6 microM for 1; 5.1 and 1.8 microM for 2, respectively...
  30. doi request reprint Structure-activity relationship of lupane-triterpene glycosides from Acanthopanax koreanum on spleen lymphocyte IL-2 and IFN-gamma
    Nguyen Xuan Nhiem
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Republic of Korea
    Bioorg Med Chem Lett 20:4927-31. 2010
    ..Compounds 4, 5, 7, and 11 (5, 25, and 100 microM) significantly increased IFN-gamma and IL-2 release in spleen cells...
  31. doi request reprint Oleanane-type triterpenoid saponins from the roots of Pulsatilla koreana and their apoptosis-inducing effects on HL-60 human promyelocytic leukemia cells
    Wei Li
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    Arch Pharm Res 36:768-74. 2013
    ..Furthermore, apoptotic characteristics such as chromatin condensation and increase in the population of sub-G1 hypodiploid cells were observed after the HL-60 cells were treated with these compounds...
  32. doi request reprint Pyrrole and furan oligoglycosides from the starfish Asterina batheri and their inhibitory effect on the production of pro-inflammatory cytokines in lipopolysaccharide-stimulated bone marrow-derived dendritic cells
    Nguyen Phuong Thao
    Institute of Marine Biochemistry, Vietnam Academy of Science and Technology VAST, 18 Hoang Quoc Viet, Nghiado, Caugiay, Hanoi, Viet Nam College of Pharmacy, Chungnam National University, Daejeon 305 764, Republic of Korea
    Bioorg Med Chem Lett 23:1823-7. 2013
    ..Compounds 2, 3, and 4 moderately inhibited IL-12 p40 production in lipopolysaccharide (LPS)-stimulated bone marrow-derived dendritic cells (BMDCs) with IC50 values of 36.4, 31.6, and 22.8μM, respectively...
  33. doi request reprint Linarin isolated from Buddleja officinalis prevents hydrogen peroxide-induced dysfunction in osteoblastic MC3T3-E1 cells
    Young Ho Kim
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Republic of Korea
    Cell Immunol 268:112-6. 2011
    ..These results demonstrate that linarin can protect osteoblasts against hydrogen peroxide-induced osteoblastic dysfunction and may exert anti-resorptive actions, at least in part, via the reduction of RANKL and oxidative damage...
  34. doi request reprint Inhibitors of osteoclastogenesis from Lawsonia inermis leaves
    Nguyen Xuan Cuong
    Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Nghiado, Caugiay, Hanoi, Viet Nam
    Bioorg Med Chem Lett 20:4782-4. 2010
    ..Compounds 4 and 5 showed a significant inhibition on receptor activator for nuclear factor-kappaB ligand-induced osteoclast formation in murine bone-marrow macrophages...
  35. doi request reprint Triterpene compounds isolated from Acer mandshuricum and their anti-inflammatory activity
    Yan Ding
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Republic of Korea
    Bioorg Med Chem Lett 20:1528-31. 2010
    ..Among the compounds tested, compound 2 showed the strongest anti-inflammatory activity with the inhibition rate up to 38.40% at the concentration of 100nM, whereas other five compounds (2-6) exhibited moderate activity...
  36. doi request reprint Cytotoxic oleane-type triterpene saponins from Glochidion eriocarpum
    Nguyen Xuan Nhiem
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    Arch Pharm Res 35:19-26. 2012
    ..These findings provide evidence demonstrating that the pro-apoptotic effects of compounds 1-4 are mediated through the activation of ERK and p38 in HCT-116 cells...
  37. ncbi request reprint Diterpenoids from the soft coral Sinularia maxima and their inhibitory effects on lipopolysaccharide-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells
    Nguyen Phuong Thao
    Institute of Marine Biochemistry, Vietnam Academy of Science and Technology VAST, 18 Hoang Quoc Viet, Nghiado, Caugiay, Hanoi, Vietnam
    Chem Pharm Bull (Tokyo) 60:1581-9. 2012
    ..35±0.12 to 18.04±0.21 µM. Compounds 2, 3, and 11 showed moderate inhibitory activity on IL-6 production with IC(50) values ranging from 17.72±0.31 to 59.77±2.34 µM...
  38. doi request reprint New phenylpropanoid esters of sucrose from Polygonum hydropiper and their antioxidant activity
    Phan Van Kiem
    Institute of Natural Products Chemistry, Vietnamese Academy of Science and Technology, 18 Hoang Quoc Viet, Nghiado, Caugiay, Hanoi, Vietnam
    Arch Pharm Res 31:1477-82. 2008
    ..Among them, compounds 2 and 3 showed significant antioxidant activity with their SC(50) values of 23.4 and 26.7 microg/mL, respectively...
  39. doi request reprint Inhibitory effect on TNF-α-induced IL-8 secretion in HT-29 cell line by glyceroglycolipids from the leaves of Ficus microcarpa
    Phan Van Kiem
    Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam
    Arch Pharm Res 35:2135-42. 2012
    ..All above galactolipids showed significant inhibition ranging 40% at a concentration of 50 μM. The results suggest that galactolipids from the leaves of F. microcarpa may be used as potent anti-inflammatory agents...
  40. ncbi request reprint Plantagiolides I and J, two new withanolide glucosides from Tacca plantaginea with nuclear factor-kappaB inhibitory and peroxisome proliferator-activated receptor transactivational activities
    Tran Hong Quang
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    Chem Pharm Bull (Tokyo) 60:1494-501. 2012
    ..1 to 29.6 µM. These results provide scientific support for the use of T. plantaginea and its components for the prevention and treatment of inflammatory and metabolic diseases...
  41. doi request reprint Dibenzocyclooctadiene lignans and lanostane derivatives from the roots of Kadsura coccinea and their protective effects on primary rat hepatocyte injury induced by t-butyl hydroperoxide
    Ninh Khac Ban
    Institute of Ecology and Biological Resources, Vietnam Academy of Science and Technology VAST, Hanoi, Vietnam
    Planta Med 75:1253-7. 2009
    ..2 mM T-butyl hydroperoxide. Compounds 1, 3, and 5 showed protective effects with ED (50) values of 135.7, 26.1, and 79.3 microM, respectively...
  42. ncbi request reprint Triterpenoids from aerial parts of Glochidion eriocarpum
    Vu Kim Thu
    Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology VAST, 18 Hoang Quoc Viet, Nghiado, Caugiay, Hanoi, Vietnam
    Nat Prod Commun 5:361-4. 2010
    ..The structures of the new compounds were elucidated on the basis of spectroscopic data, including FTICR-MS, 1D and 2D NMR...
  43. doi request reprint Diarylheptanoids and flavonoids from viscum album inhibit LPS-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells
    Nguyen X Nhiem
    College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon 406 840, Korea
    J Nat Prod 76:495-502. 2013
    ..09 ± 0.01 to 8.96 ± 0.45 μM. (+)-Medioresinol (13) showed inhibitory effects on LPS-stimulated production of IL-12p40 with an IC50 value of 2.00 ± 0.15 μM. ..
  44. doi request reprint Oleanane-type triterpenoids from Panax stipuleanatus and their anticancer activities
    Chun Liang
    College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea
    Bioorg Med Chem Lett 20:7110-5. 2010
    ..Structure-activity relationship analysis indicated that a carboxyl group at position-28 is potentially responsible for the cytotoxic effects...
  45. doi request reprint New guaiane sesquiterpene lactones from Ixeris dentata
    Mi Ran Cha
    Korea Research Institute of Chemical Technology, Daejeon, Korea
    Planta Med 77:380-2. 2011
    ..Compounds 1-12 were evaluated for their inhibitory effect on the proliferation of the cultured human tumor cell lines MES-SA, MES-SA/DX5, HCT-15, and HCT15/CL02 in vitro...
  46. doi request reprint Inhibitory effect of ginsenosides from steamed ginseng-leaves and flowers on the LPS-stimulated IL-12 production in bone marrow-derived dendritic cells
    Nguyen Huu Tung
    College of Pharmacy, Chungnam National University, Daejeon, 305 764, Korea
    Arch Pharm Res 34:681-5. 2011
    ..These results warrant further studies concerning potential of saponin extracts of steamed ginseng-leaves and flowers for medicinal uses...
  47. doi request reprint Antioxidant activity of a new C-glycosylflavone from the leaves of Ficus microcarpa
    Van Kiem Phan
    Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam
    Bioorg Med Chem Lett 21:633-7. 2011
    ..Compounds 1-6 exhibited potent antioxidant activities of 6.6-9.5μM Trolox equivalents at the concentration of 2.0μM. The results indicated 2, 3, and 5 having meaningful reducing capacity of copper (I) ions concentration of 6.1-8.4μM...
  48. doi request reprint Phenylpropanoids from the leaves of Acanthopanax koreanum and their antioxidant activity
    Nguyen Xuan Nhiem
    College of Pharmacy, Chungnam National University, Daejeon, Korea
    J Asian Nat Prod Res 13:56-61. 2011
    ..Among them, compounds 1, 2, and 4 showed significant scavenging capacity with IC(50) values of 3.8, 2.6, and 2.9 μM, respectively, and compound 3 showed weak scavenging capacity with the inhibition rate of 37% at 40 μM...
  49. doi request reprint Cytotoxic and antioxidant activities of diterpenes and sterols from the Vietnamese soft coral Lobophytum compactum
    Van Minh Chau
    Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam
    Bioorg Med Chem Lett 21:2155-9. 2011
    ..4 and 1.3 μM Trolox equivalents, respectively, at a concentration of 5 μM...
  50. doi request reprint Lupane-type triterpenoids from the steamed leaves of Acanthopanax koreanum and their inhibitory effects on the LPS-stimulated pro-inflammatory cytokine production in bone marrow-derived dendritic cells
    Jeong Ah Kim
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Republic of Korea
    Bioorg Med Chem Lett 20:6703-7. 2010
    ..5 μM on IL-12 production, compared with IC(50) value of 29.6 μM for the positive control. Compound 1 also showed significant suppression of LPS-stimulated IL-6 and tumor necrosis factor-alpha (TNF-α) production...
  51. doi request reprint Chrysoeriol isolated from Eurya cilliata leaves protects MC3T3-E1 cells against hydrogen peroxide-induced inhibition of osteoblastic differentiation
    Young Ho Kim
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    J Appl Toxicol 30:666-73. 2010
    ..These results demonstrate that chrysoeriol isolated from E. cilliata can protect osteoblasts from oxidative stress-induced toxicity...
  52. ncbi request reprint New pyrano-pyrone from Goniothalamus tamirensis enhances the proliferation and differentiation of osteoblastic MC3T3-E1 cells
    Bui Huu Tai
    College of Pharmacy, Chungnam National University, Daejeon, Korea
    Chem Pharm Bull (Tokyo) 58:521-5. 2010
    ..05). Our data suggest that the enhancement of osteoblast function by 1 and 2 may result in the prevention of osteoporosis...
  53. doi request reprint Phenylpropanoid glycosides from Heterosmilax erythrantha and their antioxidant activity
    Nguyen Xuan Nhiem
    Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology VAST, Caugiay, Hanoi, Vietnam
    Arch Pharm Res 32:1373-7. 2009
    ..Among them, compounds 5 and 6 showed significant antioxidant activity with SC(50) values of 3.7 and 6.5 microg/mL, respectively...
  54. doi request reprint New anthracene glycosides from Rhodomyrtus tomentosa stimulate osteoblastic differentiation of MC3T3-E1 cells
    Nguyen Huu Tung
    College of Pharmacy, Chungnam National University, Daejeon, 305 764, Korea
    Arch Pharm Res 32:515-20. 2009
    ..Among them, compound 1, 2, and 5 significantly (P<0.05) increased the alkaline phosphatase activity, collagen synthesis, and mineralization of the nodules of MC3T3-E1 osteoblastic cells compared to those of the control, respectively...
  55. ncbi request reprint alpha-Glucosidase inhibition properties of cucurbitane-type triterpene glycosides from the fruits of Momordica charantia
    Nguyen Xuan Nhiem
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    Chem Pharm Bull (Tokyo) 58:720-4. 2010
    ..Of which, 12 and 13 showed moderate inhibitory activity against alpha-glucosidase. Whereas, 2, 3, 6-11, and 14 showed weak inhibitory activity, and 1, 4, and 5 were inactive...
  56. doi request reprint Cytotoxic and anti-inflammatory cembranoids from the Vietnamese soft coral Lobophytum laevigatum
    Tran Hong Quang
    College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea
    Bioorg Med Chem 19:2625-32. 2011
    ..Moreover, compounds 1, 2, 8, and 9 significantly inhibited the induction of COX-2 and iNOS mRNA dose-dependently, indicating that these compounds attenuated the synthesis of these transcripts at the transcriptional level...
  57. doi request reprint A new ursane-type triterpenoid glycoside from Centella asiatica leaves modulates the production of nitric oxide and secretion of TNF-α in activated RAW 264.7 cells
    Nguyen Xuan Nhiem
    College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea
    Bioorg Med Chem Lett 21:1777-81. 2011
    ..7 cells. Asiaticoside G (1) potently inhibited the production of nitric oxide and tumor necrosis factor-α with inhibition rates of 77.3% and 69.0%, respectively, at the concentration of 100 μM...
  58. doi request reprint Dammarane-type saponins from the flower buds of Panax ginseng and their effects on human leukemia cells
    Huu Tung Nguyen
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Republic of Korea
    Bioorg Med Chem Lett 20:309-14. 2010
    ..3, 23.2, and 62.4microM. In addition, after the HL-60 cells were treated with these compounds, several apoptosis events, including chromatin condensation and increase in the population of sub-G1 hypodiploid cells, were observed...
  59. doi request reprint A new lupane-type triterpene from the seeds of Panax ginseng with its inhibition of NF-κB
    Jeong Ah Kim
    College of Pharmacy, Chungnam National University, Daejeon, 305 764, Korea
    Arch Pharm Res 35:647-51. 2012
    ..Both compounds 1 and 2 were inhibited NF-κB activity in HepG2 cells by decreasing the cellular concentrations of inflammatory factors iNOS and COX2...
  60. doi request reprint Anti-inflammatory and PPAR transactivational effects of secondary metabolites from the roots of Asarum sieboldii
    Tran Hong Quang
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Republic of Korea
    Bioorg Med Chem Lett 22:2527-33. 2012
    ..9 μM, respectively. These results provide a scientific support for the use of the roots of A. sieboldii and warrant further studies to develop new agents for the prevention and treatment of the inflammatory and metabolic diseases...
  61. ncbi request reprint Triterpenoid saponins of Pulsatilla koreana root have inhibition effects of tumor necrosis factor-α secretion in lipopolysaccharide-induced RAW264.7 cells
    Wei Li
    College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea
    Chem Pharm Bull (Tokyo) 61:471-6. 2013
    ..32 and 0.65 µm. Compounds 1-4, 7 and 10-13 exhibited inhibitory effects with inhibition rates up to 41.55-73.76% at a concentration of 5 µm, respectively...
  62. doi request reprint Chemical constituents of the rhizomes of Hedychium coronarium and their inhibitory effect on the pro-inflammatory cytokines production LPS-stimulated in bone marrow-derived dendritic cells
    Phan Van Kiem
    Institute of Marine Biochemistry, Vietnam Academy of Science and Technology VAST, 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam
    Bioorg Med Chem Lett 21:7460-5. 2011
    ..19±0.11 to 10.38±2.34 μM. The remains of compounds showed inactivity or due to cytotoxicity. These results warrant further studies concerning the potential anti-inflammatory benefits of labdane-type diterpenes from H. coronarium...
  63. doi request reprint Isoconiferoside, a new phenolic glucoside from seeds of Panax ginseng
    Jeong Ah Kim
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    Molecules 16:6577-81. 2011
    ..The structure was determined to be 9-O-[β-D-glucopyranosyl-(1 --> 6)-β-D-glucopyranosyl]-trans-coniferyl alcohol based on spectroscopic analyses (1H- and 13C-NMR, DEPT, COSY, HMQC, and HMBC) and acid hydrolysis...
  64. ncbi request reprint New neolignan component from Camellia amplexicaulis and effects on osteoblast differentiation
    Nguyen Huu Tung
    College of Pharmacy, Chungnam National University, Daejeon, Korea
    Chem Pharm Bull (Tokyo) 57:65-8. 2009
    ..Among them, compounds 2, 3, 4, and 6 significantly (p<0.05) increased the alkaline phosphatase activity and the mineralization of the nodules of the MC3T3-E1 osteoblastic cells compared to those of the control...
  65. doi request reprint A new flavan-3-ol and the anti-inflammatory effect of flavonoids from the fruit peels of Wisteria floribunda
    Bui Huu Tai
    College of Pharmacy, Chungnam National University, Daejeon, 305 764, Korea
    J Asian Nat Prod Res 13:1061-8. 2011
    ..1 μm...
  66. doi request reprint Phenolic constituents of Amorpha fruticosa that inhibit NF-kappaB activation and related gene expression
    Nguyen Tien Dat
    Molecular Cancer Research Center, Korean Research Institute of Biosciences and Biotechnology, Daejeon, Korea
    J Nat Prod 71:1696-700. 2008
    ..Further investigations showed that compounds 1, 5, and 6 blocked NF-kappaB/DNA binding activity and suppressed the expression of NF-kappaB target genes...
  67. doi request reprint Chrysoeriol isolated from the leaves of Eurya ciliata stimulates proliferation and differentiation of osteoblastic MC3T3-E1 cells
    Bui Huu Tai
    Chungnam National University, Daejeon, South Korea
    J Asian Nat Prod Res 11:817-23. 2009
    ..05). Our data indicate that the enhancement of osteoblast function by 1 may be useful in the prevention of osteoporosis...
  68. doi request reprint Inhibitory activity of Plantago major L. on angiotensin I-converting enzyme
    Nguyen Xuan Nhiem
    College of Pharmacy, Chungnam National University, Daejeon, Korea
    Arch Pharm Res 34:419-23. 2011
    ..06 ± 0.21% at a concentration of 100 μM. Compounds 2 and 8 exhibited weak activities. These results suggest that compound 1 might contribute to the ability of P. major to inhibit the activity of angiotensin I- converting enzyme...
  69. ncbi request reprint Chemical constituents and antioxidant activity of Ficus callosa
    Phan Van Kiem
    Institute of Marine Biochemistry, Vietnam Academy of Science and Technology VAST, 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam
    Nat Prod Commun 6:159-62. 2011
    ..6 microM trolox equivalents at the concentration of 2 microM. At this concentration, compounds 4-7 and 9-12 showed significant antioxidant activity with ranging of 2.1-6.1 microM trolox equivalents...
  70. doi request reprint A new diarylheptanoid from the bark of Alnus japonica
    Nguyen Huu Tung
    College of Pharmacy, Chungnam National University, Daejeon, South Korea
    J Asian Nat Prod Res 12:921-4. 2010
    ..Their structures were elucidated on the basis of extensive spectroscopic evidence. The new compound 1 showed significant hepatoprotective activity on the basis of t-butylhydroperoxide-induced hepatocyte injury in vitro assay...
  71. doi request reprint Dammarane-type saponins from the flower buds of Panax ginseng and their intracellular radical scavenging capacity
    Nguyen Huu Tung
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    J Agric Food Chem 58:868-74. 2010
    ..These results warrant further studies concerning the potential of saponin extracts of P. ginseng flowers for functional foods...
  72. doi request reprint Hypoxia-inducible factor-1 inhibitory benzofurans and chalcone-derived diels-alder adducts from Morus species
    Nguyen Tien Dat
    Center for Molecular Cancer Research, Korean Research Institute of Biosciences and Biotechnology, Daejeon, Korea
    J Nat Prod 72:39-43. 2009
    ..Furthermore, these compounds were also active against hypoxia-induced vascular endothelial growth factor (VEGF) secretion in Hep3B cells...
  73. doi request reprint Cucurbitane-type triterpene glycosides from the fruits of Momordica charantia
    Xuan Nhiem Nguyen
    Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology VAST, 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam
    Magn Reson Chem 48:392-6. 2010
    ....
  74. doi request reprint Anti-inflammatory and PPAR transactivational effects of components from the stem bark of Ginkgo biloba
    Nguyen Thi Thanh Ngan
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    J Agric Food Chem 60:2815-24. 2012
    ..biloba stem bark for the prevention and treatment of inflammatory and metabolic diseases. Moreover, these data provide the rationale for further studies of the potential of G. biloba stem bark in functional foods...
  75. doi request reprint Multiple component quantitative analysis for the pattern recognition and quality evaluation of Kalopanacis Cortex using HPLC
    Chu Van Men
    College of Pharmacy, Chungnam National University, Daejeon, 305 764, Korea
    Arch Pharm Res 34:2065-71. 2011
    ..The results indicated that the method was suitable for the quantitative analysis of liriodendrin and the quality evaluation of KC...
  76. doi request reprint Chemical-based species classification of rhubarb using simultaneous determination of five bioactive substances by HPLC and LDA analysis
    Chu Vanmen
    College of Pharmacy, Chungnam National University, Daejeon, Korea
    Phytochem Anal 23:359-64. 2012
    ..There are several species that are often misidentified as rhubarb. Taxonomical identification of these various species can be challenging. We have developed an HPLC-based species classification to identify rhubarb...
  77. ncbi request reprint Components from the steamed leaves of Acanthopanax koreanum and their effects on PPAR activity in HepG2 cells
    Jeong Ah Kim
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    Nat Prod Commun 6:1233-6. 2011
    ..In this study, the three ent-kaurane diterpenes (1-3) were found to up-regulate PPARbeta/delta and PPARgamma activities, whereas they did not activate PPARalpha activity...
  78. ncbi request reprint Achiral and chiral determination of benzophenanthridine alkaloids from methanol extracts of Hylomecon species by high performance liquid chromatography
    Jong Seong Kang
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    Arch Pharm Res 26:114-9. 2003
    ..H. hylomeconoides showed higher level of 1 and 3 in compared with H. vernale, especially in root samples permitting the possibility of chemical discrimination between two species...
  79. doi request reprint Racemization of 6-methoxydihydrosanguinarine in methanol investigated by enantioselective dynamic HPLC
    Enqi Wu
    College of Pharmacy, Chungnam National University, Yooseong Ku, Daejeon 305 764, Republic of Korea
    J Pharm Biomed Anal 51:103-6. 2010
    ..Therefore, the variety of biological activities exhibited by MS may be attributable to a combination of (+)-MS, (-)-MS, and sanguinarine...
  80. pmc An evaluation of the RNase H inhibitory effects of Vietnamese medicinal plant extracts and natural compounds
    Bui Huu Tai
    College of Pharmacy, Chungnam National University, Daejeon, Korea
    Pharm Biol 49:1046-51. 2011
    ..Thus, developing specific, potent antiviral drugs that restrain infection by human immunodeficiency virus type 1 (HIV-1), a major cause of AIDS, remains an urgent priority...
  81. ncbi request reprint Oleanolic triterpene saponins from the roots of Panax bipinnatifidus
    Huu Tung Nguyen
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    Chem Pharm Bull (Tokyo) 59:1417-20. 2011
    ..Ten oleanane-type saponins (1-10), including three new compounds, namely bifinosides A-C (1-3), were isolated from the roots of Panax bipinnatifidus SEEM. Their structures were elucidated on the basis of chemical and spectroscopic methods...
  82. doi request reprint Protective effect of components isolated from Lindera erythrocarpa against oxidative stress-induced apoptosis of H9c2 cardiomyocytes
    Jeong Ah Kim
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    Phytother Res 25:1612-7. 2011
    ..These effects were concentration-dependent. The three inhibitory compounds were identified as (-)-epicatechin, avicularin and quercitrin by spectroscopic techniques including one- and two-dimensional NMR and mass spectroscopy...
  83. ncbi request reprint Triterpenoids from Acanthopanax koreanum root and their inhibitory activities on NFAT transcription
    Xing Fu Cai
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    Arch Pharm Res 27:825-8. 2004
    ..Of these compounds, impressic acid (1) exhibited a potent inhibitory activity against NFAT transcription factor (IC50: 12.65 microM)...
  84. ncbi request reprint Inhibitory effect of kaurane type diterpenoids from Acanthopanax koreanum on TNF-alpha secretion from trypsin-stimulated HMC-1 cells
    Xing Fu Cai
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    Arch Pharm Res 26:731-4. 2003
    ..Among the isolated compounds 16alphaH,17-isovaleryloxy-ent-kauran-19-oic acid (1) showed potent inhibitory activity (IC50 value, 16.2 uM) on TNF-alpha secretion from HMC-1, a trypsin-stimulated human leukemic mast cell line...
  85. ncbi request reprint Diterpenoids with inhibitory activity against NFAT transcription factor from Acanthopanax koreanum
    Xing Fu Cai
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    Phytother Res 18:677-80. 2004
    ..7 microm) against NFAT transcription factor. However, sumogaside, 16alpha-hydroxy-ent-kauran-19-oic acid and paniculosides IV containing a hydroxy group at C-16 or a glycoside at C-4 carboxyl acid showed no activity...
  86. ncbi request reprint Quinolone alkaloids with inhibitory activity against nuclear factor of activated T cells from the fruits of Evodia rutaecarpa
    Hui Zi Jin
    Anticancer Research Laboratory, Korea Research Institute of Bioscience and Biotechnology, Yuseong, Daejeon, Korea
    Biol Pharm Bull 27:926-8. 2004
    ..These N-methylated compounds showed comparable inhibitory effects against NF-kappa B activity. However, quinolone alkaloids without the N-methyl group showed a more selective inhibition of NFAT activity...
  87. doi request reprint Oleanane-type triterpene saponins from the bark of Aralia elata and their NF-κB inhibition and PPAR activation signal pathway
    Nguyen Xuan Nhiem
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Republic of Korea
    Bioorg Med Chem Lett 21:6143-7. 2011
    ..Among of them, compounds 4-6 significantly increased PPARγ transactivation. However, compounds 4-6 did not activate in any other PPAR subtypes...
  88. doi request reprint Discrimination of cinnamon bark and cinnamon twig samples sourced from various countries using HPLC-based fingerprint analysis
    Yan Ding
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Republic of Korea
    Food Chem 127:755-60. 2011
    ..Therefore, an HPLC fingerprint in combination with pattern analysis provides a very flexible and reliable method for quality assessment of herbal drugs...
  89. ncbi request reprint Oleanane triterpenoids with inhibitory activity against NFAT transcription factor from Liquidambar formosana
    Nguyen Tien Dat
    College of Pharmacy, Chungnam National University, Daejeon, Korea
    Biol Pharm Bull 27:426-8. 2004
    ..Of these compounds, 3alpha-acetoxy-25-hydroxy-olean-12-en-28-oic acid (IC50: 4.63 microM) and lantanolic acid (IC50: 12.62 microM) exhibited strong inhibitory activity against the NFAT transcription factor...
  90. ncbi request reprint Inhibitory lignans against NFAT transcription factor from Acanthopanax koreanum
    Xing Fu Cai
    College of Pharmacy, Chungnam National University, Daejon 305 764, Korea
    Arch Pharm Res 27:738-41. 2004
    ....
  91. ncbi request reprint New inhibitor against nuclear factor of activated T cells transcription from Ribes fasciculatum var. chinense
    Nguyen Tien Dat
    College of Pharmacy, Chungnam National University, Deajeon, Korea
    Chem Pharm Bull (Tokyo) 53:114-7. 2005
    ..Compound 1 showed a potent inhibitory activity (IC50=15.6 microM), while compounds 4, 5 and 9 showed moderate inhibitory activity (IC50 22.4, 24.5 and 25.7 microM, respectively)...
  92. ncbi request reprint Distribution of (-)-yatein in Cupressaceae family analysed by high performance liquid chromatography
    Gwi Seo Hwang
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    Arch Pharm Res 27:35-9. 2004
    ..In general, the yatein content in the leaves was much higher than that in the twigs. This method could be applied for the quality control of (-)-yatein in the plants belonging to Cupressaceae family...
  93. ncbi request reprint Inhibitory effect of TNF-alpha and IL-8 secretion by pimarane-type diterpenoids from Acanthopanax koreanum
    Xing Fu Cai
    College of Pharmacy, Chungnam National University, Daejeon, Korea
    Chem Pharm Bull (Tokyo) 51:605-7. 2003
    ....
  94. ncbi request reprint Capillary electrophoretic method for the determination of diterpenoid isomers in Acanthopanax species
    Nguyen Thi Phuong
    College of Pharmacy, Chungnam National University, Yu seong Gu, Daejeon 305764, Republic of Korea
    J Pharm Biomed Anal 40:56-61. 2006
    ..albeofructus. The contents of diterpenoids in association with lignans and triterpenoids in the Acanthopanax species could provide a chemotaxonomical index able to be used in the classification and discrimination of the species...
  95. ncbi request reprint New sesquiterpene dimers from Inula britannica inhibit NF-kappaB activation and NO and TNF-alpha production in LPS-stimulated RAW264.7 cells
    Hui Zi Jin
    Anticancer Research Laboratory, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea
    Planta Med 72:40-5. 2006
    ..Consistent with their inhibitory effect on NF-kappaB activation, compounds and also strongly inhibited the production of NO and TNF-alpha in the LPS-stimulated RAW264.7 cells with IC50 values in the range of 2 microM...
  96. ncbi request reprint Quantitative determination of psoralen and angelicin from some medicinal herbs by high performance liquid chromatography
    Nguyen Thanh Dong
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    Arch Pharm Res 26:516-20. 2003
    ..The variation of the concentration of psoralen and angelicin was wide between different species. The seeds of Psoralea corylifolia showed the highest contents of psoralen (7.8 mg/g) and angelicin (2.3 mg/g) among the tested herbs...
  97. doi request reprint Terpene and phenolic constituents of Lactuca indica L
    Ki Hyun Kim
    Natural Products Laboratory, College of Pharmacy, Sungkyunkwan University, Suwon 440 746, Korea
    Arch Pharm Res 31:983-8. 2008
    ..Compounds 1-3, 5, and 7-12 were isolated for the first time from this plant source. The isolated compounds were tested for cytotoxicity against four human tumor cell lines in vitro using a Sulforhodamin B bioassay...
  98. ncbi request reprint Monoamine oxidase inhibitory coumarin from Zanthoxylum schinifolium
    Young Su Jo
    College of Pharmacy, Chungnam National University, Daejeon, Korea
    Planta Med 68:84-5. 2002
    ..2 microM. The MAO-A (IC(50) value, 5.7 microM) sensitivity to lacinartin was greater than that of MAO-B (IC(50) value, 28.6 microM). An enzyme kinetic study revealed that lacinartin inhibited MAO activity by a non-competitive mode...
  99. doi request reprint Attenuation of experimental murine colitis by acanthoic acid from Acanthopanax koreanum
    Ok Hwa Kang
    Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University and Wonkwang Oriental Medicines Research Institute, Iksan 570 749, Korea
    Arch Pharm Res 33:87-93. 2010
    ..These results suggest that AA exerts beneficial effects in experimental colitis, and therefore we propose that this compound may have therapeutic implications for ulcerative colitis...
  100. doi request reprint Four new chalcones from Erythrina abyssinica
    Long Cui
    Korea Research Institute of Bioscience and Biotechnology KRIBB, Daejeon, Korea
    Planta Med 74:422-6. 2008
    ..The compounds 1, 3, and 4 were found to exhibit moderate cytotoxic activity against the human colorectal cancer cell line (Caco2) with IC (50) values of 13.3, 15.1, and 11.1 microM, respectively...
  101. doi request reprint Stimulation of osteoblastic differentiation and inhibition of interleukin-6 and nitric oxide in MC3T3-E1 cells by pomegranate ethanol extract
    Young Ho Kim
    College of Pharmacy, Chungnam National University, Daejeon, Korea
    Phytother Res 23:737-9. 2009
    ..Treatment with PE (10 approximately 50 microg/ml) decreased the TNF-alpha (10(-10) M)-induced production of IL-6 and NO in osteoblasts...