Nam Sook Kang
Affiliation: Chungnam National University
Jannat S, Balupuri A, Ali M, Hong S, Choi C, Choi Y, et al
. Inhibition of β-site amyloid precursor protein cleaving enzyme 1 and cholinesterases by pterosins via a specific structure-activity relationship with a strong BBB permeability. Exp Mol Med. 2019;51:12 pubmed publisher
..Conclusively, our study suggested that several pterosins are potential scaffolds for multitarget-directed ligands (MTDLs) for AD therapeutics. ..
Lee M, Balupuri A, Jung Y, Choi S, Lee A, Cho Y, et al
. Design of a Novel and Selective IRAK4 Inhibitor Using Topological Water Network Analysis and Molecular Modeling Approaches. Molecules. 2018;23: pubmed publisher
..Pharmacophoric features of the hit molecules were hybridized to design a novel compound that inhibited IRAK4 at low nanomolar levels in the in vitro assay. ..
Balupuri A, Choi K, Kang N. Computational insights into the role of α-strand/sheet in aggregation of α-synuclein. Sci Rep. 2019;9:59 pubmed publisher
..Findings of this study provide novel insights into possible mechanism of α-synuclein aggregation and promising neuroprotective strategy that could aid alleviate PD and its symptoms. ..
Kim J, Jung S, Kang S, Ryu C, Kang N. The discovery of aurora kinase inhibitor by multi-docking-based virtual screening. Int J Mol Sci. 2014;15:20403-12 pubmed publisher
..Based on the explored fragment scaffold, we selected two compounds in our synthesized library and validated the biological activity against Aurora kinase. ..
Jang W, Kim J, Son H, Park S, Cho Y, Koo T, et al
. Discovery of Tyk2 inhibitors via the virtual site-directed fragment-based drug design. Bioorg Med Chem Lett. 2015;25:3947-52 pubmed publisher
..In conclusion, the potency of compound 12 to interrupt the signal transmission of Tyk2/STAT3 appeared to be equivalent or superior to that of the reference compound. ..
Balupuri A, Lee M, Chae S, Jung E, Yoon W, Kim Y, et al
. Discovery and optimization of ATX inhibitors via modeling, synthesis and biological evaluation. Eur J Med Chem. 2018;148:397-409 pubmed publisher
..23â€¯nM, FS-3 and 2.18â€¯nM, bis-pNPP). Furthermore, pharmacokinetic properties of this most promising compound are profiled. ..
Kim M, Kim D, Kang N, Kim J. The core regulatory network in human cells. Biochem Biophys Res Commun. 2017;484:348-353 pubmed publisher
..Overall, our study provides an insight into how all human cells share a common function and generate tissue-specific functional traits by transmitting and processing information through regulatory network. ..
Balupuri A, Lee D, Lee M, Chae S, Jung E, Kim Y, et al
. Design, synthesis, docking and biological evaluation of 4-phenyl-thiazole derivatives as autotaxin (ATX) inhibitors. Bioorg Med Chem Lett. 2017;27:4156-4164 pubmed publisher