Sang Hun Jung

Summary

Affiliation: Chungnam National University
Country: Korea

Publications

  1. ncbi request reprint Enantioselective preparation of metoprolol and its major metabolites
    S H Jung
    College of Pharmacy, Chungnam National University, Taejon, Korea
    Arch Pharm Res 23:226-9. 2000
  2. ncbi request reprint Evaluation of the role of imidazolidinone motif of antineoplastic 4-phenyl-1-arylsulfonylimidazolidinones using 4-phenyl-2-arylsulfonyloxazolines
    S H Jung
    College of Pharmacy, Chungnam National University, Taejon, Korea
    Arch Pharm Res 24:499-502. 2001
  3. ncbi request reprint Synthesis and cytotoxic activity of 1-(1-benzoylindoline-5-sulfonyl)-4-phenylimidazolidinones
    Sang Hun Jung
    College of Pharmacy, Chungnam National University, Taejon 305 764, Korea
    Arch Pharm Res 27:478-84. 2004
  4. ncbi request reprint Structural requirement of isoflavonones for the inhibitory activity of interleukin-5
    Sang Hun Jung
    College of Pharmacy, Chungnam National University, Daejeon 305 764, South Korea
    Eur J Med Chem 38:537-45. 2003
  5. ncbi request reprint The role of the hydrophobic group on ring A of chalcones in the inhibition of interleukin-5
    Hyun Mo Yang
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    Arch Pharm Res 29:969-76. 2006
  6. ncbi request reprint Novel benzo[d]imidazole-2(3H)-thiones as potent inhibitors of the alpha-melanocyte stimulating hormone induced melanogenesis in melanoma B16 cells
    Jee Hyun Lee
    College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, Daejeon, Korea
    Chem Pharm Bull (Tokyo) 58:918-21. 2010
  7. doi request reprint Identification of novel chromenone derivatives as interleukin-5 inhibitors
    Eeda Venkateswararao
    College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, Daejeon 305 764, Republic of Korea
    Eur J Med Chem 59:31-8. 2013
  8. ncbi request reprint Structural requirement of chalcones for the inhibitory activity of interleukin-5
    Hyun Mo Yang
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Republic of Korea
    Bioorg Med Chem 15:104-11. 2007
  9. doi request reprint Inhibitory effect of novel tetrahydropyrimidine-2(1H)-thiones on melanogenesis
    P Thanigaimalai
    College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, Daejeon 305 764, Republic of Korea
    Bioorg Med Chem 18:1135-42. 2010
  10. ncbi request reprint Recognition of the importance of imidazolidinone motif for cytotoxicity of 4-phenyl-1-arylsulfonylimidazolidinones using thiadiazolidine-1,1-dioxide analogs
    Il Whan Kim
    College of Pharmacy, Chungnam National University, Daejeon, Korea
    Arch Pharm Res 25:421-7. 2002

Collaborators

  • Won Jea Cho
  • Jong Seong Kang
  • Jae Chun Ryu
  • Jin Tae Hong
  • Young Ho Kim
  • Sang Chul Shin
  • Jae Kyung Jung
  • Jong Keun Son
  • Byung Hak Kim
  • Joo Young Lee
  • Eun Yi Moon
  • K L Park
  • K H Kim
  • H S Lee
  • H K Lim
  • Hyo Sang Kim
  • Sang Han Lee
  • W S Kwak
  • Ki Cheul Lee
  • Eeda Venkateswararao
  • Vinay K Sharma
  • Eunmiri Roh
  • Pillaiyar Thanigaimalai
  • P Thanigaimalai
  • Seong Cheol Bang
  • Pullareddy Boggu
  • Manoj Manickam
  • Bang Yeon Hwang
  • Hyun Mo Yang
  • Cheonik Joo
  • Hye Rim Shin
  • Sang Bae Han
  • Cheong Yong Yun
  • Sun Hong Park
  • Jieun Yun
  • Vinay Kumar Sharma
  • Santhosh Subramanian
  • Niti Sharma
  • Min Seok Kim
  • Enqi Wu
  • Mi Kyeong Kim
  • Hyun Hee Seo
  • Da Young Yoon
  • Il Whan Kim
  • Hyoeun Shin
  • Nam Doo Kim
  • Do Hyung Ki
  • Jong Suep Baek
  • Cheong Weon Cho
  • Chu Van Men
  • Jianbo Chen
  • Wonjae Lee
  • Guang Hua Xu
  • Tuan Anh Le Hoang
  • Le Tuan Anh Hoang
  • K H Cho
  • In Jeong Lee
  • Soo Hyun Cho
  • Gyu Yong Song
  • Son Hyok Kwak
  • Thanigaimalai Pillaiyar
  • Jang Su Jeon
  • Sang Kyum Kim
  • Dajin Kwak
  • Hitesh B Jalani
  • Seung Il Baek
  • Seon Mi Ko
  • Seung Deok Hong
  • Tae Young Heo
  • Chang Woo Lee
  • Ji Ho Lim
  • Young Wook Noh
  • Hyun Chan Jung
  • Min Sik Kyung
  • Eeda Venkateswara Rao
  • Hoang Le Tuan Anh
  • Eeda Vekateswara Rao
  • Nam Soo Kim
  • Hongmei Zhu
  • Yu Seon Jang
  • Sang Yoon Nam
  • Jeong Ah Kwak
  • Jun Ho Yun
  • So Young Kim
  • Jeong Ah Kim
  • Jung Hun Ju
  • Hwi yeol Yun
  • Ki Cheol Lee
  • S M Choo
  • J R Kim

Detail Information

Publications53

  1. ncbi request reprint Enantioselective preparation of metoprolol and its major metabolites
    S H Jung
    College of Pharmacy, Chungnam National University, Taejon, Korea
    Arch Pharm Res 23:226-9. 2000
    ....
  2. ncbi request reprint Evaluation of the role of imidazolidinone motif of antineoplastic 4-phenyl-1-arylsulfonylimidazolidinones using 4-phenyl-2-arylsulfonyloxazolines
    S H Jung
    College of Pharmacy, Chungnam National University, Taejon, Korea
    Arch Pharm Res 24:499-502. 2001
    ..This result might indicate that the imidazolidinone ring of 1 have the other roles for the activity as an essential structural motif in addition to conformational contribution...
  3. ncbi request reprint Synthesis and cytotoxic activity of 1-(1-benzoylindoline-5-sulfonyl)-4-phenylimidazolidinones
    Sang Hun Jung
    College of Pharmacy, Chungnam National University, Taejon 305 764, Korea
    Arch Pharm Res 27:478-84. 2004
    ....
  4. ncbi request reprint Structural requirement of isoflavonones for the inhibitory activity of interleukin-5
    Sang Hun Jung
    College of Pharmacy, Chungnam National University, Daejeon 305 764, South Korea
    Eur J Med Chem 38:537-45. 2003
    ..However the glucopyranosyl moiety of sophoricoside is not an essential motif for the activity...
  5. ncbi request reprint The role of the hydrophobic group on ring A of chalcones in the inhibition of interleukin-5
    Hyun Mo Yang
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    Arch Pharm Res 29:969-76. 2006
    ..The optimum alkoxy group in ring A of 2 should be one that provides the cLog P of 2 in the range of 4.22 to 4.67...
  6. ncbi request reprint Novel benzo[d]imidazole-2(3H)-thiones as potent inhibitors of the alpha-melanocyte stimulating hormone induced melanogenesis in melanoma B16 cells
    Jee Hyun Lee
    College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, Daejeon, Korea
    Chem Pharm Bull (Tokyo) 58:918-21. 2010
    ..Among all thiones 5a-e, the compound 5d strongly inhibited the formation of melanin with IC(50) value of 1.3 microM...
  7. doi request reprint Identification of novel chromenone derivatives as interleukin-5 inhibitors
    Eeda Venkateswararao
    College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, Daejeon 305 764, Republic of Korea
    Eur J Med Chem 59:31-8. 2013
    ..The electron withdrawing substituents at position 4 of phenyl ring of 5 enhances the activity possibly due to an increase in the strength of hydrogen bonding property of hydroxyl group of allylic alcohol moiety...
  8. ncbi request reprint Structural requirement of chalcones for the inhibitory activity of interleukin-5
    Hyun Mo Yang
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Republic of Korea
    Bioorg Med Chem 15:104-11. 2007
    ..4) Electron withdrawing groups with hydrogen acceptor property at 4-position of B ring enhance the activity and quantitative structure-activity relationship of 2 regarding these substituents was determined...
  9. doi request reprint Inhibitory effect of novel tetrahydropyrimidine-2(1H)-thiones on melanogenesis
    P Thanigaimalai
    College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, Daejeon 305 764, Republic of Korea
    Bioorg Med Chem 18:1135-42. 2010
    ..76 microM) exhibited potent inhibitory effect against alpha-MSH-induced melanin production. Compounds 3 inhibit the biosynthesis of tyrosinase without affecting its catalytic activity in melanogenesis...
  10. ncbi request reprint Recognition of the importance of imidazolidinone motif for cytotoxicity of 4-phenyl-1-arylsulfonylimidazolidinones using thiadiazolidine-1,1-dioxide analogs
    Il Whan Kim
    College of Pharmacy, Chungnam National University, Daejeon, Korea
    Arch Pharm Res 25:421-7. 2002
    ..Therefore the planarity of imidazolidinone ring of 1 should be an important factor for their cytotoxic activity...
  11. ncbi request reprint The role of alkoxy group on the A ring of isoflavones in the inhibition of interleukin-5
    Hyun Mo Yang
    College of Pharmacy, Chungnam National University, Daejeon, Korea
    Arch Pharm Res 30:950-4. 2007
    ..The optimum alkoxy group should be one that provides cLog P values of compounds 2 in the range of 4.13 to 4.39...
  12. doi request reprint Chiral HPLC studies on chemical behavior of 6-methoxydihydrosanguinarine in alcoholic solvent system
    Chu Van Men
    College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, Daejeon 305 764, Republic of Korea
    J Pharm Biomed Anal 56:479-83. 2011
    ..Thus, sanguinarine has a pivotal role in the chemical behavior of alkoxysanguinarine in alcoholic solvents. Such possible variation of the structure of sanguinarine may be the source of its diverse biological activities...
  13. doi request reprint Refinement of the pharmacophore of 3,4-dihydroquinazoline-2(1H)-thiones for their anti-melanogenesis activity
    Pillaiyar Thanigaimalai
    College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, Daejeon 305 764, Republic of Korea
    Bioorg Med Chem Lett 20:4771-3. 2010
    ..Thus, the pharmacophore of 3,4-dihydroquinazoline-2(1H)-thiones for their anti-melanogenesis activity could be refined as 3-hydrophobic substituted quinazolinethione...
  14. doi request reprint Structural requirement(s) of N-phenylthioureas and benzaldehyde thiosemicarbazones as inhibitors of melanogenesis in melanoma B 16 cells
    P Thanigaimalai
    College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, Daejeon 305 764, South Korea
    Bioorg Med Chem Lett 20:2991-3. 2010
    ....
  15. doi request reprint Structure--activity relationship studies of novel arylsulfonylimidazolidinones for their anticancer activity
    Santhosh Subramanian
    College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, Daejeon 305 764, Republic of Korea
    Eur J Med Chem 46:3258-64. 2011
    ....
  16. ncbi request reprint Evaluation of anticancer activity of 4-vinyl-1-arylsulfonylimidazolidinones
    Son Hyok Kwak
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    Arch Pharm Res 29:721-7. 2006
    ..Therefore phenyl at 4-position should be the optimum planar motif for the activity of 1...
  17. ncbi request reprint Identification of indoline-2-thione analogs as novel potent inhibitors of α-melanocyte stimulating hormone induced melanogenesis
    Pillaiyar Thanigaimalai
    College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, Daejeon, Korea
    Chem Pharm Bull (Tokyo) 59:1285-8. 2011
    ..In addition, the hydrophobic substituents of 3 were better than the hydrophilic one. However, conversion of thione (-C=S, 3) to thiol (-C-SH, 4) led to decrease in the potency...
  18. doi request reprint Design and synthesis of novel chromenone derivatives as interleukin-5 inhibitors
    Eeda Venkateswararao
    College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, Daejeon 305 764, Republic of Korea
    Bioorg Med Chem 21:2543-50. 2013
    ..Disappearance of IL-5 inhibitory activity upon saturation of chroman-4-one of 9 to chroman-4-ones 10 proves the critical importance of planar chromen-4-one unit of this scaffold in the IL-5 inhibition...
  19. doi request reprint Study on anti-proliferative effect of benzoxathiole derivatives through inactivation of NF-κB in human cancer cells
    Eeda Venkateswararao
    College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, Daejeon 305 764, Republic of Korea
    Bioorg Med Chem Lett 22:4523-7. 2012
    ..From the SAR results, 2-phenylimino-6,7-dihydrobenzo[d][1,3]oxathiol-4(5H)-one was identified as the lead scaffold for investigating new anticancer agent through inactivation of NF-κB...
  20. ncbi request reprint A novel stereo-selective sulfonylurea, 1-[1-(4-aminobenzoyl)-2,3-dihydro-1H-indol-6-sulfonyl]-4-phenyl-imidazolidin-2-one, has antitumor efficacy in in vitro and in vivo tumor models
    Chang Woo Lee
    Biopotency Evaluation Laboratory, Korea Research Institute of Bioscience and Biotechnology, 305 333, Taejon, South Korea
    Biochem Pharmacol 64:473-80. 2002
    ..These results suggest that DW2282, an S-isomer, could be a novel antitumor candidate with higher specificity and lower toxicity than other orally active sulfonylureas...
  21. doi request reprint Evaluation of 3,4-dihydroquinazoline-2(1H)-thiones as inhibitors of alpha-MSH-induced melanin production in melanoma B16 cells
    P Thanigaimalai
    College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, Daejeon 305 764, Republic of Korea
    Bioorg Med Chem 18:1555-62. 2010
    ..QNTs did not affect the catalytic activity of tyrosinase, but rather acted as an inhibitor of tyrosinase synthesis...
  22. doi request reprint Structure-activity relationship of naphthaldehydethiosemicarbazones in melanogenesis inhibition
    Pillaiyar Thanigaimalai
    College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, Daejeon 305 764, Republic of Korea
    Bioorg Med Chem Lett 22:886-9. 2012
    ..Conversely, concomitant substitutions decrease the inhibitory potency. In addition, the presence of sulfur in thiosemicarbazone is essential for the activity...
  23. doi request reprint Structural requirement of phenylthiourea analogs for their inhibitory activity of melanogenesis and tyrosinase
    Pillaiyar Thanigaimalai
    College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, Daejeon 305 764, Republic of Korea
    Bioorg Med Chem Lett 21:6824-8. 2011
    ....
  24. doi request reprint Structure-activity relationship study of arylsulfonylimidazolidinones as anticancer agents
    Vinay K Sharma
    College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, Daejeon 305 764, Republic of Korea
    Bioorg Med Chem Lett 21:6829-32. 2011
    ....
  25. ncbi request reprint Facile synthesis of trisaccharide moiety corresponding to antitumor activity in triterpenoid saponins isolated from Pullsatilla roots
    Seong Cheol Bang
    College of Pharmacy, Chungnam National University, Daejon 305 764, Korea
    Chem Pharm Bull (Tokyo) 55:1734-9. 2007
    ..As expected, the synthesized trisaccharide moiety 3 has no cytotoxicity (ED50: >100 microM) against three human cancer cell lines (A-549, SK-OV-3, and SK-MEL-2), respectively...
  26. doi request reprint The scope of thallium nitrate oxidative cyclization of chalcones; synthesis and evaluation of isoflavone and aurone analogs for their inhibitory activity against interleukin-5
    P Thanigaimalai
    College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, Daejeon 305 764, Republic of Korea
    Bioorg Med Chem 18:4441-5. 2010
    ..Among them, 5-(cyclohexylmethoxy)-3-(3,4,5-trimethoxyphenyl)-4H-chromen-4-one (2h, >100% inhibition at 50 microM, IC(50)=6.1 microM) gave most potent activity. All the aurones 3 were inactive...
  27. doi request reprint Structural requirements of (E)-6-benzylidene-4a-methyl-4,4a,5,6,7,8-hexahydronaphthalen-2(3H)-one derivatives as novel melanogenesis inhibitors
    Pillaiyar Thanigaimalai
    College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, Daejeon 305 764, South Korea
    Bioorg Med Chem Lett 21:1922-5. 2011
    ..The scaffold containing both rings A and B associated with α,β-unsaturated system connected to phenyl of 1 was essential for antimelanogenesis...
  28. doi request reprint Structural characteristics of thiosemicarbazones as inhibitors of melanogenesis
    Ki Cheul Lee
    College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, Daejeon 305 764, Republic of Korea
    Bioorg Med Chem Lett 20:6794-6. 2010
    ..Thus, hydrophobicity of the aryl or alkyl group on hydrazine of thiosemicarbazones is determinant factor for their inhibitory activity in melanogenesis rather than planarity...
  29. pmc cAMP-dependent activation of protein kinase A as a therapeutic target of skin hyperpigmentation by diphenylmethylene hydrazinecarbothioamide
    Hyoeun Shin
    College of Pharmacy, Chungbuk National University, Cheongju, Korea
    Br J Pharmacol 172:3434-45. 2015
    ..Here, we investigated the mechanism underlying the amelioration of skin hyperpigmentation by QNT 3-80...
  30. doi request reprint Enhanced transdermal drug delivery of zaltoprofen using a novel formulation
    Jong Suep Baek
    College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, Daejeon 305 764, South Korea
    Int J Pharm 453:358-62. 2013
    ..Also, there was a finding zaltoprofen gel containing T2 and oleic acid did not cause dermal irritations in an experimental animal. ..
  31. ncbi request reprint Enantioselective stabilization of inclusion complexes of metoprolol in carboxymethylated beta-cyclodextrin
    Kyung Lae Park
    College of Pharmacy, Chungnam National University, Daejeon 305 764, South Korea
    J Pharm Biomed Anal 27:569-76. 2002
    ..The NMR data suggested that the chiral side chain and the methoxyethyl moiety of MT are aligned in the deshielding zone, above and below the CMCD torus ring...
  32. doi request reprint Novel interleukin-5 inhibitors based on hydroxyethylaminomethyl-4H-chromen-4-one scaffold
    Cheonik Joo
    College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, Daejeon 305 764, Republic of Korea
    Bioorg Med Chem 20:5757-62. 2012
    ....
  33. doi request reprint Manassantin A inhibits cAMP-induced melanin production by down-regulating the gene expressions of MITF and tyrosinase in melanocytes
    Hwa Dong Lee
    College of Pharmacy, Yeungnam University, Kyungsan, Korea College of Pharmacy, Chungbuk National University, Cheongju, Korea College of Pharmacy, Chungnam National University, Daejeon, Korea
    Exp Dermatol 20:761-3. 2011
    ..This putative molecular mechanism of manassantin A in the inhibition of melanin production suggests its pharmacological potential in skin hyperpigmentation...
  34. doi request reprint Exploration of SAR for novel 2-benzylbenzimidazole analogs as inhibitor of transcription factor NF-κB
    Pullareddy Boggu
    College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, Daejeon, 34134, South Korea
    Arch Pharm Res . 2017
    ..However, hydrophobic (-OCH3 and -Cl) groups on phenyl ring B decrease the activity...
  35. doi request reprint Discovery of enantioselectivity of urea inhibitors of soluble epoxide hydrolase
    Manoj Manickam
    College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, Daejeon 34134, South Korea
    Eur J Med Chem 117:113-24. 2016
    ..All these ureas are proved to be specific inhibitor of sEH without inhibition against mEH. ..
  36. doi request reprint Exploration of 2-benzylbenzimidazole scaffold as novel inhibitor of NF-κB
    Pullareddy Boggu
    College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, Daejeon 305 764, Republic of Korea
    Bioorg Med Chem 24:1872-8. 2016
    ..4 μM) showed the best inhibition. The structure activity relationship revealed that 2-benzylbenzimidazole scaffold with hydrogen bonding acceptor on phenyl ring appears as a pharmacophore...
  37. doi request reprint IRAK4 as a molecular target in the amelioration of innate immunity-related endotoxic shock and acute liver injury by chlorogenic acid
    Sun Hong Park
    College of Pharmacy, Chungbuk National University, Cheongju 362 763, Korea
    J Immunol 194:1122-30. 2015
    ..Finally, this study suggests IRAK4 as a molecular target of CGA in the treatment of innate immunity-related shock and organ dysfunction following insult of various TLR pathogens from bacteria and viruses. ..
  38. doi request reprint MD-2 as the target of nonlipid chalcone in the inhibition of endotoxin LPS-induced TLR4 activity
    Eunmiri Roh
    College of Pharmacy, Chungbuk National University, Korea
    J Infect Dis 203:1012-20. 2011
    ..Taken together, this study assigns the chalcone structure as an LPS antagonist binding to MD-2 with therapeutic potential against inflammatory conditions...
  39. doi request reprint Design and synthesis of novel hydroxyalkylaminomethylchromones for their IL-5 inhibitory activity
    P Thanigaimalai
    College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, Daejeon 305 764, Republic of Korea
    Bioorg Med Chem 18:4625-9. 2010
    ....
  40. doi request reprint Exploration of benzamidochromenone derivatives with conformational restrictor as interleukin-5 inhibitors
    Eeda Venkateswararao
    College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, Daejeon 305 764, Republic of Korea
    Bioorg Med Chem 23:2498-504. 2015
    ..Therefore, these benzamidochromen-4-one analogs 8 are novel scaffold for finding potent interleukin-5 inhibitors...
  41. doi request reprint Synthesis and SAR studies of bis-chromenone derivatives for anti-proliferative activity against human cancer cells
    Eeda Venkateswararao
    College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, Daejeon 305 764, Republic of Korea
    Bioorg Med Chem Lett 24:5256-9. 2014
    ..However, saturation of one of chromenone to chromanone in bis-chromones decreased the activity. ..
  42. doi request reprint Anti-proliferative effect of chalcone derivatives through inactivation of NF-κB in human cancer cells
    Eeda Venkateswararao
    College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, Daejeon 305 764, South Korea
    Bioorg Med Chem 22:3386-92. 2014
    ..All the analogs (5b-r) maintained a good correlation between their NF-κB inhibition and anti-proliferative activity though the extent is not directly proportional to each other. ..
  43. doi request reprint Investigation of amino acid conjugates of (S)-1-[1-(4-aminobenzoyl)-2,3-dihydro-1H-indol-6-sulfonyl]-4-phenyl-imidazolidin-2-one (DW2282) as water soluble anticancer prodrugs
    Ki Cheul Lee
    College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, Daejeon 305 764, Republic of Korea
    Eur J Med Chem 80:439-46. 2014
    ..76%, 84.03%, 95.02% and 78.34%, respectively) to the parent drug in human plasma. In addition, the compounds 1e, 1g and 1j also showed good bioavailability profile along with potent in vivo anticancer activity...
  44. ncbi request reprint Importance of sulfonylimidazolidinone motif of 4-phenyl-1-arylsulfonylimidazolidinones for their cytotoxicity: synthesis of 2-benzoyl-4-phenyl[1,2,5]thiazolidine-1,1-dioxides and their cytotoxcity
    Il Whan Kim
    College of Pharmacy, Chungnam National University, Daejon 305 764, Korea
    Arch Pharm Res 26:9-14. 2003
    ..Such structural differentiation might result in the loss of activity. Therefore the inactivity of 2 and 3 could also be an indication for the necessity of planarity of imidazolidinone ring of 1 for their cytotoxic activity...
  45. doi request reprint Preformulation and formulation of newly synthesized QNT3-18 for development of a skin whitening agent
    Do Hyung Ki
    College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, Daejeon, South Korea
    Drug Dev Ind Pharm 39:526-33. 2013
    ..Taken together, this study suggests that topical formulations such as creams including SLNs with QNT3-18 might be appropriate carriers for skin whitening agents...
  46. doi request reprint A convenient preparation of a disaccharide motif and its role in the cytotoxicity of the triterpenoid saponin, alpha-hederin
    Seong Cheol Bang
    College of Pharmacy, Chungnam National University, Daejeon, 305 764, Korea
    Arch Pharm Res 31:555-61. 2008
    ..Thus the 3-O-alpha-L: -rhamnopyranosyl-(1-->2)-alpha-L: -arabinopyranoside could be used as a nontoxic carrier moiety to enhance the activity of anticancer drugs...
  47. doi request reprint Benzoxathiole derivative blocks lipopolysaccharide-induced nuclear factor-kappaB activation and nuclear factor-kappaB-regulated gene transcription through inactivating inhibitory kappaB kinase beta
    Byung Hak Kim
    College of Pharmacy, Chungbuk National University, Cheongju 361 763, Korea
    Mol Pharmacol 73:1309-18. 2008
    ..Furthermore, BOT-64 dose-dependently increases the survival rates of endotoxin LPS-shocked mice...
  48. ncbi request reprint Terpenoids and coumarins isolated from the fruits of Poncirus trifoliata
    Guang Hua Xu
    College of Pharmacy, Yeungnam University, Gyeongsan, Korea
    Chem Pharm Bull (Tokyo) 56:839-42. 2008
    ..The structures of the new compounds (1 - 5) were elucidated by interpretation of their spectroscopic data...
  49. doi request reprint Racemization of 6-methoxydihydrosanguinarine in methanol investigated by enantioselective dynamic HPLC
    Enqi Wu
    College of Pharmacy, Chungnam National University, Yooseong Ku, Daejeon 305 764, Republic of Korea
    J Pharm Biomed Anal 51:103-6. 2010
    ..Therefore, the variety of biological activities exhibited by MS may be attributable to a combination of (+)-MS, (-)-MS, and sanguinarine...
  50. ncbi request reprint Indepth diagnosis of a secondary clarifier by the application of radiotracer technique and numerical modeling
    H S Kim
    Department of Environmental Engineering, Chungnam National University, 220 Gungdong Yusunggu, Daejeon 305 764, Korea
    Water Sci Technol 54:83-92. 2006
    ..The program developed in this study shows the high potential to assist in the design and determination of optimal operating conditions to improve effluent quality in a full-scale secondary clarifier...
  51. ncbi request reprint Broiler litter supplementation improves storage and feed-nutritional value of sawdust-based spent mushroom substrate
    W S Kwak
    Animal Science, School of Life Resource and Environmental Sciences, College of Natural Sciences, Konkuk University, Danwol dong 322, Chung Ju, Chung Buk 380 701, Republic of Korea
    Bioresour Technol 99:2947-55. 2008
    ..In conclusion, blending 50% or more BL with SMS was effective for the short-term (1-wk) deepstack storage. For long-term (3-wk) storage of SMS, an ensiling method was effective with or without the addition of BL...
  52. ncbi request reprint Inhibition of prostalglandin E2 production by 2'-hydoxychalcone derivatives and the mechanism of action
    Y P Kim
    Laboratory of Pathophysiological Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Miyagi, Japan
    J Pharm Pharmacol 53:1295-302. 2001
    ....
  53. ncbi request reprint Reverse engineering of gene regulatory networks
    K H Cho
    College of Medicine, Seoul National University, Jongnogu, Seoul 110 799, South Korea
    IET Syst Biol 1:149-63. 2007
    ..In addition, recent developments in this field are introduced and discussions on the challenges and opportunities for future research are provided...