Eun Kyeong Jo
Affiliation: Chungnam National University
Kim S, Eun H, Jo E. Roles of Autophagy-Related Genes in the Pathogenesis of Inflammatory Bowel Disease. Cells. 2019;8: pubmed publisher
..Recent efforts based on direct targeting of ATGs and autophagy will further facilitate the development of new therapeutic opportunities for IBD. ..
Silwal P, Kim J, Yuk J, Jo E. AMP-Activated Protein Kinase and Host Defense against Infection. Int J Mol Sci. 2018;19: pubmed publisher
..Understanding how AMPK regulates host defenses will enable development of more effective host-directed therapeutic strategies against infectious diseases. ..
Paik S, Choi S, Lee K, Back Y, Son Y, Jo E, et al
. Mycobacterium tuberculosis acyl carrier protein inhibits macrophage apoptotic death by modulating the reactive oxygen species/c-Jun N-terminal kinase pathway. Microbes Infect. 2018;: pubmed publisher
..smegmatis. Moreover, recombinant AcpM enhanced intracellular survival of Mtb H37Rv. Taken together, these results indicate that AcpM plays a role as a virulence factor by modulating host cell apoptosis during mycobacterial infection. ..
Jo E, Kanegane H, Nonoyama S, Tsukada S, Lee J, Lim K, et al
. Characterization of mutations, including a novel regulatory defect in the first intron, in Bruton's tyrosine kinase gene from seven Korean X-linked agammaglobulinemia families. J Immunol. 2001;167:4038-45 pubmed
..Precise definition of the regulatory defect in the Btk intron 1 may provide valuable clues toward elucidating the pathogenesis of X-linked agammaglobulinemia. ..
Lee G, Lee H, Kim T, Kim J, Sohn K, Jo E. Mycobacterium fortuitum induces A20 expression that impairs macrophage inflammatory responses. Pathog Dis. 2016;74: pubmed publisher
..Taken together, these results suggest that MF-induced activation of host proinflammatory responses is negatively regulated through TLR2-dependent A20 expression. ..
Jin H, Kim T, Jo E. Emerging roles of orphan nuclear receptors in regulation of innate immunity. Arch Pharm Res. 2016;39:1491-1502 pubmed
..Discovery of new functions of orphan NRs would facilitate development of novel preventive and therapeutic strategies against human inflammatory diseases. ..
Kim J, Yuk J, Kim S, Kim T, Jin H, Yang C, et al
. MicroRNA-125a Inhibits Autophagy Activation and Antimicrobial Responses during Mycobacterial Infection. J Immunol. 2015;194:5355-65 pubmed publisher
..tuberculosis. Taken together, these data indicate that miR-125a regulates the innate host defense by inhibiting the activation of autophagy and antimicrobial effects against M. tuberculosis through targeting UVRAG. ..
Yuk J, Kim T, Kim S, Lee H, Han J, Dufour C, et al
. Orphan Nuclear Receptor ERRÎ± Controls Macrophage Metabolic Signaling and A20 Expression to Negatively Regulate TLR-Induced Inflammation. Immunity. 2015;43:80-91 pubmed publisher
..These findings unravel a previously unappreciated role for ERRÎ± as a negative regulator of TLR-induced inflammatory responses through inducing Tnfaip3 transcription and controlling the metabolic reprogramming. ..
Jin H, Lee H, Lee D, Cha G, Cho K, Jang J, et al
. Functional characterisation of the Drosophila cg6568 gene in host defence against Mycobacterium marinum. Microbes Infect. 2017;19:351-357 pubmed publisher
..Thus, we named the gene product a cathelicidin-like antimicrobial protein of D. melanogaster (dCAMP). Our results indicate that dCAMP is crucial in terms of the innate D. melanogaster defense during M. marinum infection. ..