Eun Kyeong Jo

Summary

Affiliation: Chungnam National University
Country: Korea

Publications

  1. doi request reprint Autophagy: cellular defense to excessive inflammation
    Eun Kyeong Jo
    Department of Microbiology, College of Medicine, Chungnam National University, 6 Munhwa dong, Jungku, Daejeon 301 747, South Korea
    Microbes Infect 14:119-25. 2012
  2. ncbi request reprint New insights into vitamin D and autophagy in inflammatory bowel diseases
    Hyun Woo Suh
    Department of Microbiology, Chungnam National University, 6 Munhwa dong, Jungku, Daejeon 301 747, S Korea
    Curr Med Chem . 2016
  3. pmc The 30-kDa and 38-kDa antigens from Mycobacterium tuberculosis induce partial maturation of human dendritic cells shifting CD4(+) T cell responses towards IL-4 production
    Marion Heuer
    Institute of Virology and Immunobiology, University of Wurzburg, Wurzburg, Germany
    BMC Immunol 14:48. 2013
  4. pmc Nitric Oxide Synthesis is Modulated by 1,25-Dihydroxyvitamin D3 and Interferon-gamma in Human Macrophages after Mycobacterial Infection
    Ji Sook Lee
    Department of Microbiology, College of Medicine, Chungnam National University, Daejeon 301 747, Korea
    Immune Netw 9:192-202. 2009
  5. pmc Antimicrobial Peptides in Innate Immunity against Mycobacteria
    Dong Min Shin
    Department of Microbiology and Infection Signaling Network Research Center, Chungnam National University, School of Medicine, Daejeon 301 747, Korea
    Immune Netw 11:245-52. 2011
  6. pmc Mycobacterial Heparin-binding Hemagglutinin Antigen Activates Inflammatory Responses through PI3-K/Akt, NF-κB, and MAPK Pathways
    Ki Hye Kim
    Department of Microbiology, College of Medicine, Chungnam National University, Daejeon 301 747, Korea
    Immune Netw 11:123-33. 2011
  7. pmc The role of nitric oxide in mycobacterial infections
    Chul Su Yang
    Department of Microbiology and Infection Signaling Network Research Center, College of Medicine, Chungnam National University, Daejeon 301 747, Korea
    Immune Netw 9:46-52. 2009
  8. pmc Autophagy and bacterial infectious diseases
    Jae Min Yuk
    Department of Microbiology, Chungnam National University School of Medicine, Daejeon 301 747, Korea
    Exp Mol Med 44:99-108. 2012
  9. pmc The Role of NLR-related Protein 3 Inflammasome in Host Defense and Inflammatory Diseases
    Chul Su Yang
    Department of Microbiology, Infection Signaling Network Research Center, Chungnam National University School of Medicine, Daejeon, Korea
    Int Neurourol J 16:2-12. 2012
  10. pmc Roles of autophagy in elimination of intracellular bacterial pathogens
    Eun Kyeong Jo
    Department of Microbiology, College of Medicine, Chungnam National University Daejeon, South Korea Infection Signaling Network Research Center, School of Medicine, Chungnam National University Daejeon, South Korea
    Front Immunol 4:97. 2013

Collaborators

Detail Information

Publications85

  1. doi request reprint Autophagy: cellular defense to excessive inflammation
    Eun Kyeong Jo
    Department of Microbiology, College of Medicine, Chungnam National University, 6 Munhwa dong, Jungku, Daejeon 301 747, South Korea
    Microbes Infect 14:119-25. 2012
    ..This review describes recent findings concerning the roles and mechanisms of autophagy in controlling excessive inflammation...
  2. ncbi request reprint New insights into vitamin D and autophagy in inflammatory bowel diseases
    Hyun Woo Suh
    Department of Microbiology, Chungnam National University, 6 Munhwa dong, Jungku, Daejeon 301 747, S Korea
    Curr Med Chem . 2016
    ..Vitamin D shows promise for the prevention and amelioration of pathologic responses in IBD, an effect that is mediated, at least in part, by the induction and modulation of autophagy...
  3. pmc The 30-kDa and 38-kDa antigens from Mycobacterium tuberculosis induce partial maturation of human dendritic cells shifting CD4(+) T cell responses towards IL-4 production
    Marion Heuer
    Institute of Virology and Immunobiology, University of Wurzburg, Wurzburg, Germany
    BMC Immunol 14:48. 2013
    ..Deviation of immune responses by pathogens towards a Th2 profile is a common mechanism of immune evasion, typically leading to the persistence of the microbes...
  4. pmc Nitric Oxide Synthesis is Modulated by 1,25-Dihydroxyvitamin D3 and Interferon-gamma in Human Macrophages after Mycobacterial Infection
    Ji Sook Lee
    Department of Microbiology, College of Medicine, Chungnam National University, Daejeon 301 747, Korea
    Immune Netw 9:192-202. 2009
    ..Little information is available the role of Nitric Oxide (NO) in host defenses during human tuberculosis (TB) infection. We investigated the modulating factor(s) affecting NO synthase (iNOS) induction in human macrophages...
  5. pmc Antimicrobial Peptides in Innate Immunity against Mycobacteria
    Dong Min Shin
    Department of Microbiology and Infection Signaling Network Research Center, Chungnam National University, School of Medicine, Daejeon 301 747, Korea
    Immune Netw 11:245-52. 2011
    ..The present review focuses on recent efforts to elucidate the roles of host defense peptides in innate immunity to mycobacteria...
  6. pmc Mycobacterial Heparin-binding Hemagglutinin Antigen Activates Inflammatory Responses through PI3-K/Akt, NF-κB, and MAPK Pathways
    Ki Hye Kim
    Department of Microbiology, College of Medicine, Chungnam National University, Daejeon 301 747, Korea
    Immune Netw 11:123-33. 2011
    ..However, the molecular basis of the host immune response to HBHA has not been fully characterized. In this study, we examined the molecular mechanisms by which HBHA can induce the expression of proinflammatory cytokines in macrophages...
  7. pmc The role of nitric oxide in mycobacterial infections
    Chul Su Yang
    Department of Microbiology and Infection Signaling Network Research Center, College of Medicine, Chungnam National University, Daejeon 301 747, Korea
    Immune Netw 9:46-52. 2009
    ..A greater understanding of these defense mechanisms in human tuberculosis will aid in the development of new strategies for the treatment of disease...
  8. pmc Autophagy and bacterial infectious diseases
    Jae Min Yuk
    Department of Microbiology, Chungnam National University School of Medicine, Daejeon 301 747, Korea
    Exp Mol Med 44:99-108. 2012
    ..In this review, we have summarized the recent advances in our understanding of the interaction between antibacterial autophagy (xenophagy) and different bacterial pathogens...
  9. pmc The Role of NLR-related Protein 3 Inflammasome in Host Defense and Inflammatory Diseases
    Chul Su Yang
    Department of Microbiology, Infection Signaling Network Research Center, Chungnam National University School of Medicine, Daejeon, Korea
    Int Neurourol J 16:2-12. 2012
    ..Here, we review recent advances in our understanding of the role of the NLRP3 inflammasome in host defense and various inflammatory diseases...
  10. pmc Roles of autophagy in elimination of intracellular bacterial pathogens
    Eun Kyeong Jo
    Department of Microbiology, College of Medicine, Chungnam National University Daejeon, South Korea Infection Signaling Network Research Center, School of Medicine, Chungnam National University Daejeon, South Korea
    Front Immunol 4:97. 2013
    ....
  11. pmc NLRP3 inflammasome and host protection against bacterial infection
    Jwa Jin Kim
    Department of Microbiology and Infection Signaling Network Research Center, Chungnam National University School of Medicine, Daejeon, Korea
    J Korean Med Sci 28:1415-23. 2013
    ..Understanding the roles and regulatory mechanisms of the NLRP3 inflammasome is essential for developing potential treatment approaches against pathogenic infections. ..
  12. pmc Mycobacterial signaling through toll-like receptors
    Joyoti Basu
    Department of Chemistry, Bose Institute Kolkata, India
    Front Cell Infect Microbiol 2:145. 2012
    ..In this article we describe recent advances in the recognition, responses, and regulation of mycobacterial signaling through TLRs...
  13. pmc Mycobacterium massiliense induces inflammatory responses in macrophages through Toll-like receptor 2 and c-Jun N-terminal kinase
    Tae Sung Kim
    Department of Microbiology, College of Medicine, Chungnam National University, 6 Munhwa dong, Jungku, Daejeon, 301 747, South Korea
    J Clin Immunol 34:212-23. 2014
    ..Together, these results suggest that Mmass-induced activation of host proinflammatory cytokines is mediated through TLR2-dependent JNK and ROS signaling pathways. ..
  14. doi request reprint Autophagy as an innate defense against mycobacteria
    Eun Kyeong Jo
    Department of Microbiology, Chungnam National University School of Medicine, Daejeon, Korea
    Pathog Dis 67:108-18. 2013
    ..Here, we review the triggers, host factors, and intracellular pathways that regulate host autophagy and its impact on antimicrobial host defenses during mycobacterial infection...
  15. ncbi request reprint Characterization of mutations, including a novel regulatory defect in the first intron, in Bruton's tyrosine kinase gene from seven Korean X-linked agammaglobulinemia families
    E K Jo
    Department of Microbiology, College of Medicine, Chungnam National University, 6 Munhwa dong, Chung Ku, Taejon 301 131, Korea
    J Immunol 167:4038-45. 2001
    ..Precise definition of the regulatory defect in the Btk intron 1 may provide valuable clues toward elucidating the pathogenesis of X-linked agammaglobulinemia...
  16. doi request reprint Innate immunity to mycobacteria: vitamin D and autophagy
    Eun Kyeong Jo
    Department of Microbiology, Chungnam National University School of Medicine, Jungku, Daejeon, Korea
    Cell Microbiol 12:1026-35. 2010
    ..Integrated dialog between autophagy and innate immunity may contribute to adequate host immune defences against mycobacterial infection...
  17. ncbi request reprint Dynamics of cytokine generation in patients with active pulmonary tuberculosis
    Eun Kyeong Jo
    Department of Microbiology, College of Medicine, Chungnam National University, Daejeon, Korea
    Curr Opin Infect Dis 16:205-10. 2003
    ..A better understanding of how cytokine production contributes to immunity and pathology would aid the development of new vaccines and therapeutic strategies...
  18. pmc X-linked hyper-IgM syndrome associated with Cryptosporidium parvum and Cryptococcus neoformans infections: the first case with molecular diagnosis in Korea
    Eun Kyeong Jo
    Department of Microbiology, College of Medicine, Chungnam National University, 6 Munhwa dong, Jung ku, Taejon 301 131, Korea
    J Korean Med Sci 17:116-20. 2002
    ..Genetic analysis of the mother and sister showed a heterozygote pattern, indicating carrier status. To our knowledge, this is the first report on the molecular diagnosis of an XHIM patient in Korea...
  19. doi request reprint Mycobacterial interaction with innate receptors: TLRs, C-type lectins, and NLRs
    Eun Kyeong Jo
    Department of Microbiology, College of Medicine, Chungnam National University, Jungku, Daejeon, South Korea
    Curr Opin Infect Dis 21:279-86. 2008
    ..The present review is to focus on the roles and mechanisms of specific pattern-recognition receptor-microbial interaction for the host defense against mycobacterial infections...
  20. ncbi request reprint Intracellular signalling cascades regulating innate immune responses to Mycobacteria: branching out from Toll-like receptors
    Eun Kyeong Jo
    Department of Microbiology, and Medical Research Insttitutes, College of Medicine, Chungam National University, Daejeon 301 747, South Korea
    Cell Microbiol 9:1087-98. 2007
    ..These efforts will allow for the development of novel diagnostic and therapeutic modalities for tuberculosis that targets the intracellular signalling pathways permitting the replication of this nefarious pathogen...
  21. pmc The mycobacterial 38-kilodalton glycolipoprotein antigen activates the mitogen-activated protein kinase pathway and release of proinflammatory cytokines through Toll-like receptors 2 and 4 in human monocytes
    Saet Byel Jung
    Department of Microbiology, College of Medicine, Chungnam National University, 6 Munhwa dong, Jungku, Daejeon 301 747, South Korea
    Infect Immun 74:2686-96. 2006
    ....
  22. pmc Reactive oxygen species and p47phox activation are essential for the Mycobacterium tuberculosis-induced pro-inflammatory response in murine microglia
    Chul Su Yang
    Department of Microbiology, College of Medicine, Chungnam National University, Daejeon 301 747, S Korea
    J Neuroinflammation 4:27. 2007
    ..However, little is known about the intracellular signaling mechanisms governing these inflammatory responses in microglia in response to Mycobacterium tuberculosis (Mtb)...
  23. ncbi request reprint Intracellular network of phosphatidylinositol 3-kinase, mammalian target of the rapamycin/70 kDa ribosomal S6 kinase 1, and mitogen-activated protein kinases pathways for regulating mycobacteria-induced IL-23 expression in human macrophages
    Chul Su Yang
    Department of Microbiology, College of Medicine, Chungnam National University, Daejeon 301 747, South Korea
    Cell Microbiol 8:1158-71. 2006
    ....
  24. doi request reprint Apurinic/apyrimidinic endonuclease 1 is a key modulator of keratinocyte inflammatory responses
    Hye Mi Lee
    Department of Microbiology, College of Medicine, Chungnam National University, Daejeon, South Korea
    J Immunol 183:6839-48. 2009
    ..Taken together, these findings establish a role for APE1 as a master regulator of TLR2-dependent inflammatory responses in human keratinocytes...
  25. ncbi request reprint Role of the phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways in the secretion of tumor necrosis factor-alpha and interleukin-10 by the PPD antigen of Mycobacterium tuberculosis
    Saet Byel Jung
    Department of Microbiology, College of Medicine, Chungnam National University, Daejeon, South Korea
    J Clin Immunol 25:482-90. 2005
    ..Collectively, these data suggest that the PI 3-K and MAPK pathways play a central role in the regulation of both pro- and anti-inflammatory cytokines by the PPD antigen of M. tuberculosis...
  26. pmc Mycobacterium tuberculosis lipoprotein-induced association of TLR2 with protein kinase C zeta in lipid rafts contributes to reactive oxygen species-dependent inflammatory signalling in macrophages
    Dong Min Shin
    Department of Microbiology, College of Medicine, Chungnam National University, Daejeon 301 747, Korea
    Cell Microbiol 10:1893-905. 2008
    ..In addition, PKCzeta targets to lipid rafts and may act as a critical adaptor molecule to regulate lipid raft dynamics during TLR2 signalling...
  27. ncbi request reprint ASK1-p38 MAPK-p47phox activation is essential for inflammatory responses during tuberculosis via TLR2-ROS signalling
    Chul Su Yang
    Department of Microbiology, and Infection Signaling Network Research Center, College of Medicine, Chungnam National University, Daejeon 301 747, Korea
    Cell Microbiol 10:741-54. 2008
    ..The altered regulation of this axis with an increasing free-radical burden may contribute to the immunopathogenesis of human TB...
  28. doi request reprint Glucocorticoid receptor agonist compound K regulates Dectin-1-dependent inflammatory signaling through inhibition of reactive oxygen species
    Trinh Tat Cuong
    Department of Microbiology, College of Medicine, Chungnam National University, Daejeon, South Korea
    Life Sci 85:625-33. 2009
    ..Here, the role of C-K in the regulation of zymosan-mediated inflammation was investigated in murine bone marrow-derived macrophages and the murine macrophage cell line RAW264.7...
  29. ncbi request reprint Depressed interleukin-12 production by peripheral blood mononuclear cells after in vitro stimulation with the 30-kDa antigen in recurrent pulmonary tuberculosis patients
    Ji Sook Lee
    Department of Microbiology, College of Medicine, Chungnam National University, 6 Munhwa dong, Jung ku, Taejon 301 747, Republic of Korea
    Med Microbiol Immunol 192:61-9. 2003
    ....
  30. doi request reprint Mycobacterium abscessus activates the macrophage innate immune response via a physical and functional interaction between TLR2 and dectin-1
    Dong Min Shin
    Department of Microbiology, College of Medicine, Chungnam National University, Daejeon 301 747, Korea
    Cell Microbiol 10:1608-21. 2008
    ..Collectively, these data demonstrate that Mab actively internalizes into and robustly activates innate immune responses in macrophages through a physical and functional interaction between TLR2 and dectin-1...
  31. pmc Mycobacterium tuberculosis HBHA protein reacts strongly with the serum immunoglobulin M of tuberculosis patients
    A Rum Shin
    Department of Microbiology, College of Medicine, Chungnam National University, 6 Muwha Dong, Jung ku, Daejeon 301 747, Korea
    Clin Vaccine Immunol 13:869-75. 2006
    ..tuberculosis into epithelial cells. These findings suggest that IgM antibody to HBHA may play a role in protection against extrapulmonary dissemination...
  32. ncbi request reprint Role of mitogen-activated protein kinase pathways in the production of tumor necrosis factor-alpha, interleukin-10, and monocyte chemotactic protein-1 by Mycobacterium tuberculosis H37Rv-infected human monocytes
    Chang Hwa Song
    Department of Microbiology, College of Medicine, Chungnam National University, 6 Munhwa dong, Jung ku, Daejeon 301 747, Korea
    J Clin Immunol 23:194-201. 2003
    ..Collectively, these results suggest that induction of the MAPK pathway is required for the expression of TNF-alpha, IL-10, and MCP-1 by human monocytes during M. tuberculosis H37Rv infection...
  33. doi request reprint Host cell autophagy activated by antibiotics is required for their effective antimycobacterial drug action
    Jwa Jin Kim
    Department of Microbiology, Chungnam National University, Daejeon, Korea
    Cell Host Microbe 11:457-68. 2012
    ..Together, these findings underscore the importance of host autophagy in orchestrating successful antimicrobial responses to mycobacteria during chemotherapy...
  34. doi request reprint Autophagy negatively regulates keratinocyte inflammatory responses via scaffolding protein p62/SQSTM1
    Hye Mi Lee
    Department of Microbiology, Chungnam National University, Daejeon 301 747, South Korea
    J Immunol 186:1248-58. 2011
    ..Collectively, our data provide new insights into the roles of autophagy and p62 in controlling cutaneous inflammation...
  35. doi request reprint Endoplasmic reticulum stress response is involved in Mycobacterium tuberculosis protein ESAT-6-mediated apoptosis
    Hong Hee Choi
    Department of Microbiology, College of Medicine, Chungnam National University, Daejeon, South Korea
    FEBS Lett 584:2445-54. 2010
    ..Our results uncover a novel apoptotic mechanism of ESAT-6 through ER stress responses in pathologic conditions such as tuberculosis...
  36. ncbi request reprint Identification of the new T-cell-stimulating antigens from Mycobacterium tuberculosis culture filtrate
    Jae Hyun Lim
    Department of Microbiology, College of Medicine, Chungnam National University, 6 Munhwa dong, Jung ku, Daejeon 301 747, South Korea
    FEMS Microbiol Lett 232:51-9. 2004
    ..These results suggest that MTSP11 antigen should be further evaluated as a component of a subunit vaccine...
  37. pmc Endoplasmic reticulum stress pathway-mediated apoptosis in macrophages contributes to the survival of Mycobacterium tuberculosis
    Yun Ji Lim
    Department of Microbiology, College of Medicine, Chungnam National University, Daejeon, South Korea
    PLoS ONE 6:e28531. 2011
    ..This study aims to investigate the role of endoplasmic reticulum (ER) stress mediated apoptosis in mycobacteria infected macrophages...
  38. pmc Mycobacterial lipoprotein activates autophagy via TLR2/1/CD14 and a functional vitamin D receptor signalling
    Dong Min Shin
    Department of Microbiology, Chungnam National University School of Medicine, Daejeon, Korea
    Cell Microbiol 12:1648-65. 2010
    ..Furthermore, these results establish a previously uncharacterized signalling pathway of antimycobacterial host defence through a functional link of TLR2/1/CD14-dependent sensing to the induction of autophagy...
  39. pmc Mycobacterium tuberculosis eis regulates autophagy, inflammation, and cell death through redox-dependent signaling
    Dong Min Shin
    Department of Microbiology, College of Medicine, Chungnam National University, Daejeon, Korea
    PLoS Pathog 6:e1001230. 2010
    ..Collectively, these data indicate that Mtb Eis suppresses host innate immune defenses by modulating autophagy, inflammation, and cell death in a redox-dependent manner...
  40. doi request reprint Diagnosis of pulmonary tuberculosis using MTB12 and 38-kDa antigens
    Ji Sook Lee
    Department of Microbiology, College of Medicine, Chungnam National University, Daejeon, Korea
    Respirology 13:432-7. 2008
    ..The objective of this study was to evaluate the humoral immune responses induced by MTB12 Ag during human TB...
  41. ncbi request reprint Diacyltrehalose of Mycobacterium tuberculosis inhibits lipopolysaccharide- and mycobacteria-induced proinflammatory cytokine production in human monocytic cells
    Kil Soo Lee
    Department of Microbiology and Research Institute for Medical Sciences, College of Medicine, Chungnam National University, Daejeon, Korea
    FEMS Microbiol Lett 267:121-8. 2007
    ..However, diacyltrehalose was unable to inhibit peptidoglycan-induced IL-12p40 production. These results suggest that diacyltrehalose is a mycobacterial factor capable of modulating host immune responses...
  42. pmc Interleukin-8 is differentially expressed by human-derived monocytic cell line U937 infected with Mycobacterium tuberculosis H37Rv and Mycobacterium marinum
    Chang Hwa Song
    Department of Microbiology, College of Medicine, Chungnam National University, 6 Mun hwa dong, Jung ku, Daejeon 301 747, Republic of Korea
    Infect Immun 71:5480-7. 2003
    ..Additionally, our data indicate that differential signal transduction pathways may underlie the distinct patterns of IL-8 secretion in cells infected by the two mycobacteria...
  43. ncbi request reprint Protein kinase C zeta plays an essential role for Mycobacterium tuberculosis-induced extracellular signal-regulated kinase 1/2 activation in monocytes/macrophages via Toll-like receptor 2
    Chul Su Yang
    Department of Microbiology, College of Medicine, Chungnam National University, Daejeon 301 747, Seoul, Korea
    Cell Microbiol 9:382-96. 2007
    ..This is the first demonstration that PKCzeta interacts with TLR2 to play an essential role in MTB-induced ERK 1/2 activation and subsequent TNF-alpha expression in monocytes/macrophages...
  44. pmc Small heterodimer partner-targeting therapy inhibits systemic inflammatory responses through mitochondrial uncoupling protein 2
    Chul Su Yang
    Department of Microbiology, Chungnam National University School of Medicine, Daejeon, S Korea
    PLoS ONE 8:e63435. 2013
    ..These data strongly suggest that the SHP-inducing drug fenofibrate paves the way for novel therapies for systemic inflammation by targeting SHP...
  45. pmc Mycobacterium abscessus activates the NLRP3 inflammasome via Dectin-1-Syk and p62/SQSTM1
    Hye Mi Lee
    Department of Microbiology, Chungnam National University School of Medicine, Daejeon, Korea
    Immunol Cell Biol 90:601-10. 2012
    ..Taken together, these data demonstrate the induction mechanism of the NLRP3/ASC inflammasome and its role in innate immunity to Mabc infection...
  46. doi request reprint Role of apoptosis-regulating signal kinase 1 in innate immune responses by Mycobacterium bovis bacillus Calmette-Guérin
    Jae Min Yuk
    Department of Microbiology, College of Medicine, Chungnam National University, Daejeon, South Korea
    Immunol Cell Biol 87:100-7. 2009
    ..Thus, the results of this study suggest a novel role of the TLR-ROS-TRAF6-ASK1 axis in the innate immune response to mycobacteria as a signaling intermediate...
  47. pmc Roles of peroxiredoxin II in the regulation of proinflammatory responses to LPS and protection against endotoxin-induced lethal shock
    Chul Su Yang
    Department of Microbiology, College of Medicine, Chungnam National University, Daejeon 301 747, Korea
    J Exp Med 204:583-94. 2007
    ....
  48. doi request reprint NADPH oxidase 2 interaction with TLR2 is required for efficient innate immune responses to mycobacteria via cathelicidin expression
    Chul Su Yang
    Department of Microbiology, Infection Signaling Network Research Center, College of Medicine, Chungnam National University, Daejeon, South Korea
    J Immunol 182:3696-705. 2009
    ..Our data collectively demonstrate a novel regulatory mechanism for TLR2-dependent innate responses to Mtb involving crosstalk between NOX2 and TLR2 and the expression of cathelicidin...
  49. doi request reprint Roles of reactive oxygen species in CXCL8 and CCL2 expression in response to the 30-kDa antigen of Mycobacterium tuberculosis
    Hye Mi Lee
    Department of Microbiology, College of Medicine, Chungnam National University, 6 Munhwa dong, Jung ku, Daejeon, 301 747, South Korea
    J Clin Immunol 29:46-56. 2009
    ..tuberculosis) is a strong inducer of innate and adaptive immune responses in human tuberculosis. The generation of reactive oxygen species (ROS) plays an important role in inflammatory signaling as well as antimicrobial defense...
  50. ncbi request reprint Bacillus calmette-guerin cell wall cytoskeleton enhances colon cancer radiosensitivity through autophagy
    Jae Min Yuk
    Department of Microbiology, College of Medicine, Chungnam National University, Daejeon, Korea
    Autophagy 6:46-60. 2010
    ..Our data suggest that BCG/CWS in combination with IR is a promising therapeutic strategy for enhancing radiation therapy in colon cancer cells through the induction of autophagy...
  51. ncbi request reprint Characterization of a novel nonsense mutation in the interleukin-7 receptor alpha gene in a Korean patient with severe combined immunodeficiency
    Eun Kyeong Jo
    Department of Microbiology, College of Medicine, Chungnam National University, Daejeon, Korea
    Int J Hematol 80:332-5. 2004
    ..The results of this study emphasize the importance of characterization of IL-7Ralpha mutations in SCID patients with diminished T-cell numbers but normal numbers of B-cells and NK cells...
  52. doi request reprint Nanoparticles up-regulate tumor necrosis factor-alpha and CXCL8 via reactive oxygen species and mitogen-activated protein kinase activation
    Hye Mi Lee
    Department of Microbiology, College of Medicine, Daejeon 301 747, South Korea
    Toxicol Appl Pharmacol 238:160-9. 2009
    ..These results provide novel insights into the QD-mediated chemokine induction and inflammatory toxic responses in vitro and in vivo...
  53. pmc Small heterodimer partner interacts with NLRP3 and negatively regulates activation of the NLRP3 inflammasome
    Chul Su Yang
    1 Department of Microbiology, Chungnam National University School of Medicine, Daejeon 301 747, South Korea 2 Infection Signaling Network Research Center, Chungnam National University School of Medicine, Daejeon 301 747, South Korea 3 Department of Molecular and Life Science, College of Science and Technology, Hanyang University, Ansan 426 791, South Korea
    Nat Commun 6:6115. 2015
    ..These data are suggestive of a role for SHP in controlling NLRP3 inflammasome activation through a mechanism involving interaction with NLRP3 and maintenance of mitochondrial homeostasis. ..
  54. doi request reprint Transcriptional regulatory defects in the first intron of Bruton's tyrosine kinase
    Dong Min Shin
    Department of Microbiology, College of Medicine, Chungnam National University, Daejon, Korea
    Pediatr Int 50:801-5. 2008
    ..Mutations in intron 1 positions +5 (G-->A) and +6 (T-->G) of the BTK gene have been identified, and these changes were associated with reduced transcriptional activity...
  55. pmc X-linked severe combined immunodeficiency syndrome: the first Korean case with gamma c chain gene mutation and subsequent genetic counseling
    Eun Kyeong Jo
    Department of Microbiology, College of Medicine, Chungnam National University, Daejeon, Korea
    J Korean Med Sci 19:123-6. 2004
    ..This is the first report of the molecular diagnosis of X-SCID in Korea. Genetic analysis of the gamma c chain gene is useful for definite diagnosis and genetic counseling for X-SCID...
  56. doi request reprint TLR3-triggered reactive oxygen species contribute to inflammatory responses by activating signal transducer and activator of transcription-1
    Chul Su Yang
    Department of Microbiology, Chungnam National University, Daejeon 301 747, South Korea
    J Immunol 190:6368-77. 2013
    ..Collectively, these results provide a novel insight into the crucial role that TLR3-ROS signaling plays in innate immune responses by activating STAT1...
  57. doi request reprint Microglial activation of the NLRP3 inflammasome by the priming signals derived from macrophages infected with mycobacteria
    Hye Mi Lee
    Department of Microbiology, College of Medicine, Chungnam National University, Daejeon, South Korea
    Glia 61:441-52. 2013
    ....
  58. doi request reprint Effects of mycobacterial infection on proliferation of hematopoietic precursor cells
    Hong Hee Choi
    Department of Microbiology, College of Medicine, Chungnam National University, 6 Munhwa dong, Jungku, Daejeon 301 747, Republic of Korea
    Microbes Infect 13:1252-60. 2011
    ..Expansion of hematopoietic progenitor cells may, therefore, play an important role during mycobacterial infection...
  59. doi request reprint Mycobacterial cell-wall skeleton as a universal vaccine vehicle for antigen conjugation
    Tae Hyun Paik
    Department of Microbiology, College of Medicine, Chungnam National University, Daejeon 301 747, South Korea
    Vaccine 28:7873-80. 2010
    ....
  60. ncbi request reprint Differential cytokine levels and immunoreactivities against Mycobacterium tuberculosis antigens between tuberculous and malignant effusions
    Chul Su Yang
    Department of Microbiology, College of Medicine, Chungnam National University, Daejeon 301 747, South Korea
    Respir Med 102:280-6. 2008
    ..These data indicate that selected mycobacterial antigens (ESAT-6 and MTB12) and cytokine markers (IFN-gamma, IL-12p40, and IL-6) provide useful information for differentiating tuberculous and malignant effusions in clinical practice...
  61. doi request reprint Dectin-1 is inducible and plays an essential role for mycobacteria-induced innate immune responses in airway epithelial cells
    Hye Mi Lee
    Department of Microbiology, College of Medicine, Chungnam National University, Daejeon, South Korea
    J Clin Immunol 29:795-805. 2009
    ..The c-type lectin Dectin-1 is expressed predominantly on the surface of myeloid lineage cells. In this study, we examined the induction, regulation, and functions of Dectin-1 in pulmonary epithelial cells...
  62. doi request reprint Mycobacterium abscessus ESX-3 plays an important role in host inflammatory and pathological responses during infection
    Yi Sak Kim
    Department of Microbiology, College of Medicine, Chungnam National University, Daejeon 301 747, South Korea Department of Medical Science, College of Medicine, Chungnam National University, Daejeon 301 747, South Korea
    Microbes Infect . 2016
    ..Taken together, our data suggest that Mab ESX-3 plays an important role in inflammatory and pathological responses during Mab infection...
  63. doi request reprint Orphan Nuclear Receptor ERRα Controls Macrophage Metabolic Signaling and A20 Expression to Negatively Regulate TLR-Induced Inflammation
    Jae Min Yuk
    Department of Microbiology, Chungnam National University School of Medicine, Daejeon 301 747, South Korea Department of Infection Biology, Chungnam National University School of Medicine, Daejeon 301 747, South Korea Infection Signaling Network Research Center, Chungnam National University School of Medicine, Daejeon 301 747, South Korea
    Immunity 43:80-91. 2015
    ..These findings unravel a previously unappreciated role for ERRα as a negative regulator of TLR-induced inflammatory responses through inducing Tnfaip3 transcription and controlling the metabolic reprogramming...
  64. doi request reprint Ionizing Radiation Induces Innate Immune Responses in Macrophages by Generation of Mitochondrial Reactive Oxygen Species
    Sup Kim
    Department of aRadiation oncology, Chungnam National University School of Medicine, Daejeon, Korea
    Radiat Res . 2016
    ..These data suggest a key role for radiation-induced pro-inflammatory responses and activation of the MAPK and NF-κB pathways through a triggering mechanism involving mROS generation...
  65. ncbi request reprint Polymorphisms of interleukin-10 and tumour necrosis factor-alpha genes are associated with newly diagnosed and recurrent pulmonary tuberculosis
    Jae Hee Oh
    Department of Microbiology, College of Medicine, Chungnam University, Daejeon, Korea
    Respirology 12:594-8. 2007
    ..The present study investigated the relationship between susceptibility to tuberculosis and human tumour necrosis factor-alpha (TNF-alpha) and interleukin-10 genes (IL-10)...
  66. doi request reprint A dual regulatory role of apurinic/apyrimidinic endonuclease 1/redox factor-1 in HMGB1-induced inflammatory responses
    Jae Min Yuk
    Department of Microbiology, College of Medicine, Chungnam National University, Daejeon, South Korea
    Antioxid Redox Signal 11:575-88. 2009
    ..The modulation of cytosolic APE1 expression might be useful as a potential therapeutic modality for the treatment of inflammatory or autoimmune diseases...
  67. doi request reprint MicroRNA-125a Inhibits Autophagy Activation and Antimicrobial Responses during Mycobacterial Infection
    Jin Kyung Kim
    Department of Microbiology, Chungnam National University School of Medicine, Daejeon 301 747, South Korea Infection Signaling Network Research Center, Chungnam National University School of Medicine, Daejeon 301 747, South Korea
    J Immunol 194:5355-65. 2015
    ..tuberculosis. Taken together, these data indicate that miR-125a regulates the innate host defense by inhibiting the activation of autophagy and antimicrobial effects against M. tuberculosis through targeting UVRAG. ..
  68. doi request reprint The orphan nuclear receptor SHP acts as a negative regulator in inflammatory signaling triggered by Toll-like receptors
    Jae Min Yuk
    Department of Microbiology, Chungnam National University School of Medicine, Daejeon, South Korea
    Nat Immunol 12:742-51. 2011
    ..Our data identify a previously unrecognized role for SHP in the regulation of TLR signaling...
  69. pmc The ginsenoside metabolite compound K, a novel agonist of glucocorticoid receptor, induces tolerance to endotoxin-induced lethal shock
    Chul Su Yang
    Department of Microbiology, College of Medicine, Chungnam National University, Daejeon, S Korea
    J Cell Mol Med 12:1739-53. 2008
    ..Collectively, these results demonstrate that C-K, as a functional ligand of GR, regulates distinct TLR4-mediated inflammatory responses, and suggest a novel therapy for Gram-negative septic shock...
  70. doi request reprint In vitro and ex vivo activity of new derivatives of acetohydroxyacid synthase inhibitors against Mycobacterium tuberculosis and non-tuberculous mycobacteria
    Hosung Sohn
    Department of Microbiology, College of Medicine, Chungnam National University, 6 Munhwa dong, Jung ku, Daejeon 301 747, South Korea
    Int J Antimicrob Agents 31:567-71. 2008
    ..These compounds exhibit significant activity against intracellular M. tuberculosis (including the drug-resistant M. tuberculosis strains), and NTM Mycobacterium abscessus and Mycobacterium kansasii, respectively...
  71. doi request reprint Vitamin D3 induces autophagy in human monocytes/macrophages via cathelicidin
    Jae Min Yuk
    Department of Microbiology, College of Medicine, Chungnam National University, Daejeon, Korea
    Cell Host Microbe 6:231-43. 2009
    ..These results indicate that human cathelicidin, a protein that has direct antimicrobial activity, also serves as a mediator of vitamin D3-induced autophagy...
  72. doi request reprint Innate immune responses to Mycobacterium ulcerans via toll-like receptors and dectin-1 in human keratinocytes
    Hye Mi Lee
    Department of Microbiology, Chungnam National University, Daejeon, South Korea
    Cell Microbiol 11:678-92. 2009
    ..Our results demonstrate that TLR2, TLR4 and Dectin-1 actively sense, internalize and respond in an innate way to MU in human epidermal keratinocytes...
  73. ncbi request reprint Identification of mutations in the Bruton's tyrosine kinase gene, including a novel genomic rearrangements resulting in large deletion, in Korean X-linked agammaglobulinemia patients
    Eun Kyeong Jo
    Department of Microbiology, College of Medicine, Chungnam National University, Daejeon, Korea
    J Hum Genet 48:322-6. 2003
    ..This study suggests that large genomic rearrangements involving Alu repeats are few but an important component of the spectrum of BTK mutations...
  74. ncbi request reprint Transcriptional repression of vimentin gene expression by pyrroline dithiocarbamate during 12-O-tetradecanoylphorbol-13-acetate-dependent differentiation of HL-60 cells
    Meizi Zheng
    Department of Biochemistry, College of Medicine, Chungnam National University, Daejeon 301 747, Korea
    Oncol Rep 14:713-7. 2005
    ..Taken together, these results suggest that NF-kappaB may be an essential transacting factor for transcriptional repression of the vimentin gene by PDTC during TPA-dependent differentiation of HL-60 cells...
  75. doi request reprint Identification of plasma APE1/Ref-1 in lipopolysaccharide-induced endotoxemic rats: implication of serological biomarker for an endotoxemia
    Myoung Soo Park
    Department of Physiology, School of Medicine, Chungnam National University, Daejeon 301 747, Republic of Korea
    Biochem Biophys Res Commun 435:621-6. 2013
    ..Taken together, the level of plasma APE1/Ref-1 increased in LPS-induced endotoxemic rats, suggesting that plasma APE1/Ref-1 might serve as a serological biomarker for endotoxemia...
  76. pmc Upregulated NLRP3 inflammasome activation in patients with type 2 diabetes
    Hye Mi Lee
    Infection Signaling Network Research Center, Chungnam National University School of Medicine, Daejeon, South Korea
    Diabetes 62:194-204. 2013
    ....
  77. doi request reprint Identification of novel metronidazole-inducible genes in Mycobacterium smegmatis using a customized amplification library
    Su Young Kim
    Department of Microbiology, College of Medicine, Chungnam National University, Daejeon, Korea
    FEMS Microbiol Lett 282:282-9. 2008
    ..In addition, the genes may play a role in dormancy. The genes identified in this study may lead to a better understanding of the mechanisms of metronidazole resistance during dormancy...
  78. ncbi request reprint Peroxiredoxin I deficiency attenuates phagocytic capacity of macrophage in clearance of the red blood cells damaged by oxidative stress
    Ying Hao Han
    Aging Research Center, KRIBB, Daejeon, Korea
    BMB Rep 45:560-4. 2012
    ....
  79. doi request reprint Secretory phospholipase A2 plays an essential role in microglial inflammatory responses to Mycobacterium tuberculosis
    Chul Su Yang
    Department of Microbiology, College of Medicine, Chungnam National University, Daejeon, South Korea
    Glia 57:1091-103. 2009
    ....
  80. ncbi request reprint Thyrotropin-mediated repression of class II trans-activator expression in thyroid cells: involvement of STAT3 and suppressor of cytokine signaling
    Ho Kim
    Laboratory of Endocrine Cell Biology, Department of Internal Medicine, Chungnam National University School of Medicine, Daejon, Korea
    J Immunol 171:616-27. 2003
    ..This report suggests that TSH is also engaged in immunomodulation through signal cross-talk with the cytokines in thyroid cells...
  81. pmc Induction of protective immune responses by a multiantigenic DNA vaccine encoding GRA7 and ROP1 of Toxoplasma gondii
    Juan Hua Quan
    Department of Infection Biology, Research Institute for Medical Sciences, Chungnam National University School of Medicine, Daejeon, South Korea
    Clin Vaccine Immunol 19:666-74. 2012
    ..Our data suggest that the multiantigenic DNA antigen pGRA7-ROP1 was more effective in stimulating host protective immune responses than separately injected single antigens, and that IL-12 serves as a good DNA adjuvant...
  82. pmc A functional promoter polymorphism in monocyte chemoattractant protein-1 is associated with increased susceptibility to pulmonary tuberculosis
    Pedro O Flores-Villanueva
    Center for Biomedical Research, University of Texas Health Center at Tyler, Tyler, TX 75708, USA
    J Exp Med 202:1649-58. 2005
    ..tuberculosis and increases the likelihood that M. tuberculosis infection will progress to active pulmonary tuberculosis...
  83. ncbi request reprint Mutational analysis of the WASP gene in 2 Korean families with Wiskott-Aldrich syndrome
    Eun Kyeong Jo
    Department of Microbiology, College of Medicine, Chungnam National University, Daejeon, Korea
    Int J Hematol 78:40-4. 2003
    ..To our knowledge, this is the first report on molecular diagnosis of WAS in Korea. In addition, we detected normal WASP expression in lymphocytes from carrier mothers, a finding consistent with the data on skewed X inactivation...
  84. ncbi request reprint Expression, production and release of the Eis protein by Mycobacterium tuberculosis during infection of macrophages and its effect on cytokine secretion
    Linoj P Samuel
    Department of Microbiology and Immunology, University of Arizona, Tucson, AZ 85724, USA
    Microbiology 153:529-40. 2007
    ..These results suggest that Eis is a mycobacterial effector that is released into the host cell to modulate inflammatory responses, possibly via transcriptional or post-translational means...
  85. ncbi request reprint A critical role of toll-like receptor 2 in nerve injury-induced spinal cord glial cell activation and pain hypersensitivity
    DongHoon Kim
    Program in Molecular and Cellular Neuroscience, Dental Research Institute, BK21, and Department of Oral Physiology, School of Dentistry, Seoul National University, Seoul 110 749, Korea
    J Biol Chem 282:14975-83. 2007
    ..These data demonstrate that toll-like receptor 2 contributes to the nerve injury-induced spinal cord glial cell activation and subsequent pain hypersensitivity...