Gang Min Hur

Summary

Affiliation: Chungnam National University
Country: Korea

Publications

  1. pmc Disruption of microtubules sensitizes the DNA damage-induced apoptosis through inhibiting nuclear factor κB (NF-κB) DNA-binding activity
    Hyunji Lee
    Department of Pharmacology, Research Institute for Medical Science, Daejeon Regional Cancer Center, Daejeon, Korea
    J Korean Med Sci 25:1574-81. 2010
  2. doi request reprint Regulation of OPA1-mediated mitochondrial fusion by leucine zipper/EF-hand-containing transmembrane protein-1 plays a role in apoptosis
    Longzhen Piao
    Department of Pharmacology, Daejeon Regional Cancer Center, Cancer Research Institute, Research Institute for Medical Sciences, College of Medicine, Chungnam National University, Taejeon, 301 131, Republic of Korea
    Cell Signal 21:767-77. 2009
  3. doi request reprint Apoptosis signal-regulating kinase1 is inducible by protein kinase Cδ and contributes to phorbol ester-mediated G1 phase arrest through persistent JNK activation
    Young Rae Kim
    Department of Pharmacology, Research Institute for Medical Science, Infection Signaling Network Research Center, Daejeon Regional Cancer Center, College of Medicine, Chungnam National University, Daejeon 301 131, Republic of Korea
    Cell Biochem Biophys 61:199-207. 2011
  4. pmc Modulatory role of phospholipase D in the activation of signal transducer and activator of transcription (STAT)-3 by thyroid oncogenic kinase RET/PTC
    Young Rae Kim
    Department of Pharmacology, College of Medicine, Chungnam National University, Daejeon, 301 131, South Korea
    BMC Cancer 8:144. 2008
  5. doi request reprint Association of LETM1 and MRPL36 contributes to the regulation of mitochondrial ATP production and necrotic cell death
    Longzhen Piao
    Department of Pharmacology, Daejeon Regional Cancer Center, Cancer Research Institute, Research Institute for Medical Sciences, South Korea
    Cancer Res 69:3397-404. 2009
  6. ncbi request reprint Phorbol 12-myristate 13-acetate protects against tumor necrosis factor (TNF)-induced necrotic cell death by modulating the recruitment of TNF receptor 1-associated death domain and receptor-interacting protein into the TNF receptor 1 signaling complex: Im
    Hee Sun Byun
    Department of Pharmacology, College of Medicine, Chungnam National University, 6 Munhwa dong, Jung Gu, Daejeon 301 131, Korea
    Mol Pharmacol 70:1099-108. 2006
  7. doi request reprint PKB-mediated PHF20 phosphorylation on Ser291 is required for p53 function in DNA damage
    Yuwen Li
    Department of Pharmacology, Metabolic Diseases and Cell Signaling Laboratory, Cancer Research Institute, Research Institute for Medical Sciences, College of Medicine, Chungnam National University, Daejeon, 301 131, South Korea
    Cell Signal 25:74-84. 2013
  8. pmc Heat shock protein 70-mediated sensitization of cells to apoptosis by Carboxyl-Terminal Modulator Protein
    Longzhen Piao
    Department of Pharmacology, Daejeon Regional Cancer Center, Cancer Research Institute, Research Institute for Medical Sciences, College of Medicine, Chungnam National University, Taejeon, 301 131, Korea
    BMC Cell Biol 10:53. 2009
  9. doi request reprint Protein kinase SGK1 enhances MEK/ERK complex formation through the phosphorylation of ERK2: implication for the positive regulatory role of SGK1 on the ERK function during liver regeneration
    Minho Won
    Department of Pharmacology, Research Institute for Medical Science, Infection Signaling Network Research Center, Daejeon Regional Cancer Center, College of Medicine, Chungnam National University, 6 Munhwa dong, Jung Gu, Daejeon 301 131, Republic of Korea
    J Hepatol 51:67-76. 2009
  10. doi request reprint Cucurbitacin induces autophagy through mitochondrial ROS production which counteracts to limit caspase-dependent apoptosis
    Tiejun Zhang
    Department of Pharmacology, Research Institute for Medical Science, Infection Signaling Network Research Center, Daejeon Regional Cancer Center, Daejeon, Republic of Korea
    Autophagy 8:559-76. 2012

Collaborators

Detail Information

Publications19

  1. pmc Disruption of microtubules sensitizes the DNA damage-induced apoptosis through inhibiting nuclear factor κB (NF-κB) DNA-binding activity
    Hyunji Lee
    Department of Pharmacology, Research Institute for Medical Science, Daejeon Regional Cancer Center, Daejeon, Korea
    J Korean Med Sci 25:1574-81. 2010
    ..Therefore, our study provided a possible anti-cancer mechanism of microtubule disrupting agent to overcome resistance against to chemotherapy such as DNA damaging agent...
  2. doi request reprint Regulation of OPA1-mediated mitochondrial fusion by leucine zipper/EF-hand-containing transmembrane protein-1 plays a role in apoptosis
    Longzhen Piao
    Department of Pharmacology, Daejeon Regional Cancer Center, Cancer Research Institute, Research Institute for Medical Sciences, College of Medicine, Chungnam National University, Taejeon, 301 131, Republic of Korea
    Cell Signal 21:767-77. 2009
    ..Taken together, these data suggest that LETM1 is a novel binding partner for CTMP that may play an important role in mitochondrial fragmentation via OPA1-cleavage...
  3. doi request reprint Apoptosis signal-regulating kinase1 is inducible by protein kinase Cδ and contributes to phorbol ester-mediated G1 phase arrest through persistent JNK activation
    Young Rae Kim
    Department of Pharmacology, Research Institute for Medical Science, Infection Signaling Network Research Center, Daejeon Regional Cancer Center, College of Medicine, Chungnam National University, Daejeon 301 131, Republic of Korea
    Cell Biochem Biophys 61:199-207. 2011
    ....
  4. pmc Modulatory role of phospholipase D in the activation of signal transducer and activator of transcription (STAT)-3 by thyroid oncogenic kinase RET/PTC
    Young Rae Kim
    Department of Pharmacology, College of Medicine, Chungnam National University, Daejeon, 301 131, South Korea
    BMC Cancer 8:144. 2008
    ..Based on the observation of high levels of PLD expression in human papillary thyroid cancer tissues, we investigated whether PLD plays a role in the regulating the RET/PTC-induced STAT3 activation...
  5. doi request reprint Association of LETM1 and MRPL36 contributes to the regulation of mitochondrial ATP production and necrotic cell death
    Longzhen Piao
    Department of Pharmacology, Daejeon Regional Cancer Center, Cancer Research Institute, Research Institute for Medical Sciences, South Korea
    Cancer Res 69:3397-404. 2009
    ..The increased expression of LETM1 in human cancer suggests that dysregulation of LETM1 is a key feature of tumorigenesis...
  6. ncbi request reprint Phorbol 12-myristate 13-acetate protects against tumor necrosis factor (TNF)-induced necrotic cell death by modulating the recruitment of TNF receptor 1-associated death domain and receptor-interacting protein into the TNF receptor 1 signaling complex: Im
    Hee Sun Byun
    Department of Pharmacology, College of Medicine, Chungnam National University, 6 Munhwa dong, Jung Gu, Daejeon 301 131, Korea
    Mol Pharmacol 70:1099-108. 2006
    ..Taken together, these results suggest that PKC activation ensures effective shutdown of the death receptor-mediated necrotic cell death pathway by modulating formation of the death receptor signaling complex...
  7. doi request reprint PKB-mediated PHF20 phosphorylation on Ser291 is required for p53 function in DNA damage
    Yuwen Li
    Department of Pharmacology, Metabolic Diseases and Cell Signaling Laboratory, Cancer Research Institute, Research Institute for Medical Sciences, College of Medicine, Chungnam National University, Daejeon, 301 131, South Korea
    Cell Signal 25:74-84. 2013
    ..Taken together, these data suggest that PHF20 is a novel substrate for PKB and its phosphorylation by PKB plays an important role in tumorigenesis via regulating of p53 mediated signaling...
  8. pmc Heat shock protein 70-mediated sensitization of cells to apoptosis by Carboxyl-Terminal Modulator Protein
    Longzhen Piao
    Department of Pharmacology, Daejeon Regional Cancer Center, Cancer Research Institute, Research Institute for Medical Sciences, College of Medicine, Chungnam National University, Taejeon, 301 131, Korea
    BMC Cell Biol 10:53. 2009
    ..In the present study we investigate novel mechanisms by which CTMP plays a role in apoptosis process...
  9. doi request reprint Protein kinase SGK1 enhances MEK/ERK complex formation through the phosphorylation of ERK2: implication for the positive regulatory role of SGK1 on the ERK function during liver regeneration
    Minho Won
    Department of Pharmacology, Research Institute for Medical Science, Infection Signaling Network Research Center, Daejeon Regional Cancer Center, College of Medicine, Chungnam National University, 6 Munhwa dong, Jung Gu, Daejeon 301 131, Republic of Korea
    J Hepatol 51:67-76. 2009
    ....
  10. doi request reprint Cucurbitacin induces autophagy through mitochondrial ROS production which counteracts to limit caspase-dependent apoptosis
    Tiejun Zhang
    Department of Pharmacology, Research Institute for Medical Science, Infection Signaling Network Research Center, Daejeon Regional Cancer Center, Daejeon, Republic of Korea
    Autophagy 8:559-76. 2012
    ....
  11. pmc Prevention of TNF-induced necrotic cell death by rottlerin through a Nox1 NADPH oxidase
    Hee Sun Byun
    Department of Pharmacology, Research Institute for Medical Science, Infection Signaling Network Research Center, College of Medicine, Chungnam National University, Daejeon 301 131, Korea
    Exp Mol Med 40:186-95. 2008
    ..Therefore, our study suggests that Nox1 NADPH oxidase is a new molecular target for anti-necrotic activity of rottlerin upon death-receptor ligation...
  12. pmc Long-term Activation of c-Jun N-terminal Kinase through Receptor Interacting Protein is Associated with DNA Damage-induced Cell Death
    Jeong Ho Seok
    Department of Pharmacology, Research Institute for Medical Sciences, College of Medicine, Chungnam National University, Daejeon 301 131, Korea
    Korean J Physiol Pharmacol 12:185-91. 2008
    ....
  13. ncbi request reprint Regulation of 3-phosphoinositide-dependent protein kinase-1 (PDK1) by Src involves tyrosine phosphorylation of PDK1 and Src homology 2 domain binding
    Keum Jin Yang
    Department of Pharmacology, Daejeon Regional Cancer Center, Cancer Research Institute, Chungnam National University, 6 Munhwa dong, Jung Gu, Taejeon 301 131, South Korea
    J Biol Chem 283:1480-91. 2008
    ..Furthermore, Tyr(9) phosphorylation is critical for the stabilization of both PDK1 and the PDK1/Src complex via Hsp90-mediated protection of PDK1 degradation...
  14. doi request reprint Intron-derived aberrant splicing of A20 transcript in rheumatoid arthritis
    Hyun Kyung Yoon
    Department of Pharmacology, College of Medicine, Chungnam National University, 6 Munhwa dong, Jung Gu, Daejeon, Korea
    Rheumatology (Oxford) 52:427-37. 2013
    ....
  15. doi request reprint Brazilin selectively disrupts proximal IL-1 receptor signaling complex formation by targeting an IKK-upstream signaling components
    Juhee Jeon
    Department of Pharmacology, Daejeon Regional Cancer Center, College of Medicine, Chungnam National University, 6 Munhwa dong, Jung Gu, Daejeon 301 747, Republic of Korea
    Biochem Pharmacol 89:515-25. 2014
    ..Taken together, the results suggest that the anti-IKK activity of brazilin is induced by targeting IKK upstream signaling components and subsequently disrupting proximal IL-1 receptor signaling complex formation. ..
  16. doi request reprint Role of protein kinase C delta in X-ray-induced apoptosis of keratinocyte
    Young Sook Lee
    Department of Dermatology and Research Institute for Medical Sciences, School of Medicine, Chungnam National University, Daejeon, Korea
    Exp Dermatol 18:50-6. 2009
    ..These results demonstrate that PKCdelta is a key regulator in X-ray-induced apoptosis of keratinocyte and suggest that there is subtle difference in downstream signalling cascade between UVB and X-ray response of keratinocyte...
  17. doi request reprint Water extract of Cynanchi atrati Radix regulates inflammation and apoptotic cell death through suppression of IKK-mediated NF-κB signaling
    Juhee Jeon
    Department of Pharmacology, Research Institute for Medical Science, Daejeon Regional Cancer Center, College of Medicine, Chungnam National University, Daejeon 301 131, Republic of Korea
    J Ethnopharmacol 137:626-34. 2011
    ..Cynanchi atrati Radix has been traditionally used as an anti-inflammatory agent to treat febrile diseases, acute urinary infection or subcutaneous pyogenic infection with invasion of the pathogenic factors...
  18. pmc Imiquimod induces apoptosis of squamous cell carcinoma (SCC) cells via regulation of A20
    Kyung Cheol Sohn
    Department of Dermatology and Research Institute for Medical Sciences, School of Medicine, Chungnam National University, Daejeon, Korea
    PLoS ONE 9:e95337. 2014
    ..Finally, imiquimod-induced apoptosis of SCC12 cells was taken place in a TLR7-independent manner. Our data provide new insight into the mechanism underlying imiquimod effect in cutaneous cancer treatment...
  19. ncbi request reprint Sustained activation of protein kinase C downregulates nuclear factor-kappaB signaling by dissociation of IKK-gamma and Hsp90 complex in human colonic epithelial cells
    Kyeong Ah Park
    Department of Pharmacology, Cancer Research Institute, College of Medicine, Chungnam National University, 6 Munhwa dong, Jung Gu, Daejeon 301 131, Korea
    Carcinogenesis 28:71-80. 2007
    ....