Genomes and Genes


Sung Wook Choi


Affiliation: Chungnam National University
Country: Korea


  1. Lee M, Balupuri A, Jung Y, Choi S, Lee A, Cho Y, et al. Design of a Novel and Selective IRAK4 Inhibitor Using Topological Water Network Analysis and Molecular Modeling Approaches. Molecules. 2018;23: pubmed publisher
    ..Pharmacophoric features of the hit molecules were hybridized to design a novel compound that inhibited IRAK4 at low nanomolar levels in the in vitro assay. ..
  2. Kim B, Park H, Lee S, Park S, Koo T, Kang N, et al. Systemic optimization and structural evaluation of quinoline derivatives as transthyretin amyloidogenesis inhibitors. Eur J Med Chem. 2016;123:777-787 pubmed publisher
    ..Additionally, the most potent compound 14c exhibited good pharmacokinetics properties. Taken together, the novel quinoline derivatives could potentially be explored as potential drug candidates to treat the human TTR amyloidosis. ..
  3. Lee E, Pokharel S, Jan A, Huh S, Galope R, Lim J, et al. Transthyretin: A Transporter Protein Essential for Proliferation of Myoblast in the Myogenic Program. Int J Mol Sci. 2017;18: pubmed publisher
    ..The results of this study will be highly useful to the strategic development of novel therapeutics to combat muscular dystrophies. ..