KiHwan Bae

Summary

Affiliation: Chungnam National University
Country: Korea

Publications

  1. ncbi request reprint A new naphthopyrone from the root of Pleuropterus ciliinervis
    Byung Sun Min
    Laboratory of Immunomodulator, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea
    Chem Pharm Bull (Tokyo) 51:1322-4. 2003
  2. ncbi request reprint A new flavonoid glycoside from the leaf of Cephalotaxus koreana
    KiHwan Bae
    College of Pharmacy, Chungnam National University, Daejeon, South Korea
    Fitoterapia 78:409-13. 2007
  3. ncbi request reprint Inhibition of human low density lipoprotein and high density lipoprotein oxidation by oligostilbenes from rhubarb
    Tran Minh Ngoc
    College of Pharmacy, Chungnam National University, Daejeon, Korea
    Biol Pharm Bull 31:1809-12. 2008
  4. ncbi request reprint Effect of the rhizomes of Astilbe chinensis on UVB-induced inflammatory response
    Minkyun Na
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    Phytother Res 18:1000-4. 2004
  5. ncbi request reprint Cytotoxicity of triterpenes isolated from Aceriphyllum rossii
    IkSoo Lee
    College of Pharmacy, Chungnam National University, Daejeon, Korea
    Chem Pharm Bull (Tokyo) 55:1376-8. 2007
  6. ncbi request reprint Antioxidant activity of caffeoyl quinic acid derivatives from the roots of Dipsacus asper Wall
    Tran Manh Hung
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Republic of Korea
    J Ethnopharmacol 108:188-92. 2006
  7. doi request reprint Stilbenes and oligostilbenes from leaf and stem of Vitis amurensis and their cytotoxic activity
    Do Thi Ha
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    Arch Pharm Res 32:177-83. 2009
  8. ncbi request reprint Anti-inflammatory activity of flavonoids from Populus davidiana
    Xinfeng Zhang
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    Arch Pharm Res 29:1102-8. 2006
  9. doi request reprint Anti-inflammatory activity of 4-methoxyhonokiol is a function of the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via NF-kappaB, JNK and p38 MAPK inactivation
    Hong Yu Zhou
    Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 151 742, South Korea
    Eur J Pharmacol 586:340-9. 2008
  10. doi request reprint Cholinesterase inhibitory and anti-amnesic activity of alkaloids from Corydalis turtschaninovii
    Tran Manh Hung
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Republic of Korea
    J Ethnopharmacol 119:74-80. 2008

Collaborators

Detail Information

Publications101 found, 100 shown here

  1. ncbi request reprint A new naphthopyrone from the root of Pleuropterus ciliinervis
    Byung Sun Min
    Laboratory of Immunomodulator, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea
    Chem Pharm Bull (Tokyo) 51:1322-4. 2003
    ..The structure of pleuropyrone A (1) was determined to be 2,5-dimethyl-8-hydroxynaphthopyrone 10-O-beta-D-glucopyranoside by spectroscopic methods including 2D-NMR. Compounds 2 and 3 showed moderate antioxidant activity...
  2. ncbi request reprint A new flavonoid glycoside from the leaf of Cephalotaxus koreana
    KiHwan Bae
    College of Pharmacy, Chungnam National University, Daejeon, South Korea
    Fitoterapia 78:409-13. 2007
    ..Compounds 2-5 exhibited antioxidant activity in scavenging DPPH and superoxide radicals with IC(50) values ranging from 5.7 to 22.3 microM...
  3. ncbi request reprint Inhibition of human low density lipoprotein and high density lipoprotein oxidation by oligostilbenes from rhubarb
    Tran Minh Ngoc
    College of Pharmacy, Chungnam National University, Daejeon, Korea
    Biol Pharm Bull 31:1809-12. 2008
    ..In addition, compounds 1-2 also showed strong ability to protect HDL oxidation induced by both Cu(2+) and AAPH with low IC(50) values. The results suggest that oligostilbenes 1-2 may have a role in preventing lipoprotein oxidation...
  4. ncbi request reprint Effect of the rhizomes of Astilbe chinensis on UVB-induced inflammatory response
    Minkyun Na
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    Phytother Res 18:1000-4. 2004
    ..The results suggest that the A. chinensis extract may have a protective effect on the UVB-injured keratinocytes by inhibiting PGE2 and NO production, possibly through the inhibition of intracellular ROS accumulation...
  5. ncbi request reprint Cytotoxicity of triterpenes isolated from Aceriphyllum rossii
    IkSoo Lee
    College of Pharmacy, Chungnam National University, Daejeon, Korea
    Chem Pharm Bull (Tokyo) 55:1376-8. 2007
    ..Olean-12-en-27-oic acid derivatives (1-6) exhibited considerable cytotoxicity against K562 and HL-60 cell lines with IC(50) values ranging from 12.2 to 28.7 microM and from 12.1 to 25.8 microM, respectively...
  6. ncbi request reprint Antioxidant activity of caffeoyl quinic acid derivatives from the roots of Dipsacus asper Wall
    Tran Manh Hung
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Republic of Korea
    J Ethnopharmacol 108:188-92. 2006
    ..These results suggested that Dipsacus asper due to its antioxidant constituents, 1-6, may have a role to play in preventing the development and progression of atherosclerotic disease...
  7. doi request reprint Stilbenes and oligostilbenes from leaf and stem of Vitis amurensis and their cytotoxic activity
    Do Thi Ha
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    Arch Pharm Res 32:177-83. 2009
    ..1 +/- 4.23 microM. On the other hand, r-2-viniverin (1), trans-amurensin B (2), trans-epsilon-viniferin (3), (+)-ampelopsin F (7), and piceatannol (9) exhibited no activity on three cancer cell lines...
  8. ncbi request reprint Anti-inflammatory activity of flavonoids from Populus davidiana
    Xinfeng Zhang
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    Arch Pharm Res 29:1102-8. 2006
    ..Moreover, compounds 5-8 exhibited suppressive effects on xanthine oxidase (XO). These results may explain, in part, the traditional uses of P. davidiana in ethnomedicine...
  9. doi request reprint Anti-inflammatory activity of 4-methoxyhonokiol is a function of the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via NF-kappaB, JNK and p38 MAPK inactivation
    Hong Yu Zhou
    Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 151 742, South Korea
    Eur J Pharmacol 586:340-9. 2008
    ..7 macrophages...
  10. doi request reprint Cholinesterase inhibitory and anti-amnesic activity of alkaloids from Corydalis turtschaninovii
    Tran Manh Hung
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Republic of Korea
    J Ethnopharmacol 119:74-80. 2008
    ..05). These results indicated that Corydalis turtschaninovii due to its alkaloids have anti-cholinesterase activity and pseudoberberine and other alkaloids have anti-amnesic activities that may be useful for cognitive impairment treatment...
  11. doi request reprint Steroids and triterpenes from the fruit bodies of Ganoderma lucidum and their anti-complement activity
    Hyo Won Seo
    College of Pharmacy, Catholic University of Daegu, Gyeongsan, Gyeongbuk 712 702, Korea
    Arch Pharm Res 32:1573-9. 2009
    ..Our findings suggested that in addition to the ketone group at C-3, the delta7(8), delta9(11)-lanostadiene type triterpene also plays an important role in inhibiting the hemolytic activity of human serum against erythrocytes...
  12. ncbi request reprint Inhibitory effects of a new iridoid, patridoid II and its isomers, on nitric oxide and TNF-alpha production in cultured murine macrophages
    Hye Kyung Ju
    College of Pharmacy, Yeungnam University, Gyongsan, Korea
    Planta Med 69:950-3. 2003
    ..These results suggest that the orientations of the C-3 and C-5 methoxy groups in the patridoids have a significant role in the expression of their biological activity...
  13. doi request reprint Effects of schisandrin on transcriptional factors in lipopolysaccharide-pretreated macrophages
    Lian Yu Guo
    Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul, 151 742, Korea
    Arch Pharm Res 32:399-405. 2009
    ....
  14. ncbi request reprint Antioxidant activity of cleomiscosins A and C isolated from Acer okamotoanum
    WenYi Jin
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    Arch Pharm Res 30:275-81. 2007
    ..4 and 8.1 microM, respectively; 2, IC50s of 23.6 and 3.9 microM, respectively). These findings suggest that 1 and 2 could be beneficial in preventing LDL oxidation in atherosclerotic lesions...
  15. ncbi request reprint Phenolic glycosides with antioxidant activity from the stem bark of Populus davidiana
    Xinfeng Zhang
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea, College of Pharmacy, Catholic University of Daegu, Gyeongbuk 712 702, Korea
    J Nat Prod 69:1370-3. 2006
    ..Of these, populosides A-C (1-3), populoside (4), grandidentatin (8), salireposide (9), and coumaroyl-beta-D-glucoside (10) exhibited antioxidant activity in this assay...
  16. doi request reprint Antioxidant and lipoxygenase inhibitory activity of oligostilbenes from the leaf and stem of Vitis amurensis
    Do Thi Ha
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Republic of Korea
    J Ethnopharmacol 125:304-9. 2009
    ..Recent studies, its root and stem possess anti-inflammatory, anti-tumor activities, and protective effects against beta-amyloid-induced oxidative stress...
  17. doi request reprint Flavonoids and isoflavonoids from Sophorae Flos improve glucose uptake in vitro
    Quan Cheng Chen
    College of Pharmacy, Chungnam National University, Daejeon, Korea
    Planta Med 76:79-81. 2010
    ..Therefore, these findings demonstrate a potential to develop these flavonoids and isoflavonoids as hypoglycemic drugs...
  18. ncbi request reprint Protective effect of magnoflorine isolated from coptidis rhizoma on Cu2+-induced oxidation of human low density lipoprotein
    Tran Manh Hung
    College of Pharmacy, Chungnam National University, Daejeon, Korea
    Planta Med 73:1281-4. 2007
    ..These results suggest that magnoflorine may be useful for preventing the oxidation of various LDL forms...
  19. ncbi request reprint Two new lignans from the stem bark of Magnolia obovata and their cytotoxic activity
    UiJoung Youn
    College of Pharmacy, Chungnam National University, Daejeon, Korea
    Chem Pharm Bull (Tokyo) 56:115-7. 2008
    ..Among the compounds tested, compound 1 showed the strongest cytotoxic activity against the HCT116 cancer cell line, with an IC(50) value of 1.3 microg/ml...
  20. doi request reprint Antioxidant activities of coumarins from Korean medicinal plants and their structure-activity relationships
    Phuong Thien Thuong
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    Phytother Res 24:101-6. 2010
    ..The results also demonstrate that the alpha-pyrone ring of coumarins significantly enhanced the capacity of inhibiting oxidative reactions of coumarins...
  21. doi request reprint Effects of Gardeniae Fructus extract and geniposide on promoting ligament cell proliferation and collagen synthesis
    Quan Cheng Chen
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    Phytother Res 24:S1-5. 2010
    ..However, the use of diclofenac to treat acute ligament injuries should be reassessed although it possesses a potential effect on relieving symptoms...
  22. ncbi request reprint New anti-inflammatory formulation containing Synurus deltoides extract
    Yong Hwan Choi
    College of Pharmacy, Kangwon National University, Chunchon 200 701, Korea
    Arch Pharm Res 28:848-53. 2005
    ..Although the anti-inflammatory potencies of SAG were less than those of currently used anti-inflammatory drugs, this formulation may have beneficial effect on inflammatory disorders as a neutraceutical...
  23. doi request reprint Tyrosinase-inhibitory constituents from the twigs of Cinnamomum cassia
    Tran Minh Ngoc
    College of Pharmacy, Chungnam National University, Daejeon 305 764, South Korea
    J Nat Prod 72:1205-8. 2009
    ..The structures of the new compounds were determined by spectroscopic data interpretation. Compounds 1-6 and 8-13 showed strong inhibitory activity against tyrosinase, with IC(50) values ranging from 0.24 to 0.94 mM...
  24. ncbi request reprint Anti-complementary activity of ursane-type triterpenoids from Weigela subsessilis
    Phuong Thien Thuong
    College of Pharmacy, Chungnam National University, Daejeon, Korea
    Biol Pharm Bull 29:830-3. 2006
    ..This shows that a carboxylic group of ursane-type triterpenoids seems to play an important role in inhibiting the hemolytic activity of human serum against erythrocytes...
  25. doi request reprint Selected compounds derived from Moutan Cortex stimulated glucose uptake and glycogen synthesis via AMPK activation in human HepG2 cells
    Do Thi Ha
    College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea
    J Ethnopharmacol 131:417-24. 2010
    ..To evaluate the effect of selected compounds derived from Moutan Cortex on glucose uptake and glycogen synthesis associated with AMPK activation in insulin-resistant human HepG2 cell...
  26. ncbi request reprint Cytotoxic and COX-2 inhibitory constituents from the aerial parts of Aralia cordata
    Ik Soo Lee
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    Arch Pharm Res 29:548-55. 2006
    ..Although most compounds, except for 2, 10, and 12, showed a strong inhibitory activity against COX-1, they exhibited a moderate or weak inhibitory activity against COX-2...
  27. ncbi request reprint Magnoflorine from Coptidis Rhizoma protects high density lipoprotein during oxidant stress
    Tran Manh Hung
    College of Pharmacy, Chungnam National University, Daejeon, Korea
    Biol Pharm Bull 30:1157-60. 2007
    ..The results suggest that magnoflorine may have a role to play in preventing the HDL oxidation...
  28. ncbi request reprint Lignans from the Fruits of Forsythia suspensa (Thunb.) Vahl Protect High-Density Lipoprotein during Oxidative Stress
    Min Jung Chang
    College of Pharmacy, Catholic University of Daegu, Gyeongsan, Korea
    Biosci Biotechnol Biochem 72:2750-5. 2008
    ..0 microM. These results suggest that the antioxidative effects of F. suspensa are due to its lignans and that these constituents may be useful for preventing the oxidation of HDL...
  29. doi request reprint Biphenyl and biphenyl ether quinolizidine N-oxide alkaloids from Lagerstroemia indica L
    IkSoo Lee
    College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea
    Planta Med 77:2037-41. 2011
    ..In addition, the inhibitory effects of isolated compounds on rat lens aldose reductase (RLAR) were examined...
  30. doi request reprint A new flavan-3-ol and the anti-inflammatory effect of flavonoids from the fruit peels of Wisteria floribunda
    Bui Huu Tai
    College of Pharmacy, Chungnam National University, Daejeon, 305 764, Korea
    J Asian Nat Prod Res 13:1061-8. 2011
    ..1 μm...
  31. ncbi request reprint Reticulone, a novel free radical scavenger produced by Aspergillus sp
    In Ja Ryoo
    Korea Research Institute of Bioscience and Biotechnology, Daejeon 305 806, Korea
    J Microbiol Biotechnol 19:1573-5. 2009
    ..Compound 1 exhibited more potent free radical scavenging activity on ABTS.+ (2,2'-azino-bis [3-ethylbenzthiazoline-6-sulphonic acid]) and DPPH radicals than did butylated hydroxyanisole (BHA) and caffeic acid...
  32. ncbi request reprint Antiinflammatory activity of Synurus deltoides
    Joon Hyun Park
    College of Pharmacy, Kangwon National University, Chunchon 200 701, Korea
    Phytother Res 18:930-3. 2004
    ..31% and 0.37% (w/w), respectively, based on the dried extract by HPLC analysis. All the results obtained indicate that this plant material may be used beneficially as an antiinflammatory agent having analgesic action...
  33. doi request reprint Inhibitors of aldose reductase and formation of advanced glycation end-products in moutan cortex (Paeonia suffruticosa)
    Do Thi Ha
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    J Nat Prod 72:1465-70. 2009
    ..Compounds 3 and 6 inhibited AGE formation with IC(50) values of 10.8 and 11.3 microM, respectively. Compound 2 had an IC(50) value of 177.0 microM, whereas the positive control, aminoguanidine, had an IC(50) value of 1026.8 microM...
  34. doi request reprint Dammarane-type glycosides from Gynostemma pentaphyllum and their effects on IL-4-induced eotaxin expression in human bronchial epithelial cells
    Tran Manh Hung
    College of Pharmacy, Catholic University of Daegu, Kyeongbuk 712 702, Korea
    J Nat Prod 73:192-6. 2010
    ..Their structures were elucidated by 1D and 2D NMR spectroscopic interpretation as well as by chemical studies. The isolated compounds showed potential inhibitory effects on eotaxin expression in BEAS-2B bronchial epithelial cells...
  35. ncbi request reprint Isolation of constituents and anti-complement activity from Acer okamotoanum
    WenYi Jin
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    Arch Pharm Res 30:172-6. 2007
    ..In addition, the novel compound was found to exhibit a significant inhibitory effect (IC50 value of 0.2 microM) on the complement system activated by the classical pathway...
  36. ncbi request reprint Anti-oxidant constituents from Sedum takesimense
    Phuong Thien Thuong
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Republic of Korea
    Phytochemistry 68:2432-8. 2007
    ..0 and 10.8 microM, respectively) and LDL oxidation induced by a metal ion Cu(2+) (IC(50) 5.7 and 3.3 microM, respectively)...
  37. doi request reprint Alkaloids from roots of Stephania rotunda and their cholinesterase inhibitory activity
    Tran Manh Hung
    College of Pharmacy, Catholic University of Daegu, Gyeongbuk, Korea
    Planta Med 76:1762-4. 2010
    ..The chemical structures of the isolated compounds were elucidated based on extensive 1D and 2D NMR spectroscopic data. Compounds 1-8 were investigated in vitro for their anticholinesterase activity using a rat cortex AChE enzyme...
  38. doi request reprint Effect of lanostane triterpenes from the fruiting bodies of Ganoderma lucidum on adipocyte differentiation in 3T3-L1 cells
    IkSoo Lee
    College of Pharmacy, Chungnam National University, Daejeon, Korea
    Planta Med 76:1558-63. 2010
    ..Our findings demonstrate that the lanostane triterpenes isolated in this study contribute to the inhibitory effect of the fruiting bodies of G. LUCIDUM on adipocyte differentiation in 3T3-L1 cells...
  39. ncbi request reprint Diarylheptanoids from Alnus hirsuta inhibit the NF-kB activation and NO and TNF-alpha production
    WenYi Jin
    College of Pharmacy, Chungnam National University, Korea
    Biol Pharm Bull 30:810-3. 2007
    ..This is the first report of NF-kB-inhibitory activity of these compounds and supports the pharmacological use of A. hirsuta, which has been employed as a herbal medicine for the treatment of inflammatory diseases...
  40. doi request reprint Two new lignans from the roots of Pulsatilla koreana
    To Dao Cuong
    College of Pharmacy, Catholic University of Daegu, Gyeongsan, Gyeongbuk, Korea
    Planta Med 77:66-9. 2011
    ..Among them, compound 6 showed significant inhibitory activity with an IC (50) value of 75.9 µM, compounds 8 and 9 had moderate effects with IC (50) values of 182.2 and 166.5 µM, respectively...
  41. ncbi request reprint Anti-inflammatory activity of pectolinarigenin and pectolinarin isolated from Cirsium chanroenicum
    Hyun Lim
    College of Pharmacy, Kangwon National University, Chunchon, Korea
    Biol Pharm Bull 31:2063-7. 2008
    ..These activities certainly contribute to the anti-inflammatory mechanism of C. chanroenicum...
  42. doi request reprint Fatty acid synthase inhibitory activity of dibenzocyclooctadiene lignans isolated from Schisandra chinensis
    Minkyun Na
    College of Pharmacy, Yeungnam University, Gyeongbuk, South Korea
    Phytother Res 24:S225-8. 2010
    ..The findings may be partially related to the anticancer effect of the medicinal plant, suggesting a further study on the anticancer potential of dibenzocyclooctadiene derivatives...
  43. doi request reprint Biphenylquinolizidine alkaloids from Lagerstroemia indica
    Hong Jin Kim
    College of Pharmacy, Chungnam National University, Daejeon, Korea
    J Nat Prod 72:749-52. 2009
    ..The structures of compounds 1-3 were elucidated by extensive spectroscopic techniques...
  44. ncbi request reprint Antioxidative activities of galloyl glucopyranosides from the stem-bark of Juglans mandshurica
    Tran Minh Ngoc
    College of Pharmacy, Chungnam National University, Daejeon, Korea
    Biosci Biotechnol Biochem 72:2158-63. 2008
    ..In comparison, the antioxidative activities of compounds 1 and 2, together with gallic acid, indicated that the number of galloyl moieties could play an important role in the antioxidative activity...
  45. ncbi request reprint Cytoprotective effect on oxidative stress and inhibitory effect on cellular aging of Uncaria sinensis Havil
    Minkyun Na
    College of Pharmacy, Chungnam National University, Daejeon 305 764, South Korea
    J Ethnopharmacol 95:127-32. 2004
    ....
  46. doi request reprint Triterpenoids and a sterol from the stem-bark of Styrax japonica and their protein tyrosine phosphatase 1B inhibitory activities
    Joo Hee Kwon
    College of Pharmacy, Catholic University of Daegu, Gyeongbuk 712 702, Korea
    Phytother Res 22:1303-6. 2008
    ..Among the isolated compounds, 3beta-acetoxyolean-12-en-28-acid (2) and 3beta-acetoxyolean-12-en-28-aldehyde (3) had the most potent inhibitory PTP1B activity, with IC50 values of 7.8 and 9.3 microm, respectively...
  47. ncbi request reprint Antiinflammatory activity of astilbic acid from Astilbe chinensis
    Tae Chul Moon
    College of Pharmacy, Yeungnam University, Gyongsan, Korea
    Biol Pharm Bull 28:24-6. 2005
    ..4-50 mg/kg) after being administered orally, while aspirin (200 mg/kg) showed 62% inhibition. These results suggest that astilbic acid may be beneficial in regulating various inflammatory processes...
  48. ncbi request reprint Iridoid esters from Patrinia saniculaefolia
    Ren Bo An
    College of Pharmacy, Chungnam National University, Daejeon, Korea
    Chem Pharm Bull (Tokyo) 51:583-5. 2003
    ..The structures of compounds 1 and 2 were established on the basis of spectroscopic methods, including two dimensional (2D NMR) and high resolution fast atom bombardment mass spectrometry (HR-FAB-MS)...
  49. doi request reprint Protein tyrosine phosphatase 1B inhibitory activity of 24-norursane triterpenes isolated from Weigela subsessilis
    Minkyun Na
    College of Pharmacy, Yeungnam University, Gyeongsan, Gyeongbuk 712 749, Korea
    Phytother Res 24:1716-9. 2010
    ..Kinetic studies suggest that both 1 and 2 are non-competitive inhibitors of PTP1B. The findings indicate that the free carboxyl group at C-28 in this type of triterpenes plays a critical role in the inhibition of PTP1B...
  50. doi request reprint Anticomplementary activity of triterpenoids from the whole plant of Aceriphyllum rossii against the classical pathway
    Byung Sun Min
    College of Pharmacy, Catholic University of Daegu, Gyeongsan, Korea
    Planta Med 74:726-9. 2008
    ..Our findings suggest that both the ketone at C-3 and the methyl at C-23 in the oleanane triterpenoids with a carboxyl group at C-27 are important for the anticomplement activity against the classical pathway...
  51. doi request reprint Lanostane triterpenes from the fruiting bodies of Ganoderma lucidum and their inhibitory effects on adipocyte differentiation in 3T3-L1 Cells
    IkSoo Lee
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    J Nat Prod 73:172-6. 2010
    ..The structures of the new triterpenes were established by extensive spectroscopic studies and chemical evidence. In addition, the inhibitory effect of isolated compounds on adipocyte differentiation in 3T3-L1 cells was examined...
  52. ncbi request reprint Anti-apoptotic and hepatoprotective effects of gomisin A on fulminant hepatic failure induced by D-galactosamine and lipopolysaccharide in mice
    Sung Hwa Kim
    College of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi Do, Korea
    J Pharmacol Sci 106:225-33. 2008
    ..The liver protection afforded by gomisin A is the result of the reduced oxidative stress and its anti-apoptotic activity...
  53. ncbi request reprint Gymnasterkoreayne G, a new inhibitory polyacetylene against NFAT transcription factor from Gymnaster koraiensis
    Nguyen Tien Dat
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    Chem Pharm Bull (Tokyo) 53:1194-6. 2005
    ..44+/-0.59 microM). In term of the isomers, compound 1 (IC(50) 43.9+/-2.24 microM) with an erythro-configuration showed less inhibition than 2 (IC(50) 7.24+/-0.42 microM) with a threo-configuration...
  54. ncbi request reprint Anti-inflammatory activity of Sedum kamtschaticum
    Dong Wook Kim
    College of Pharmacy, Kangwon National University, Chunchon 200 701, South Korea
    J Ethnopharmacol 90:409-14. 2004
    ..Using lipopolysaccharide-treated RAW 264.7 cells, down-regulation of cyclooxygenase-2 expression was found to be one of the cellular action mechanisms of anti-inflammation by Sedum kamtschaticum...
  55. ncbi request reprint Cytotoxic constituents from angelicae sinensis radix
    Quan Cheng Chen
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    Arch Pharm Res 30:565-9. 2007
    ..45 +/- 0.19 and 9.87 +/- 0.14 microM. Two polyacetylenes, 3 and 4, showed cytotoxicity only against L1210 cell line with IC50 values of 2.60 +/- 0.90 and 2.87 +/- 0.49 microM, respectively...
  56. doi request reprint Anti-inflammatory activity of constituents from Glechoma hederacea var. longituba
    JinPyo Kim
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Republic of Korea
    Bioorg Med Chem Lett 21:3483-7. 2011
    ..Each compound was tested by NF-κB luciferase assay and three rosmarinic acid analogues inhibited NF-κB production and the induction of COX-2 and iNOS mRNA in HepG2 cells...
  57. doi request reprint New sesquiterpene lactones from Glechoma hederacea L. and their cytotoxic effects on human cancer cell lines
    JinPyo Kim
    College of Pharmacy, Chungnam National University, Daejeon, Korea
    Planta Med 77:955-7. 2011
    ..Cytotoxic effects of the isolated compounds were examined against MDA-MB-231 (breast), HCT116 (colon), SW620 (colon), and DU145 (prostate) human cancer cell lines...
  58. doi request reprint Ergosta-7,22-diene-2β,3α,9α-triol from the fruit bodies of Ganoderma lucidum induces apoptosis in human myelocytic HL-60 cells
    Mi Kyoung Lee
    College of Pharmacy, Catholic University of Daegu, Gyeongbuk 712 702, Korea
    Phytother Res 25:1579-85. 2011
    ..p.) of EGDT to Lewis lung carcinoma (LLC)-inoculated mice evidenced a significant inhibition of tumor growth. These results indicate that EGDT was one of the apoptotic constituents of G. lucidum, and might be an antitumor agent...
  59. doi request reprint Iridoid glycosides from Gardeniae Fructus for treatment of ankle sprain
    Quan Cheng Chen
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Republic of Korea
    Phytochemistry 70:779-84. 2009
    ..01) with approximately 21-34% reduction in swelling ratio compared with those of the vehicle treated control group. This indicated the potential effect of geniposide (4) for the treatment of disorders such as ankle sprain...
  60. doi request reprint Rhusonoside A, a new megastigmane glycoside from Rhus sylvestris, increases the function of osteoblastic MC3T3-E1 cells
    Yan Ding
    College of Pharmacy, Chungnam National University, Daejeon, Korea
    Planta Med 75:158-62. 2009
    ..39 %, 171.27 %, and 134.25 %, respectively, of the basal value at 10 muM ( P < 0.05). In addition, 0.1 muM of compound 1 significantly increased mineralization of MC3T3-E1 cells to 142.78 % ( P < 0.05) of the basal value...
  61. ncbi request reprint Inhibitory effect of coumarins from Weigela subsessilis on low density lipoprotein oxidation
    Phuong Thien Thuong
    College of Pharmacy, Chungnam National University, Daejeon, Korea
    Biol Pharm Bull 28:1095-7. 2005
    ..These results suggest that W. subsessilis and its active coumarins, 1 and 2, may have a role to play in preventing the LDL oxidation involved in atherogenesis...
  62. doi request reprint The antimicrobial activity of compounds from the leaf and stem of Vitis amurensis against two oral pathogens
    Namhui Yim
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Republic of Korea
    Bioorg Med Chem Lett 20:1165-8. 2010
    ..amurensis. Thus, this result suggests that natural antimicrobial compounds derived from V. amurensis may benefit oral health as plaque-control agents for the prevention of dental caries and periodontal disease...
  63. doi request reprint The selected flavonol glycoside derived from Sophorae Flos improves glucose uptake and inhibits adipocyte differentiation via activation AMPK in 3T3-L1 cells
    Do Thi Ha
    College of Pharmacy, Chungnam National University, Daejeon, South Korea
    Bioorg Med Chem Lett 20:6076-81. 2010
    ..It also reduced FAS gene expression in a dose-dependent manner, which is crucial for adipogenesis in vitro...
  64. doi request reprint Lanostane triterpenes from Ganoderma lucidum suppress the adipogenesis in 3T3-L1 cells through down-regulation of SREBP-1c
    IkSoo Lee
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Republic of Korea
    Bioorg Med Chem Lett 20:5577-81. 2010
    ....
  65. doi request reprint Adlay seed extract (Coix lachryma-jobi L.) decreased adipocyte differentiation and increased glucose uptake in 3T3-L1 cells
    Do Thi Ha
    College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea
    J Med Food 13:1331-9. 2010
    ..ECLJ decreased mean droplet size. These results suggest a possible role for AMPK in the process of adipose differentiation and that ECLJ targeted for adipocyte functions could be effective in improving the symptoms of metabolic syndrome...
  66. ncbi request reprint Inhibitory effect on TNF-alpha-induced IL-8 production in the HT29 cell of constituents from the leaf and stem of Weigela subsessilis
    Phuong Thien Thuong
    College of Pharmacy, Chungnam National University, Daejeon, Korea
    Arch Pharm Res 28:1135-41. 2005
    ..H. Bailey. In addition, three compounds 7, 9, and 12 were found to display a strong inhibitory effect on the production of IL-8 in the HT29 cells stimulated by TNF-alpha...
  67. doi request reprint Lipoxygenase inhibitory constituents from rhubarb
    Tran Minh Ngoc
    College of Pharmacy, Chungnam National University, Daejeon, 305 764, Korea
    Arch Pharm Res 31:598-605. 2008
    ..These results indicated that stilbene derivatives were considerate to be mainly lipoxygenase inhibitor and free radical scavenger constituents of rhubarb...
  68. ncbi request reprint Triterpenoids from Camellia japonica and their cytotoxic activity
    Nguyen Thi Phuong Thao
    College of Pharmacy, Catholic University of Daegu, Korea
    Chem Pharm Bull (Tokyo) 58:121-4. 2010
    ..Among them, compound 8 showed cytotoxicity against LLC and HL-60 cancer cell lines with IC(50) values of 25.2 and 21.7 microM, respectively...
  69. ncbi request reprint Polyacetylene glycosides from Gymnaster koraiensis
    JinYoung Park
    College of Pharmacy, Chungnam National University, Taejon, Korea
    Chem Pharm Bull (Tokyo) 50:685-7. 2002
    ....
  70. ncbi request reprint Furo-1,2-naphthoquinones from Crataegus pinnatifida with ICAM-1 expression inhibition activity
    Byung Sun Min
    Laboratory of Immunomodulator, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea
    Planta Med 70:1166-9. 2004
    ..The two compounds 1 and 2 showed significant inhibitory activity with IC50 values of 33 and 90 microM, respectively, against the expression of intercellular adhesion molecule-1 (ICAM-1)...
  71. ncbi request reprint Antioxidant activity of anthraquinones and flavonoids from flower of Reynoutria sachalinensis
    Xinfeng Zhang
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    Arch Pharm Res 28:22-7. 2005
    ..3, 54.7, and 46.2 microM (DPPH scavenging), the IC50 values of 6.0, 6.7, and 4.4 microM (superoxide radical scavenging) and the IC50 values of 3.8, 3.2, and 5.4 microM against LDL oxidation, respectively...
  72. ncbi request reprint The inhibition of diacylglycerol acyltransferase by terpenoids from Youngia koidzumiana
    Nguyen Tien Dat
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    Arch Pharm Res 28:164-8. 2005
    ..7, 26.4, and 44.3 microM, respectively. However, sesquiterpenoids showed only weak inhibitory effects toward DGAT...
  73. ncbi request reprint Inhibitory constituents against cyclooxygenases from Aralia cordata Thunb
    Nguyen Hai Dang
    College of Pharmacy, Chungnam National University, Taejon 305 764, Korea
    Arch Pharm Res 28:28-33. 2005
    ..7 microM, 99.6 microM, and 69.6 microM, respectively. But, most of these compounds weakly inhibited COX-2 dependent PGE2 generation. Among them, only compound 4 showed relatively significant inhibitory activity (IC50: 127.6 microM)...
  74. ncbi request reprint Cytoprotective effect on oxidative stress and inhibitory effect on cellular aging of Terminalia chebula fruit
    Minkyun Na
    College of Pharmacy, Chungnam National University, Daejeon, Korea
    Phytother Res 18:737-41. 2004
    ..chebula extract on the age-dependent shortening of the telomere, length as shown by the Southern blots of the terminal restriction fragments (TRFs) of DNA extracted from subculture passages...
  75. ncbi request reprint Gymnastone, a new benzofuran derivative from Gymnaster koraiensis
    Nguyen Tien Dat
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    Arch Pharm Res 27:1106-8. 2004
    ..The structures of both compounds were identified by physico-chemical and spectral analysis including COSY, HMQC, and HMBC experiments...
  76. ncbi request reprint Cytotoxic coumarins from the root of Angelica dahurica
    Pham Ngoc Thanh
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    Arch Pharm Res 27:1211-5. 2004
    ..6 to 14.6 microg/mL against four kinds of tumor cell lines. Other compounds showed the moderate cytotoxic activity or no activity against the tumor cell lines...
  77. ncbi request reprint Triterpenoid saponins from the seeds of Pharbitis nil
    Da Young Jung
    Department of Drug Research and Development, Korea Institute of Oriental Medicine, Daejeon, Korea
    Chem Pharm Bull (Tokyo) 56:203-6. 2008
    ..Pharbitoside B (2) is a 21alpha-hydroxyoleanolic acid saponin carrying the same sugar moiety as that of pharbitoside A (1)...
  78. ncbi request reprint Inhibitory effects of paeonol on morphine-induced locomotor sensitization and conditioned place preference in mice
    Jae Soon Eun
    College of Pharmacy, Woosuk University, Samrye 565 701, Korea
    Arch Pharm Res 29:904-10. 2006
    ..These results provide evidence that paeonol exerts anti-dopaminergic activity, and it is suggested that paeonol may be useful for the prevention and therapy of these adverse actions of morphine...
  79. ncbi request reprint Inhibitory effects of nardostachin on nitric oxide, prostaglandin E2, and tumor necrosis factor-alpha production in lipopolysaccharide activated macrophages
    Hye Kyung Ju
    College of Pharmacy, Yeungnam University, Gyongsan, Korea
    Biol Pharm Bull 26:1375-8. 2003
    ..These results suggest that nardostachin may be useful for inhibiting the production of inflammatory mediators such as TNF-alpha, NO and PGE(2) in inflammatory diseases...
  80. ncbi request reprint Hydoroxyhibiscone A, a novel human neutrophil elastase inhibitor from Hibiscus syriacus
    In Ja Ryoo
    Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea
    J Microbiol Biotechnol 20:1189-91. 2010
    ..Compounds 1 and 2 were found to possess significant anti-aging properties on the human neutrophil elastase (HNE) assay, exhibiting HNE inhibitory activities with IC50 values of 5.2 and 4.6 micronM, respectively...
  81. ncbi request reprint Anti-inflammatory activity of Elsholtzia splendens
    Dong Wook Kim
    College of Pharmacy, Kangwon National University, Chunchon, Korea
    Arch Pharm Res 26:232-6. 2003
    ..7 cells, suggesting that cyclooxygenase-2 inhibition might be one of the cellular mechanisms of anti-inflammation...
  82. ncbi request reprint Monoamine oxidase inhibitory coumarin from Zanthoxylum schinifolium
    Young Su Jo
    College of Pharmacy, Chungnam National University, Daejeon, Korea
    Planta Med 68:84-5. 2002
    ..2 microM. The MAO-A (IC(50) value, 5.7 microM) sensitivity to lacinartin was greater than that of MAO-B (IC(50) value, 28.6 microM). An enzyme kinetic study revealed that lacinartin inhibited MAO activity by a non-competitive mode...
  83. ncbi request reprint Effect of Astilbe koreana on ultraviolet B (UVB)-induced inflammatory response in human keratinocytes
    Minkyun Na
    College of Pharmacy, Chungnam National University, Daejeon, Korea
    Biol Pharm Bull 27:1301-4. 2004
    ..The results suggest that the A. koreana extract may have a protective effect on the UVB-injured keratinocytes by inhibiting PGE2 and NO production, possibly through the inhibition of intracellular ROS accumulation...
  84. doi request reprint Total peroxyl radical-scavenging capacity of the chemical components from the stems of Acer tegmentosum maxim
    Nguyen Huu Tung
    College of Pharmacy, and Research Center for Transgenic Cloned Pigs, Chungnam National University, Daejeon, Korea
    J Agric Food Chem 56:10510-4. 2008
    ..Among them, the most active components belong to the flavonoids. Among these, quercitrin (1), 6-hydroxy-quercetin-3-O-galactose (6), and (+)-catechin (8) showed stronger activity than the positive control Trolox...
  85. doi request reprint Silymarin inhibits melanin synthesis in melanocyte cells
    Soo Jin Choo
    Functional Metabolomics Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea
    J Pharm Pharmacol 61:663-7. 2009
    ..The aim was to search for inhibitors of melanogenesis from natural resources...
  86. ncbi request reprint A phenylpropanoid glycoside with antioxidant activity from Picria tel-ferae
    Nguyen Duy Thuan
    National Institute of Medicinal Materials, 3B Quangtrung, Hanoi, Vietnam
    Arch Pharm Res 30:1062-6. 2007
    ..These findings, together with those of previous studies, suggest that P. tel-ferae possesses abundant phenylpropanoid glycosides, and the plant might be used beneficially in the treatment of oxidative stress-related human diseases...
  87. ncbi request reprint Dimeric sesquiterpenoids isolated from Chloranthus japonicus inhibited the expression of cell adhesion molecules
    Oh Eok Kwon
    Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology, 52 Eoun dong, Yusong gu, Taejeon 305 333, Republic of Korea
    J Ethnopharmacol 104:270-7. 2006
    ..4 nM, 13.6 microM and 95.6 nM, respectively. The present findings suggest that 1-3 prevent monocyte adhesion to HUVEC through the inhibition of cell adhesion molecules expression stimulated by TNF-alpha...
  88. ncbi request reprint Neuroprotective effect of oxyresveratrol from smilacis chinae rhizome on amyloid Beta protein (25-35)-induced neurotoxicity in cultured rat cortical neurons
    Ju Yeon Ban
    College of Veterinary Medicine and Research Institute of Herbal Medicine, Chungbuk National University, South Korea
    Biol Pharm Bull 29:2419-24. 2006
    ..Furthermore, these effects of oxyresveratrol may be associated with the neuroprotective effect of Smilacis chinae rhizome...
  89. ncbi request reprint A new acylated triterpene from the roots of Chaenomeles japonica
    Yong Nan Xu
    Natural Products Research Institute, Seoul National University, Seoul, Korea
    Chem Pharm Bull (Tokyo) 50:1124-5. 2002
    ..LINDL. (Rosaceae) and determined to be 3-O-(E)-3, 5-dihydroxycinnamoylursolic acid on the basis of NMR and FAB-MS experiments...
  90. ncbi request reprint Chemical constituents of the root of Dystaenia takeshimana and their anti-inflammatory activity
    Ju Sun Kim
    Natural Products Research Institute and College of Pharmacy, Seoul National University, Seoul 110 460, Korea
    Arch Pharm Res 29:617-23. 2006
    ..These results suggest that the anti-inflammatory activity of D. takeshimana might in part occur via the inhibition of the generation of eicosanoids...
  91. ncbi request reprint Neuroprotective effect of Smilacis chinae rhizome on NMDA-induced neurotoxicity in vitro and focal cerebral ischemia in vivo
    Ju Yeon Ban
    College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, Korea
    J Pharmacol Sci 106:68-77. 2008
    ....
  92. ncbi request reprint Constituents of the fruits and leaves of Euodia daniellii
    Sang Woo Yoo
    Natural Products Research Institute and College of Pharmacy, Seoul National University, Seoul 110 460, Korea
    Arch Pharm Res 25:824-30. 2002
    ..2 microg/ml. Flavonoids isolated from this plant exhibited no cytotoxic activity against the human tumor cell lines, A549, SKOV-3, SKMEL-2, XF498, and HCT15...
  93. ncbi request reprint Quantitative determination of psoralen and angelicin from some medicinal herbs by high performance liquid chromatography
    Nguyen Thanh Dong
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    Arch Pharm Res 26:516-20. 2003
    ..The variation of the concentration of psoralen and angelicin was wide between different species. The seeds of Psoralea corylifolia showed the highest contents of psoralen (7.8 mg/g) and angelicin (2.3 mg/g) among the tested herbs...
  94. ncbi request reprint Cytotoxic saponins from the root of Dipsacus asper Wall
    Tran Manh Hung
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    Arch Pharm Res 28:1053-6. 2005
    ..7 to 8.7 microg/mL, with the exception of compound 7, which exhibited weak cytotoxic activity against SK-OV-3 (IC50 22.5 microg/mL). Other compounds did not exhibit any cytotoxic activity (IC50 > 30 microg/mL)...
  95. ncbi request reprint Alkaloidal constituents from Aconitum jaluense
    Sang Hee Shim
    Natural Products Research Institute and College of Pharmacy, Seoul National University, Seoul 110 460, Korea
    Arch Pharm Res 26:709-15. 2003
    ..Structures of those alkaloids were determined on the basis of their spectral data. It is of interest to note that a comparison of the present work and the previous report showed some differences in the alkaloidal contents...
  96. ncbi request reprint Green tea catechins as a BACE1 (beta-secretase) inhibitor
    So Young Jeon
    Division of Applied Biology and Chemistry, College of Agriculture and Life Sciences, Kyungpook National University, 1370 Sankyuk Dong, Daegu 702 701, South Korea
    Bioorg Med Chem Lett 13:3905-8. 2003
    ..The active catechins inhibited BACE1 activity in a non-competitive manner with a substrate in Dixon plots...
  97. ncbi request reprint Quality evaluation of Alismatis Rhizoma by high performance liquid chromatography
    Sang Myung Lee
    KT and G Central Research Institute, Daejon 305 805, Korea
    Arch Pharm Res 27:460-4. 2004
    ..Alisol B 23-acetate contents in Alismatis Rhizoma obtained from several herbal markets were varied from 0.15% to 0.56%...
  98. ncbi request reprint Phenolic glycosides from Pyrola japonica
    Ju Sun Kim
    Natural Products Research Institute and College of Pharmacy, Seoul National University, Seoul 110 460, Korea
    Chem Pharm Bull (Tokyo) 52:714-7. 2004
    ....
  99. ncbi request reprint Triterpenoid saponins from the roots of Sophora koreensis
    Ji Hye Byun
    Natural Products Research Institute and College of Pharmacy, Seoul National University, Korea
    Chem Pharm Bull (Tokyo) 52:870-3. 2004
    ..The conformation of the arabinopyranosyl moiety existing in the trisaccharide moiety was determined to be (1)C(4), whereas that of the arabinopyranosyl unit at C-22 was identified as (4)C(1)...
  100. ncbi request reprint Saponins and other constituents from the leaves of Aralia elata
    Ju Sun Kim
    Natural Products Research Institute and College of Pharmacy, Seoul National University, Seoul 110 460, Korea
    Chem Pharm Bull (Tokyo) 53:696-700. 2005
    ..In addition, two known lipids, Arisaema glyceride 3 and ceramide mixtures were also isolated and characterized. Collinsonidin and two known lipids were isolated for the first time from this plant...
  101. ncbi request reprint Plant phenolics as prolyl endopeptidase inhibitors
    Seung Ho Lee
    College of Agriculture and Life Sciences, Kyungpook National University, Daegu 702 701, Korea
    Arch Pharm Res 30:827-33. 2007
    ..They did not show significant effects against other serine proteases such as trypsin, chymotrypsin and elastase, indicating that they were relatively specific PEP inhibitors...