Sang Bae Han


Affiliation: Chungbuk National University
Country: Korea


  1. Han J, Lee Y, Im J, Ham Y, Lee H, Han S, et al. Astaxanthin Ameliorates Lipopolysaccharide-Induced Neuroinflammation, Oxidative Stress and Memory Dysfunction through Inactivation of the Signal Transducer and Activator of Transcription 3 Pathway. Mar Drugs. 2019;17: pubmed publisher
    ..These results indicated AXT inhibits LPS-induced oxidant activity, neuroinflammatory response and amyloidogenesis via the blocking of STAT3 activity through direct binding. ..
  2. Kim J, Kim B, Lee H, Kim H, Park E, Choi Y, et al. Characterization of morphological changes of B16 melanoma cells under natural killer cell attack. Int Immunopharmacol. 2019;67:366-371 pubmed publisher
  3. Kim J, Kim J, Lee H, Kim H, Park E, Choi J, et al. CXCR3-deficient natural killer cells fail to migrate to B16F10 melanoma cells. Int Immunopharmacol. 2018;63:66-73 pubmed publisher
  4. Dung D, Dung P, Oanh D, Hai P, Huong L, Loi V, et al. Novel 3-substituted-2-oxoindoline-based N-hydroxypropenamides as histone deacetylase inhibitors and antitumor agents. Med Chem. 2015;11:725-35 pubmed
    ..Our present results demonstrate that these novel 3-substituted-2-oxoindoline-based N-hydroxypropenamides are potential for further development as anticancer agents. ..
  5. Kang J, Yoon Y, Lee M, Lee C, Lee S, Han S. Testing Cell-Based Immunotherapy for Colorectal Cancer. Methods Mol Biol. 2018;1765:299-305 pubmed publisher
    ..We also describe a xenograft model of human colorectal cancer. This model can be used for applied to preclinical evaluation of various cell-based therapy regimens for colorectal cancer treatment. ..
  6. Kang M, Jo S, Yoon Y, Park K, Oh S, Yun J, et al. Agelasine D suppresses RANKL-induced osteoclastogenesis via down-regulation of c-Fos, NFATc1 and NF-κB. Mar Drugs. 2014;12:5643-56 pubmed publisher
    ..Our results also suggest that AD might be a potential therapeutic agent for prevention and treatment of osteoporosis. ..
  7. Ryu H, Lee H, Kim J, Kim Y, Pyo M, Yun J, et al. Saucerneol D inhibits dendritic cell activation by inducing heme oxygenase-1, but not by directly inhibiting toll-like receptor 4 signaling. J Ethnopharmacol. 2015;166:92-101 pubmed publisher
    ..Taken together, these data suggest that SD suppresses LPS-induced activation of DCs through the induction of HO-1, but not by directly affecting Toll-like receptor 4 signaling. ..
  8. Park M, Hong J, Park E, Yoon H, Seo D, Hyun B, et al. Anticancer effect of tectochrysin in colon cancer cell via suppression of NF-kappaB activity and enhancement of death receptor expression. Mol Cancer. 2015;14:124 pubmed publisher
    ..Tectochrysin can be a useful agent for the treatment of colon cancer cell growth as well as an adjuvant agent for chemo-resistant cancer cells growth. ..
  9. Lee H, Kim Y, Kim J, Park E, Kim B, Park K, et al. Cytokine-induced killer cells interact with tumor lysate-pulsed dendritic cells via CCR5 signaling. Cancer Lett. 2016;378:142-9 pubmed publisher
    ..Taken together, our data provide insight into the mechanism of CIK cell activation by tDCs at the single-cell level. ..

More Information


  1. Kim H, Park K, Lee H, Kim J, Kim Y, Lee J, et al. Curdlan activates dendritic cells through dectin-1 and toll-like receptor 4 signaling. Int Immunopharmacol. 2016;39:71-78 pubmed publisher
    ..In summary, our data show that curdlan activates DCs through dectin-1 and TLR4 signaling and the combination of curdlan and DCs efficiently inhibit tumor growth in mice. ..
  2. Kim J, Kim Y, Lee H, Park E, Kim B, Kang J, et al. Cytokine-induced killer cells hunt individual cancer cells in droves in a mouse model. Cancer Immunol Immunother. 2017;66:193-202 pubmed publisher
    ..Our data have implications for the rational design of CIK cell-based immunotherapy of cancer patients. ..
  3. Huong T, Dung D, Huan N, Cuong L, Hai P, Huong L, et al. Novel N-hydroxybenzamides incorporating 2-oxoindoline with unexpected potent histone deacetylase inhibitory effects and antitumor cytotoxicity. Bioorg Chem. 2017;71:160-169 pubmed publisher
  4. Son D, Jung Y, Park M, Lee H, Song M, Yoo H, et al. Activated Natural Killer Cells Mediate the Suppressive Effect of Interleukin-4 on Tumor Development via STAT6 Activation in an Atopic Condition Melanoma Model. Neoplasia. 2017;19:537-548 pubmed publisher
    ..Overall, these results showed that allergy responses further accelerated the IL-4-induced inhibition of tumor development through the activation of STAT6 pathways. ..
  5. Choi J, Jang J, Son D, Im H, Kim J, Park J, et al. Antarctic Krill Oil Diet Protects against Lipopolysaccharide-Induced Oxidative Stress, Neuroinflammation and Cognitive Impairment. Int J Mol Sci. 2017;18: pubmed publisher
    ..These results suggest that krill oil ameliorated impairment via anti-inflammatory, antioxidative, and anti-amyloidogenic mechanisms. ..
  6. Hieu D, Anh D, Tuan N, Hai P, Huong L, Kim J, et al. Design, synthesis and evaluation of novel N-hydroxybenzamides/N-hydroxypropenamides incorporating quinazolin-4(3H)-ones as histone deacetylase inhibitors and antitumor agents. Bioorg Chem. 2018;76:258-267 pubmed publisher
    ..Importantly, the free binding energy computed was found to have high quantitative correlation (R2 ∼ 95%) with experimental results. ..