Hyunjung Ha

Summary

Affiliation: Chungbuk National University
Country: Korea

Publications

  1. pmc Serine-threonine kinase receptor-associated protein inhibits apoptosis signal-regulating kinase 1 function through direct interaction
    Haiyoung Jung
    Department of Biochemistry, Biotechnology Research Institute, School of Life Sciences, Chungbuk National University, Cheongju 361 763, Korea
    J Biol Chem 285:54-70. 2010
  2. pmc PDK1 protein phosphorylation at Thr354 by murine protein serine-threonine kinase 38 contributes to negative regulation of PDK1 protein activity
    Hyun A Seong
    Department of Biochemistry, School of Life Sciences, Chungbuk National University, Cheongju 361 763, Republic of Korea
    J Biol Chem 287:20811-22. 2012
  3. ncbi request reprint Regulation of transforming growth factor-beta signaling and PDK1 kinase activity by physical interaction between PDK1 and serine-threonine kinase receptor-associated protein
    Hyun A Seong
    Department of Biochemistry, Research Center for Bioresource and Health, Biotechnology Research Institute, School of Life Sciences, Chungbuk National University, Cheongju 361 763
    J Biol Chem 280:42897-908. 2005
  4. ncbi request reprint Enhancement of B-MYB transcriptional activity by ZPR9, a novel zinc finger protein
    Hyun A Seong
    Department of Biochemistry, School of Life Sciences, Research Center for Bioresource and Health, Chungbuk National University, Cheongju 361 763, Republic of Korea
    J Biol Chem 278:9655-62. 2003
  5. pmc Reciprocal negative regulation of PDK1 and ASK1 signaling by direct interaction and phosphorylation
    Hyun A Seong
    Department of Biochemistry, Biotechnology Research Institute, School of Life Sciences, Chungbuk National University, Cheongju 361 763, Republic of Korea
    J Biol Chem 285:2397-414. 2010
  6. doi request reprint Thioredoxin inhibits MPK38-induced ASK1, TGF-β, and p53 function in a phosphorylation-dependent manner
    Ravi Manoharan
    Department of Biochemistry, School of Life Sciences, Chungbuk National University, Cheongju 361 763, Korea
    Free Radic Biol Med 63:313-24. 2013
  7. ncbi request reprint 3-Phosphoinositide-dependent PDK1 negatively regulates transforming growth factor-beta-induced signaling in a kinase-dependent manner through physical interaction with Smad proteins
    Hyun A Seong
    Department of Biochemistry, Research Center for Bioresource and Health, Biotechnology Research Institute, School of Life Sciences, Chungbuk National University, Cheongju 361 763, Republic of Korea
    J Biol Chem 282:12272-89. 2007
  8. ncbi request reprint NM23-H1 tumor suppressor physically interacts with serine-threonine kinase receptor-associated protein, a transforming growth factor-beta (TGF-beta) receptor-interacting protein, and negatively regulates TGF-beta signaling
    Hyun A Seong
    Department of Biochemistry, Research Center for Bioresource and Health, Biotechnology Research Institute, School of Life Sciences, Chungbuk National University, Cheongju 361 763, Republic of Korea
    J Biol Chem 282:12075-96. 2007
  9. pmc Positive regulation of apoptosis signal-regulating kinase 1 signaling by ZPR9 protein, a zinc finger protein
    Hyun A Seong
    Department of Biochemistry, School of Life Sciences, Chungbuk National University, Cheongju 361 763, Republic of Korea
    J Biol Chem 286:31123-35. 2011
  10. pmc Murine protein serine/threonine kinase 38 stimulates TGF-beta signaling in a kinase-dependent manner via direct phosphorylation of Smad proteins
    Hyun A Seong
    Department of Biochemistry, School of Life Sciences, Chungbuk National University, Cheongju 361 763, Republic of Korea
    J Biol Chem 285:30959-70. 2010

Collaborators

  • Kyong Tai Kim
  • Sung Jin Kim
  • Hidenori Ichijo
  • Sang Chul Park
  • Li Wang
  • Michael Lee
  • Hyun A Seong
  • Haiyoung Jung
  • Ravi Manoharan
  • Hueng Sik Choi
  • Bo Hwa Choi
  • Joon Young Kim
  • Minho Shong
  • Kosuke Takeda
  • Sung Jin Lee
  • Ji Ho Suh
  • Yun Yong Park
  • Hyun Lee
  • In Kyu Lee
  • Byung Chang Suh
  • Ki Cheol Park
  • Han Jong Kim
  • Jeong W Lee
  • Ihn Soon Lee
  • Atsuo T Sasaki
  • Hyun A Seung
  • Richard A Firtel
  • Keesook Lee
  • Dong Chan Kim
  • Dongwook Kim
  • Jiansheng Huang
  • Dong Jae Jun
  • Byung Sun Suh
  • Jong Hee Lee
  • Myoung Sool Do
  • Jun Takeda
  • Tae Ju Park
  • Sabyasachi Sanyal
  • Ming Jer Tsai
  • Shin Sung Kang
  • Jisun Oh
  • Hee Don Chae
  • Khoi Chu
  • Jinkyu Lim
  • Ki D Shin
  • In Ja Rhee
  • Mi Y Han
  • Sang S Han
  • Tae C Jeong
  • Woo S Koh
  • Duk Su Koh
  • Eun J Kim
  • Eun Mi Hur
  • Mean Hwan Kim
  • Minchan Gil

Detail Information

Publications27

  1. pmc Serine-threonine kinase receptor-associated protein inhibits apoptosis signal-regulating kinase 1 function through direct interaction
    Haiyoung Jung
    Department of Biochemistry, Biotechnology Research Institute, School of Life Sciences, Chungbuk National University, Cheongju 361 763, Korea
    J Biol Chem 285:54-70. 2010
    ..In addition, STRAP suppressed H(2)O(2)-mediated apoptosis in a dose-dependent manner by inhibiting ASK1 activity through direct interaction. These results suggest that STRAP can act as a negative regulator of ASK1...
  2. pmc PDK1 protein phosphorylation at Thr354 by murine protein serine-threonine kinase 38 contributes to negative regulation of PDK1 protein activity
    Hyun A Seong
    Department of Biochemistry, School of Life Sciences, Chungbuk National University, Cheongju 361 763, Republic of Korea
    J Biol Chem 287:20811-22. 2012
    ..Together, these findings suggest an important role for MPK38-mediated phosphorylation of PDK1 in the negative regulation of PDK1 activity...
  3. ncbi request reprint Regulation of transforming growth factor-beta signaling and PDK1 kinase activity by physical interaction between PDK1 and serine-threonine kinase receptor-associated protein
    Hyun A Seong
    Department of Biochemistry, Research Center for Bioresource and Health, Biotechnology Research Institute, School of Life Sciences, Chungbuk National University, Cheongju 361 763
    J Biol Chem 280:42897-908. 2005
    ..Taken together, these results suggested that STRAP acts as an intermediate signaling molecule linking between the phosphatidylinositol 3-kinase/PDK1 and the TGF-beta signaling pathways...
  4. ncbi request reprint Enhancement of B-MYB transcriptional activity by ZPR9, a novel zinc finger protein
    Hyun A Seong
    Department of Biochemistry, School of Life Sciences, Research Center for Bioresource and Health, Chungbuk National University, Cheongju 361 763, Republic of Korea
    J Biol Chem 278:9655-62. 2003
    ..These results strongly suggest that ZPR9 plays an important role in modulation of the transactivation by B-MYB and cellular growth of neuroblastoma cells...
  5. pmc Reciprocal negative regulation of PDK1 and ASK1 signaling by direct interaction and phosphorylation
    Hyun A Seong
    Department of Biochemistry, Biotechnology Research Institute, School of Life Sciences, Chungbuk National University, Cheongju 361 763, Republic of Korea
    J Biol Chem 285:2397-414. 2010
    ..These results provide evidence that PDK1 and ASK1 directly interact and phosphorylate each other and act as negative regulators of their respective kinases in resting cells...
  6. doi request reprint Thioredoxin inhibits MPK38-induced ASK1, TGF-β, and p53 function in a phosphorylation-dependent manner
    Ravi Manoharan
    Department of Biochemistry, School of Life Sciences, Chungbuk National University, Cheongju 361 763, Korea
    Free Radic Biol Med 63:313-24. 2013
    ..These results indicate that Trx functions as a physiological inhibitor of MPK38, which plays an important role in inducing ASK1-, TGF-β-, and p53-mediated activity. ..
  7. ncbi request reprint 3-Phosphoinositide-dependent PDK1 negatively regulates transforming growth factor-beta-induced signaling in a kinase-dependent manner through physical interaction with Smad proteins
    Hyun A Seong
    Department of Biochemistry, Research Center for Bioresource and Health, Biotechnology Research Institute, School of Life Sciences, Chungbuk National University, Cheongju 361 763, Republic of Korea
    J Biol Chem 282:12272-89. 2007
    ....
  8. ncbi request reprint NM23-H1 tumor suppressor physically interacts with serine-threonine kinase receptor-associated protein, a transforming growth factor-beta (TGF-beta) receptor-interacting protein, and negatively regulates TGF-beta signaling
    Hyun A Seong
    Department of Biochemistry, Research Center for Bioresource and Health, Biotechnology Research Institute, School of Life Sciences, Chungbuk National University, Cheongju 361 763, Republic of Korea
    J Biol Chem 282:12075-96. 2007
    ..These results suggest that the direct interaction of NM23-H1 and STRAP is important for the regulation of TGF-beta-dependent biological activity as well as NM23-H1 activity...
  9. pmc Positive regulation of apoptosis signal-regulating kinase 1 signaling by ZPR9 protein, a zinc finger protein
    Hyun A Seong
    Department of Biochemistry, School of Life Sciences, Chungbuk National University, Cheongju 361 763, Republic of Korea
    J Biol Chem 286:31123-35. 2011
    ..Moreover, ZPR9 inhibited PDK1-mediated signaling through ASK1 activation. These results suggest that ZPR9 functions as a novel positive regulator of ASK1...
  10. pmc Murine protein serine/threonine kinase 38 stimulates TGF-beta signaling in a kinase-dependent manner via direct phosphorylation of Smad proteins
    Hyun A Seong
    Department of Biochemistry, School of Life Sciences, Chungbuk National University, Cheongju 361 763, Republic of Korea
    J Biol Chem 285:30959-70. 2010
    ..Together, these results indicate that MPK38 functions as a stimulator of TGF-β signaling through direct interaction with and phosphorylation of Smad proteins...
  11. pmc Phosphorylation of a novel zinc-finger-like protein, ZPR9, by murine protein serine/threonine kinase 38 (MPK38)
    Hyun A Seong
    Department of Biochemistry, School of Life Sciences, Research Center for Bioresource and Health, Chungbuk National University, 48 Gaeshin dong, Cheongju, Chungbuk 361 763, Korea
    Biochem J 361:597-604. 2002
    ..These findings suggest a potentially important role for ZPR9 in MPK38-mediated signal transduction, and that ZPR9 is a physiological substrate of MPK38 in vivo...
  12. ncbi request reprint NM23-H1 tumor suppressor and its interacting partner STRAP activate p53 function
    Haiyoung Jung
    Department of Biochemistry, Biotechnology Research Institute, School of Life Sciences, Chungbuk National University, Cheongju 361 763, Republic of Korea
    J Biol Chem 282:35293-307. 2007
    ..These results suggest that NM23-H1 and its interacting partner STRAP physically interact with p53 and positively regulate its functions, including p53-induced apoptosis and cell cycle arrest...
  13. pmc Murine protein serine/threonine kinase 38 activates apoptosis signal-regulating kinase 1 via Thr 838 phosphorylation
    Haiyoung Jung
    Department of Biochemistry, Biotechnology Research Institute, School of Life Sciences, Chungbuk National University, Cheongju 361 763, Republic of Korea
    J Biol Chem 283:34541-53. 2008
    ..MPK38 also stimulated H(2)O(2)-mediated apoptosis by enhancing the ASK1 activity through Thr(838) phosphorylation. These results suggest that MPK38 physically interacts with ASK1 in vivo and acts as a positive upstream regulator of ASK1...
  14. pmc B-MYB positively regulates serine-threonine kinase receptor-associated protein (STRAP) activity through direct interaction
    Hyun A Seong
    Department of Biochemistry, School of Life Sciences, Chungbuk National University, Cheongju 361 763, Republic of Korea
    J Biol Chem 286:7439-56. 2011
    ..Confocal microscopy showed that B-MYB prevents the normal translocation of SMAD3 in response to TGF-β1 and stimulates p53 nuclear translocation. These results suggest that B-MYB acts as a positive regulator of STRAP...
  15. doi request reprint Direct interaction between NM23-H1 and macrophage migration inhibitory factor (MIF) is critical for alleviation of MIF-mediated suppression of p53 activity
    Haiyoung Jung
    Department of Biochemistry, Biotechnology Research Institute, School of Life Sciences, Chungbuk National University, Cheongju 361 763, Republic of Korea
    J Biol Chem 283:32669-79. 2008
    ..The results of the current study suggest that the NM23-H1 functions as a negative regulator of MIF...
  16. doi request reprint Critical role of cysteine residue 81 of macrophage migration inhibitory factor (MIF) in MIF-induced inhibition of p53 activity
    Haiyoung Jung
    Department of Biochemistry, Biotechnology Research Institute, School of Life Sciences, Chungbuk National University, Cheongju, Republic of Korea
    J Biol Chem 283:20383-96. 2008
    ..We also demonstrated that MIF suppresses p53 activity by stabilizing the physical association between p53 and Mdm2. These results suggest that MIF physically associates with p53 and negatively regulates p53 function...
  17. pmc Murine protein serine-threonine kinase 38 activates p53 function through Ser15 phosphorylation
    Hyun A Seong
    Department of Biochemistry, School of Life Sciences, Chungbuk National University, Cheongju 361 763, Republic of Korea
    J Biol Chem 287:20797-810. 2012
    ..This leads to the enhancement of p53 stability. Together, these results suggest that MPK38 may act as a novel regulator for promoting p53 activity through direct phosphorylation of p53 at Ser(15)...
  18. ncbi request reprint Orphan nuclear receptor small heterodimer partner inhibits transforming growth factor-beta signaling by repressing SMAD3 transactivation
    Ji Ho Suh
    Hormone Research Center, School of Biological Science and Technology, Chonnam National University, Kwangju 500 757, Republic of Korea
    J Biol Chem 281:39169-78. 2006
    ..Taken together, these data indicate that SHP is a novel co-regulator of Smad3, and this study provides new insights into regulation of TGF-beta signaling...
  19. ncbi request reprint Role of metabolism by flavin-containing monooxygenase in thioacetamide-induced immunosuppression
    Jeong W Lee
    Korea Institute of Toxicology, 100 Jangdong, Yusung, Taejon 305 600, South Korea
    Toxicol Lett 136:163-72. 2003
    ..In conclusion, thioacetamide-induced immunosuppression was, at least in part, due to the metabolites produced by FMO as well as by P450...
  20. ncbi request reprint Dual roles of P2 purinergic receptors in insulin-stimulated leptin production and lipolysis in differentiated rat white adipocytes
    Hyun Lee
    Department of Life Science, Pohang University of Science and Technology, Pohang 790 784, Korea
    J Biol Chem 280:28556-63. 2005
    ....
  21. ncbi request reprint Regulation of p53 by activated protein kinase C-delta during nitric oxide-induced dopaminergic cell death
    Sung Jin Lee
    Systems Bio Dynamics NCRC, Division of Molecular and Life Science, POSTECH, Pohang 790 784, Korea
    J Biol Chem 281:2215-24. 2006
    ..These findings may be expanded to provide new insight into the cellular mechanisms of Parkinson disease...
  22. ncbi request reprint Role of phosphatidylinositol 3-kinases in chemotaxis in Dictyostelium
    Kosuke Takeda
    Section of Cell and Developmental Biology, Division of Biological Sciences and Center for Molecular Genetics, University of California, San Diego, La Jolla, California 92093 0380, USA
    J Biol Chem 282:11874-84. 2007
    ..Our data suggest that the output of other signaling pathways suffices to mediate directional sensing when cells perceive a strong signal, but PI3K signaling is crucial for detecting weaker signals...
  23. ncbi request reprint Protein kinase A- and C-induced insulin release from Ca2+ -insensitive pools
    Ihn Soon Lee
    Department of Life Science, Division of Molecular and Life Science, Pohang University of Science and Technology, POSTECH, San 31, Hyoja Dong, Pohang 790 784, Republic of Korea
    Cell Signal 15:529-37. 2003
    ..Our data suggest that PKC and PKA can elicit insulin secretion not only in a Ca(2+)-sensitive manner but also in a Ca(2+)-independent manner from separate releasable pools...
  24. ncbi request reprint Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD
    Joon Young Kim
    Hormone Research Center, School of Biological Resources and Technology, Chonnam National University, Kwangju 500 757, Republic of Korea
    Mol Endocrinol 18:776-90. 2004
    ....
  25. ncbi request reprint Orphan nuclear receptor small heterodimer partner represses hepatocyte nuclear factor 3/Foxa transactivation via inhibition of its DNA binding
    Joon Young Kim
    Hormone Research Center, Chonnam National University, Gwangju 500 757, Korea
    Mol Endocrinol 18:2880-94. 2004
    ....
  26. ncbi request reprint Protein kinase C regulates the activity and stability of serotonin N-acetyltransferase
    Bo Hwa Choi
    Department of Life Science, Division of Molecular and Life Science, Pohang University of Science and Technology, Pohang, Korea
    J Neurochem 90:442-54. 2004
    ..These results suggest that AANAT was phosphorylated at Thr29 by PKC activation through the alpha(1)-adrenergic receptor in rat pineal glands, and that its phosphorylation might contribute to the stability and the activity of AANAT...
  27. ncbi request reprint Upregulation of Daxx mediates apoptosis in response to oxidative stress
    Kyung Soon Kim
    Center for Systems Biology, Korea Research Institute of Bioscience and Biotechnology, Taejon 305 333, Korea
    J Cell Biochem 96:330-8. 2005
    ..Taken together, these results suggest that Daxx acts as an intermediary messenger of pro-apoptotic signals triggered by oxidative stress...