Young Ki Choi
Affiliation: Chungbuk National University
- Park J, Kim C, Um J, Ju Y, Lee Y, Choi Y, et al. Development of infectious clones of a wild-type Korean rabies virus and evaluation of their pathogenic potential. Virus Res. 2016;223:122-30 pubmed publisher..Our RG system is a useful tool for studying differences in the cell-to-cell spreading efficiency and replication with respect to the different internalization patterns of street and fixed laboratory-adapted viruses. ..
- Song M, Baek Y, Pascua P, Kwon H, Kim E, Park S, et al. Growth and Pathogenic Potential of Naturally Selected Reassortants after Coinfection with Pandemic H1N1 and Highly Pathogenic Avian Influenza H5N1 Viruses. J Virol. 2016;90:616-23 pubmed publisher..Thus, this demonstrates a possible natural reassortment following coinfection as well as the pathogenicity of the potential reassortants. ..
- Kim S, Kim Y, Park S, Kim E, Kwon H, Si Y, et al. Vaccine Efficacy of Inactivated, Chimeric Hemagglutinin H9/H5N2 Avian Influenza Virus and Its Suitability for the Marker Vaccine Strategy. J Virol. 2017;91: pubmed publisher..Therefore, this chimeric vaccine is suitable as a DIVA vaccine against H5 avian influenza viruses. ..
- Park S, Si Y, Kim J, Song M, Kim S, Kim E, et al. Cross-protective efficacies of highly-pathogenic avian influenza H5N1 vaccines against a recent H5N8 virus. Virology. 2016;498:36-43 pubmed publisher..Further, we demonstrated that antibody-dependent cell-mediated cytotoxicity (ADCC) of an antibody-coated target cell by cytotoxic effector cells also plays a role in the heterologous protection of H5N1 vaccines against H5N8 challenge. ..
- Park S, Lee E, Choi E, Pascua P, Kwon H, Kim E, et al. Avian-derived NS gene segments alter pathogenicity of the A/Puerto Rico/8/34 virus. Virus Res. 2014;179:64-72 pubmed publisher..These results clearly demonstrate that the NS genes of diverse influenza A strains can variable impact pathogenicity, histopathology, and cytokine production in mice even when expressed in an identical genetic background. ..
- Kim Y, Kim S, Si Y, Kwon H, Park S, Kim E, et al. Genetic diversity and pathogenic potential of low pathogenic H7 avian influenza viruses isolated from wild migratory birds in Korea. Infect Genet Evol. 2016;45:268-284 pubmed publisher..These results reinforce growing pandemic concerns regarding recent H7 viruses and emphasize the importance of continued surveillance of avian influenza viruses in the wild. ..
- Kwon H, Kim Y, Park S, Song M, Kim E, Kim S, et al. Evaluation of the Immune Responses to and Cross-Protective Efficacy of Eurasian H7 Avian Influenza Viruses. J Virol. 2017;91: pubmed publisher..This suggests that Anhui1/13-like H7N9 viruses may be viable vaccine candidates for broad protection against Eurasian H7 viruses. ..
- Kim Y, Park S, Kwon H, Kim E, Si Y, Jeong J, et al. Genetic and phylogenetic characterizations of a novel genotype of highly pathogenic avian influenza (HPAI) H5N8 viruses in 2016/2017 in South Korea. Infect Genet Evol. 2017;53:56-67 pubmed publisher..At least four reassortment events occurred with different subtypes (H5N8, H7N7, H3N8 and H10N7) and a chicken challenge study revealed that they were classified as HPAI viruses according to OIE criteria. ..