Young Ki Choi

Summary

Affiliation: Chungbuk National University
Country: Korea

Publications

  1. Han H, Song M, Park S, Byun H, Robles N, Ha S, et al. Efficacy of A/H1N1/2009 split inactivated influenza A vaccine (GC1115) in mice and ferrets. J Microbiol. 2019;57:163-169 pubmed publisher
    ..Taken together, this study demonstrates the immunogenicity and protective efficacy of GC1115 as a non-adjuvanted vaccine. ..
  2. Park S, Kim Y, Park A, Kwon H, Kim E, Si Y, et al. Ferret animal model of severe fever with thrombocytopenia syndrome phlebovirus for human lethal infection and pathogenesis. Nat Microbiol. 2019;4:438-446 pubmed publisher
    ..Thus, this immunocompetent age-dependent ferret model should be useful for anti-SFTSV therapy and vaccine development. ..
  3. Jeong J, Kim E, Lloren K, Kwon J, Kwon H, Ahn S, et al. Preclinical evaluation of the efficacy of an H5N8 vaccine candidate (IDCDC-RG43A) in mouse and ferret models for pandemic preparedness. Vaccine. 2019;37:484-493 pubmed publisher
    ..The protective and immunogenic characteristic of the candidate vaccine are essential attributes to be considered for further clinical trials as a pre-pandemic vaccine for a potential pandemic virus. ..
  4. Yu K, Yu M, Park S, Kim Y, Robles N, Kwon H, et al. Seroprevalence and genetic characterization of severe fever with thrombocytopenia syndrome virus in domestic goats in South Korea. Ticks Tick Borne Dis. 2018;9:1202-1206 pubmed publisher
    ..Collectively, this study suggests that relatively high numbers of goats are infected by antigenically different SFTSV strains, which might have a potential for zoonotic infection. ..
  5. Lee J, Pascua P, Decano A, Kim S, Park S, Kwon H, et al. Evaluation of the zoonotic potential of a novel reassortant H1N2 swine influenza virus with gene constellation derived from multiple viral sources. Infect Genet Evol. 2015;34:378-93 pubmed publisher
  6. Kwon H, Kim E, Kim Y, Park S, Si Y, Lee I, et al. Comparison of the pathogenic potential of highly pathogenic avian influenza (HPAI) H5N6, and H5N8 viruses isolated in South Korea during the 2016-2017 winter season. Emerg Microbes Infect. 2018;7:29 pubmed publisher
  7. Baek Y, Song M, Lee E, Kim Y, Kim E, Park S, et al. Profiling and characterization of influenza virus N1 strains potentially resistant to multiple neuraminidase inhibitors. J Virol. 2015;89:287-99 pubmed publisher
    ..Our study highlights the importance of vigilance and continued surveillance of potential NAI multidrug-resistant influenza virus variants, as well as the development of alternative therapeutics. ..
  8. Lee I, Kim Y, Lim G, Kwon H, Si Y, Park S, et al. Comparison of the virulence and transmissibility of canine H3N2 influenza viruses and characterization of their canine adaptation factors. Emerg Microbes Infect. 2018;7:17 pubmed publisher
    ..Importantly, we elucidated the genetic contributions of the NA, NP, and M genes to the adaptability of CIVs derived from the avian H3N2 virus. ..
  9. Si Y, Choi W, Kim Y, Lee I, Kwon H, Park S, et al. Genetic characteristics of highly pathogenic H5N8 avian influenza viruses isolated from migratory wild birds in South Korea during 2014-2015. Arch Virol. 2016;161:2749-64 pubmed publisher
    ..Taken together, our results suggested that the 2014-2015 Korean H5N8 viruses were genetically and serologically different from those of 2013-2014 winter season H5N8 viruses, including those from Europe and North America. ..

More Information

Publications17

  1. Park J, Kim C, Um J, Ju Y, Lee Y, Choi Y, et al. Development of infectious clones of a wild-type Korean rabies virus and evaluation of their pathogenic potential. Virus Res. 2016;223:122-30 pubmed publisher
    ..Our RG system is a useful tool for studying differences in the cell-to-cell spreading efficiency and replication with respect to the different internalization patterns of street and fixed laboratory-adapted viruses. ..
  2. Song M, Baek Y, Pascua P, Kwon H, Kim E, Park S, et al. Growth and Pathogenic Potential of Naturally Selected Reassortants after Coinfection with Pandemic H1N1 and Highly Pathogenic Avian Influenza H5N1 Viruses. J Virol. 2016;90:616-23 pubmed publisher
    ..Thus, this demonstrates a possible natural reassortment following coinfection as well as the pathogenicity of the potential reassortants. ..
  3. Kim S, Kim Y, Park S, Kim E, Kwon H, Si Y, et al. Vaccine Efficacy of Inactivated, Chimeric Hemagglutinin H9/H5N2 Avian Influenza Virus and Its Suitability for the Marker Vaccine Strategy. J Virol. 2017;91: pubmed publisher
    ..Therefore, this chimeric vaccine is suitable as a DIVA vaccine against H5 avian influenza viruses. ..
  4. Park S, Si Y, Kim J, Song M, Kim S, Kim E, et al. Cross-protective efficacies of highly-pathogenic avian influenza H5N1 vaccines against a recent H5N8 virus. Virology. 2016;498:36-43 pubmed publisher
    ..Further, we demonstrated that antibody-dependent cell-mediated cytotoxicity (ADCC) of an antibody-coated target cell by cytotoxic effector cells also plays a role in the heterologous protection of H5N1 vaccines against H5N8 challenge. ..
  5. Park S, Lee E, Choi E, Pascua P, Kwon H, Kim E, et al. Avian-derived NS gene segments alter pathogenicity of the A/Puerto Rico/8/34 virus. Virus Res. 2014;179:64-72 pubmed publisher
    ..These results clearly demonstrate that the NS genes of diverse influenza A strains can variable impact pathogenicity, histopathology, and cytokine production in mice even when expressed in an identical genetic background. ..
  6. Kim Y, Kim S, Si Y, Kwon H, Park S, Kim E, et al. Genetic diversity and pathogenic potential of low pathogenic H7 avian influenza viruses isolated from wild migratory birds in Korea. Infect Genet Evol. 2016;45:268-284 pubmed publisher
    ..These results reinforce growing pandemic concerns regarding recent H7 viruses and emphasize the importance of continued surveillance of avian influenza viruses in the wild. ..
  7. Kwon H, Kim Y, Park S, Song M, Kim E, Kim S, et al. Evaluation of the Immune Responses to and Cross-Protective Efficacy of Eurasian H7 Avian Influenza Viruses. J Virol. 2017;91: pubmed publisher
    ..This suggests that Anhui1/13-like H7N9 viruses may be viable vaccine candidates for broad protection against Eurasian H7 viruses. ..
  8. Kim Y, Park S, Kwon H, Kim E, Si Y, Jeong J, et al. Genetic and phylogenetic characterizations of a novel genotype of highly pathogenic avian influenza (HPAI) H5N8 viruses in 2016/2017 in South Korea. Infect Genet Evol. 2017;53:56-67 pubmed publisher
    ..At least four reassortment events occurred with different subtypes (H5N8, H7N7, H3N8 and H10N7) and a chicken challenge study revealed that they were classified as HPAI viruses according to OIE criteria. ..