Research Topics
Genomes and Genes | S C LimSummaryAffiliation: Chosun University Country: Korea Publications
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Publications
Homeobox gene Dlx-2 is implicated in metabolic stress-induced necrosisSu Yeon Lee
Department of Molecular Biology, College of Natural Sciences, Pusan National University, Pusan 609 735, Korea
Mol Cancer 10:113. 2011..Thus, necrosis has important clinical implications in tumor development; however, its molecular mechanism remains poorly understood...
Expression of Fas ligand and sFas ligand in human gastric adenocarcinomasSung Chul Lim
Department of Pathology, College of Medicine Chosun University, Kwangju, Korea
Oncol Rep 9:103-7. 2002..The clinical stages of gastric adenocarcinoma of the intestinal and the diffuse type did not differ in their expression of Fas and sFas-L...
The role of CD24 in various human epithelial neoplasiasSung Chul Lim
Department of Pathology and Research Center for Resistant Cells, Chosun University College of Medicine, Gwangju, Republic of Korea
Pathol Res Pract 201:479-86. 2005....
Fas-related apoptosis in gastric adenocarcinomaSung Chul Lim
Department of Pathology, College of Medicine, Chosun University, Kwangju, South Korea
Oncol Rep 10:57-63. 2003..Furthermore, gastric carcinoma cells of the intestinal and the diffuse type did not differ in their expression of the Fas-apoptotic system...
Extraskeletal osteochondroma of the buttockSung Chul Lim
Department of Pathology, Chosun University Hospital, 588 Seosuk dong, Dong Gu, Gwangju 501 140, Korea
J Korean Med Sci 18:127-30. 2003..A case of pathologically proven extraskeletal osteochondroma of the buttock is presented with a literature review, magnetic resonance imaging, and radiological findings...
Correlation of cyclooxygenase-2 pathway and VEGF expression in head and neck squamous cell carcinomaSung Chul Lim
Department of Pathology, Chosun University Hospital, Kwangju City 501 140, South Korea
Oncol Rep 10:1073-9. 2003..The present findings support the efforts to initiate clinical trials on the efficacy of COX-2 inhibitors in adjuvant treatment of HNSCC...
Bilateral primary ovarian leiomyoma in a young woman: case report and literature reviewSung Chul Lim
Department of Pathology, Chosun University College of Medicine, Gwangju, South Korea
Gynecol Oncol 95:733-5. 2004..Primary ovarian leiomyoma is a very rare tumor and usually it is small, unilateral-, and concomitantly seen with uterine leiomyomata in middle-aged to postmenopausal women...
Role of COX-2, VEGF and cyclin D1 in mammary infiltrating duct carcinomaSung Chul Lim
Department of Pathology, Chosun University Hospital, Kwangju City 501 140, Korea
Oncol Rep 10:1241-9. 2003..The present findings support the efforts to initiate clinical trials on the efficacy of COX-2 inhibitors in adjuvant treatment of breast cancer...
Intrarenal epidermal cystSung Chul Lim
Department of Pathology, Chosun University College of Medicine, Gwangju, Korea
Pathol Int 53:574-8. 2003..The diagnosis of an epidermal cyst was not made preoperatively in the present case, or in the cases described in the literature. This diagnosis should be included in the differentiation of calcified intrarenal masses...
Expression of c-erbB receptors, MMPs and VEGF in head and neck squamous cell carcinomaS C Lim
Department of Pathology and Research Center for Resistant Cells, Chosun University College of Medicine, Gwangju, South Korea
Biomed Pharmacother 59:S366-9. 2005..c-erbB receptors, MMPs and VEGF might aid the clinician in the selection of an appropriate therapy for individual patients and help to predict the prognosis of patients...
Effects of various implant materials on regeneration of calvarial defects in ratsS C Lim
Department of Pathology, College of Medicine, Chosun University, Kwangju, Korea
Pathol Int 50:594-602. 2000....
Cerebellar pleomorphic xanthoastrocytoma in an infantS C Lim
Departments of Pathology, Chosun University College of Medicine, Kwangju, South Korea
Pathol Int 49:811-5. 1999..We report the morphologic and immunophenotypical features, and literature review with regard to the clinicopathologic aspects of a case of unusual PXA...
CD24 and human carcinoma: tumor biological aspectsS C Lim
Department of Pathology and Research Center for Resistant Cells, Chosun University College of Medicine, Gwangju, South Korea
Biomed Pharmacother 59:S351-4. 2005..Understanding the functions and implications CD24 might aid the clinician in the selection of an appropriate therapy for individual patients: for example, the intravenous administration of C1324-specific antibodies to treat cancers...
A case of small cell carcinoma arising in a mature cystic teratoma of the ovaryS C Lim
Department of Pathology, College of Medicine Chosun University, Kwangju, Korea
Pathol Int 48:834-9. 1998..This report gives a literature review, and the histological, immunohistochemical, flow cytometric and ultrastructural features are described...
Giant hidradenocarcinoma: a report of malignant transformation from nodular hidradenomaS C Lim
Department of Pathology, Chosun University College of Medicine, Kwangju, South Korea
Pathol Int 48:818-23. 1998..Histologically, this case was concluded as a hidradenocarcinoma arising from a long-standing nodular hidradenoma. A literature review is presented and the histological, immunohistochemical and ultrastructural features are described...
Significance of E-cadherin/beta-catenin complex and cyclin D1 in breast cancerSung Chul Lim
Department of Pathology, College of Medicine, Chosun University Hospital, Dong Ku, Kwangju, Korea
Oncol Rep 9:915-28. 2002....
Comparison of Tc-99m sestamibi, serum neuron-specific enolase and lactate dehydrogenase as predictors of response to chemotherapy in small cell lung cancerS C Lim
Department of Internal Medicine, Chonnam University Hospital, Kwangju, Korea
Cancer Biother Radiopharm 15:381-6. 2000..Increase of T:NL after dipyridamole infusion was a strong negative predictor of chemotherapeutic response in SCLC patients, while NSE and LDH could not predict it...
Dipyridamole modulated Tc-99m sestamibi lung SPECT in small cell lung cancerH S Bom
Department of Nuclear Medicine, Chonnam University Hospital, Kwangju, Korea
Clin Nucl Med 24:97-101. 1999..In this study, the authors wanted to determine whether dipyridamole-modulated MIBI (dipyridamole-MIBI) could enhance the prediction of the response to chemotherapy in patients with small cell lung cancer...
Different cutoff values of Cyfra 21-1 for cavitary and noncavitary lung cancersY C Kim
Department of Internal Medicine, Chonnam National University Medical School, Dongku, Kwangju, South Korea
Lung Cancer 30:187-92. 2000..The serum cytokeratin level can also be elevated in benign cavitary lung diseases. The purpose of this study was to evaluate whether Cyfra 21-1 can differentiate malignant lung diseases from benign diseases with cavitary lesions...
The role of E-cadherin expression in non-small cell lung cancerS C Lim
Department of Internal Medicine, Chonnam National University Medical School, Kwangju, Korea
J Korean Med Sci 15:501-6. 2000..6% (> or = N2), indicating that loss of E-cadherin expression is responsible for acquisition of invasive potential of lung cancer as well as the possible role of E-cadherin in the histological differentiation of lung cancer...
Malignant mixed Müllerian tumor (homologous type) of the adnexa with neuroendocrine differentiation: a case reportS C Lim
Department of Pathology, Chosun University College of Medicine, Kwangju, Korea
J Korean Med Sci 13:207-10. 1998..Histologically, the tumor involved the left adnexa, abdominal peritoneum, surface of the bladder dome, omentum and left external iliac lymph node (stage IIIc)...
A rapid and transient ROS generation by cadmium triggers apoptosis via caspase-dependent pathway in HepG2 cells and this is inhibited through N-acetylcysteine-mediated catalase upregulationSeon-Hee Oh
Research Center for Resistant Cells, College of Medicine, Chosun University, Seosuk-dong, Dong-gu, Gwangju 501-759, South Korea
Toxicol Appl Pharmacol 212:212-23. 2006..NAC inhibits Cd-induced apoptosis through the blocking of ROS generation as well as the catalase upregulation...
Protection of betulin against cadmium-induced apoptosis in hepatoma cellsSeon-Hee Oh
Research Center for Resistant Cells, College of Medicine, Chosun University, Dong-gu, Gwangju 501-759, Republic of Korea
Toxicology 220:1-12. 2006..However, the observed protective effects of BT were clearly more sensitive to Fas-expressing HepG2 cells than to Fas-deficient Hep3B cells...
Myxopapillary ependymoma of the fourth ventricleSung Chul Lim
Department of Pathology, Chosun University College of Medicine, 375, Seosuk dong, Dong Ku, Gwangju 501 759, Republic of Korea
Clin Neurol Neurosurg 108:211-4. 2006..The patient's postoperative course was uneventful, and she was doing well on follow-up, 15 months after surgery. This is the second reported case of fourth ventricular myxopapillary ependymoma...
Large cystic cavernous angioma of the cerebellum mimicking pilocytic astrocytomaSung Chul Lim
Department of Pathology, Chosun University College of Medicine, Gwangju, Korea
J Neurooncol 79:169-70. 2006..Cavernous angiomas, accompanied by a large cyst, are very rare. We present a case of a cavernous angioma with the unusual MRI findings of a large cyst and a small mural nodule...
Prenatal detection of a congenital pancreatic cyst by ultrasoundSang Joon Choi
Department of Obstetrics and Gynecology, College of Medicine, Chosun University, Gwangju, Korea
J Korean Med Sci 22:156-8. 2007..Histopathologic and immunohistochemical diagnosis revealed the cyst to be a pancreatic cyst. Surgical outcome was excellent. Thus, we report this case of a pancreatic cyst detected via prenatal ultrasonography...
Severe scrub typhus confirmed early via immunohistochemical stainingDong Min Kim
Department of Internal Medicine, Chosun University College of Medicine, Gwangju, Korea
Am J Trop Med Hyg 77:719-22. 2007..IHC staining of an eschar could be used as an early-confirmation diagnostic method to establish scrub typhus...
Significance of p-STAT3 expression in human colorectal adenocarcinomaJae Kyoung Park
Department of Pathology, College of Medicine, Chosun University, Gwangju 501 140, Korea
Oncol Rep 20:597-604. 2008..Moreover, IHC analysis is a reliable and useful modality of assessing the status of p-STAT3 expression in formalin-fixed samples...
Expression of c-erbB receptors, MMPs and VEGF in squamous cell carcinoma of the head and neckNam Yong Do
Department of Otolaryngology, Chosun University College of Medicine, Kwangju, Korea
Oncol Rep 12:229-37. 2004..The authors conclude that EGFR, c-erbB-2, MMP-2 and -9 could be good independent prognostic markers, but not VEGF and MMP-3...
Use of particulate dentin-plaster of Paris combination with/without platelet-rich plasma in the treatment of bone defects around implantsSu Gwan Kim
Department of Oral and Maxillofacial Surgery, Oral Biology Research Institute, College of Dentistry, Chosun University, Gwangju City, Korea
Int J Oral Maxillofac Implants 17:86-94. 2002..Histologic sections and histomorphometric analysis of the defects were obtained at 6 and 12 weeks after surgery...
Cadmium induces apoptotic cell death in WI 38 cells via caspase-dependent Bid cleavage and calpain-mediated mitochondrial Bax cleavage by Bcl-2-independent pathwaySeon Hee Oh
Research Center for Resistant Cells, College of Medicine, Chosun University, Seosuk dong, Dong Gu, Gwangju 501 759, South Korea
Biochem Pharmacol 68:1845-55. 2004..Moreover, we found that the function of Bid and Bax was not dependent of Bcl-2, and that ROS can also contribute in the Cd-induced cell death...
The effect of high local concentrations of antibiotics on demineralized bone induction in ratsSu Gwan Kim
Department of Oral and Maxillofacial Surgery, College of Dentistry, Chosun University, Gwang Ju, Korea
J Oral Maxillofac Surg 62:708-13. 2004..This study evaluated the effect of high local concentrations of antibiotics on bone repair induced by demineralized bone in rats...
Vascular endothelial growth factor in malignant and tuberculous pleural effusionsS C Lim
Department of Internal Medicine, Chonnam National University Medical School, Kwangju, Korea
J Korean Med Sci 15:279-83. 2000..Further studies are needed to determine the clinical value of VEGF as a tumor marker and a prognostic factor...
Effect of betulinic acid on anticancer drug-resistant colon cancer cellsGwon Ryul Jung
Department of Pharmacology, College of Medicine, Chosun University, 488 Seosuk dong, Dong Gu, Gwangju 501 140, Korea
Basic Clin Pharmacol Toxicol 101:277-85. 2007..These findings indicate that the use of BetA as a chemosensitizer may be a new strategy to enhance the efficacy of chemotherapy. However, further studies will be needed for confirmation...
Effects on bone formation in ovariectomized rats after implantation of tooth ash and plaster of Paris mixtureSo-Young Kim
Oral Biology Research Institute, College of Dentistry, Chosun University, Gwangju, Korea
J Oral Maxillofac Surg 62:852-7. 2004..048). CONCLUSIONS: Ovariectomy acts as a negative factor in new bone formation. For a critical size bony defect, the tooth ash-plaster treatment of the osseous defect produces more stable, effective, and rapid new bone formation...
Fas (Apo-1/CD95) and Fas ligand interaction between gastric cancer cells and immune cellsTae Bum Lee
Department of Pharmacology, Chosun University Medical School, Gwangju, South Korea
J Gastroenterol Hepatol 17:32-8. 2002..It has been proposed that the expression of Fas ligand (Fas L) in tumors may play an important role in immune escape. This study was undertaken to test a 'counterattack' theory as a mechanism of immune escape in gastric carcinoma...
Proyl isomerase Pin1 facilitates ubiquitin-mediated degradation of cyclin-dependent kinase 10 to induce tamoxifen resistance in breast cancer cellsP Khanal
BK21 Project Team, College of Pharmacy, Chosun University, Gwangju, Republic of Korea
Oncogene 31:3845-56. 2012..On the basis of these findings, we suggest that the Pin1-mediated CDK10 ubiquitination is a major regulator of tamoxifen-resistant breast cancer cell growth and survival...
Apoptosis and bcl-2 expression as predictors of survival in radiation-treated non-small-cell lung cancerJ H Hwang
Department of Internal Medicine, Chonnam National University Medical School, 8 Hak-dong, Dong-Ku, Kwangju, 501-757, South Korea
Int J Radiat Oncol Biol Phys 50:13-8. 2001..CONCLUSION: A low level of spontaneous apoptosis and expression of apoptosis blocking bcl-2 protein in pretreatment histology predict a poor prognosis for radiation-treated NSCLC patients...
Histologic and histomorphometric evaluation of early and immediately loaded implants in the dog mandibleSeong Yong Moon
Department of Oral and Maxillofacial Surgery, College of Dentistry, Chosun University, Gwangju, Korea
J Biomed Mater Res A 86:1122-7. 2008..00, 73.37, and 62.04%, respectively. It was thus concluded that early stability was achieved in early and IL implants using fixed provisional restoration, thereby resulting in the high rate of peri-implant bone formation...
The incidence of epiglottic cysts in a cohort of adults with acute epiglottitisT M Yoon
Department of Otolaryngology Head and Neck Surgery, Chonnam National University Medical School and Hwasun Hospital, Research Institute of Medical Sciences, Dong Gu, Gwangju, South Korea
Clin Otolaryngol 35:18-24. 2010..A review of the airway risk factors were studied in adults with acute epiglottitis in South Korea from 1997 to 2009...
Ethyl pyruvate induces necrosis-to-apoptosis switch and inhibits high mobility group box protein 1 release in A549 lung adenocarcinoma cellsSung Chul Lim
Research Center for Resistant Cells, Department of Pathology, College of Medicine, Chosun University, Gwangju 501 759, Korea
Int J Mol Med 20:187-92. 2007....
Expression of cyclooxygenase-2 and its relationship to p53 accumulation in colorectal cancersSung Chul Lim
Department of Surgery, Chosun University College of Medicine, 375 Seosuk dong, Dong Gu, Gwangju 501 759, Korea
Yonsei Med J 48:495-501. 2007..The aim of this study was to determine the relationship between COX-2 expression and p53 levels in CRC...
Pathological significance of connexin 26 expression in colorectal adenocarcinomaRan Hong
Department of Pathology, College of Medicine, Chosun University, Gwangju 501 140, Korea
Oncol Rep 19:913-9. 2008..In conclusion, loss of intercellular and gain of intracytoplasmic Cx26 expression may play a role in colorectal carcinogenesis and tumor progression...
Hyperthermia switches glucose depletion-induced necrosis to apoptosis in A549 lung adenocarcinoma cellsSong Iy Han
Research Center for Resistant Cells, College of Medicine, Chosun University, Gwangju 501 759, Korea
Int J Oncol 32:851-60. 2008....
Diagnosis of scrub typhus by immunohistochemical staining of Orientia tsutsugamushi in cutaneous lesionsDong Min Kim
Division of Infectious Diseases, Department of Internal Medicine, Chosun University College of Medicine, Gwangju, Republic of Korea
Am J Clin Pathol 130:543-51. 2008..Immunohistochemical staining of skin biopsy specimens, particularly that of eschars, is sensitive and specific, and this technique can be reliable for confirming the diagnosis of scrub typhus...
Protective effect of morin on the imipenem-induced nephrotoxicity in rabbitsSung Chul Lim
Department of Pathology, College of Medicine, Chosun University, Gwangju, Korea
Arch Pharm Res 31:1060-5. 2008..In conclusion, the present study suggests that morin might be beneficial to reduce the nephrotoxicity of imipenem, at least in part, via the inhibition of OAT3-mediated renal excretion of imipenem...
The relationship between microvessel count and the expression of vascular endothelial growth factor, p53, and K-ras in non-small cell lung cancerY H Kang
Department of Internal Medicine, Chonnam National University Medical School, Research Institute of Medical Science, Kwangju, Korea
J Korean Med Sci 16:417-23. 2001..Correlations between variables in close approximation and the lack of prognostic significance of individual molecular alterations suggest that tumorigenesis and metastasis are multifactorial processes...
Sodium salicylate switches glucose depletion-induced necrosis to autophagy and inhibits high mobility group box protein 1 release in A549 lung adenocarcinoma cellsSung Chul Lim
Research Center for Resistant Cells, College of Medicine, Chosun University, Gwangju 501 759, Korea
Oncol Rep 19:1165-71. 2008....
Acute renal failure due to acute tubular necrosis caused by direct invasion of Orientia tsutsugamushiDong Min Kim
Department of Internal Medicine, Chosun University College of Medicine, 588 Seosuk dong, Dong Gu, Gwangju 501 717, South Korea
J Clin Microbiol 46:1548-50. 2008..For our case, we demonstrated by IHC staining and EM that renal failure was caused by acute tubular necrosis due to a direct invasion of Orientia tsutsugamushi...
Prognostic significance of cyclooxygenase-2 expression and nuclear p53 accumulation in patients with colorectal cancerSung Chul Lim
Research Center for Resistant Cells, Chosun University College of Medicine, Gwangju, Korea
J Surg Oncol 97:51-6. 2008..The aim of this study was to investigate COX-2 expression and its relationship with nuclear p53 accumulation and their prognostic significance in CRC...
Fine-needle aspiration cytology of a lipoblastoma: a case reportRan Hong
Department of Pathology, College of Medicine, Chosun University, Gwangju, Korea
Diagn Cytopathol 36:508-11. 2008..However, the fine-needle aspiration cytological features of a lipoblastoma are sufficiently characteristic to make a specific preoperative diagnosis...
A myxoid liposarcoma arising in a leiomyoma of the uterus: a case reportRan Hong
Department of Pathology, College of Medicine, Chosun University Hospital, Dong Gu, Gwangju, South Korea
Arch Gynecol Obstet 277:445-8. 2008..Indeed, a liposarcoma coexistent with a leiomyoma is even rarer and there is only one case has been reported in the English literature to date...
OEIS complex with glomerulocystic kidney disease: a case reportRan Hong
College of Medicine, Chosun University, Gwangju, Korea
Pediatr Dev Pathol 10:121-4. 2007..The postoperative course was uneventful during a period of 4 months of follow up. We herein report a case of the very rare OEIS complex in a newborn male baby and review the available literature...
A case of completely resolved pneumatocoeles in desquamative interstitial pneumoniaKyu-Sik Kim
Department of Internal Medicine, Research Institute of Medical Sciences, College of Medicine, Chonnam National University, Kwangju, Korea
Respirology 8:389-95. 2003..This complete resolution is believed to have resulted from the clearance of check-valve-like bronchiolar obstructions that may be another interesting terminal airway pathology in DIP...
Protein kinase C-ERK1/2 signal pathway switches glucose depletion-induced necrosis to apoptosis by regulating superoxide dismutases and suppressing reactive oxygen species production in A549 lung cancer cellsCho Hee Kim
Department of Molecular Biology, College of Natural Sciences, and Research Institute of Genetic Engineering, Pusan National University, Pusan, Korea
J Cell Physiol 211:371-85. 2007....
Transient hemodynamic effects of recruitment maneuvers in three experimental models of acute lung injurySung-Chul Lim
Pulmonary/Critical Care Medicine, Regions Hospital/HealthPartners, University of Minnesota, St. Paul, MN 55101, USA
Crit Care Med 32:2378-84. 2004..The results imply that a lung recruiting maneuver should be used with caution, especially when using sustained inflation in the setting of pneumonia...
Interaction characteristics of flavonoids with human organic anion transporter 1 (hOAT1) and 3 (hOAT3)Soon Sun Hong
School of Medicine, Inha University, Incheon, Republic of Korea
Pharmacol Res 56:468-73. 2007..In conclusion, the present study identified some of flavonoids as a new class of hOAT1 inhibitors, suggesting a potential for flavonoid-drug interactions via the modulation of hOAT1 activity...
Surgically resected isolated hepatic metastasis from non-small cell lung cancer: a case reportKyu-Sik Kim
Lung and Esophageal Cancer Clinic, Chonnam National University Hwasun Hospital, South Korea
J Thorac Oncol 1:494-6. 2006..This shows that the surgical resection of an isolated hepatic metastasis may be an option in carefully selected patients with NSCLC without evidence of disease outside the liver...
Ultrastructural changes of the gemifloxacin on Achilles tendon in immature rats: comparison with those of ciproxacin and ofloxacinChun-Sik Bae
College of Veterinary Medicine, Biotechnology Research Institute, Chonnam National University, Gwangju 500-757, Korea
Basic Clin Pharmacol Toxicol 98:406-10. 2006..However, these results show that gemifloxacin causes less changes in the connective tissue structures...
Effect of low-level laser therapy on osteoarthropathy in rabbitHyung-Jin Cho
College of Veterinary Medicine, Chonnam National University, Gwangju, Korea
In Vivo 18:585-91. 2004..Conversely, the 4-week treatment group showed chondrocyte replacement, with sometimes close to normal articular cartilage on the articular surface. These results suggest that LLLT was effective in the treatment of chemically-induced OA...
Intercomparison of recruitment maneuver efficacy in three models of acute lung injurySung-Chul Lim
Department of Pulmonary/Critical Care Medicine, Regions Hospital, University of Minnesota, St. Paul, MN, USA
Crit Care Med 32:2371-7. 2004..Although RM may improve PaO2 in certain injury settings when traditional tidal volumes are used, sustained improvement depends on the post-RM positive end-expiratory pressure value...
Predictors of the response to gefitinib in refractory non-small cell lung cancerKyu-Sik Kim
Lung and Esophageal Cancer Clinic, Chonnam National University Hwasun Hospital, 160 Ilsim-Ri, Hwasun, Jeollanam-do, 519-809 South Korea
Clin Cancer Res 11:2244-51. 2005..Given that 9.5% of smokers and 6.7% of those with non-adenocarcinoma showed a mutation of the EGFR gene, the genetic profile may replace those variables as an independent predictor of a response...
Efficacy of gemcitabine in patients with non-small cell lung cancer according to promoter polymorphisms of the ribonucleotide reductase M1 geneSoo Ok Kim
Department of Internal Medicine, Chonnam National University Medical School, Chonnam National University Hwasun Hospital, Jeonnam, South Korea
Clin Cancer Res 14:3083-8. 2008....
