Yong Wook Park
Affiliation: Chonnam National University
Kwon Y, Cho Y, Kim M, Jin H, Jung H, Kang J, et al
. Mucosal-associated invariant T cells are numerically and functionally deficient in patients with mycobacterial infection and reflect disease activity. Tuberculosis (Edinb). 2015;95:267-74 pubmed publisher
..This study shows that MAIT cells are numerically and functionally deficient in TB and NTM patients and these deficiencies could contribute to immune system dysreguation in mycobacterial infection. ..
Lee O, Cho Y, Kee S, Kim M, Jin H, Lee S, et al
. Circulating mucosal-associated invariant T cell levels and their cytokine levels in healthy adults. Exp Gerontol. 2014;49:47-54 pubmed publisher
..Our data suggest that aging is associated with a reduction in circulating MAIT cells, accompanied with alterations in subset composition and cytokine profile. ..
Park Y, Kee S, Cho Y, Lee E, Lee H, Kim E, et al
. Impaired differentiation and cytotoxicity of natural killer cells in systemic lupus erythematosus. Arthritis Rheum. 2009;60:1753-63 pubmed publisher
..Furthermore, the differentiation of HSCs into NK cells was found to be defective. These abnormalities possibly contribute to immune system dysregulation in SLE. ..
Cho Y, Kee S, Kim T, Jin H, Kim M, Jung H, et al
. Mucosal-associated invariant T cell deficiency in systemic lupus erythematosus. J Immunol. 2014;193:3891-901 pubmed publisher
..In addition, we report a novel finding that this MAIT cell deficiency is associated with NKT cell deficiency and elevated PD-1 expression. These abnormalities possibly contribute to dysregulated mucosal immunity in SLE. ..
Jo Y, Choi H, Kim J, Cho Y, Kang J, Jin H, et al
. Deficiencies of Circulating Mucosal-associated Invariant T Cells and Natural Killer T Cells in Patients with Multiple Trauma. J Korean Med Sci. 2017;32:750-756 pubmed publisher
..In addition, these invariant T cell deficiencies were found to be associated with disease severity. These findings provide important information for predicting the prognosis of multiple trauma. ..
Jin H, Kim T, Choi J, Kim M, Cho Y, Nam K, et al
. MicroRNA-155 as a proinflammatory regulator via SHIP-1 down-regulation in acute gouty arthritis. Arthritis Res Ther. 2014;16:R88 pubmed publisher
..The production of inflammatory cytokines was markedly increased in MSU crystal induced peritonitis mice. Overexpression of miR-155 in the gouty SFMC leads to suppress SHIP-1 levels and enhance proinflammatory cytokines. ..
Lee S, Nam K, Jin H, Cho Y, Lee S, Kim T, et al
. Bone destruction by receptor activator of nuclear factor ?B ligand-expressing T cells in chronic gouty arthritis. Arthritis Res Ther. 2011;13:R164 pubmed publisher
..Furthermore, our data show that MSU crystals have the potential to induce pro-resorptive cytokines, and T cells are involved in osteoclastogenesis in chronic gout. ..