Hee Sae Park
Affiliation: Chonnam National University
Yoon J, Mo J, Ann E, Ahn J, Jo E, Lee H, et al
. NOTCH1 intracellular domain negatively regulates PAK1 signaling pathway through direct interaction. Biochim Biophys Acta. 2016;1863:179-88 pubmed publisher
..Together, these results suggest that NOTCH1-IC is a new regulator of the PAK1 signaling pathway that directly interacts with PAK1 and regulates its shuttling between the nucleus and the cytoplasm. ..
Ann E, Kim M, Yoon J, Ahn J, Jo E, Lee H, et al
. Tumor Suppressor HIPK2 Regulates Malignant Growth via Phosphorylation of Notch1. Cancer Res. 2016;76:4728-40 pubmed publisher
..In revealing an important mechanism of Notch1 stability, the results of this study could offer a therapeutic strategy to block Notch1-dependent progression in many types of cancer. Cancer Res; 76(16); 4728-40. ©2016 AACR. ..
Baek H, Yoon J, Ann E, Kim M, Ahn J, Kim S, et al
. Alpha-synuclein negatively regulates Notch1 intracellular domain protein stability through promoting interaction with Fbw7. Neurosci Lett. 2015;600:6-11 pubmed publisher
..Together, these results suggest that SNCA is a novel regulator of Notch1-IC transcriptional activity with acting as an enhancer of the interaction of Notch1-IC and Fbw7 with increasing degradation of Notch1-IC. ..
Lee H, Yoon J, Ahn J, Jo E, Kim M, Lee Y, et al
. Fe65 negatively regulates Jagged1 signaling by decreasing Jagged1 protein stability through the E3 ligase Neuralized-like 1. Biochim Biophys Acta. 2015;1853:2918-28 pubmed publisher
..Consequently, Jagged1 is a novel binding partner of Fe65, and Fe65 may act as a novel effector of Jagged1 signaling. ..
Yoon J, Mo J, Kim M, Ann E, Ahn J, Jo E, et al
. LRRK2 functions as a scaffolding kinase of ASK1-mediated neuronal cell death. Biochim Biophys Acta Mol Cell Res. 2017;1864:2356-2368 pubmed publisher
..These results clearly indicate that LRRK2 acts as an upstream kinase in the ASK1 pathway and plays an important role in the pathogenesis of PD. ..
Kumar S, Lee H, Park H, Lee K. Testis-Specific GTPase (TSG): An oligomeric protein. BMC Genomics. 2016;17:792 pubmed
..Further investigation of TSG function in vivo may provide new clues for uncovering the secrets of spermatogenesis. ..