Shin Seok Lee


Affiliation: Chonnam National University
Country: Korea


  1. Park D, Kim S, Nah S, Lee J, Kim S, Lee Y, et al. Association between brain-derived neurotrophic factor gene polymorphisms and fibromyalgia in a Korean population: a multicenter study. Arthritis Res Ther. 2018;20:220 pubmed publisher
    ..Our results imply that some BDNF single-nucleotide polymorphisms and haplotypes are associated with susceptibility to, and contribute to the symptoms of, FM. ..
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    Park D, Kang J, Lee K, Bae S, Chung W, Choe J, et al. Efficacy and safety of mycophenolate mofetil and tacrolimus combination therapy in patients with lupus nephritis: a nationwide multicentre study. Clin Exp Rheumatol. 2018;: pubmed
    ..8%). Our findings suggest that a combined MMF and TAC treatment, with a favourable adverse-event profile, may be a beneficial option for LN patients with inadequate response to either MMF or TAC treatments. ..
  3. Choi J, Park D, Kang J, Yim Y, Lee K, Lee J, et al. Comparison of clinical and serological differences among juvenile-, adult-, and late-onset systemic lupus erythematosus in Korean patients. Lupus. 2015;24:1342-9 pubmed publisher
    ..JSLE patients have more severe disease activity and more frequent renal involvement and LSLE patients have milder disease activity, more commonly accompanied by Sjögren's syndrome, at disease onset. ..
  4. Wen L, Shin M, Kang J, Yim Y, Kim J, Lee J, et al. The relationships between bone mineral density and radiographic features of hand or knee osteoarthritis in older adults: data from the Dong-gu Study. Rheumatology (Oxford). 2016;55:495-503 pubmed publisher
    ..Knee JSN and hand subchondral cysts exerted the greatest effects on BMD. Separate analysis of the radiographic features of OA better reveals associations of OA with the BMD of the lumbar spine and femoral neck. ..
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    Lee K, Kang J, Yim Y, Kim J, Lee J, Wen L, et al. Predictive significance of CCL21 and CXCL13 levels in the minor salivary glands of patients with Sjögren's syndrome. Clin Exp Rheumatol. 2017;35:234-240 pubmed
    ..CCL21 and CXCL13 levels can therefore serve as useful markers to predict the disease activity and prognosis of patients with SS. ..
  6. Park D, Choi S, Shin K, Kim H, Park Y, Kang S, et al. Switching profiles in a population-based cohort of rheumatoid arthritis receiving biologic therapy: results from the KOBIO registry. Clin Rheumatol. 2017;36:1013-1022 pubmed publisher
    ..In this registry, we showed diverse prescribing patterns and differing baseline profiles based on the chronological order of biologic agents. ..
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    Kim J, Park D, Choi S, Kang J, Yim Y, Lee J, et al. Predictors of a favourable outcome in patients with fibromyalgia: results of 1-year follow-up. Clin Exp Rheumatol. 2016;34:521-6 pubmed
    ..Two-thirds of our Korean FM patients experienced some clinical improvement by 1-year follow-up. A high baseline STAI-II score and treatment with pregabalin were the important predictor of improved FM. ..
  8. Wen L, Kang J, Yim Y, Kim J, Lee J, Lee K, et al. Associations between body composition measurements of obesity and radiographic osteoarthritis in older adults: Data from the Dong-gu Study. BMC Musculoskelet Disord. 2016;17:192 pubmed publisher
    ..Otherwise, fat deposition correlated with hand and knee radiographic OA in both genders, while the distribution of fat tissue was significantly associated with hand and knee radiographic OA only in females. ..
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    Kang J, Park D, Kim S, Nah S, Lee J, Kim S, et al. Severity of fibromyalgia symptoms is associated with socioeconomic status and not obesity in Korean patients. Clin Exp Rheumatol. 2016;34:S83-8 pubmed
    ..In contrast to Western patients, symptom severity in Korean FM patients is associated with SES, but not with obesity. ..

More Information


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    Park D, Kang J, Lee K, Kang S, Kwok S, Kim S, et al. Association of depression with socioeconomic status, anticardiolipin antibodies, and organ damage in patients with systemic lupus erythematosus: results from the KORNET registry. Clin Exp Rheumatol. 2018;36:627-635 pubmed
    ..Our results show that depression is prevalent in patients with SLE and multiple factors are associated with depression in SLE. These data could help guide target programmes for those at high risk of depression in SLE. ..
  2. Jin H, Kim T, Choi J, Kim M, Cho Y, Nam K, et al. MicroRNA-155 as a proinflammatory regulator via SHIP-1 down-regulation in acute gouty arthritis. Arthritis Res Ther. 2014;16:R88 pubmed publisher
    ..The production of inflammatory cytokines was markedly increased in MSU crystal induced peritonitis mice. Overexpression of miR-155 in the gouty SFMC leads to suppress SHIP-1 levels and enhance proinflammatory cytokines. ..
  3. Lee S, Nam K, Jin H, Cho Y, Lee S, Kim T, et al. Bone destruction by receptor activator of nuclear factor ?B ligand-expressing T cells in chronic gouty arthritis. Arthritis Res Ther. 2011;13:R164 pubmed publisher
    ..Furthermore, our data show that MSU crystals have the potential to induce pro-resorptive cytokines, and T cells are involved in osteoclastogenesis in chronic gout. ..
  4. Kang J, Park D, Lee K, Lee J, Choi Y, Lee S. Comparison of clinical, serological, and prognostic differences among juvenile-, adult-, and late-onset lupus nephritis in Korean patients. Clin Rheumatol. 2017;36:1289-1295 pubmed publisher
    ..LLN patients showed higher chronicity indices and deterioration of kidney function and death in long-term follow-up compared with JLN and ALN patients. Therefore, LLN patients should be carefully monitored to avoid poor outcomes. ..
  5. Lee K, Choi S, Xu H, Kang J, Park D, Lee S. HAQ score is an independent predictor of sustained remission in patients with rheumatoid arthritis. Rheumatol Int. 2017;37:2027-2034 pubmed publisher
    ..012). A lower HAQ score at baseline was an independent predictor of sustained remission at 2 years, according to DAS28-CRP. Thus, HAQ scores could be useful when stratifying patients according to risk for flare-ups in the clinic. ..
  6. Wen L, Shin M, Kang J, Yim Y, Kim J, Lee J, et al. The value of high-sensitivity C-reactive protein in hand and knee radiographic osteoarthritis: data from the Dong-gu Study. Clin Rheumatol. 2018;37:1099-1106 pubmed publisher
    ..Of the various types of radiographic damage, all of sclerosis, erosion, and malalignment were significantly associated with hs-CRP levels. ..
  7. Park D, Kim S, Nah S, Lee J, Kim S, Lee Y, et al. Polymorphisms of the TRPV2 and TRPV3 genes associated with fibromyalgia in a Korean population. Rheumatology (Oxford). 2016;55:1518-27 pubmed publisher
    ..Our results suggest that certain TRPV2 haplotypes may have a protective role against FM and that some genotypes and haplotypes of TRPV3 contribute towards the symptoms of FM. ..
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    Lee S, Park M, Yoon H, Park Y, Park I, Park K. Evaluating the Korean version of the Multidimensional Health Assessment Questionnaire in patients with rheumatoid arthritis. Clin Rheumatol. 2006;25:353-7 pubmed
    ..001). The correlations between the MDHAQ scores and the ACR core set, BDI, and STAI were all high and statistically significant. The Korean version of the MDHAQ is a reliable, valid tool for assessing Korean patients with RA. ..
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    Park D, Takahashi Y, Kang J, Yim Y, Kim J, Lee J, et al. Anti-N-methyl-D-aspartate receptor antibodies are associated with fibromyalgia in patients with systemic lupus erythematosus: a case-control study. Clin Exp Rheumatol. 2017;35 Suppl 105:54-60 pubmed
    ..To our knowledge, this report is the first to suggest that anti-NMDAR antibodies are associated with the pathogenesis of FM with SLE. ..
  10. Lee J, Kang J, Lee K, Park D, Kang S, Kwok S, et al. Effects of risk factors for and components of metabolic syndrome on the quality of life of patients with systemic lupus erythematosus: a structural equation modeling approach. Qual Life Res. 2018;27:105-113 pubmed publisher
    ..The latter had a negative indirect impact on HRQOL, through depression. Clinicians should consider socioeconomic status and medication and seek to modify disease activity, MetS, and depression to improve the HRQOL of SLE patients. ..