Affiliation: Chonnam National University
Kumar S, Kang H, Park E, Park H, Lee K. The expression of CKLFSF2B is regulated by GATA1 and CREB in the Leydig cells, which modulates testicular steroidogenesis. Biochim Biophys Acta Gene Regul Mech. 2018;1861:1063-1075 pubmed publisher
..Altogether, these findings suggest that CKLFSF2B might be involved in the development and function of Leydig cells and regulate testicular testosterone production by fine-tuning the expression of steroidogenic genes. ..
Lee S, Song C, Xie Y, Jung C, Choi H, Lee K. SMILE upregulated by metformin inhibits the function of androgen receptor in prostate cancer cells. Cancer Lett. 2014;354:390-7 pubmed publisher
..Taken together, these results suggest that SMILE, which is induced by metformin, functions as a novel AR corepressor and may mediate the inhibitory effect of metformin on androgen-dependent growth of prostate cancer cells. ..
Park E, Lee B, Clurman B, Lee K. NUP50 is necessary for the survival of primordial germ cells in mouse embryos. Reproduction. 2016;151:51-8 pubmed publisher
..Taken together, these results suggest that NUP50 plays an essential role in the survival of PGCs during embryonic development. ..
Park E, Kumar S, Lee B, Kim K, Seo J, Choi H, et al
. Estrogen receptor-related receptor Î³ regulates testicular steroidogenesis through direct and indirect regulation of steroidogenic gene expression. Mol Cell Endocrinol. 2017;452:15-24 pubmed publisher
..Taken together, these findings suggest that ERRÎ³ regulates testicular steroidogenesis, both directly controlling and indirectly fine-tuning the expression of steroidogenic genes. ..
Kumar S, Lee H, Park H, Lee K. Testis-Specific GTPase (TSG): An oligomeric protein. BMC Genomics. 2016;17:792 pubmed
..Further investigation of TSG function in vivo may provide new clues for uncovering the secrets of spermatogenesis. ..