Genomes and Genes


Hueng Sik Choi


Affiliation: Chonnam National University
Country: Korea


  1. Lee J, Seo W, Han H, Oh K, Lee Y, Kim D, et al. Insulin-Inducible SMILE Inhibits Hepatic Gluconeogenesis. Diabetes. 2016;65:62-73 pubmed publisher
    ..Therefore, SMILE is an insulin-inducible corepressor that suppresses hepatic gluconeogenesis. Small molecules that enhance SMILE expression would have potential for treating hyperglycemia in diabetes. ..
  2. Noh J, Kim Y, Kim D, Hwang J, Kim K, Choi D, et al. Small heterodimer partner negatively regulates C-X-C motif chemokine ligand 2 in hepatocytes during liver inflammation. Sci Rep. 2018;8:15222 pubmed publisher
    ..Collectively, SHP regulates Cxcl2 transcription in hepatocytes, playing a pivotal role in the recruitment of neutrophils. SHP-targeting strategies may represent alternative approaches to control fulminant hepatitis. ..
  3. Lee J, Han H, Jung Y, Harris R, Koo S, Choi H. The SMILE transcriptional corepressor inhibits cAMP response element-binding protein (CREB)-mediated transactivation of gluconeogenic genes. J Biol Chem. 2018;293:13125-13133 pubmed publisher
    ..These results reveal that SMILE represses CREB/CRTC2-induced PGC-1? expression, an insight that may help inform potential therapeutic approaches targeting PGC-1?-mediated regulation of hepatic glucose metabolism. ..
  4. Jang W, Jeong B, Kim E, Choi H, Oh S, Kim D, et al. Cyclic AMP Response Element-binding Protein H (CREBH) Mediates the Inhibitory Actions of Tumor Necrosis Factor α in Osteoblast Differentiation by Stimulating Smad1 Degradation. J Biol Chem. 2015;290:13556-66 pubmed publisher
    ..Taken together, these results suggest that CREBH is a novel negative regulator of osteoblast differentiation and bone formation. ..
  5. Zhang Y, Kim D, Jung Y, Kim Y, Lee Y, Kim J, et al. Inverse agonist of ERR? reduces cannabinoid receptor type 1-mediated induction of fibrinogen synthesis in mice with a high-fat diet-intoxicated liver. Arch Toxicol. 2018;92:2885-2896 pubmed publisher
    ..Taken together, targeting ERR? with its inverse agonist GSK5182 represents a promising therapeutic strategy for ameliorating hyperfibrinogenemia. ..
  6. Zhang Y, Kim D, Lee J, Park S, Jeong W, Kim S, et al. Orphan nuclear receptor oestrogen-related receptor γ (ERRγ) plays a key role in hepatic cannabinoid receptor type 1-mediated induction of CYP7A1 gene expression. Biochem J. 2015;470:181-93 pubmed publisher
    ..Finally, GSK5182 significantly reduced hepatic CB1 receptor-mediated induction of CYP7A1 expression and bile acid synthesis in alcohol-treated mice. These results provide the molecular mechanism linking ERRγ and bile acid metabolism. ..
  7. Han Y, Kim D, Na T, Ka N, Choi H, Lee M. RORα switches transcriptional mode of ERRγ that results in transcriptional repression of CYP2E1 under ethanol-exposure. Nucleic Acids Res. 2016;44:1095-104 pubmed publisher
    ..Thus, this non-classical RORα pathway switched the transcriptional mode of ERRγ, leading to repression of alcohol-induced CYP2E1 expression, and this finding may provide a new therapeutic strategy against ALDs. ..
  8. Kim J, Im C, Yoo E, Ma M, Kim S, Hong E, et al. Identification of Selective ERRγ Inverse Agonists. Molecules. 2016;21:80 pubmed publisher
    ..This novel class of ERRγ inverse agonists shows promise in the development of drugs targeting ERRγ-related diseases. ..
  9. Misra J, Kim D, Jung Y, Kim H, Kim Y, Yoo E, et al. O-GlcNAcylation of Orphan Nuclear Receptor Estrogen-Related Receptor ? Promotes Hepatic Gluconeogenesis. Diabetes. 2016;65:2835-48 pubmed publisher
    ..We conclude that O-GlcNAcylation of ERR? serves as a major signal to promote hepatic gluconeogenesis. ..

More Information


  1. Misra J, Kim D, Choi H. ERR?: a Junior Orphan with a Senior Role in Metabolism. Trends Endocrinol Metab. 2017;28:261-272 pubmed publisher
    ..These findings corroborate the importance of ERR? in metabolic homeostasis, and suggest that ERR? is a good target for the treatment of metabolic diseases. ..