Jung Hoon Kang

Summary

Affiliation: Chongju University
Country: Korea

Publications

  1. ncbi request reprint Oxidative modification of human ceruloplasmin by peroxyl radicals
    J H Kang
    Department of Genetic Engineering, Chongju University, South Korea
    Biochim Biophys Acta 1568:30-6. 2001
  2. ncbi request reprint Modification and inactivation of human Cu,Zn-superoxide dismutase by methylglyoxal
    Jung Hoon Kang
    Department of Genetic Engineering, Chongju University, Chongju 360 764, Korea
    Mol Cells 15:194-9. 2003
  3. ncbi request reprint Enhanced oligomerization of the alpha-synuclein mutant by the Cu,Zn-superoxide dismutase and hydrogen peroxide system
    Jung Hoon Kang
    Department of Genetic Engineering, Chongju University, Chongju 360 764, Korea
    Mol Cells 15:87-93. 2003
  4. ncbi request reprint Oxidative damage of DNA by the reaction of amino acid with methylglyoxal in the presence of Fe(III)
    Jung Hoon Kang
    Department of Genetic Engineering, Chongju University, Chongju 360 764, South Korea
    Int J Biol Macromol 33:43-8. 2003
  5. ncbi request reprint Carnosine and related dipeptides protect human ceruloplasmin against peroxyl radical-mediated modification
    Jung Hoon Kang
    Department of Genetic Engineering, Chongju University, Korea
    Mol Cells 13:498-502. 2002
  6. ncbi request reprint Oxidative damage of DNA induced by methylglyoxal in vitro
    Jung Hoon Kang
    Department of Genetic Engineering, Chongju University, Chongju 360 764, South Korea
    Toxicol Lett 145:181-7. 2003
  7. ncbi request reprint Modification of Cu,Zn-superoxide dismutase by oxidized catecholamines
    Jung Hoon Kang
    Department of Genetic Engineering, Chongju University, Chongju 360 764, Korea
    J Biochem Mol Biol 37:325-9. 2004
  8. ncbi request reprint Protective effects of carnosine, homocarnosine and anserine against peroxyl radical-mediated Cu,Zn-superoxide dismutase modification
    Jung Hoon Kang
    Department of Genetic Engineering, Division of Natural Sciences, Chongju University, 360 764, South Korea
    Biochim Biophys Acta 1570:89-96. 2002
  9. ncbi request reprint Oxidative modification of human ceruloplasmin by methylglyoxal: an in vitro study
    Jung Hoon Kang
    Department of Genetic Engineering, Cheongju University, Korea
    J Biochem Mol Biol 39:335-8. 2006
  10. ncbi request reprint Protection by carnosine-related dipeptides against hydrogen peroxide-mediated ceruloplasmin modification
    Jung Hoon Kang
    Department of Genetic Engineering, Chongju University, Korea
    Mol Cells 13:107-12. 2002

Collaborators

  • Soo Young Choi
  • Tae Cheon Kang
  • Moo Ho Won
  • Eun Young Lee
  • K S Kim
  • Jong Soo Chang
  • Won Sik Eum
  • Dae Won Kim
  • Jinseu Park
  • Hee Soon Choi
  • Sung Woo Cho
  • Sung Ho An
  • Oh Shin Kwon
  • Sang Ho Jang
  • So Young Kim
  • Nam Hoon Kim
  • Kil Soo Lee
  • Jae Jin An
  • Hyeok Yil Kwon
  • Ki Yeon Yoo
  • In Koo Hwang
  • Myeong Seon Lee
  • Jung Hwan Yoon
  • Sun Hwa Lee
  • Inn Goo Kyeong
  • Moon Sik Jeong
  • Chang Sik Yoon
  • Young Hoon Kim
  • Hyeon Yong Lee
  • Jae Hoon Bahn
  • Li Hua Jin
  • Sung Kuk Kim
  • Hyung Joo Kwon
  • Jin Hi Choi
  • Kyuhyung Han
  • Tae Yoon Kim
  • In Soon Choung
  • A Yeon Kim
  • Dong Heui Kim
  • Sang Chul Kwon
  • Min Jung Lee
  • Yeom Pyo Lee
  • Min Seop Jeong
  • In Bum Lee
  • Jang Hyun Choi
  • Sang Min Cho
  • Young Han Lee
  • Pann Ghill Suh
  • Seok Il Hwang
  • Jun Hwi Cho
  • Yong Joon Cho
  • Ming Zhen Li
  • Dae Keun Yoon
  • Byung Ryong Lee
  • Nam In Baek
  • Mi Ryoung Jung
  • Hae Young Yoon
  • Ju A Kim
  • Kyu Hyung Han
  • Yong Je Lee
  • Jiyoon Ryu

Detail Information

Publications47

  1. ncbi request reprint Oxidative modification of human ceruloplasmin by peroxyl radicals
    J H Kang
    Department of Genetic Engineering, Chongju University, South Korea
    Biochim Biophys Acta 1568:30-6. 2001
    ..Subsequently, when the amino acid composition of CP reacted with AAPH was analyzed, cysteine, tryptophan, methionine, histidine, tyrosine, and lysine residues were particularly sensitive...
  2. ncbi request reprint Modification and inactivation of human Cu,Zn-superoxide dismutase by methylglyoxal
    Jung Hoon Kang
    Department of Genetic Engineering, Chongju University, Chongju 360 764, Korea
    Mol Cells 15:194-9. 2003
    ..It is suggested that oxidative damage to Cu,Zn-SOD by MG may perturb cellular antioxidant defense systems and damage cells. This effect may account, in part, for organ deterioration in diabetes...
  3. ncbi request reprint Enhanced oligomerization of the alpha-synuclein mutant by the Cu,Zn-superoxide dismutase and hydrogen peroxide system
    Jung Hoon Kang
    Department of Genetic Engineering, Chongju University, Chongju 360 764, Korea
    Mol Cells 15:87-93. 2003
    ..Therefore, these compounds may be explored as potential therapeutic agents for PD patients. The present experiments, in part, may provide an explanation for the association between PD and the alpha-synuclein mutant...
  4. ncbi request reprint Oxidative damage of DNA by the reaction of amino acid with methylglyoxal in the presence of Fe(III)
    Jung Hoon Kang
    Department of Genetic Engineering, Chongju University, Chongju 360 764, South Korea
    Int J Biol Macromol 33:43-8. 2003
    ..This mechanism, in part, may provide an explanation for the deterioration of organs under diabetic conditions...
  5. ncbi request reprint Carnosine and related dipeptides protect human ceruloplasmin against peroxyl radical-mediated modification
    Jung Hoon Kang
    Department of Genetic Engineering, Chongju University, Korea
    Mol Cells 13:498-502. 2002
    ..It is proposed that carnosine and related peptides might be explored as potential therapeutic agents for pathologies that involve CP modification mediated by peroxyl radicals generated in the lipid peroxidation...
  6. ncbi request reprint Oxidative damage of DNA induced by methylglyoxal in vitro
    Jung Hoon Kang
    Department of Genetic Engineering, Chongju University, Chongju 360 764, South Korea
    Toxicol Lett 145:181-7. 2003
    ..This mechanism may be linked to several diverse biological processes including mutagenesis, aging, carcinogenesis, and diabetic complications...
  7. ncbi request reprint Modification of Cu,Zn-superoxide dismutase by oxidized catecholamines
    Jung Hoon Kang
    Department of Genetic Engineering, Chongju University, Chongju 360 764, Korea
    J Biochem Mol Biol 37:325-9. 2004
    ..These results suggest that the modification of Cu,Zn-SOD by oxidized catecholamines might induce the perturbation of cellular antioxidant systems and led to a deleterious cell condition...
  8. ncbi request reprint Protective effects of carnosine, homocarnosine and anserine against peroxyl radical-mediated Cu,Zn-superoxide dismutase modification
    Jung Hoon Kang
    Department of Genetic Engineering, Division of Natural Sciences, Chongju University, 360 764, South Korea
    Biochim Biophys Acta 1570:89-96. 2002
    ..It is proposed that carnosine and related dipeptides might be explored as potential therapeutic agents for pathologies that involve Cu,Zn-SOD modification mediated by peroxyl radicals...
  9. ncbi request reprint Oxidative modification of human ceruloplasmin by methylglyoxal: an in vitro study
    Jung Hoon Kang
    Department of Genetic Engineering, Cheongju University, Korea
    J Biochem Mol Biol 39:335-8. 2006
    ..The proposed mechanism, in part, may provide an explanation for the deterioration of organs in the diabetic patient...
  10. ncbi request reprint Protection by carnosine-related dipeptides against hydrogen peroxide-mediated ceruloplasmin modification
    Jung Hoon Kang
    Department of Genetic Engineering, Chongju University, Korea
    Mol Cells 13:107-12. 2002
    ..These results suggest that carnosine, homocarnosine, and anserine might protect ceruloplasmin against H2O2-mediated oxidative damage through a combination of copper chelation and free radical scavenging...
  11. doi request reprint Oxidative modification of neurofilament-L and neuronal cell death induced by the catechol neurotoxin, tetrahydropapaveroline
    Inn Goo Kyeong
    Department of Genetic Engineering, Cheongju University, Cheongju 360 764, South Korea
    Toxicol Lett 217:59-66. 2013
    ..5-fold compared with control cells. Furthermore, treatment of cells with THP increased NF-L aggregate formation, suggesting the involvement of NF-L modification in THP-induced cell damage...
  12. ncbi request reprint Protective effects of histidine dipeptides on the modification of neurofilament-L by the cytochrome c/hydrogen peroxide system
    Nam Hoon Kim
    Department of Genetic Engineering, Cheongju University, Cheongju 360 764, Korea
    J Biochem Mol Biol 40:125-9. 2007
    ..Our results suggest that carnosine and histidine dipeptides have antioxidant effects on brain proteins under pathophysiological conditions leading to degenerative damage, such as, those caused by neurodegenerative disorders...
  13. ncbi request reprint The ceruloplasmin and hydrogen peroxide system induces alpha-synuclein aggregation in vitro
    Kyung Sik Kim
    Department of Genetic Engineering, Chongju University, Chongju 360 764, Republic of Korea
    Biochimie 84:625-31. 2002
    ..These results suggest that the CP/H(2)O(2) system may be related to abnormal aggregation of alpha-synuclein which may be involved in the pathogenesis of PD and related disorders...
  14. ncbi request reprint In vivo protein transduction: biologically active intact pep-1-superoxide dismutase fusion protein efficiently protects against ischemic insult
    Won Sik Eum
    Department of Genetic Engineering, Research Institute for Bioscience and Biotechnology, Hallym University, 1 1 Okchon Dong, Chunchon, Kangwon Do, Korea, 200 702, Korea
    Free Radic Biol Med 37:1656-69. 2004
    ..These results suggest that the biologically active intact forms of PEP-1-SOD provide a more efficient strategy for therapeutic delivery in various human diseases related to this antioxidant enzyme or to ROS, including stroke...
  15. ncbi request reprint Aggregation of alpha-synuclein induced by the Cu,Zn-superoxide dismutase and hydrogen peroxide system
    Kyung Sik Kim
    Department of Genetic Engineering, Division of Natural Sciences, Chongju University, Chongju 360 764, South Korea
    Free Radic Biol Med 32:544-50. 2002
    ..These results suggest that the Cu,Zn-SOD/H(2)O(2) system might be related to abnormal aggregation of alpha-synuclein, which may be involved in the pathogenesis of PD and related disorders...
  16. doi request reprint Oxidative modification of ferritin induced by hydrogen peroxide
    Jung Hwan Yoon
    Department of Genetic Engineering, Cheongju University, Korea
    BMB Rep 44:165-9. 2011
    ..It is assumed that oxidative damage of ferritin by H(2)O(2) may induce the increase of iron content in cells and subsequently lead to the deleterious condition...
  17. doi request reprint Ferritin enhances salsolinol-mediated DNA strand breakage: protection by carnosine and related compounds
    Jung Hoon Kang
    Department of Genetic Engineering, Cheongju University, Cheongju 360 764, Republic of Korea
    Toxicol Lett 188:20-5. 2009
    ..These results indicate that carnosine and related compounds effectively suppressed the salsolinol/ferritin system-mediated DNA strand breakage via hydroxyl radical scavenging...
  18. ncbi request reprint Modification and inactivation of Cu,Zn-superoxide dismutase by the lipid peroxidation product, acrolein
    Jung Hoon Kang
    Department of Genetic Engineering, Cheongju University, Cheongju 360 764, Korea
    BMB Rep 46:555-60. 2013
    ..It is suggested that the modification and inactivation of Cu,Zn-SOD by acrolein could be produced by more oxidative cell environments...
  19. ncbi request reprint Oxidative damage of DNA induced by the reaction of methylglyoxal with lysine in the presence of ferritin
    Sung Ho An
    Department of Genetic Engineering, Cheongju University, Cheongju 360 764, Korea
    BMB Rep 46:225-9. 2013
    ..Our data suggest that DNA cleavage caused by the ferritin/MG/lysine system via the generation of ROS by the Fenton-like reaction of free iron ions released from oxidatively damaged ferritin...
  20. ncbi request reprint Salsolinol, a catechol neurotoxin, induces oxidative modification of cytochrome c
    Jung Hoon Kang
    Department of Genetic Engineering, Cheongju University, Cheongju 360 764, Korea
    BMB Rep 46:119-23. 2013
    ..This mechanism may, in part, provide an explanation for the deterioration of organs under neurodegenerative disorders such as PD...
  21. ncbi request reprint Oxidative modification of cytochrome c by hydrogen peroxide
    Nam Hoon Kim
    Department of Genetic Engineering, Cheongju University, Korea
    Mol Cells 22:220-7. 2006
    ....
  22. ncbi request reprint Oxidative damage of DNA induced by the cytochrome C and hydrogen peroxide system
    Nam Hoon Kim
    Department of Genetic Engineering, Cheongju University, Cheongju 360 764, Korea
    J Biochem Mol Biol 39:452-6. 2006
    ....
  23. doi request reprint Protective effects of carnosine and homocarnosine on ferritin and hydrogen peroxide-mediated DNA damage
    Jung Hoon Kang
    Department of Genetic Engineering, Cheongju University, Cheongju 360 764, Korea
    BMB Rep 43:683-7. 2010
    ..Our results suggest that carnosine and related compounds might have antioxidant effects on DNA under pathophysiological conditions leading to degenerative damage such as neurodegenerative disorders...
  24. doi request reprint Salsolinol, a tetrahydroisoquinoline-derived neurotoxin, induces oxidative modification of neurofilament-L protection by histidyl dipeptides
    Jung Hoon Kang
    Department of Genetic Engineering, Cheongju University, Cheongju 360 764, Korea
    BMB Rep 45:114-9. 2012
    ..Both compounds also inhibited the generation of •OH induced by salsolinol. The results indicated that carnosine and related compounds may prevent salsolinol-mediated NF-L modification via free radical scavenging...
  25. ncbi request reprint Reaction of ferritin with hydrogen peroxide induces lipid peroxidation
    Jung Hwan Yoon
    Department of Genetic Engineering, Cheongju University, Cheongju 360 764, Korea
    BMB Rep 43:219-24. 2010
    ..These results indicated that carnosine and related compounds may prevent ferritin/H2O2 system-mediated lipid peroxidation via free radical scavenging...
  26. ncbi request reprint Molecular gene cloning, expression, and characterization of bovine brain glutamate dehydrogenase
    Dae Won Kim
    Department of Genetic Engineering, Division of Life Sciences, Hallym University, Chunchon 200 702, Korea
    J Biochem Mol Biol 36:545-51. 2003
    ..3-fold. These results indicate that the recombinant-expressed bovine brain GDH that is produced has biochemical properties that are very similar to those of the purified GDH enzyme...
  27. ncbi request reprint Salsolinol, a tetrahydroisoquinoline catechol neurotoxin, induces human Cu,Zn-superoxidie dismutase modificaiton
    Jung Hoon Kang
    Department of Genetic Engineering, Cheongju University, Cheongju 360 764, Korea
    J Biochem Mol Biol 40:684-9. 2007
    ..Therefore, the results indicate that free radical may play a role in the modification and inactivation of Cu,Zn-SOD by salsolinol...
  28. ncbi request reprint Oxidative modification of neurofilament-L by copper-catalyzed reaction
    Nam Hoon Kim
    Department of Genetic Engineering, Chongju University, Chongju 360 764, Korea
    J Biochem Mol Biol 36:488-92. 2003
    ..This study suggests that copper-mediated NF-L modification might be closely related to oxidative reactions which may play a critical role in neurodegenerative diseases...
  29. ncbi request reprint Acrolein, the toxic endogenous aldehyde, induces neurofilament-L aggregation
    Moon Sik Jeong
    Department of Genetic Engineering, Cheongju University, Cheongju, South Korea
    BMB Rep 41:635-9. 2008
    ..This study suggests that acrolein-mediated NF-L aggregation might be closely related to oxidative reactions, thus these reactions may play a critical role in neurodegenerative diseases...
  30. doi request reprint Vitamin C increases the apoptosis via up-regulation p53 during cisplatin treatment in human colon cancer cells
    Sung Ho An
    Genetic Engineering, Cheongju University, Korea
    BMB Rep 44:211-6. 2011
    ..These results suggest that VC enhanced CDDP sensitivity and apoptosis via upregulation of p53...
  31. doi request reprint Oxidative modification of ferritin induced by methylglyoxal
    Sung Ho An
    Department of Genetic Engineering, Cheongju University, Cheongju, Korea
    BMB Rep 45:147-52. 2012
    ..This mechanism, in part, may provide an explanation or the deterioration of organs under diabetic conditions...
  32. ncbi request reprint Human glutamate dehydrogenase is immunologically distinct from other mammalian orthologues
    Sang Ho Jang
    Department of Genetic Engineering, Division of Life Sciences, Hallym University, Chunchon 200 702, Korea
    Exp Mol Med 35:249-56. 2003
    ....
  33. ncbi request reprint Transduction of familial amyotrophic lateral sclerosis-related mutant PEP-1-SOD proteins into neuronal cells
    Jae Jin An
    Department of Biomedical Science and Research Institute for Bioscience and Biotechnology, Hallym University, Chunchon 200 702, Korea
    Mol Cells 25:55-63. 2008
    ..The effects of the transduced SOD1 fusion proteins may provide an explanation for the association of SOD1 with FALS, and Hsps could be candidate agents for the treatment of ALS...
  34. ncbi request reprint Transduction efficacy of Tat-Cu,Zn-superoxide dismutase is enhanced by copper ion recovery of the fusion protein
    Won Sik Eum
    Department of Physiology, College of Medicine, Hallym University, Chunchon, Korea
    Mol Cells 13:334-40. 2002
    ..These then significantly increase the biological effectiveness of this antioxidant enzyme...
  35. ncbi request reprint 9-polylysine protein transduction domain: enhanced penetration efficiency of superoxide dismutase into mammalian cells and skin
    Jinseu Park
    Division of Life Sciences, Hallym University, Chunchon, Korea
    Mol Cells 13:202-8. 2002
    ..These results suggest Tat-SOD and 9Lys-SOD fusion proteins can be used as anti-aging cosmetics, or in protein therapy, for various disorders that are related to this antioxidant enzyme and ROS...
  36. ncbi request reprint Transduced Tat-SOD fusion protein protects against ischemic brain injury
    Dae Won Kim
    Department of Genetic Engineering and Research, Institute for Bioscience and Biotechnology, Hallym University, Chunchon 200 702, Korea
    Mol Cells 19:88-96. 2005
    ..These results suggest that Tat-SOD provides a strategy for therapeutic delivery in various hu-man diseases, including stroke, related to this anti-oxidant enzyme or to ROS...
  37. ncbi request reprint Enhanced transduction of Cu,Zn-superoxide dismutase with HIV-1 Tat protein transduction domains at both termini
    Won Sik Eum
    Department of Genetic Engineering and Research Institute for Bioscience and Biotechnology, Hallym University, Chunchon 200 702, Korea
    Mol Cells 19:191-7. 2005
    ..The availability of a more efficient SOD fusion protein provides a powerful vehicle for therapy in human diseases related to this anti-oxidant enzyme and to reactive oxygen species...
  38. ncbi request reprint Transduced human copper chaperone for Cu,Zn-SOD (PEP-1-CCS) protects against neuronal cell death
    Soo Hyun Choi
    Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chunchon 200 702, Korea
    Mol Cells 20:401-8. 2005
    ..These results suggest that CCS is essential to activate SOD, and that transduction of PEP-1-CCS provides a potential strategy for therapeutic delivery in various human diseases including stroke related to SOD or ROS...
  39. ncbi request reprint HIV-1 Tat-mediated protein transduction of Cu,Zn-superoxide dismutase into pancreatic beta cells in vitro and in vivo
    Won Sik Eum
    Department of Physiology, College of Medicine, Hallym University, Chunchon 200 702, South Korea
    Free Radic Biol Med 37:339-49. 2004
    ..These results suggest that the transduction of Tat-SOD offers a new strategy for protecting pancreatic beta cells from destruction by relieving oxidative stress in ROS-implicated diabetes...
  40. ncbi request reprint PEP-1-SOD fusion protein efficiently protects against paraquat-induced dopaminergic neuron damage in a Parkinson disease mouse model
    Hee Soon Choi
    Department of Biomedical Science and Research Institute for Bioscience and Biotechnology, Hallym University, Chunchon 200 702, Korea
    Free Radic Biol Med 41:1058-68. 2006
    ..These results suggest that PEP-1-SOD provides a strategy for therapeutic delivery in various human diseases related to reactive oxygen species, including PD...
  41. ncbi request reprint Transduced Tat-alpha-synuclein protects against oxidative stress in vitro and in vivo
    Hee Soon Choi
    Department of Biomedical Sciences, Hallym University, Chunchon, Korea
    J Biochem Mol Biol 39:253-62. 2006
    ....
  42. pmc Copper chaperone for Cu,Zn-SOD supplement potentiates the Cu,Zn-SOD function of neuroprotective effects against ischemic neuronal damage in the gerbil hippocampus
    In Koo Hwang
    Department of Anatomy, College of Medicine, Hallym University, Chunchon 200 702, South Korea
    Free Radic Biol Med 39:392-402. 2005
    ....
  43. ncbi request reprint Production and characterization of monoclonal antibodies against human ceruloplasmin
    Won Sik Eum
    Department of Genetic Engineering and Research Institute for Bioscience and Biotechnology, Hallym University, Chunchon 200 702, Korea
    J Biochem Mol Biol 38:71-6. 2005
    ..The CP mAbs could be of great benefit to design the diagnostic kit for CP-related diseases such as Wilson's disease...
  44. ncbi request reprint Ischemia-related change of ceruloplasmin immunoreactivity in neurons and astrocytes in the gerbil hippocampus and dentate gyrus
    In Koo Hwang
    Department of Anatomy, College of Medicine, Hallym University, Chunchon 200 702, South Korea
    Neurochem Int 44:601-7. 2004
    ..This delayed neuronal injury 1 day after ischemic insult might provide a window of opportunity for therapeutic interventions using antioxidants...
  45. ncbi request reprint Isolation and identification of an antioxidant enzyme catalase stimulatory compound from Garnoderma lucidum
    Hyeon Yong Lee
    Division of Life Sciences, Hallym University, Chunchon 200 702, Korea
    J Biochem Mol Biol 36:450-5. 2003
    ..These results suggest that methyl linoleate that is produced by G. lucidum stimulates the catalase expression at the transcription level...
  46. ncbi request reprint Human liver catalase: cloning, expression and characterization of monoclonal antibodies
    Li Hua Jin
    Division of Life Sciences, Hallym University, Chunchon 200 702, Korea
    Mol Cells 15:381-6. 2003
    ..These results indicate that mammalian livers and human cell lines contain only one major type of immunologically reactive catalase, even though some of catalases have been previously reported to differ in certain properties...
  47. ncbi request reprint In vitro assay of neurofilament light chain self-assembly using truncated mutants
    Sung Kuk Kim
    Department of Life Science, College of Natural Science, Daejin University, Kyeonggido 487 711, Republic of Korea
    J Neurosci Methods 161:199-204. 2007
    ..Our results collectively imply that GST-fused head-rod domains of NF-L are critical tools for analyzing NF-L self-assembly in vitro...