Yong C Lee

Summary

Affiliation: Chonbuk National University
Country: Korea

Publications

  1. ncbi request reprint The involvement of matrix metalloproteinase-9 in airway inflammation of patients with acute asthma
    Y C Lee
    Department of Internal Medicine, Research Institute of Clinical Medicine, Chonbuk National University Medical School, Chonju, South Korea
    Clin Exp Allergy 31:1623-30. 2001
  2. ncbi request reprint The role of PTEN in allergic inflammation
    Yong C Lee
    Department of Internal Medicine, Research Center for Allergic Immune Diseases, Chonbuk National University Medical School, Jeonju, South Korea
    Arch Immunol Ther Exp (Warsz) 52:250-4. 2004
  3. ncbi request reprint Contribution of vascular endothelial growth factor to airway hyperresponsiveness and inflammation in a murine model of toluene diisocyanate-induced asthma
    Yong C Lee
    Department of Internal Medicine, Research Institute of Clinical Medicine, Chonbuk National University Medical School, Chonju, South Korea
    J Immunol 168:3595-600. 2002
  4. ncbi request reprint Serum levels of interleukins (IL)-4, IL-5, IL-13, and interferon-gamma in acute asthma
    Y C Lee
    Department of Internal Medicine, Research Institute of Clinical Medicine, Chonbuk National University Medical School, Chonju, South Korea
    J Asthma 38:665-71. 2001
  5. ncbi request reprint PPAR-gamma modulates allergic inflammation through up-regulation of PTEN
    Kyung S Lee
    Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, South Korea
    FASEB J 19:1033-5. 2005
  6. pmc Involvement of PTEN in airway hyperresponsiveness and inflammation in bronchial asthma
    Yong Geun Kwak
    Department of Pharmacology, Institute of Cardiovascular Research, Research Center for Allergic Immune Diseases, Chonbuk National University Medical School, Chonju, South Korea
    J Clin Invest 111:1083-92. 2003
  7. ncbi request reprint Inhibition of phosphoinositide 3-kinase delta attenuates allergic airway inflammation and hyperresponsiveness in murine asthma model
    Kyung S Lee
    Department of Internal Medicine, Research Center for Allergic Immune Diseases, Chonbuk National University Medical School, Jeonju, South Korea
    FASEB J 20:455-65. 2006
  8. ncbi request reprint Doxycycline reduces airway inflammation and hyperresponsiveness in a murine model of toluene diisocyanate-induced asthma
    Kyung S Lee
    Department of Internal Medicine, Research Center for Allergic Immune Diseases, Chonbuk National University Medical School, 634 18 Keumamdong, Jeonju 561 712, South Korea
    J Allergy Clin Immunol 113:902-9. 2004
  9. ncbi request reprint Matrix metalloproteinase inhibitor regulates inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression in a murine model of toluene diisocyanate-induced asthma
    Kyung S Lee
    Department of Internal Medicine, Research Center for Allergic Immune Diseases, Chonbuk National University Medical School, 634 18 Keumamdong, Chonju 561 712, South Korea
    J Allergy Clin Immunol 111:1278-84. 2003
  10. ncbi request reprint The involvement of VEGF in endothelial permeability: a target for anti-inflammatory therapy
    Yong C Lee
    Department of Internal Medicine, Research Center for Allergic Immune Diseases, Chonbuk National University Medical School, 634 18 Keumamdong, Jeonju 561 712, South Korea
    Curr Opin Investig Drugs 6:1124-30. 2005

Collaborators

Detail Information

Publications14

  1. ncbi request reprint The involvement of matrix metalloproteinase-9 in airway inflammation of patients with acute asthma
    Y C Lee
    Department of Internal Medicine, Research Institute of Clinical Medicine, Chonbuk National University Medical School, Chonju, South Korea
    Clin Exp Allergy 31:1623-30. 2001
    ..Matrix metalloproteinase-9 (MMP-9) is the major proteolytic enzyme that induces bronchial remodelling in asthma. MMP-9 is also important in the migration of inflammatory cells through basement membrane components...
  2. ncbi request reprint The role of PTEN in allergic inflammation
    Yong C Lee
    Department of Internal Medicine, Research Center for Allergic Immune Diseases, Chonbuk National University Medical School, Jeonju, South Korea
    Arch Immunol Ther Exp (Warsz) 52:250-4. 2004
    ..These findings indicate that use of PTEN may be a good therapeutic strategy for the management of allergic inflammation...
  3. ncbi request reprint Contribution of vascular endothelial growth factor to airway hyperresponsiveness and inflammation in a murine model of toluene diisocyanate-induced asthma
    Yong C Lee
    Department of Internal Medicine, Research Institute of Clinical Medicine, Chonbuk National University Medical School, Chonju, South Korea
    J Immunol 168:3595-600. 2002
    ..Administration of VEGFR inhibitors reduced all these pathophysiological symptoms. These results suggest that VEGF is one of the major determinants of TDI-induced asthma and that the inhibition of VEGF may be a good therapeutic strategy...
  4. ncbi request reprint Serum levels of interleukins (IL)-4, IL-5, IL-13, and interferon-gamma in acute asthma
    Y C Lee
    Department of Internal Medicine, Research Institute of Clinical Medicine, Chonbuk National University Medical School, Chonju, South Korea
    J Asthma 38:665-71. 2001
    ..Our results suggest that serum levels of IL-4, IL-5, and IL-13 may be elevated in acute asthma, and that higher levels of IL-5 and/or lower levels of IFN-gamma are associated with severe airway obstruction...
  5. ncbi request reprint PPAR-gamma modulates allergic inflammation through up-regulation of PTEN
    Kyung S Lee
    Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, South Korea
    FASEB J 19:1033-5. 2005
    ..These findings demonstrate a protective role of PPARgamma in the pathogenesis of the asthma phenotype through regulation of PTEN expression...
  6. pmc Involvement of PTEN in airway hyperresponsiveness and inflammation in bronchial asthma
    Yong Geun Kwak
    Department of Pharmacology, Institute of Cardiovascular Research, Research Center for Allergic Immune Diseases, Chonbuk National University Medical School, Chonju, South Korea
    J Clin Invest 111:1083-92. 2003
    ..Intratracheal administration of PI3K inhibitors or AdPTEN remarkably reduced bronchial inflammation and airway hyperresponsiveness. These findings indicate that PTEN may play a pivotal role in the pathogenesis of the asthma phenotype...
  7. ncbi request reprint Inhibition of phosphoinositide 3-kinase delta attenuates allergic airway inflammation and hyperresponsiveness in murine asthma model
    Kyung S Lee
    Department of Internal Medicine, Research Center for Allergic Immune Diseases, Chonbuk National University Medical School, Jeonju, South Korea
    FASEB J 20:455-65. 2006
    ..Taken together, our findings implicate that inhibition of p110delta signaling pathway may have therapeutic potential for the treatment of allergic airway inflammation...
  8. ncbi request reprint Doxycycline reduces airway inflammation and hyperresponsiveness in a murine model of toluene diisocyanate-induced asthma
    Kyung S Lee
    Department of Internal Medicine, Research Center for Allergic Immune Diseases, Chonbuk National University Medical School, 634 18 Keumamdong, Jeonju 561 712, South Korea
    J Allergy Clin Immunol 113:902-9. 2004
    ..Previous studies have reported that MMP-9 might play a role in chronic airway inflammation and remodeling in asthma...
  9. ncbi request reprint Matrix metalloproteinase inhibitor regulates inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression in a murine model of toluene diisocyanate-induced asthma
    Kyung S Lee
    Department of Internal Medicine, Research Center for Allergic Immune Diseases, Chonbuk National University Medical School, 634 18 Keumamdong, Chonju 561 712, South Korea
    J Allergy Clin Immunol 111:1278-84. 2003
    ..This traffic is mediated by adhesion molecules. However, little is known about the migration of inflammatory cells through the endothelial and epithelial basement membranes in toluene diisocyanate (TDI)-induced asthma...
  10. ncbi request reprint The involvement of VEGF in endothelial permeability: a target for anti-inflammatory therapy
    Yong C Lee
    Department of Internal Medicine, Research Center for Allergic Immune Diseases, Chonbuk National University Medical School, 634 18 Keumamdong, Jeonju 561 712, South Korea
    Curr Opin Investig Drugs 6:1124-30. 2005
    ....
  11. ncbi request reprint Cysteinyl leukotriene receptor antagonist regulates vascular permeability by reducing vascular endothelial growth factor expression
    Kyung S Lee
    Department of Internal Medicine, Research Center for Allergic Immune Diseases, Chonbuk National University Medical School, 634 18 Keumamdong, Jeonju 561 712, South Korea
    J Allergy Clin Immunol 114:1093-9. 2004
    ..However, the mechanisms by which cysLTs induce increased vascular permeability are not clearly understood...
  12. doi request reprint Phosphoinositide 3-kinase delta inhibitor as a novel therapeutic agent in asthma
    Seoung J Park
    Department of Internal Medicine and Airway Remodeling Laboratory, Chonbuk National University Medical School, Jeonju, South Korea
    Respirology 13:764-71. 2008
    ..In this review the biological role of PI3Ks, especially PI3Kdelta, are highlighted and the therapeutic potential of selective PI3Kdelta inhibitor in asthma discussed...
  13. ncbi request reprint The role of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in cryptogenic organizing pneumonia
    Koang H Choi
    Department of Internal Medicine, Research Institute of Clinical Medicine, Chonbuk National University Medical School, Chonju, South Korea
    Chest 121:1478-85. 2002
    ..However, not much is known about the roles of MMP-9 and/or TIMP-1 in COP...
  14. doi request reprint Sclerosing hemangioma, presenting as a pneumonic pattern with mucinous adenomatous hyperplasia of the lung
    Keum H Choi
    Department of Pathology, Chonbuk National University Medical School, San 2 20 Keumam dong, Dukjin, Jeonju, Korea
    Pathol Int 58:735-40. 2008
    ..Because this lesion did not have expression of thyroid transcription factor-1, it is described as mucinous adenomatous hyperplasia...