Research Topics
| Yong C LeeSummaryAffiliation: Chonbuk National University Country: Korea Publications
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Detail Information
Publications
The involvement of matrix metalloproteinase-9 in airway inflammation of patients with acute asthmaY C Lee
Department of Internal Medicine, Research Institute of Clinical Medicine, Chonbuk National University Medical School, Chonju, South Korea
Clin Exp Allergy 31:1623-30. 2001..Matrix metalloproteinase-9 (MMP-9) is the major proteolytic enzyme that induces bronchial remodelling in asthma. MMP-9 is also important in the migration of inflammatory cells through basement membrane components...- The role of PTEN in allergic inflammationYong C Lee
Department of Internal Medicine, Research Center for Allergic Immune Diseases, Chonbuk National University Medical School, Jeonju, South Korea
Arch Immunol Ther Exp (Warsz) 52:250-4. 2004..These findings indicate that use of PTEN may be a good therapeutic strategy for the management of allergic inflammation... - Contribution of vascular endothelial growth factor to airway hyperresponsiveness and inflammation in a murine model of toluene diisocyanate-induced asthmaYong C Lee
Department of Internal Medicine, Research Institute of Clinical Medicine, Chonbuk National University Medical School, Chonju, South Korea
J Immunol 168:3595-600. 2002..Administration of VEGFR inhibitors reduced all these pathophysiological symptoms. These results suggest that VEGF is one of the major determinants of TDI-induced asthma and that the inhibition of VEGF may be a good therapeutic strategy... - Serum levels of interleukins (IL)-4, IL-5, IL-13, and interferon-gamma in acute asthmaY C Lee
Department of Internal Medicine, Research Institute of Clinical Medicine, Chonbuk National University Medical School, Chonju, South Korea
J Asthma 38:665-71. 2001..Our results suggest that serum levels of IL-4, IL-5, and IL-13 may be elevated in acute asthma, and that higher levels of IL-5 and/or lower levels of IFN-gamma are associated with severe airway obstruction... - PPAR-gamma modulates allergic inflammation through up-regulation of PTENKyung S Lee
Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, South Korea
FASEB J 19:1033-5. 2005..These findings demonstrate a protective role of PPARgamma in the pathogenesis of the asthma phenotype through regulation of PTEN expression... 
Involvement of PTEN in airway hyperresponsiveness and inflammation in bronchial asthmaYong Geun Kwak
Department of Pharmacology, Institute of Cardiovascular Research, Research Center for Allergic Immune Diseases, Chonbuk National University Medical School, Chonju, South Korea
J Clin Invest 111:1083-92. 2003..Intratracheal administration of PI3K inhibitors or AdPTEN remarkably reduced bronchial inflammation and airway hyperresponsiveness. These findings indicate that PTEN may play a pivotal role in the pathogenesis of the asthma phenotype...- Inhibition of phosphoinositide 3-kinase delta attenuates allergic airway inflammation and hyperresponsiveness in murine asthma modelKyung S Lee
Department of Internal Medicine, Research Center for Allergic Immune Diseases, Chonbuk National University Medical School, Jeonju, South Korea
FASEB J 20:455-65. 2006..Taken together, our findings implicate that inhibition of p110delta signaling pathway may have therapeutic potential for the treatment of allergic airway inflammation... - Doxycycline reduces airway inflammation and hyperresponsiveness in a murine model of toluene diisocyanate-induced asthmaKyung S Lee
Department of Internal Medicine, Research Center for Allergic Immune Diseases, Chonbuk National University Medical School, 634-18 Keumamdong, Jeonju 561-712, South Korea
J Allergy Clin Immunol 113:902-9. 2004..CONCLUSION: These findings suggest that doxycycline may reduce airway inflammation and hyperresponsiveness through phosphatidylinositol 3-kinase pathway in a murine model of TDI-induced asthma... - Matrix metalloproteinase inhibitor regulates inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression in a murine model of toluene diisocyanate-induced asthmaKyung S Lee
Department of Internal Medicine, Research Center for Allergic Immune Diseases, Chonbuk National University Medical School, 634-18 Keumamdong, Chonju 561-712, South Korea
J Allergy Clin Immunol 111:1278-84. 2003..CONCLUSIONS: These results suggest that MMP inhibitors regulate inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression and possibly also by suppressing IL-1beta, IL-4, and TNF-alpha expression... - The involvement of VEGF in endothelial permeability: a target for anti-inflammatory therapyYong C Lee
Department of Internal Medicine, Research Center for Allergic Immune Diseases, Chonbuk National University Medical School, 634 18 Keumamdong, Jeonju 561 712, South Korea
Curr Opin Investig Drugs 6:1124-30. 2005.... - Cysteinyl leukotriene receptor antagonist regulates vascular permeability by reducing vascular endothelial growth factor expressionKyung S Lee
Department of Internal Medicine, Research Center for Allergic Immune Diseases, Chonbuk National University Medical School, 634-18 Keumamdong, Jeonju 561-712, South Korea
J Allergy Clin Immunol 114:1093-9. 2004..CONCLUSION: These results indicate that cysLT receptor antagonists modulate vascular permeability by reducing VEGF expression and suggest that cysLT receptor may regulate the VEGF expression... 
Phosphoinositide 3-kinase delta inhibitor as a novel therapeutic agent in asthmaSeoung J Park
Department of Internal Medicine and Airway Remodeling Laboratory, Chonbuk National University Medical School, Jeonju, South Korea
Respirology 13:764-71. 2008..In this review the biological role of PI3Ks, especially PI3Kdelta, are highlighted and the therapeutic potential of selective PI3Kdelta inhibitor in asthma discussed...- The role of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in cryptogenic organizing pneumoniaKoang H Choi
Department of Internal Medicine, Research Institute of Clinical Medicine, Chonbuk National University Medical School, Chonju, South Korea
Chest 121:1478-85. 2002..CONCLUSIONS: These data suggest that overproduction of MMP-9 and TIMP-1, and an imbalance between MMP-9 and TIMP-1, may have a role as diagnostic references in COP... - Sclerosing hemangioma, presenting as a pneumonic pattern with mucinous adenomatous hyperplasia of the lungKeum H Choi
Department of Pathology, Chonbuk National University Medical School, San 2 20 Keumam dong, Dukjin, Jeonju, Korea
Pathol Int 58:735-40. 2008..Because this lesion did not have expression of thyroid transcription factor-1, it is described as mucinous adenomatous hyperplasia...