Kyung Chul Choi

Summary

Country: Korea

Publications

  1. Shin H, Hwang K, Choi K. Antitumor Effect of Various Phytochemicals on Diverse Types of Thyroid Cancers. Nutrients. 2019;11: pubmed publisher
    ..These results suggest that thyroid cancer can be more effectively treated by the combinations of phytochemicals and the existing therapies or substances. ..
  2. Jang Y, Hwang K, Choi K. Rosmarinic Acid, a Component of Rosemary Tea, Induced the Cell Cycle Arrest and Apoptosis through Modulation of HDAC2 Expression in Prostate Cancer Cell Lines. Nutrients. 2018;10: pubmed publisher
    ..Taken together, treatment of RA to PCa cell lines inhibits the cell survival and induces cell apoptosis, and it can be used as a novel therapeutic agent toward PCa. ..
  3. Kim S, Hwang K, Choi D, Choi K. The cigarette smoke components induced the cell proliferation and epithelial to mesenchymal transition via production of reactive oxygen species in endometrial adenocarcinoma cells. Food Chem Toxicol. 2018;121:657-665 pubmed publisher
    ..Taken together, these results indicate that CS components can promote progression of endometrial adenocarcinoma via increasing cell proliferation and the ROS-mediated EMT process. ..
  4. Park G, Heo J, Kim S, Choi K. The growth of K562 human leukemia cells was inhibited by therapeutic neural stem cells in cellular and xenograft mouse models. Cytotherapy. 2018;20:1191-1201 pubmed publisher
    ..Taken together, these results suggest that gene therapy using genetically engineered stem cells expressing CD and IFN-β may be effective for treating CML in these mouse models. ..
  5. Kim J, Yi B, Go R, Hwang K, Nam K, Choi K. Methoxychlor and triclosan stimulates ovarian cancer growth by regulating cell cycle- and apoptosis-related genes via an estrogen receptor-dependent pathway. Environ Toxicol Pharmacol. 2014;37:1264-74 pubmed publisher
    ..In conclusion, the results of our investigation indicate that two potential EDCs, MXC and TCS, may stimulate ovarian cancer growth by regulating cell cycle- and apoptosis-related genes via an ER-dependent pathway. ..
  6. Kim S, Hwang K, Shim S, Choi K. Growth and migration of LNCaP prostate cancer cells are promoted by triclosan and benzophenone-1 via an androgen receptor signaling pathway. Environ Toxicol Pharmacol. 2015;39:568-76 pubmed publisher
    ..Taken together, these results indicated that TCS and BP-1 may enhance the progression of PCa by regulating cell cycle and metastasis-related genes via AR signaling pathway. ..
  7. Kim Y, Choi K, Hwang K. Genistein suppressed epithelial-mesenchymal transition and migration efficacies of BG-1 ovarian cancer cells activated by estrogenic chemicals via estrogen receptor pathway and downregulation of TGF-β signaling pathway. Phytomedicine. 2015;22:993-9 pubmed publisher
    ..Taken together, GEN suppressed EMT and migration capacities of BG-1 ovarian cancer cells enhanced by E2, BPA, and NP via ER signaling and the downregulation of TGF-β signal. ..
  8. Kim C, Go R, Hwang K, Bae O, Lee K, Choi K. Effects of cigarette smoke extracts on apoptosis and oxidative stress in two models of ovarian cancer in vitro. Toxicol In Vitro. 2018;52:161-169 pubmed publisher
    ..Taken together, these results suggest that CSE may induce cell proliferation inhibition and oxidative stress in ovarian cells. ..
  9. Go R, Hwang K, Choi K. Cytochrome P450 1 family and cancers. J Steroid Biochem Mol Biol. 2015;147:24-30 pubmed publisher
    ..Thus, this review focuses on the role(s) of CYP1 family in ER-dependent or ER-independent cancers and the potential for cancer therapy to target CYP1 family in these cancers. ..

More Information

Publications34

  1. Go R, Kim C, Choi K. Effect of fenhexamid and cyprodinil on the expression of cell cycle- and metastasis-related genes via an estrogen receptor-dependent pathway in cellular and xenografted ovarian cancer models. Toxicol Appl Pharmacol. 2015;289:48-57 pubmed publisher
    ..Taken together, these results imply that fenhexamid and cyprodinil may have disruptive effects on ER-expressing cancer by altering the cell cycle- and metastasis-related gene expression via an ER-dependent pathway. ..
  2. Kim C, Go R, Lee G, Kim C, Chun Y, Choi K. Immortalization of human corneal epithelial cells using simian virus 40 large T antigen and cell characterization. J Pharmacol Toxicol Methods. 2016;78:52-7 pubmed publisher
    ..These cells may be an excellent model for detecting the adverse effects of standard toxic materials and could replace the traditional eye irritation test as an animal-free alternative method. ..
  3. Kim S, Nam K, Hwang K, Choi K. Influence of hexabromocyclododecane and 4-nonylphenol on the regulation of cell growth, apoptosis and migration in prostatic cancer cells. Toxicol In Vitro. 2016;32:240-7 pubmed publisher
    ..Taken together, these results indicate that HBCD and NP may enhance progression of prostate cancer by modulating growth and migration of LNCaP prostate cells by acting on cell cycle, apoptosis, and metastasis. ..
  4. Lee J, Ahn C, Kang H, Hong E, Hyun S, Choi K, et al. Effects of Octylphenol and Bisphenol A on the Metal Cation Transporter Channels of Mouse Placentas. Int J Environ Res Public Health. 2016;13: pubmed
    ..The fetus relies on the mother for ionic transportation, and, therefore, pregnant women should avoid exposure to cation-channel-disrupting chemicals. ..
  5. Go R, Hwang K, Park G, Lee H, Lee G, Kim C, et al. Effects of microalgal polyunsaturated fatty acid oil on body weight and lipid accumulation in the liver of C57BL/6 mice fed a high fat diet. J Biomed Res. 2016;30:234-42 pubmed publisher
    ..Collectively, these findings suggest that microalgal oil, derived from Thraustochytriidae sp. derived mutant, is a prominent candidate for replacement of omega-3 fish oils based on its apparent anti-obesity effect in vivo. ..
  6. Jeon S, Go R, Heo J, Kim C, Hwang K, Choi K. Effects of cigarette smoke extracts on the progression and metastasis of human ovarian cancer cells via regulating epithelial-mesenchymal transition. Reprod Toxicol. 2016;65:1-10 pubmed publisher
    ..Based on the results, cigarette smokers of women might be at a higher risk of ovarian cancer than non-smokers. ..
  7. Lee G, Choi K, Hwang K. Kaempferol, a phytoestrogen, suppressed triclosan-induced epithelial-mesenchymal transition and metastatic-related behaviors of MCF-7 breast cancer cells. Environ Toxicol Pharmacol. 2017;49:48-57 pubmed publisher
  8. Kim C, Hwang K, Choi K. Anti-metastatic potential of resveratrol and its metabolites by the inhibition of epithelial-mesenchymal transition, migration, and invasion of malignant cancer cells. Phytomedicine. 2016;23:1787-1796 pubmed publisher
    ..Although these findings display the anti-metastatic potential of resveratrol, more patient-oriented clinical studies demonstrating the marked efficacies of resveratrol in humans are still needed. ..
  9. Kim C, Park G, Bae O, Noh M, Choi K. Application of SV40 T-transformed human corneal epithelial cells to evaluate potential irritant chemicals for in vitro alternative eye toxicity. J Pharmacol Toxicol Methods. 2016;80:82-9 pubmed publisher
    ..Taken together, these results suggest that SHCE cells could be an excellent alternative in vitro model to replace in vivo animal models for eye irritation tests. ..
  10. Shin S, Go R, Kim C, Hwang K, Nam K, Choi K. Effect of benzophenone-1 and octylphenol on the regulation of epithelial-mesenchymal transition via an estrogen receptor-dependent pathway in estrogen receptor expressing ovarian cancer cells. Food Chem Toxicol. 2016;93:58-65 pubmed publisher
  11. Jeon S, Hwang K, Choi K. Effect of steroid hormones, estrogen and progesterone, on epithelial mesenchymal transition in ovarian cancer development. J Steroid Biochem Mol Biol. 2016;158:1-8 pubmed publisher
  12. Heo J, Lee G, Kim G, Hwang K, Choi K. Phytochemical-induced reactive oxygen species and endoplasmic reticulum stress-mediated apoptosis and differentiation in malignant melanoma cells. Phytomedicine. 2018;39:100-110 pubmed publisher
    ..These results indicate that phytochemicals are potentially useful in treatments for melanoma due to their ability to inhibit melanoma cell growth and division via the ROS and ER stress pathway. ..
  13. Lee H, Kim C, Hwang K, Choi D, Choi K. Three components of cigarette smoke altered the growth and apoptosis of metastatic colon cancer cells via inducing the synthesis of reactive oxygen species and endoplasmic reticulum stress. Environ Toxicol Pharmacol. 2016;45:80-9 pubmed publisher
    ..e., FA, Bz, and IP, inhibited the cell viability of SW620 cells by down-regulating the protein expression of cyclin D1 & E1 and induced apoptosis of SW620 cells by increasing ROS production and simultaneously activating ER-stress. ..
  14. Kim B, Kim J, Kim S, Go R, Hwang K, Choi K. 3,3'-Diindolylmethane Suppressed Cyprodinil-Induced Epithelial-Mesenchymal Transition and Metastatic-Related Behaviors of Human Endometrial Ishikawa Cells via an Estrogen Receptor-Dependent Pathway. Int J Mol Sci. 2018;19: pubmed publisher
  15. Lee H, Hwang K, Choi K. Diverse pathways of epithelial mesenchymal transition related with cancer progression and metastasis and potential effects of endocrine disrupting chemicals on epithelial mesenchymal transition process. Mol Cell Endocrinol. 2017;457:103-113 pubmed publisher
    ..Therefore, it is considered that the exposure to these EDCs can increase the risk aggravating the disease for the patients suffering cancer and that more regulations about the use of these EDCs are needed. ..
  16. Kim C, Lee H, Lee K, Kim B, Lee M, Choi K. Effects of cigarette smoke extracts on cell cycle, cell migration and endocrine activity in human placental cells. Reprod Toxicol. 2017;73:8-19 pubmed publisher
    ..CSE exposure may also decrease hCG-? production as an endocrine marker, implying that cigarette smoke has adverse effects during pregnancy. ..
  17. Lee H, Kim S, Choi K. Treatment of Human Placental Choriocarcinoma Cells with Formaldehyde and Benzene Induced Growth and Epithelial Mesenchymal Transition via Induction of an Antioxidant Effect. Int J Environ Res Public Health. 2017;14: pubmed publisher
    ..Taken together, these results indicated that FA and Bz induce the growth and migration of human choriocarcinoma cells via regulation of the cell cycle and EMT and activation of ROS and antioxidant related markers. ..
  18. Kim C, Kim C, Choi K. Establishment and evaluation of immortalized human epidermal keratinocytes for an alternative skin irritation test. J Pharmacol Toxicol Methods. 2017;88:130-139 pubmed publisher
    ..Overall, these findings suggest that SV-HEK2 cells could be a good alternative in vitro model for skin irritation tests. ..
  19. Lee G, Hwang K, Choi K. Inhibitory effects of 3,3'-diindolylmethane on epithelial-mesenchymal transition induced by endocrine disrupting chemicals in cellular and xenograft mouse models of breast cancer. Food Chem Toxicol. 2017;109:284-295 pubmed publisher
    ..Taken together, DIM is a potent chemopreventive compound for preventing metastatic behaviors of breast cancer cells induced by EDCs with cancer-related toxicity. ..
  20. Kim S, Hwang K, Choi K. Treatment with kaempferol suppresses breast cancer cell growth caused by estrogen and triclosan in cellular and xenograft breast cancer models. J Nutr Biochem. 2016;28:70-82 pubmed publisher
  21. Lee H, Kim C, Hwang K, Sung J, Lee J, Choi K. Cigarette smoke impaired maturation of ovarian follicles and normal growth of uterus inner wall of female wild-type and hypertensive rats. Reprod Toxicol. 2017;73:232-240 pubmed publisher
    ..In addition, this harmful effect of CS may be displayed more seriously in rats with HT. ..
  22. Kim G, Heo J, Kim S, Choi K. Cancer-Specific Inhibitory Effects of Genetically Engineered Stem Cells Expressing Cytosine Deaminase and Interferon-? Against Choriocarcinoma in Xenografted Metastatic Mouse Models. Transl Oncol. 2017;11:74-85 pubmed publisher
    ..v. injected hNSCs in a metastasis model; therefore, the results indicate that this stem cell therapy can be used as an alternative novel tool to treat metastatic choriocarcinoma. ..
  23. Kim S, Lee H, Hwang K, Choi K. Benzo(a)pyrene induced cell cycle arrest and apoptosis in human choriocarcinoma cancer cells through reactive oxygen species-induced endoplasmic reticulum-stress pathway. Food Chem Toxicol. 2017;107:339-348 pubmed publisher
    ..Taken together, these results suggest that B(a)P has the potential to induce apoptosis of JEG-3 and BeWo human choriocarcinoma cancer cells by increasing the ROS level and simultaneously activating ER-stress. ..
  24. Park G, Go R, Lee H, Lee G, Kim C, Seo J, et al. Potential Anti-proliferative and Immunomodulatory Effects of Marine Microalgal Exopolysaccharide on Various Human Cancer Cells and Lymphocytes In Vitro. Mar Biotechnol (NY). 2017;19:136-146 pubmed publisher
    ..GA has an anti-proliferative activity against cancer cells and an immunomodulatory effect by having an influence on B cell proliferation and cytokine secretion of T cells. ..
  25. Lee G, Hwang K, Choi K. Roles of Dietary Phytoestrogens on the Regulation of Epithelial-Mesenchymal Transition in Diverse Cancer Metastasis. Toxins (Basel). 2016;8: pubmed publisher
    ..In this review, we focused on the important roles of phytoestrogens in inhibiting EMT in many types of cancer and suggested phytoestrogens as prominent alternative compounds to chemotherapy. ..