Wonku Kang

Summary

Affiliation: Catholic University of Daegu
Country: Korea

Publications

  1. doi request reprint Contribution of pH to systemic exposure of niflumic acid following oral administration of talniflumate
    Eunyoung Kim
    College of Pharmacy, Chungnam National University, Daejeon, 305 764, Korea
    Eur J Clin Pharmacol 67:425-8. 2011
  2. ncbi request reprint Determination of talniflumate and niflumic acid in human plasma by liquid chromatography-tandem mass spectrometry
    Wonku Kang
    College of Pharmacy, Catholic University of Daegu, Kyoungbuk 712 702, South Korea
    Anal Sci 25:571-4. 2009
  3. doi request reprint Enantioselective determination of sibutramine and its active metabolites in human plasma
    Wonku Kang
    College of Pharmacy, Catholic University of Daegu, Kyoungbuk, South Korea
    J Pharm Biomed Anal 51:264-7. 2010
  4. ncbi request reprint Simple and sensitive determination of nisoldipine in plasma using liquid chromatography-tandem mass spectrometry
    Wonku Kang
    College of Pharmacy, Catholic University of Daegu, Kyoungbuk, South Korea
    Anal Sci 22:1597-9. 2006
  5. doi request reprint Effect of food on systemic exposure to niflumic acid following postprandial administration of talniflumate
    Wonku Kang
    College of Pharmacy, Catholic University of Daegu, Kyoungbuk, Korea
    Eur J Clin Pharmacol 64:1027-30. 2008
  6. ncbi request reprint Protective role of intestinal bacterial metabolism against baicalin-induced toxicity in HepG2 cell cultures
    Tilak Khanal
    Department of Toxicology, College of Pharmacy, Chungnam National University, Daejeon, South Korea
    J Toxicol Sci 37:363-71. 2012
  7. doi request reprint Determination of daumone in mouse plasma by HPLC/MS-MS
    Keumhan Noh
    College of Pharmacy, Yeungnam University, Kyoungsan, Kyoungbuk 712 749, South Korea
    Biomed Chromatogr 26:152-5. 2012
  8. doi request reprint Protective role of metabolism by intestinal microflora in butyl paraben-induced toxicity in HepG2 cell cultures
    Tilak Khanal
    Department of Toxicology, College of Pharmacy, Chungnam National University, Daejeon 305 764, South Korea
    Toxicol Lett 213:174-83. 2012
  9. doi request reprint Biotransformation of geniposide by human intestinal microflora on cytotoxicity against HepG2 cells
    Tilak Khanal
    Department of Toxicology, College of Pharmacy, Chungnam National University, Daejeon 305 764, South Korea
    Toxicol Lett 209:246-54. 2012
  10. doi request reprint Effects of rutaecarpine on the metabolism and urinary excretion of caffeine in rats
    Keumhan Noh
    College of Pharmacy, Yeungnam University, Gyeongsan, Korea
    Arch Pharm Res 34:119-25. 2011

Collaborators

  • Eunyoung Kim
  • Hye Gwang Jeong
  • Dong Hyun Kim
  • Eunsook Ma
  • Mankil Jung
  • Hunjoo Ha
  • Sun Ok Choi
  • Yurngdong Jahng
  • Jong Seong Kang
  • Jong Soo Woo
  • Jung Mi Oh
  • Seo Young Kim
  • Minkyun Na
  • Michael Weiss
  • Keumhan Noh
  • Kwang Il Kwon
  • Tae Cheon Jeong
  • Mi Jeong Kang
  • Tilak Khanal
  • Kyeumhan Noh
  • Hwi yeol Yun
  • Hyung Gyun Kim
  • Jung Woo Chae
  • Sang Kyu Lee
  • Kyoungjin Bae
  • Hee Kyung Yeo
  • Hwa Jeong Lee
  • Jae Ho Choi
  • Beom Soo Shin
  • In hwan Baek
  • Minh Truong Do
  • Saurav Ghimire
  • Jong Hee Park
  • Dae Hun Lee
  • Young Tae Ahn
  • Min Jeong Kong
  • Minkyu Kim
  • Eunhee Ji
  • Taecheon Jeong
  • Dong Xun Li
  • Han Gon Choi
  • Chul Soon Yong
  • Jung hwa An
  • Bong Hwan Park
  • Eol Shim
  • Sunkyoung Park
  • Kil Soo Kim
  • Sun Woo Jin
  • Tae Ho Oh
  • Jin Yeul Ma
  • Pillippe Archimbault
  • Eunjung Kyung
  • Hwa Jeong Han
  • Byoungki Ahn
  • Mi Young Kim
  • Kyung Im Kim
  • Moon Chang Baek
  • Wan Gyoon Shin
  • Yoo Lim Kam
  • Young Min Seo
  • Sudeep R Bista
  • Hye Suk Lee
  • Hea Young Park Choo
  • Jung Hyun Park
  • In Wha Kim
  • Kwang Hyeon Liu
  • Pil Hoon Park
  • Gyu Sub Ko
  • Mann Hyung Lee
  • Tae Won Jeon
  • Byung yo Lee
  • Young Ran Kim
  • Youn Gee Seo
  • Ki Young Jang
  • Won Seok Lyoo
  • Jun Pil Jee
  • Bokyoung Min
  • Dong Hoon Oh
  • Young Joon Park
  • Yu Kyoung Oh
  • Jong Oh Kim
  • Jin Woo Yoo
  • Jianbo Chen
  • Geon Wook Kang
  • Manhyung Lee
  • Nam Deuk Kim
  • Hyung Sik Kim
  • Kiyoung Jang
  • Ju Hyun Kim
  • Sil Shin

Detail Information

Publications35

  1. doi request reprint Contribution of pH to systemic exposure of niflumic acid following oral administration of talniflumate
    Eunyoung Kim
    College of Pharmacy, Chungnam National University, Daejeon, 305 764, Korea
    Eur J Clin Pharmacol 67:425-8. 2011
    ..To clarify the underlying mechanism, an in vitro dissolution study of talniflumateonducted at different pH values, and magnesium hydroxide was co-administered in healthy volunteers...
  2. ncbi request reprint Determination of talniflumate and niflumic acid in human plasma by liquid chromatography-tandem mass spectrometry
    Wonku Kang
    College of Pharmacy, Catholic University of Daegu, Kyoungbuk 712 702, South Korea
    Anal Sci 25:571-4. 2009
    ..This method was used to measure the plasma concentrations of both compounds from healthy subjects after a single oral dose of talniflumate, 740 mg...
  3. doi request reprint Enantioselective determination of sibutramine and its active metabolites in human plasma
    Wonku Kang
    College of Pharmacy, Catholic University of Daegu, Kyoungbuk, South Korea
    J Pharm Biomed Anal 51:264-7. 2010
    ..This method was successfully used to profile the plasma concentrations of the stereoisomers of sibutramine and its two active metabolites with time in healthy volunteers...
  4. ncbi request reprint Simple and sensitive determination of nisoldipine in plasma using liquid chromatography-tandem mass spectrometry
    Wonku Kang
    College of Pharmacy, Catholic University of Daegu, Kyoungbuk, South Korea
    Anal Sci 22:1597-9. 2006
    ..7%, and the accuracy ranged from 86 to 112%. The limit of quantification was 0.1 ng/ml. This method was used to measure the plasma concentration of nisoldipine from healthy subjects after a single 5-mg oral dose of nisoldipine...
  5. doi request reprint Effect of food on systemic exposure to niflumic acid following postprandial administration of talniflumate
    Wonku Kang
    College of Pharmacy, Catholic University of Daegu, Kyoungbuk, Korea
    Eur J Clin Pharmacol 64:1027-30. 2008
    ..The prandial effect on talniflumate absorption remains unclear; therefore, this study investigated the effect of food on the systemic exposure to niflumic acid in healthy volunteers...
  6. ncbi request reprint Protective role of intestinal bacterial metabolism against baicalin-induced toxicity in HepG2 cell cultures
    Tilak Khanal
    Department of Toxicology, College of Pharmacy, Chungnam National University, Daejeon, South Korea
    J Toxicol Sci 37:363-71. 2012
    ..Taken all together, the findings suggested that metabolism of baicalin by human fecalase to baicalein might have protective effects against baicalin-induced toxicity in HepG2 cells...
  7. doi request reprint Determination of daumone in mouse plasma by HPLC/MS-MS
    Keumhan Noh
    College of Pharmacy, Yeungnam University, Kyoungsan, Kyoungbuk 712 749, South Korea
    Biomed Chromatogr 26:152-5. 2012
    ..This method was applied to measure the plasma daumone concentrations following a 5-week repeated oral administration of daumone in mice...
  8. doi request reprint Protective role of metabolism by intestinal microflora in butyl paraben-induced toxicity in HepG2 cell cultures
    Tilak Khanal
    Department of Toxicology, College of Pharmacy, Chungnam National University, Daejeon 305 764, South Korea
    Toxicol Lett 213:174-83. 2012
    ..Taken together, the findings suggested that metabolism of BP by human fecalase might have protective effects against BP-induced toxicity in HepG2 cells...
  9. doi request reprint Biotransformation of geniposide by human intestinal microflora on cytotoxicity against HepG2 cells
    Tilak Khanal
    Department of Toxicology, College of Pharmacy, Chungnam National University, Daejeon 305 764, South Korea
    Toxicol Lett 209:246-54. 2012
    ..Moreover, activated GS-induced cell death was reversed by SP600125. Taken together, these findings suggest that human IM is able to metabolize GS into GP, and the related biological activities induce apoptosis through ROS/JNK signaling...
  10. doi request reprint Effects of rutaecarpine on the metabolism and urinary excretion of caffeine in rats
    Keumhan Noh
    College of Pharmacy, Yeungnam University, Gyeongsan, Korea
    Arch Pharm Res 34:119-25. 2011
    ..These results clearly suggest that rutaecarpine increases the metabolism of caffeine, theophylline, theobromine, and paraxanthine by inducing CYP1A2 and CYP2E1 in rats...
  11. doi request reprint Enantioselective pharmacokinetics of sibutramine in rat
    Keumhan Noh
    College of Pharmacy, Catholic University of Daegu, Kyoungbuk 712 702, Korea
    Arch Pharm Res 33:267-73. 2010
    ..The present study is the first to elucidate the enantioselective pharmacokinetics of sibutramine in rats...
  12. doi request reprint Effect of decursinol angelate on the pharmacokinetics of theophylline and its metabolites in rats
    Jung Woo Chae
    College of Pharmacy, Chungnam National University, Daejeon, South Korea
    Food Chem Toxicol 50:3666-72. 2012
    ....
  13. doi request reprint Role of metabolism in 1-bromopropane-induced hepatotoxicity in mice
    Sang Kyu Lee
    College of Pharmacy, Yeungnam University, Gyeongsan, Korea
    J Toxicol Environ Health A 73:1431-40. 2010
    ..In addition, the hepatotoxicity induced by 1-BP was prevented by pretreatment with SKF-525A. Taken together, the formation of reactive metabolites by CYP and depletion of GSH may play important roles in hepatotoxicity induced by 1-BP...
  14. ncbi request reprint The effects of food on the bioavailability of fenofibrate administered orally in healthy volunteers via sustained-release capsule
    Hwi yeol Yun
    College of Pharmacy, Chungnam National University, Daejeon, Korea
    Clin Pharmacokinet 45:425-32. 2006
    ..To examine the effects of food on plasma concentration and bioavailability of fenofibrate administered as a sustained-release capsule...
  15. doi request reprint Simultaneous determination of zolazepam and tiletamine in dog plasma by liquid chromatography coupled to a tandem mass spectrometry
    Kyeumhan Noh
    College of Pharmacy, Yeungnam University, Kyoungbuk, South Korea
    Biomed Chromatogr 26:1133-6. 2012
    ..This method was used to measure the concentrations of zolazepam and tiletamine in plasma after a single intramuscular 10 mg dose of each in beagle dogs...
  16. doi request reprint Simultaneous determination of L-arginine, asymmetric dimethylarginine, and symmetric dimethylarginine in the plasma of rodents with LC-MS/MS
    Jung Woo Chae
    College of Pharmacy, Chungnam National University, Daejeon, Korea
    Arzneimittelforschung 61:340-6. 2011
    ..81 +/- 19.38 microM, 0.66 +/- 0.21 microM, and 0.42 +/- 0.10 microM, respectively, in mice. These results will provide a basis on which to evaluate cardiovascular drug effects on ARG, ADMA, and SDMA levels in new drug development...
  17. doi request reprint Simultaneous determination of glimepiride and its metabolites in human plasma by liquid chromatography coupled to a tandem mass spectrometry
    Kyeumhan Noh
    College of Pharmacy, Yeungnam University, Kyoungbuk, 712 749, Korea
    Arch Pharm Res 34:2073-8. 2011
    ..This method was used to measure the concentrations of glimepiride, M1, and M2 in plasma after a single oral 2-mg dose of glimepiride in volunteers...
  18. doi request reprint Quantitative determination of daumone in rat plasma by liquid chromatography-mass spectrometry
    Keumhan Noh
    College of Pharmacy, Yeungnam University, Kyoungsan, Kyoungbuk 712 749, South Korea
    J Pharm Biomed Anal 56:114-7. 2011
    ..This method was applied to measure the plasma daumone concentrations after a single intravenous administration of daumone in rats...
  19. doi request reprint Quantitative determination of cefetamet in human plasma by liquid chromatography-mass spectrometry
    Keumhan Noh
    College of Pharmacy, Catholic University of Daegu, Kyoungsan, Kyoungbuk 712 702, South Korea
    Biomed Chromatogr 25:779-82. 2011
    ..This method was used to measure the concentrations of the cefetamet in plasma after a single oral administration of 500 mg cefetamet pivoxyl...
  20. doi request reprint Analysis of enantiomers of sibutramine and its metabolites in rat plasma by liquid chromatography-mass spectrometry using a chiral stationary-phase column
    Kyoungjin Bae
    College of Pharmacy, Catholic University of Daegu, Hayang eup, Kyoungbuk 712 702, South Korea
    J Pharm Biomed Anal 50:267-70. 2009
    ..This method was used to measure the concentrations of the enantiomers of sibutramine, MDS, and DDS in plasma after a single oral dose of 10 mg/kg racemic sibutramine in rats...
  21. ncbi request reprint Simple and sensitive determination of menatetrenone and its epoxide metabolite in human plasma
    Wonku Kang
    College of Pharmacy, Catholic University of Daegu, Kyoungbuk 712 702, South Korea
    J Pharm Biomed Anal 44:1178-82. 2007
    ..5 and 0.2 ng/ml, respectively. This method was used to simultaneously measure the plasma concentration of menatetrenone and its epoxide metabolite from healthy subjects after a single 30 mg oral dose of menatetrenone...
  22. ncbi request reprint Determination of afloqualone in human plasma using liquid chromatography/tandem mass spectrometry: Application to pharmacokinetic studies in humans
    Hwi yeol Yun
    College of Pharmacy, Chungnam National University, Daejeon, Korea
    Talanta 73:635-43. 2007
    ..We believe that this phenomenon was related to the cleanness of the sample and its chemical nature...
  23. doi request reprint Quantitative determination of aceclofenac and its three major metabolites in rat plasma by HPLC-MS/MS
    Eunyoung Kim
    College of Pharmacy, Ewha Womans University, Seoul, South Korea
    J Sep Sci 35:2219-22. 2012
    ..This method was successfully used to measure the concentrations of aceclofenac and its three major metabolites in rat plasma following the oral administration of a single 20 mg/kg oral dose of aceclofenac...
  24. doi request reprint Role of metabolism by intestinal bacteria in arbutin-induced toxicity in vitro
    Mi Jeong Kang
    College of Pharmacy, Yeungnam University, Gyeongsan, 712 749, Korea
    Arch Pharm Res 34:687-93. 2011
    ..The results indicate that the present toxicity testing system might be applied for assessing the possible role of metabolism by intestinal bacteria in certain chemical-induced toxicity in mammalian cell cultures...
  25. ncbi request reprint Enhanced solubility and bioavailability of sibutramine base by solid dispersion system with aqueous medium
    Dong Xun Li
    College of Pharmacy, Yeungnam University, 214 1 Dae Dong, Gyongsan 712 749, South Korea
    Biol Pharm Bull 33:279-84. 2010
    ..Thus, this solid dispersion system would be useful to deliver poorly water-soluble sibutramine base with enhanced bioavailability...
  26. doi request reprint Quantitative determination of sparfloxacin in rat plasma by liquid chromatography/tandem mass spectrometry
    Keumhan Noh
    College of Pharmacy, Catholic University of Daegu, Kyoungbuk 712 702, South Korea
    Biomed Chromatogr 24:1199-202. 2010
    ..This method was applied to measure the plasma sparfloxacin concentrations after a single oral administration of sparfloxacin in rats...
  27. doi request reprint Determination of a novel low-voltage-activated calcium channel blocker (HYP-10) in rat plasma by liquid chromatography-mass spectrometry
    Keumhan Noh
    College of Pharmacy, Catholic University of Daegu, Kyoungbuk 712 702, South Korea
    J Pharm Biomed Anal 54:568-71. 2011
    ..This method was applied to measure the plasma HYP-10 concentration after a single intravenous administration of the compound in rats...
  28. pmc Assessment of adherence to the CONSORT statement for quality of reports on randomized controlled trial abstracts from four high-impact general medical journals
    Saurav Ghimire
    Department of Clinical Pharmacy, College of Pharmacy, Chungnam National University, 99, Dehak ro, Yuseong Gu, Daejeon, 305 764, South Korea
    Trials 13:77. 2012
    ..To date, few data exist regarding whether it has achieved this goal. We evaluated the extent of adherence to the CONSORT for Abstract statement for quality of reports on RCT abstracts by four high-impact general medical journals...
  29. ncbi request reprint Simultaneous determination of aceclofenac and its three metabolites in plasma using liquid chromatography-tandem mass spectrometry
    Wonku Kang
    College of Pharmacy, Catholic University of Daegu, Kyoungbuk 712 702, South Korea
    J Pharm Biomed Anal 46:587-91. 2008
    ..This analytic method is a very simple, sensitive, and accurate way to determine the pharmacokinetics of aceclofenac and its metabolites...
  30. doi request reprint Population pharmacokinetics of cyclosporine in Korean adults undergoing living-donor kidney transplantation
    Eunhee Ji
    College of Pharmacy, Seoul National University, Seoul, South Korea
    Pharmacotherapy 31:574-84. 2011
    ..To estimate the population pharmacokinetic parameters of cyclosporine in Korean adults undergoing living-donor kidney transplantation, and to identify clinical factors affecting cyclosporine pharmacokinetics...
  31. doi request reprint Nephrotoxic potential and toxicokinetics of tetrabromobisphenol A in rat for risk assessment
    Mi Jeong Kang
    College of Pharmacy, Yeungnam University, Gyeongsan, South Korea
    J Toxicol Environ Health A 72:1439-45. 2009
    ..The present results suggested that TBBPA may not be toxic to kidney, as the chemical is not bioavailable and is not present in renal tissue...
  32. doi request reprint Comparison of average, scaled average, and population bioequivalence methods for assessment of highly variable drugs: an experience with doxifluridine in beagle dogs
    In hwan Baek
    College of Pharmacy, Chungnam National University, Daejeon 305 764, South Korea
    Eur J Pharm Sci 39:175-80. 2010
    ..73) of the PBE (population bioequivalence), calculated using total variance. Our results suggest that the SABE method may be useful for evaluating the BE of HVDs and for meeting the need for international guidelines for BE...
  33. ncbi request reprint Analysis of benidipine enantiomers in human plasma by liquid chromatography-mass spectrometry using a macrocyclic antibiotic (Vancomycin) chiral stationary phase column
    Wonku Kang
    Department of Pharmacology and PharmacoGenomics Research Center, College of Medicine, Inje University, Busan 614 735, Republic of Korea
    J Chromatogr B Analyt Technol Biomed Life Sci 814:75-81. 2005
    ..96- and 1.85-fold, respectively (p<0.001), whereas, the T(max) and t(1/2) for each of the benidipine stereoisomers were not significantly different...
  34. ncbi request reprint Determination of benidipine in human plasma using liquid chromatography-tandem mass spectrometry
    Wonku Kang
    Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan, Republic of Korea
    J Chromatogr B Analyt Technol Biomed Life Sci 805:311-4. 2004
    ..This method is a very simple, sensitive, and accurate way to determine the plasma benidipine concentration...
  35. ncbi request reprint P-glycoprotein inhibitors enhance saturable uptake of idarubicin in rat heart: pharmacokinetic/pharmacodynamic modeling
    Michael Weiss
    Section of Pharmacokinetics, Department of Pharmacology, Martin Luther University Halle Wittenberg, Halle, Germany
    J Pharmacol Exp Ther 300:688-94. 2002
    ..Verapamil and amiodarone attenuated the negative inotropic action of idarubicin, which was linked to the intracellular concentration of idarubicin...