In Kyoung Lim

Summary

Affiliation: Ajou University
Country: Korea

Publications

  1. ncbi request reprint Spectrum of molecular changes during hepatocarcinogenesis induced by DEN and other chemicals in Fischer 344 male rats
    In Kyoung Lim
    Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon 442 721, South Korea
    Mech Ageing Dev 123:1665-80. 2002
  2. pmc B-cell translocation gene 2 mediates crosstalk between PI3K/Akt1 and NFκB pathways which enhances transcription of MnSOD by accelerating IκBα degradation in normal and cancer cells
    Santhoshkumar Sundaramoorthy
    Department of Biochemistry and Molecular Biology, BK21 Cell Transformation and Restoration, Ajou University School of Medicine, Suwon 443 721, Republic of Korea
    Cell Commun Signal 11:69. 2013
  3. ncbi request reprint TIS21 (/BTG2/PC3) as a link between ageing and cancer: cell cycle regulator and endogenous cell death molecule
    In Kyoung Lim
    Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon 443 721, Korea
    J Cancer Res Clin Oncol 132:417-26. 2006
  4. ncbi request reprint Spectrum of molecular changes during hepatocarcinogenesis induced by DEN and other chemicals in Fisher 344 male rats [Mechanisms of Ageing and Development 123 (2002) 1665-1680]
    In Kyoung Lim
    Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Gyunggi Do, Suwon, South Korea
    Mech Ageing Dev 124:697-708. 2003
  5. doi request reprint TIS21 negatively regulates hepatocarcinogenesis by disruption of cyclin B1-Forkhead box M1 regulation loop
    Tae Jun Park
    Department of Biochemistry and Molecular Biology, Ajou University, School of Medicine, Suwon, Republic of Korea
    Hepatology 47:1533-43. 2008
  6. ncbi request reprint Phosphorylation of serine 147 of tis21/BTG2/pc3 by p-Erk1/2 induces Pin-1 binding in cytoplasm and cell death
    Jong Wook Hong
    Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon 443 721, Korea
    J Biol Chem 280:21256-63. 2005
  7. pmc Phosphorylated extracellular signal-regulated protein kinases 1 and 2 phosphorylate Sp1 on serine 59 and regulate cellular senescence via transcription of p21Sdi1/Cip1/Waf1
    Hong Seok Kim
    Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon 443 721, Korea
    J Biol Chem 284:15475-86. 2009
  8. pmc B cell translocation gene 2 enhances susceptibility of HeLa cells to doxorubicin-induced oxidative damage
    Young Bin Lim
    Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon, 443 721, Korea
    J Biol Chem 283:33110-8. 2008
  9. doi request reprint TIS21/(BTG2) negatively regulates estradiol-stimulated expansion of hematopoietic stem cells by derepressing Akt phosphorylation and inhibiting mTOR signal transduction
    Bong Cho Kim
    Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon 443 721, Korea
    Stem Cells 26:2339-48. 2008
  10. doi request reprint TIS21(/BTG2/PC3) accelerates the repair of DNA double strand breaks by enhancing Mre11 methylation and blocking damage signal transfer to the Chk2(T68)-p53(S20) pathway
    Kyu Sung Choi
    Department of Biochemistry and Molecular Biology, Brain Korea 21 Division of Cell Transformation and Restoration, Ajou University, School of Medicine, Suwon 443 721, Republic of Korea
    DNA Repair (Amst) 11:965-75. 2012

Collaborators

  • Ji Yeon Kim
  • Suk Paul Oh
  • Manuel Rojo
  • Hee Jung Wang
  • Katsutoshi Yoshizato
  • Mei Jie Jou
  • Hirota Fujiki
  • Yasuhito Yuasa
  • L K Rogers
  • Sang Chul Park
  • Hyo Soo Kim
  • Tae Jun Park
  • Yong Won Choi
  • Min Sook Ryu
  • Muhammad Imran
  • Young Hwa Kim
  • Gyesoon Yoon
  • Seo Kyung Lim
  • Ok Ran Choi
  • Linh Nguyen Quy
  • Jung A Choi
  • Santhoshkumar Sundaramoorthy
  • Kyu Sung Choi
  • Jong Wook Hong
  • So Young Kang
  • Yong Hak Seo
  • Bong Cho Kim
  • Young Bin Lim
  • Hae Young Chung
  • Young Sil Yoon
  • Kye Yong Song
  • In Hae Kwak
  • Katrina S Jopperi-Davis
  • Myoung Ho Choi
  • Yeong Hwa Kim
  • Yong Joon Chwae
  • Hyunee Yim
  • Chise Tateno
  • Hyun Taek Shin
  • You Mie Kim
  • Bo Ra Jeong
  • Hyun Jung Jung
  • Bong Wan Kim
  • Tomohiro Ogawa
  • Yang Kyu Choi
  • Florence Malka
  • Dong Sun Yoon
  • Jean Claude Martinou
  • Young Suk Won
  • Soo Han Yoon
  • Myung Soog Lee
  • Charles V Smith
  • Tae Ryong Hahn
  • Min Soo Park
  • Eunpyo Moon
  • Carl H Backes
  • Son Hyang Sohn
  • Woon Ki Paik

Detail Information

Publications32

  1. ncbi request reprint Spectrum of molecular changes during hepatocarcinogenesis induced by DEN and other chemicals in Fischer 344 male rats
    In Kyoung Lim
    Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon 442 721, South Korea
    Mech Ageing Dev 123:1665-80. 2002
    ..Induction of TGF-beta1 expression with loss of its receptor expression occurred rapidly in the altered hepatocytes by DEN-nodularin treatment...
  2. pmc B-cell translocation gene 2 mediates crosstalk between PI3K/Akt1 and NFκB pathways which enhances transcription of MnSOD by accelerating IκBα degradation in normal and cancer cells
    Santhoshkumar Sundaramoorthy
    Department of Biochemistry and Molecular Biology, BK21 Cell Transformation and Restoration, Ajou University School of Medicine, Suwon 443 721, Republic of Korea
    Cell Commun Signal 11:69. 2013
    ....
  3. ncbi request reprint TIS21 (/BTG2/PC3) as a link between ageing and cancer: cell cycle regulator and endogenous cell death molecule
    In Kyoung Lim
    Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon 443 721, Korea
    J Cancer Res Clin Oncol 132:417-26. 2006
    ....
  4. ncbi request reprint Spectrum of molecular changes during hepatocarcinogenesis induced by DEN and other chemicals in Fisher 344 male rats [Mechanisms of Ageing and Development 123 (2002) 1665-1680]
    In Kyoung Lim
    Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Gyunggi Do, Suwon, South Korea
    Mech Ageing Dev 124:697-708. 2003
    ..Induction of TGF-beta1 expression with loss of its receptor expression occurred rapidly in the altered hepatocytes by DEN-nodularin treatment...
  5. doi request reprint TIS21 negatively regulates hepatocarcinogenesis by disruption of cyclin B1-Forkhead box M1 regulation loop
    Tae Jun Park
    Department of Biochemistry and Molecular Biology, Ajou University, School of Medicine, Suwon, Republic of Korea
    Hepatology 47:1533-43. 2008
    ....
  6. ncbi request reprint Phosphorylation of serine 147 of tis21/BTG2/pc3 by p-Erk1/2 induces Pin-1 binding in cytoplasm and cell death
    Jong Wook Hong
    Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon 443 721, Korea
    J Biol Chem 280:21256-63. 2005
    ..These data suggest, for the first time, a mechanism of how EGF can be antiproliferative in human tumor cells: binding of tis21/BTG2/pc3 to Pin-1 or cyclin B1-Cdc2 complex and induction of mitochondrial depolarization...
  7. pmc Phosphorylated extracellular signal-regulated protein kinases 1 and 2 phosphorylate Sp1 on serine 59 and regulate cellular senescence via transcription of p21Sdi1/Cip1/Waf1
    Hong Seok Kim
    Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon 443 721, Korea
    J Biol Chem 284:15475-86. 2009
    ..Sp1-enhanced transcription of p21(Sdi1) resulted in regulation of cellular senescence in primary human diploid fibroblast cells...
  8. pmc B cell translocation gene 2 enhances susceptibility of HeLa cells to doxorubicin-induced oxidative damage
    Young Bin Lim
    Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon, 443 721, Korea
    J Biol Chem 283:33110-8. 2008
    ..In summary, BTG2/TIS21/PC3 enhances cancer cell death by accumulating H2O2 via imbalance of the antioxidant enzymes in response to chemotherapy...
  9. doi request reprint TIS21/(BTG2) negatively regulates estradiol-stimulated expansion of hematopoietic stem cells by derepressing Akt phosphorylation and inhibiting mTOR signal transduction
    Bong Cho Kim
    Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon 443 721, Korea
    Stem Cells 26:2339-48. 2008
    ..Our results suggest that TIS21 plays a pivotal role in maintaining the hematopoietic stem cell compartment and hematopoiesis...
  10. doi request reprint TIS21(/BTG2/PC3) accelerates the repair of DNA double strand breaks by enhancing Mre11 methylation and blocking damage signal transfer to the Chk2(T68)-p53(S20) pathway
    Kyu Sung Choi
    Department of Biochemistry and Molecular Biology, Brain Korea 21 Division of Cell Transformation and Restoration, Ajou University, School of Medicine, Suwon 443 721, Republic of Korea
    DNA Repair (Amst) 11:965-75. 2012
    ..Expression of TIS21 promoted the repair of DSBs and reduced apoptosis by blocking the damage signal from p-ATM(S1981) to Chk2(T68)-p53(S20)via the activation of Mre11 and PRMT1...
  11. doi request reprint BTG2 suppresses cancer cell migration through inhibition of Src-FAK signaling by downregulation of reactive oxygen species generation in mitochondria
    Seo Kyung Lim
    Department of Biochemistry and Molecular Biology, Brain Korea 21 Division of Cell Transformation and Restoration, School of Medicine, Ajou University, Suwon, Korea
    Clin Exp Metastasis 29:901-13. 2012
    ..In conclusion, our study reveals that BTG2 negatively regulated cancer cell migration by inhibiting Src activity through downregulation of ROS generation in mitochondria...
  12. ncbi request reprint Skp2 enhances polyubiquitination and degradation of TIS21/BTG2/PC3, tumor suppressor protein, at the downstream of FoxM1
    Tae Jun Park
    Department of Biochemistry and Molecular Biology, Brain Korea 21 Division of Cell Transformation and Restoration, Ajou University, School of Medicine, Suwon, 443 721, Republic of Korea
    Exp Cell Res 315:3152-62. 2009
    ..These data indicate that TIS21 is a novel target of SCF-Skp2 ubiquitin ligase, which is regulated by expression of FoxM1...
  13. doi request reprint Signals regulating necrosis of cardiomyoblast by BTG2(/TIS21/PC3) via activation of GSK3β and opening of mitochondrial permeability transition pore in response to H2O2
    Yong Won Choi
    Department of Biochemistry and Molecular Biology, BK21 Cell Transformation and Restoration Project, Ajou University School of Medicine, Suwon 443 721, Republic of Korea
    Biochem Biophys Res Commun 434:559-65. 2013
    ..Here, we suggest tumor suppressor, BTG2, as one of the regulators of necrosis in myocardium via inhibiting Akt/Erk, but activating GSK3β and cyclophilin D, which resulted in mPTP opening in response to H2O2...
  14. doi request reprint Reduction of exportin 6 activity leads to actin accumulation via failure of RanGTP restoration and NTF2 sequestration in the nuclei of senescent cells
    Su Hyun Park
    Department of Biochemistry and Molecular Biology, BK21 Division of Cell Transformation and Restoration, Ajou University School of Medicine, Suwon 443 721, Republic of Korea
    Exp Cell Res 317:941-54. 2011
    ....
  15. ncbi request reprint Formation of elongated giant mitochondria in DFO-induced cellular senescence: involvement of enhanced fusion process through modulation of Fis1
    Young Sil Yoon
    Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon, South Korea
    J Cell Physiol 209:468-80. 2006
    ..These data suggest that mitochondrial elongation may play an important role as a mediator in stress-induced premature senescence...
  16. doi request reprint Pleiotrophin inhibits transforming growth factor beta1-induced apoptosis in hepatoma cell lines
    Tae Jun Park
    Biochemistry and Molecular Biology, School of Medicine, Ajou University, Suwon, South Korea
    Mol Carcinog 47:784-96. 2008
    ..In summary, PTN was expressed in HSCs, Kupffer cells, and hepatocytes in fibrotic liver. We propose that PTN specifically antagonizes the TGFbeta1 activity during liver fibrosis...
  17. ncbi request reprint TIS21/BTG2/PC3 is expressed through PKC-delta pathway and inhibits binding of cyclin B1-Cdc2 and its activity, independent of p53 expression
    Min Sook Ryu
    Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon 443 721, South Korea
    Exp Cell Res 299:159-70. 2004
    ..In summary, TPA-induced TIS21 mRNA expression is mediated by PKC-delta, and TIS21 induces G2/M arrest and cell death by inhibiting cyclin B1-Cdc2 binding and the kinase activity through its binding to Cdc2...
  18. doi request reprint C-terminus-deleted FoxM1 is expressed in cancer cell lines and induces chromosome instability
    Young Hwa Kim
    Department of Biochemistry and Molecular Biology, Brain Korea 21 Division of Cell Transformation and Restoration, Ajou University, School of Medicine, Suwon, Korea
    Carcinogenesis 34:1907-17. 2013
    ..In conclusion, FoxM1ΔC is expressed in cancer cells and dysregulates normal cell cycle and induces chromosome instability. ..
  19. ncbi request reprint Sensitization of metformin-cytotoxicity by dichloroacetate via reprogramming glucose metabolism in cancer cells
    Yong Won Choi
    Department of Biochemistry and Molecular Biology, BK21 Cell Transformation and Restoration Project, Ajou University School of Medicine, Suwon 443 721, Republic of Korea
    Cancer Lett 346:300-8. 2014
    ....
  20. ncbi request reprint Nuclear accumulation of globular actin as a cellular senescence marker
    In Hae Kwak
    Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon, Korea
    Cancer Res 64:572-80. 2004
    ..Nuclear actin accumulation was much more sensitive and an earlier event than the well-known, senescence-associated beta-galactosidase activity...
  21. doi request reprint TIS21/BTG2 inhibits invadopodia formation by downregulating reactive oxygen species level in MDA-MB-231 cells
    Jung A Choi
    Department of Biochemistry and Molecular Biology, Brain Korea 21 Division of Cell Transformation and Restoration, Ajou University School of Medicine, Suwon, 443 721, Korea
    J Cancer Res Clin Oncol 139:1657-65. 2013
    ..However, the mechanisms underlying invadopodia formation in cancer cells remain largely unknown...
  22. doi request reprint Enhanced glycogenesis is involved in cellular senescence via GSK3/GS modulation
    Yong Hak Seo
    Department of Molecular Science and Technology, The Graduate School, Ajou University, Suwon 443 721, Korea
    Aging Cell 7:894-907. 2008
    ....
  23. doi request reprint Loss of p21(Sdi1) expression in senescent cells after DNA damage accompanied with increase of miR-93 expression and reduced p53 interaction with p21(Sdi1) gene promoter
    Ok Ran Choi
    Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon 443 721, Republic of Korea
    Biochem Biophys Res Commun 407:406-11. 2011
    ....
  24. ncbi request reprint Direct activation of TGF-beta1 transcription by androgen and androgen receptor complex in Huh7 human hepatoma cells and its tumor in nude mice
    Gyesoon Yoon
    Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon 443 721, Korea
    J Cell Biochem 97:393-411. 2006
    ..This work presents in vivo and in vitro evidences of activation of TGF-beta1 expression by androgen and AR, and implicates the modulation of hepatocarcinogenesis by AR through the regulation of TGF-beta1 expression...
  25. ncbi request reprint Constitutive induction of p-Erk1/2 accompanied by reduced activities of protein phosphatases 1 and 2A and MKP3 due to reactive oxygen species during cellular senescence
    Hong Seok Kim
    Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon 442 721, Korea
    J Biol Chem 278:37497-510. 2003
    ....
  26. ncbi request reprint Marked inhibition of testosterone biosynthesis by the hepatotoxin nodularin due to apoptosis of Leydig cells
    Tae Jun Park
    Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon, Korea
    Mol Carcinog 34:151-63. 2002
    ..In conclusion, the potential causes of impaired testosterone biosynthesis might have been apoptosis of Leydig cells induced by direct toxicity of the hepatotoxin on testes or hypothalamopituitary dysfunction...
  27. doi request reprint TIS21(/BTG2/PC3) inhibits interleukin-6 expression via downregulation of STAT3 pathway
    Linh Nguyen Quy
    Department of Biochemistry and Molecular Biology, Ajou University, School of Medicine, Suwon 443 721, Republic of Korea
    Cell Signal 25:2391-9. 2013
    ..These results indicate that TIS21 negatively regulated cancer cell growth by inhibiting IL-6 expression through downregulation of STAT3 activation. ..
  28. doi request reprint TIS21/BTG2/PC3 enhances downregulation of c-Myc during differentiation of HL-60 cells by activating Erk1/2 and inhibiting Akt in response to all-trans-retinoic acid
    Muhammad Imran
    Department of Biochemistry and Molecular Biology, BK21 Cell Transformation and Restoration, Ajou University School of Medicine, Suwon 443 721, Republic of Korea
    Eur J Cancer 48:2474-85. 2012
    ....
  29. doi request reprint Regulation of Btg2(/TIS21/PC3) expression via reactive oxygen species-protein kinase C-ΝFκΒ pathway under stress conditions
    Muhammad Imran
    Department of Biochemistry and Molecular Biology, BK21 Cell Transformation and Restoration Project, Ajou University School of Medicine, Suwon 443 721, Republic of Korea
    Cell Signal 25:2400-12. 2013
    ..The present data imply that oxidative stress upregulates Btg2 expression via ROS-PKC-ΝFκΒ cascade, independent of p53 status that in turn could be involved in mediating various biological phenotypes depending on the cellular context. ..
  30. ncbi request reprint Induction of thermal and chemical stability of O6-methylguanine-DNA methyltransferase by Ca2+
    Tae Jun Park
    Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon 442 721, Gyunggi Do, South Korea
    Biochim Biophys Acta 1599:36-44. 2002
    ....
  31. doi request reprint Friendship in research: the Japan-Korea Symposia on Cancer and Ageing
    Hirota Fujiki
    J Cancer Res Clin Oncol 134:813-7. 2008
  32. ncbi request reprint Compartmental inhibition of hepatic glutathione reductase activities by 1,3-bis(2-chloroethyl)-N-nitrosourea (BCNU) in Sprague-Dawley and Fischer-344 rats
    Katrina S Jopperi-Davis
    Section of Neonatology, Department of Pediatrics, Center for Developmental Pharmacology and Toxicology, Columbus Children s Research Institute, 700 Children s Drive, Rm W202, Columbus, OH 43205, USA
    Toxicol Lett 147:219-28. 2004
    ....