Seung U Kim

Summary

Affiliation: Ajou University
Country: Korea

Publications

  1. ncbi request reprint Production of immortalized human neural crest stem cells
    Seung U Kim
    Division of Neurology, UBC Hospital, University of British Columbia, Vancouver, Canada
    Methods Mol Biol 198:55-65. 2002
  2. ncbi request reprint Adenosine triphosphate induces proliferation of human neural stem cells: Role of calcium and p70 ribosomal protein S6 kinase
    Jae K Ryu
    Brain Disease Research Center, Ajou University, Suwon, Korea
    J Neurosci Res 72:352-62. 2003
  3. ncbi request reprint Sonic hedgehog and FGF8 collaborate to induce dopaminergic phenotypes in the Nurr1-overexpressing neural stem cell
    Tae Eun Kim
    Brain Disease Research Center, Ajou University School of Medicine, Suwon 442 749, Republic of Korea
    Biochem Biophys Res Commun 305:1040-8. 2003
  4. ncbi request reprint Genetically engineered human neural stem cells for brain repair in neurological diseases
    Seung U Kim
    Brain Disease Research Center, Ajou University School of Medicine, Suwon 442 721, Republic of Korea
    Brain Dev 29:193-201. 2007
  5. ncbi request reprint Human neural stem cells genetically modified for brain repair in neurological disorders
    Seung U Kim
    Brain Disease Research Center, Ajou University School of Medicine, Suwon, Korea
    Neuropathology 24:159-71. 2004
  6. ncbi request reprint Brain transplantation of human neural stem cells transduced with tyrosine hydroxylase and GTP cyclohydrolase 1 provides functional improvement in animal models of Parkinson disease
    Seung U Kim
    Brain Disease Research Center, Ajou University School of Medicine, Suwon, Korea
    Neuropathology 26:129-40. 2006
  7. doi request reprint Differential and cooperative actions of Olig1 and Olig2 transcription factors on immature proliferating cells after contusive spinal cord injury
    Hyuk M Kim
    Brain Disease Research Center, Institute for Medical Sciences, Ajou University School of Medicine, Suwon, Korea
    Glia 59:1094-106. 2011
  8. doi request reprint Capsaicin sensitizes malignant glioma cells to TRAIL-mediated apoptosis via DR5 upregulation and survivin downregulation
    Jin Yeop Kim
    Department of Molecular Science and Technology, Institute for Medical Sciences, Ajou University School of Medicine, Suwon 443 749, Korea
    Carcinogenesis 31:367-75. 2010
  9. ncbi request reprint ATP-induced in vivo neurotoxicity in the rat striatum via P2 receptors
    Jae K Ryu
    Brain Disease Research Center, Ajou University School of Medicine, Suwon 442 749, Korea
    Neuroreport 13:1611-5. 2002
  10. ncbi request reprint Inhibition of thrombin-induced microglial activation and NADPH oxidase by minocycline protects dopaminergic neurons in the substantia nigra in vivo
    Sang H Choi
    Neuroscience Graduate Program and Brain Disease Research Center, Ajou University School of Medicine, Suwon, Korea
    J Neurochem 95:1755-65. 2005

Collaborators

Detail Information

Publications83

  1. ncbi request reprint Production of immortalized human neural crest stem cells
    Seung U Kim
    Division of Neurology, UBC Hospital, University of British Columbia, Vancouver, Canada
    Methods Mol Biol 198:55-65. 2002
  2. ncbi request reprint Adenosine triphosphate induces proliferation of human neural stem cells: Role of calcium and p70 ribosomal protein S6 kinase
    Jae K Ryu
    Brain Disease Research Center, Ajou University, Suwon, Korea
    J Neurosci Res 72:352-62. 2003
    ..The increase in NSC proliferation observed following ATP application can also be mediated by PI3-kinase-dependent p70 S6 kinase activation...
  3. ncbi request reprint Sonic hedgehog and FGF8 collaborate to induce dopaminergic phenotypes in the Nurr1-overexpressing neural stem cell
    Tae Eun Kim
    Brain Disease Research Center, Ajou University School of Medicine, Suwon 442 749, Republic of Korea
    Biochem Biophys Res Commun 305:1040-8. 2003
    ....
  4. ncbi request reprint Genetically engineered human neural stem cells for brain repair in neurological diseases
    Seung U Kim
    Brain Disease Research Center, Ajou University School of Medicine, Suwon 442 721, Republic of Korea
    Brain Dev 29:193-201. 2007
    ..The promising field of stem cell research as it applies to regenerative medicine is still in infancy, but its potential appears limitless, and we are blessed to be involved in this exciting realm of research...
  5. ncbi request reprint Human neural stem cells genetically modified for brain repair in neurological disorders
    Seung U Kim
    Brain Disease Research Center, Ajou University School of Medicine, Suwon, Korea
    Neuropathology 24:159-71. 2004
    ..There is further need for investigation into the neurogenic potential of the human bone marrow stem cell lines and their utility in animal models of neurological diseases...
  6. ncbi request reprint Brain transplantation of human neural stem cells transduced with tyrosine hydroxylase and GTP cyclohydrolase 1 provides functional improvement in animal models of Parkinson disease
    Seung U Kim
    Brain Disease Research Center, Ajou University School of Medicine, Suwon, Korea
    Neuropathology 26:129-40. 2006
    ..These results indicate that human NSC, genetically transduced with TH and GTPCH1 genes, have great potential in clinical utility for cell replacement therapy in patients suffering from Parkinson disease...
  7. doi request reprint Differential and cooperative actions of Olig1 and Olig2 transcription factors on immature proliferating cells after contusive spinal cord injury
    Hyuk M Kim
    Brain Disease Research Center, Institute for Medical Sciences, Ajou University School of Medicine, Suwon, Korea
    Glia 59:1094-106. 2011
    ..Activation of both Olig1 and Olig2 may be beneficial by both increasing the progenitor cell proliferation and enhancing OL differentiation in the injured spinal cord...
  8. doi request reprint Capsaicin sensitizes malignant glioma cells to TRAIL-mediated apoptosis via DR5 upregulation and survivin downregulation
    Jin Yeop Kim
    Department of Molecular Science and Technology, Institute for Medical Sciences, Ajou University School of Medicine, Suwon 443 749, Korea
    Carcinogenesis 31:367-75. 2010
    ..Thus, a combined regimen using capsaicin and TRAIL may provide a safe and effective strategy for treating malignant gliomas...
  9. ncbi request reprint ATP-induced in vivo neurotoxicity in the rat striatum via P2 receptors
    Jae K Ryu
    Brain Disease Research Center, Ajou University School of Medicine, Suwon 442 749, Korea
    Neuroreport 13:1611-5. 2002
    ....
  10. ncbi request reprint Inhibition of thrombin-induced microglial activation and NADPH oxidase by minocycline protects dopaminergic neurons in the substantia nigra in vivo
    Sang H Choi
    Neuroscience Graduate Program and Brain Disease Research Center, Ajou University School of Medicine, Suwon, Korea
    J Neurochem 95:1755-65. 2005
    ..These results suggest that microglial NADPH oxidase may be a viable target for neuroprotection against oxidative damage...
  11. doi request reprint Combination of multifaceted strategies to maximize the therapeutic benefits of neural stem cell transplantation for spinal cord repair
    Dong H Hwang
    Brain Disease Research Center, Institute of Medical Sciences, Ajou University School of Medicine, Suwon, Republic of Korea
    Cell Transplant 20:1361-79. 2011
    ..We demonstrate that combining multifaceted strategies can maximize the therapeutic benefits of NSC transplantation for SCI. Our results may have important clinical implications for the design of future NSC-based strategies...
  12. ncbi request reprint Sodium butyrate sensitizes human glioma cells to TRAIL-mediated apoptosis through inhibition of Cdc2 and the subsequent downregulation of survivin and XIAP
    Eun Hee Kim
    Institute for Medical Sciences, Ajou University School of Medicine, Wonchon dong, Youngtong Gu, Suwon, South Korea
    Oncogene 24:6877-89. 2005
    ..Therefore, Cdc2-mediated downregulation of survivin and XIAP by sodium butyrate may contribute to the recovery of TRAIL sensitivity in glioma cells...
  13. ncbi request reprint Transient receptor potential vanilloid subtype 1 mediates microglial cell death in vivo and in vitro via Ca2+-mediated mitochondrial damage and cytochrome c release
    Sang R Kim
    Brain Disease Research Center, Ajou University School of Medicine, Suwon 443 479, Korea
    J Immunol 177:4322-9. 2006
    ..To our knowledge, this study is the first to demonstrate that microglia express TRPV1, and that activation of this receptor may contribute to microglial damage via Ca(2+) signaling and mitochondrial disruption...
  14. pmc Transplantation of human neural stem cells transduced with Olig2 transcription factor improves locomotor recovery and enhances myelination in the white matter of rat spinal cord following contusive injury
    Dong H Hwang
    Brain Disease Research Center, Institute for Medical Sciences, Ajou University School of Medicine, Suwon, Korea
    BMC Neurosci 10:117. 2009
    ....
  15. ncbi request reprint Proactive transplantation of human neural stem cells prevents degeneration of striatal neurons in a rat model of Huntington disease
    Jae K Ryu
    Brain Disease Research Center, Ajou University School of Medicine, Suwon, South Korea
    Neurobiol Dis 16:68-77. 2004
    ..The findings in this work have particular relevance to a rat model of HD in that proactive transplanted hNSCs protect host striatal neurons against neuronal injury and improve motor impairment induced by 3-NP toxicity...
  16. ncbi request reprint Microglial activation and cell death induced by the mitochondrial toxin 3-nitropropionic acid: in vitro and in vivo studies
    Jae K Ryu
    Brain Disease Research Center, Ajou University School of Medicine, Suwon, Korea
    Neurobiol Dis 12:121-32. 2003
    ..The present results indicate that metabolic impairment in the CNS could involve both activation and cell death of microglia and contribute to pathology in neurodegenerative diseases...
  17. pmc Human neural stem cells over-expressing VEGF provide neuroprotection, angiogenesis and functional recovery in mouse stroke model
    Hong J Lee
    Brain Disease Research Center, Ajou University School of Medicine, Suwon, Korea
    PLoS ONE 2:e156. 2007
    ....
  18. ncbi request reprint Thrombin-induced microglial activation produces degeneration of nigral dopaminergic neurons in vivo
    Sang H Choi
    Brain Disease Research Center, Neuroscience Graduate Program, Ajou University School of Medicine, Suwon 442 749, Korea
    J Neurosci 23:5877-86. 2003
    ....
  19. ncbi request reprint Regulation of human tyrosine hydroxylase gene by neuron-restrictive silencer factor
    Soo Min Kim
    Neuroscience Graduate Program, Ajou University School of Medicine, Suwon, Republic of Korea
    Biochem Biophys Res Commun 346:426-35. 2006
    ..Our data strongly suggest that NRSF/REST functions as a repressor of TH transcription in NSCs via a mechanism dependent on the TH NRSE/RE1 sites...
  20. ncbi request reprint Effects of sabiporide, a specific Na+/H+ exchanger inhibitor, on neuronal cell death and brain ischemia
    Hye Seong Park
    Department of Physiology, School of Medicine, Ajou University, Suwon, Kyungkido 442 749, Republic of Korea
    Brain Res 1061:67-71. 2005
    ..In in vivo brain ischemia model, sabiporide produced protective effects, decreasing the infarct size and edema volume. Our results suggest that sabiporide elicits neuroprotective effect both in vitro and in vivo...
  21. doi request reprint Arsenic trioxide sensitizes human glioma cells, but not normal astrocytes, to TRAIL-induced apoptosis via CCAAT/enhancer-binding protein homologous protein-dependent DR5 up-regulation
    Eun Hee Kim
    Department of Molecular Science and Technology, Institute for Medical Sciences, Ajou University School of Medicine, Suwon, Korea
    Cancer Res 68:266-75. 2008
    ..Taken together, the present results suggest that the combined treatment of glioma cells with As(2)O(3) plus TRAIL may provide an effective and selective therapeutic strategy...
  22. pmc Cross talk between P2 purinergic receptors modulates extracellular ATP-mediated interleukin-10 production in rat microglial cells
    Dong Reoyl Seo
    Neuroscience Graduate Program, Ajou University School of Medicine, Suwon 443 721, Korea
    Exp Mol Med 40:19-26. 2008
    ....
  23. pmc Amiodarone sensitizes human glioma cells but not astrocytes to TRAIL-induced apoptosis via CHOP-mediated DR5 upregulation
    In Young Kim
    Department of Molecular Science and Technology Institute for Medical Sciences, Ajou University School of Medicine, Suwon 443 749, Korea
    Neuro Oncol 13:267-79. 2011
    ..These results collectively suggest that a combined regimen of amiodarone plus TRAIL may offer an effective therapeutic strategy for safely and selectively treating resistant gliomas...
  24. doi request reprint Overexpression of Bcl-XL in human neural stem cells promotes graft survival and functional recovery following transplantation in spinal cord injury
    Seung I Lee
    Brain Disease Research Center, Institute for Medical Sciences, Ajou University School of Medicine, Suwon, Korea
    J Neurosci Res 87:3186-97. 2009
    ..These results suggest that enhancing graft survival with antiapoptotic gene can potentiate therapeutic benefits of NSC-based therapy for SCI...
  25. ncbi request reprint Differential regulation of tyrosine hydroxylase expression by sonic hedgehog
    Ii Sun Kwon
    Department of Anatomy bNeuroscience Graduate Program, Ajou University, School of Medicine, Suwon, Korea
    Neuroreport 17:693-8. 2006
    ....
  26. pmc Paxilline enhances TRAIL-mediated apoptosis of glioma cells via modulation of c-FLIP, survivin and DR5
    You Jung Kang
    Department of Molecular Science and Technology, Institute for Medical Sciences, Ajou University School of Medicine, Suwon, Korea
    Exp Mol Med 43:24-34. 2011
    ..Thus, combined treatment regimens involving paxilline and TRAIL may offer an attractive strategy for safely treating resistant gliomas...
  27. ncbi request reprint Transient receptor potential vanilloid subtype 1 mediates cell death of mesencephalic dopaminergic neurons in vivo and in vitro
    Sang R Kim
    Brain Disease Research Center, Ajou University School of Medicine, Suwon 442 749, Korea
    J Neurosci 25:662-71. 2005
    ..Our findings suggest that these two types of receptors, TRPV1 and CB1, may contribute to neurodegeneration in response to endogenous ligands such as AEA...
  28. doi request reprint Stereological analysis on migration of human neural stem cells in the brain of rats bearing glioma
    Jae Ho Kim
    Department of Neurosurgery, Ajou University School of Medicine, Suwon, Korea
    Neurosurgery 66:333-42; discussion 342. 2010
    ..The objective of this study was to determine the rate and pattern of NSC migration in the brain and its time course after NSC transplantation...
  29. ncbi request reprint Silibinin sensitizes human glioma cells to TRAIL-mediated apoptosis via DR5 up-regulation and down-regulation of c-FLIP and survivin
    Yong Gyu Son
    Department of Molecular Science and Technology, Institute for Medical Sciences, Ajou University School of Medicine, Suwon, Korea
    Cancer Res 67:8274-84. 2007
    ..Taken together, our results show that the activity of silibinin to modulate multiple components in the death receptor-mediated apoptotic pathway is responsible for its ability to recover TRAIL sensitivity in TRAIL-resistant glioma cells...
  30. doi request reprint Free radical production in CA1 neurons induces MIP-1alpha expression, microglia recruitment, and delayed neuronal death after transient forebrain ischemia
    Hyo Kyun Wang
    Neuroscience Graduate Program, Brain Disease Research Center, Ajou University School of Medicine, Suwon 443 721, Korea
    J Neurosci 28:1721-7. 2008
    ..Our data suggest that free radicals produced in CA1 neurons contribute to the recruitment and activation of microglia and neurodegeneration through MIP-1alpha expression...
  31. ncbi request reprint Sodium selenite induces superoxide-mediated mitochondrial damage and subsequent autophagic cell death in malignant glioma cells
    Eun Hee Kim
    Department of Molecular Science and Technology, Institute for Medical Sciences, Ajou University School of Medicine, Suwon, Korea
    Cancer Res 67:6314-24. 2007
    ..Taken together, our study clearly shows that superoxide anion generated by selenite triggers mitochondrial damage and subsequent mitophagy, leading to irreversible cell death in glioma cells...
  32. doi request reprint Implantation of polymer scaffolds seeded with neural stem cells in a canine spinal cord injury model
    Byung Gon Kim
    Brain Disease Research Center, Institute for Medical Sciences and Department of Neurology, Ajou University School of Medicine, Suwon, Korea
    Cytotherapy 12:841-5. 2010
    ..Before translation into the clinic, the feasibility and therapeutic potential of such combinatorial strategies in larger animal species need to be examined...
  33. ncbi request reprint Cloning and cell type-specific regulation of the human tyrosine hydroxylase gene promoter
    Tae Eun Kim
    Brain Disease Research Center, School of Medicine, Ajou University, Suwon, South Korea
    Biochem Biophys Res Commun 312:1123-31. 2003
    ..Our results may provide insight into neuronal cell-specific expression of the human TH gene and allow a better understanding of catecholaminergic neuron disorders such as Parkinson's disease and schizophrenia...
  34. pmc Ex vivo VEGF delivery by neural stem cells enhances proliferation of glial progenitors, angiogenesis, and tissue sparing after spinal cord injury
    Hyuk Min Kim
    Brain Disease Research Center, Institute for Medical Sciences, Ajou University School of Medicine, Suwon, Korea
    PLoS ONE 4:e4987. 2009
    ..These anatomical results were accompanied by improved BBB locomotor scores. The multifaceted effects of VEGF on endogenous gliogenesis, angiogenesis, and tissue sparing could be utilized to improve functional outcomes following SCI...
  35. ncbi request reprint Roscovitine sensitizes glioma cells to TRAIL-mediated apoptosis by downregulation of survivin and XIAP
    Eun Hee Kim
    Institute for Medical Sciences, Ajou University School of Medicine, Suwon, South Korea
    Oncogene 23:446-56. 2004
    ..Taken together, these results suggest that downregulation of survivin and XIAP by subtoxic doses of roscovitine contributes to the amplification of caspase cascades, thereby overcoming glioma cell resistance to TRAIL-mediated apoptosis...
  36. ncbi request reprint Activation of protein kinase C-delta attenuates kainate-induced cell death of cortical neurons
    Yi Sook Jung
    Department of Physiology, School of Medicine, Ajou University, Suwon, Kyungkido 442 749, Korea
    Neuroreport 16:741-4. 2005
    ..These results suggest that activation of PKC-delta attenuates the kainate-induced cell death of cortical neurons...
  37. doi request reprint Transgenic mice expressing yellow fluorescent protein under control of the human tyrosine hydroxylase promoter
    Eun Yang Choi
    Brain Disease Research Center, and Institute for Medical Sciences, Ajou University School of Medicine, Suwon, Korea
    J Neurosci Res 90:1949-59. 2012
    ..2-kb sequence upstream of the TH gene is not sufficient for proper expression and that the 2-kb sequence from the translation start site to exon 3 is necessary for expression of EYFP in a subset of catecholaminergic neurons...
  38. ncbi request reprint Interleukin-13 enhances cyclooxygenase-2 expression in activated rat brain microglia: implications for death of activated microglia
    Myung Soon Yang
    Department of Pharmacology, Ajou University School of Medicine, Suwon 442 721, Korea
    J Immunol 177:1323-9. 2006
    ..Furthermore, COX-2 products, PGE(2) and 15d-PGJ(2), caused microglial death, which terminates brain inflammation...
  39. ncbi request reprint Stem cell-based cell therapy for spinal cord injury
    Byung Gon Kim
    Brain Disease Research Center, Ajou University School of Medicine, Suwon, 443 721, Republic of Korea
    Cell Transplant 16:355-64. 2007
    ..Combinatorial approaches using polymer scaffolds to fill the lesion cavity or introducing regeneration-promoting genes will greatly increase the efficacy of cellular transplantation strategies for SCI...
  40. ncbi request reprint Lovastatin enhances Abeta production and senile plaque deposition in female Tg2576 mice
    In Ho Park
    Brain Disease Research Center, Ajou University School of Medicine, Suwon, South Korea
    Neurobiol Aging 24:637-43. 2003
    ..Our results suggest that low plasma cholesterol levels might be a risk factor for AD in females...
  41. ncbi request reprint Trisialoganglioside GT1b induces in vivo degeneration of nigral dopaminergic neurons: role of microglia
    Jae K Ryu
    Brain Disease Research Center, Ajou University School of Medicine, Suwon, South Korea
    Glia 38:15-23. 2002
    ....
  42. pmc Behavioral improvement in a primate Parkinson's model is associated with multiple homeostatic effects of human neural stem cells
    D Eugene Redmond
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 104:12175-80. 2007
    ..We propose that multiple modes of reciprocal interaction between exogenous hNSCs and the pathological host milieu underlie the functional improvement observed in this model of PD...
  43. ncbi request reprint Distribution and in situ proliferation patterns of intravenously injected immortalized human neural stem-like cells in rats with focal cerebral ischemia
    Kon Chu
    Department of Neurology, Clinical Research Institute, Seoul National University Hospital, 28 Yongon Dong, Chongro Gu, Seoul 110 744, South Korea
    Neurosci Res 50:459-65. 2004
    ..Our findings show that intravenously injected human neural stem-like cells may incorporate into the ischemic brain, and undergo proliferation responding to the endogenous mitotic signal during the acute period of focal ischemia...
  44. ncbi request reprint Intravenously transplanted human neural stem cells migrate to the injured spinal cord in adult mice in an SDF-1- and HGF-dependent manner
    Hiroki Takeuchi
    Department of Neurosurgery, Nagoya University School of Medicine, Nagoya, Japan
    Neurosci Lett 426:69-74. 2007
    ..Our study suggests that intravenously administered NSCs can be employed as a renewable source for replacing lost cells for the treatment of spinal cord injuries...
  45. pmc Multilineage potential of stable human mesenchymal stem cell line derived from fetal marrow
    Atsushi Nagai
    Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, Canada
    PLoS ONE 2:e1272. 2007
    ....
  46. ncbi request reprint Human neural stem cells improve sensorimotor deficits in the adult rat brain with experimental focal ischemia
    Kon Chu
    Department of Neurology, Stroke and Neural Stem Cell Laboratory in Clinical Research Institute, Seoul National University Hospital, Seoul National University, 28, Yongon Dong, Chongro Gu, Seoul 110 744, South Korea
    Brain Res 1016:145-53. 2004
    ..Our data suggest intravenously transplanted human NSCs can migrate and differentiate in the rat brain with focal ischemia and improve functional recovery...
  47. doi request reprint Neuroprotective effect of neural stem cell-conditioned media in in vitro model of Huntington's disease
    Heon Chang Lim
    Department of Anatomay, College of Medicine, Seoul National University, Seoul, South Korea
    Neurosci Lett 435:175-80. 2008
    ..In summary, NSC-CM was neuroprotective in in vitro model of Huntington's disease with modulating mutant huntingtin-induced cytotoxicity...
  48. doi request reprint Production and characterization of immortal human neural stem cell line with multipotent differentiation property
    Seung U Kim
    Division of Neurology, UBC Hospital, University of British Columbia, Vancouver, BC, Canada
    Methods Mol Biol 438:103-21. 2008
    ....
  49. doi request reprint Transplantation of human neural stem cells protect against ischemia in a preventive mode via hypoxia-inducible factor-1alpha stabilization in the host brain
    Kon Chu
    Stroke and Neural Stem Cell Laboratory in Clinical Research Institute, Department of Neurology, Seoul National University Hospital, Seoul, South Korea
    Brain Res 1207:182-92. 2008
    ..These findings provide evidence that HIF-1alpha stabilization in human NSCs can be achieved effectively by DFX, and HIF-1alpha-stabilized NSCs protect against ischemia in a preventive mode...
  50. ncbi request reprint Human neural stem cell transplantation promotes functional recovery in rats with experimental intracerebral hemorrhage
    Sang Wuk Jeong
    Department of Neurology, Ilsan Paik Hospital, Inje University, Ilsan, Korea
    Stroke 34:2258-63. 2003
    ..We hypothesize that intravenously transplanted human neural stem cells (NSCs) can migrate and differentiate into neurons or glial cells, thereby improving functional outcome in ICH...
  51. ncbi request reprint Fractalkine and fractalkine receptors in human neurons and glial cells
    Kozo Hatori
    Division of Neurology, Department of Medicine, UBC Hospital, University of British Columbia, Vancouver, Canada
    J Neurosci Res 69:418-26. 2002
    ..These observations suggest that fractalkine released by injured neurons could induce proliferation, activation and/or migration of microglia at the injured brain sites...
  52. ncbi request reprint Novel method for visualizing and modeling the spatial distribution of neural stem cells within intracranial glioma
    David Lin
    Division of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA 91010, USA
    Neuroimage 37:S18-26. 2007
    ..We estimate that NSC-mediated therapy would eradicate 70-90% of the primary tumor mass and the majority of invasive tumor foci. Our method may serve as a model for optimizing the efficacy of NSC-based glioma therapy...
  53. ncbi request reprint Combined treatment of vascular endothelial growth factor and human neural stem cells in experimental focal cerebral ischemia
    Kon Chu
    Stroke and Neural Stem Cell Laboratory in Clinical Research Institute, Department of Neurology, Seoul National University Hospital, 28, Yongon Dong, Chongro Gu, Seoul 110 744, South Korea
    Neurosci Res 53:384-90. 2005
    ..The distribution of VEGF was not co-localized with NSCs. Our results suggest that VEGF may act synergistically on NSC-transplanted, ischemic brain via a pro-angiogenic effect...
  54. ncbi request reprint Upregulation of protease-activated receptor-1 in astrocytes in Parkinson disease: astrocyte-mediated neuroprotection through increased levels of glutathione peroxidase
    Yuri Ishida
    Department of Neurology and Department of Laboratory Medicine, Shimane University School of Medicine, Izumo, Japan
    J Neuropathol Exp Neurol 65:66-77. 2006
    ....
  55. ncbi request reprint Broad-spectrum effects of 4-aminopyridine to modulate amyloid beta1-42-induced cell signaling and functional responses in human microglia
    Sonia Franciosi
    Departments of Anesthesiology, University of British Columbia, Vancouver, British Columbia, Canada
    J Neurosci 26:11652-64. 2006
    ..1) and intracellular signaling pathways in human microglia could serve as a therapeutic strategy for neuroprotection in Alzheimer's disease pathology...
  56. ncbi request reprint Transplantation of human neural stem cells exerts neuroprotection in a rat model of Parkinson's disease
    Takao Yasuhara
    Department of Neurology, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Neurosci 26:12497-511. 2006
    ..These results suggest that HB1.F3 cell transplantation exerts neuroprotective effects against dopaminergic depletion in vitro and in vivo because of trophic factor secretion and neuronal differentiation...
  57. ncbi request reprint Noninvasive method of immortalized neural stem-like cell transplantation in an experimental model of Huntington's disease
    Soon Tae Lee
    Department of Neurology, Seoul National University Hospital, Neuroscience Research Institute of SNUMRC, 28 Yongondong, Chongnoku, Seoul 110 744, South Korea
    J Neurosci Methods 152:250-4. 2006
    ..This study shows that NSC migrate into the striatum, either from ventricle or from the systemic circulation, providing less invasive routes for stem cell application in HD...
  58. ncbi request reprint Intravascular administration of tumor tropic neural progenitor cells permits targeted delivery of interferon-beta and restricts tumor growth in a murine model of disseminated neuroblastoma
    Paxton V Dickson
    Department of Surgery, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Pediatr Surg 42:48-53. 2007
    ..We investigated the potential of targeted delivery using tumor-tropic neural progenitor cells (NPCs) transduced to express human IFN-beta (hIFN-beta)...
  59. pmc Brain tumor tropism of transplanted human neural stem cells is induced by vascular endothelial growth factor
    Nils Ole Schmidt
    Neurosurgical Oncology Laboratory, Department of Neurosurgery, Brigham and Women s Hospital and Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neoplasia 7:623-9. 2005
    ..Our results indicate that tumor-upregulated VEGF and angiogenic-activated microvasculature are relevant guidance signals for NSC tropism toward brain tumors...
  60. ncbi request reprint Brain transplantation of immortalized human neural stem cells promotes functional recovery in mouse intracerebral hemorrhage stroke model
    Hong J Lee
    Division of Neurology, Department of Medicine, University of British Columbia Hospital, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
    Stem Cells 25:1204-12. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  61. ncbi request reprint Quantification of human neural stem cell engraftments in rat brains using ERV-3 real-time PCR
    Soon Tae Lee
    Stroke and Neural Stem Cell Laboratory in Clinical Research Institute, Stem Cell Research Center, Department of Neurology, Seoul National University Hospital, Seoul, South Korea
    J Neurosci Methods 157:225-9. 2006
    ..In conclusion, the developed quantitative ERV-3 assay enables a simple, fast, and reproducible detection and quantitation of hNSC numbers in the rat brain...
  62. ncbi request reprint G-CSF protects human cerebral hybrid neurons against in vitro ischemia
    Keun Hwa Jung
    Stroke and Neural Stem Cell Laboratory in Clinical Research Institute, Department of Neurology, Seoul National University Hospital, Seoul, South Korea
    Neurosci Lett 394:168-73. 2006
    ..G-CSF reduced early apoptotic (annexin V+/PI-), and late apoptotic or necrotic (annexin V+/PI+) cells, and decreased active caspase-3 immunoreactivity. G-CSF could protect human cerebral neurons following in vitro ischemia...
  63. ncbi request reprint Intravenous administration of human neural stem cells induces functional recovery in Huntington's disease rat model
    Soon Tae Lee
    Department of Neurology, Clinical Research Institute, Seoul National University Hospital, 28, Yongon Dong, Chongro Gu, Seoul 110 744, South Korea
    Neurosci Res 52:243-9. 2005
    ....
  64. ncbi request reprint VEGF protects human cerebral hybrid neurons from in vitro ischemia
    Moon Ku Han
    Department of Neurology, Seoul University School of Medicine, Seoul, Yongon Dong, Chongro Gu, Seoul, 110 744, Korea
    Neuroreport 15:847-50. 2004
    ..Our results suggest that VEGF can protect human cerebral neurons from cell death after an ischemic insult in vitro, which is correlated to both increased expression of VEGFR-2/Flk-1 and VEGF within the cells...
  65. ncbi request reprint Neuroprotective effects of pyruvate in the quinolinic acid rat model of Huntington's disease
    Jae K Ryu
    Department of Pharmacology and Therapeutics, Faculty of Medicine, The University of British Columbia, V6T 1Z3, Vancouver, BC, Canada
    Exp Neurol 183:700-4. 2003
    ..These results suggest that pyruvate may be effective in reducing neuronal damage in HD...
  66. ncbi request reprint Granulocyte colony-stimulating factor stimulates neurogenesis via vascular endothelial growth factor with STAT activation
    Keun Hwa Jung
    Stroke and Neural Stem Cell Laboratory in Clinical Research Institute, Department of Neurology, Seoul National University Hospital, Seoul, South Korea
    Brain Res 1073:190-201. 2006
    ..G-CSF also activated endothelial cell proliferation in adult rat brain in vivo. Our results indicate that G-CSF stimulates neurogenesis through reciprocal interaction with VEGF and STAT activation...
  67. ncbi request reprint Human neural stem cells can migrate, differentiate, and integrate after intravenous transplantation in adult rats with transient forebrain ischemia
    Kon Chu
    Department of Neurology, Seoul National University Hospital, Seoul, South Korea
    Neurosci Lett 343:129-33. 2003
    ..Our findings show that transplanted human neural stem cells differentiate into mature neurons to replace lost neural cells in the adult hippocampus with human-rat neural chimeras...
  68. ncbi request reprint Cystatin C induces neuronal cell death in vivo
    Atsushi Nagai
    Third Department of Internal Medicine, Shimane Medical University, 89 1 Enya cho, Izumo 693 8501, Japan
    Ann N Y Acad Sci 977:315-21. 2002
  69. ncbi request reprint Generation and characterization of human hybrid neurons produced between embryonic CNS neurons and neuroblastoma cells
    Atsushi Nagai
    Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, Canada
    Neurobiol Dis 11:184-98. 2002
    ..The present study indicates that the A1 human hybrid neuronal cell line should serve as a valuable in vitro model for studies of biology, physiology, and pathology of human neurons in health and disease...
  70. ncbi request reprint Neuronal cell death induced by cystatin C in vivo and in cultured human CNS neurons is inhibited with cathepsin B
    Atsushi Nagai
    Department of Neurology, University of British Columbia, Vancouver, Canada
    Brain Res 1066:120-8. 2005
    ....
  71. ncbi request reprint Downregulation of GFAP, TSP-1, and p53 in human glioblastoma cell line, U373MG, by IE1 protein from human cytomegalovirus
    Karim Lee
    Institute of Molecular Biology and Genetics, Seoul National University, Seoul, Korea
    Glia 51:1-12. 2005
    ..Our data strongly suggested that HCMV IE1 could modulate the expression of cellular genes that might play important roles in the pathogenesis of glial tumors...
  72. doi request reprint Neural progenitor NT2N cell lines from teratocarcinoma for transplantation therapy in stroke
    Koichi Hara
    Department of Neurology and Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Prog Neurobiol 85:318-34. 2008
    ..Such highly potent neuronal lineage commitment and neurotrophic factor secretory function of NT2.Nurr1 cells make them an appealing graft source for transplantation therapy...
  73. ncbi request reprint Neural stem cell targeting of glioma is dependent on phosphoinositide 3-kinase signaling
    Stephen E Kendall
    Division of Molecular Medicine, Beckman Research Institute, City of Hope, 1500 East Duarte Road, Duarte, California 91010, USA
    Stem Cells 26:1575-86. 2008
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  74. ncbi request reprint Transplantation of post-mitotic human neuroteratocarcinoma-overexpressing Nurr1 cells provides therapeutic benefits in experimental stroke: in vitro evidence of expedited neuronal differentiation and GDNF secretion
    Koichi Hara
    Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
    J Neurosci Res 85:1240-51. 2007
    ..Nurr1 cell grafts in ischemic stroke, with in vitro evidence suggesting the cells' excellent neuronal differentiation capability and ability to secrete GDNF as likely mechanisms mediating the observed therapeutic benefits...
  75. ncbi request reprint PEX-producing human neural stem cells inhibit tumor growth in a mouse glioma model
    Seung Ki Kim
    Department of Neurosurgery, Brigham and Women s Hospital and Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Clin Cancer Res 11:5965-70. 2005
    ..8%, P < 0.03) and proliferation (23.6%, P < 0.03). These results support the use of neural stem cells as delivery vehicle for targeting therapeutic genes against human glioma...
  76. ncbi request reprint Down-regulation of MHC class I expression in human neuronal stem cells using viral stealth mechanism
    Eun Mi Lee
    Stem Cell Laboratory in Clinical Research Institute and Xenotransplantation Research Center, Seoul National University Hospital, Seoul 110 744, Republic of Korea
    Biochem Biophys Res Commun 326:825-35. 2005
    ..In addition, the various viral stealth mechanisms can be exploited for stem cell transplantation...
  77. ncbi request reprint The free-radical scavenger edaravone restores the differentiation of human neural precursor cells after radiation-induced oxidative stress
    Jun Ishii
    Department of Biosciences, Teikyo University of Science and Technology, Uenohara, Yamanashi 409 0193, Japan
    Neurosci Lett 423:225-30. 2007
    ..Our study may shed some light on the beneficial effects of free-radical scavengers in impaired neurogenesis following cranial radiation therapy...
  78. ncbi request reprint Human neural stem cells target experimental intracranial medulloblastoma and deliver a therapeutic gene leading to tumor regression
    Seung Ki Kim
    Department of Neurosurgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Clin Cancer Res 12:5550-6. 2006
    ....
  79. ncbi request reprint Minocycline inhibits neuronal death and glial activation induced by beta-amyloid peptide in rat hippocampus
    Jae K Ryu
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Glia 48:85-90. 2004
    ..The results from this study suggest that minocycline may have efficacy in the treatment of AD...
  80. ncbi request reprint Anti-inflammatory mechanism of intravascular neural stem cell transplantation in haemorrhagic stroke
    Soon Tae Lee
    Stroke and Stem Cell Laboratory, Clinical Research Institute, Stem Cell Research Center, Department of Neurology, Seoul National University Hospital, Seoul, South Korea
    Brain 131:616-29. 2008
    ..In summary, early intravenous NSC injection displayed anti-inflammatory functionality that promoted neuroprotection, mainly by interrupting splenic inflammatory responses after ICH...
  81. ncbi request reprint Phosphatidylinositol-3 kinase/Akt and GSK-3 mediated cytoprotective effect of epigallocatechin gallate on oxidative stress-injured neuronal-differentiated N18D3 cells
    Seong Ho Koh
    Department of Neurology, College of Medicine, Hanyang University, Seongdong Gu, Seoul 133 791, South Korea
    Neurotoxicology 25:793-802. 2004
    ..These results imply that EGCG has neuroprotective effect by increasing PI3K/Akt-dependent anti-apoptotic signals...
  82. ncbi request reprint Amyloid beta peptide directly inhibits PKC activation
    Woojin Lee
    Department of Biology, College of Natural Sciences, Seoul National University, South Korea
    Mol Cell Neurosci 26:222-31. 2004
    ..These results suggest that Abeta peptides inhibit PKC activation via direct interactions, which may play a role in pathogenesis of AD...
  83. ncbi request reprint Stem cell-based cell therapy for Huntington disease: a review
    Manho Kim
    Department of Neurology, Seoul National University College of Medicine, Seoul, Korea
    Neuropathology 28:1-9. 2008
    ..In this review, we summarize the current state of cell therapy utilizing stem cells in experimental HD animal models, and discuss the future considerations for developing new therapeutic strategies using neural stem cells...