Uri Kopylov

Summary

Publications

  1. doi request reprint Subcutaneous ustekinumab for the treatment of anti-TNF resistant Crohn's disease--the McGill experience
    U Kopylov
    Division of Gastroenterology, McGill University Health Center, Montreal, Quebec, Canada Electronic address
    J Crohns Colitis 8:1516-22. 2014
  2. doi request reprint Hematologic indices as surrogate markers for monitoring thiopurine therapy in IBD
    Uri Kopylov
    Division of Gastroenterology, McGill University Health Centre, Montreal, QC, Canada
    Dig Dis Sci 60:478-84. 2015
  3. doi request reprint Adalimumab monotherapy versus combination therapy with immunomodulators in patients with Crohn's disease: a systematic review and meta-analysis
    Uri Kopylov
    Division of Gastroenterology, McGill University Health Center, Montreal, Quebec, Canada Electronic address
    J Crohns Colitis 8:1632-41. 2014
  4. pmc Magnetic resonance enterography in pregnant women with Crohn's disease: case series and literature review
    Myriam D Stern
    Department of Gastroenterology, Sheba Medical Center, Ramat Gan, Israel
    BMC Gastroenterol 14:146. 2014
  5. doi request reprint Obesity, metabolic syndrome and the risk of development of colonic diverticulosis
    Uri Kopylov
    Department of Gastroenterology and Hepatology, Chaim Sheba Medical Center, Tel Hashomer, Israel
    Digestion 86:201-5. 2012
  6. doi request reprint Idiopathic liver function test abnormality in pregnancy is associated with assisted reproduction techniques
    Uri Kopylov
    Department of Gastroenterology and Hepatology, Sheba Medical Center, Tel Hashomer, Israel
    Fertil Steril 99:377-81. 2013
  7. doi request reprint Anti-tumor necrosis factor and postoperative complications in Crohn's disease: systematic review and meta-analysis
    Uri Kopylov
    Department of Gastroenterology, Chaim Sheba Medical Center, Tel Hashomer, Israel
    Inflamm Bowel Dis 18:2404-13. 2012
  8. doi request reprint Clinical utility of antihuman lambda chain-based enzyme-linked immunosorbent assay (ELISA) versus double antigen ELISA for the detection of anti-infliximab antibodies
    Uri Kopylov
    Department of Gastroenterology, Chaim Sheba Medical Center, Tel Hashomer and Sackler School of Medicine, Tel Aviv University, Israel
    Inflamm Bowel Dis 18:1628-33. 2012
  9. doi request reprint Prior varicella zoster virus exposure in IBD patients treated by anti-TNFs and other immunomodulators: implications for serological testing and vaccination guidelines
    U Kopylov
    Department of Gastroenterology, Sheba Medical Center, Tel Hashomer, Israel
    Aliment Pharmacol Ther 36:145-50. 2012
  10. doi request reprint Clinical and radiographic presentation of superior mesenteric vein thrombosis in Crohn's disease: a single center experience
    Uri Kopylov
    Department of Gastroenterology, Chaim Sheba Medical Center, Israel
    J Crohns Colitis 6:543-9. 2012

Collaborators

Detail Information

Publications33

  1. doi request reprint Subcutaneous ustekinumab for the treatment of anti-TNF resistant Crohn's disease--the McGill experience
    U Kopylov
    Division of Gastroenterology, McGill University Health Center, Montreal, Quebec, Canada Electronic address
    J Crohns Colitis 8:1516-22. 2014
    ..The aim of the study was to describe the real-life experience with open-label use of ustekinumab in anti-TNF resistant CD patients...
  2. doi request reprint Hematologic indices as surrogate markers for monitoring thiopurine therapy in IBD
    Uri Kopylov
    Division of Gastroenterology, McGill University Health Centre, Montreal, QC, Canada
    Dig Dis Sci 60:478-84. 2015
    ..Therapeutic monitoring of thiopurine metabolites is not widely available. Surrogate markers such as hematologic indices (MCV, leukopenia) have been proposed...
  3. doi request reprint Adalimumab monotherapy versus combination therapy with immunomodulators in patients with Crohn's disease: a systematic review and meta-analysis
    Uri Kopylov
    Division of Gastroenterology, McGill University Health Center, Montreal, Quebec, Canada Electronic address
    J Crohns Colitis 8:1632-41. 2014
    ..The aim of this study was to compare the efficacy of adalimumab monotherapy with combination therapy for induction and maintenance of response and remission in CD using a meta-analysis of the current literature...
  4. pmc Magnetic resonance enterography in pregnant women with Crohn's disease: case series and literature review
    Myriam D Stern
    Department of Gastroenterology, Sheba Medical Center, Ramat Gan, Israel
    BMC Gastroenterol 14:146. 2014
    ..The aim of the study was to describe the experience with MRE in pregnant CD patients in a tertiary referral center...
  5. doi request reprint Obesity, metabolic syndrome and the risk of development of colonic diverticulosis
    Uri Kopylov
    Department of Gastroenterology and Hepatology, Chaim Sheba Medical Center, Tel Hashomer, Israel
    Digestion 86:201-5. 2012
    ....
  6. doi request reprint Idiopathic liver function test abnormality in pregnancy is associated with assisted reproduction techniques
    Uri Kopylov
    Department of Gastroenterology and Hepatology, Sheba Medical Center, Tel Hashomer, Israel
    Fertil Steril 99:377-81. 2013
    ....
  7. doi request reprint Anti-tumor necrosis factor and postoperative complications in Crohn's disease: systematic review and meta-analysis
    Uri Kopylov
    Department of Gastroenterology, Chaim Sheba Medical Center, Tel Hashomer, Israel
    Inflamm Bowel Dis 18:2404-13. 2012
    ..The aim was to evaluate the impact of preoperative treatment with anti-TNF antibodies on postoperative complications in CD patients undergoing abdominal surgery...
  8. doi request reprint Clinical utility of antihuman lambda chain-based enzyme-linked immunosorbent assay (ELISA) versus double antigen ELISA for the detection of anti-infliximab antibodies
    Uri Kopylov
    Department of Gastroenterology, Chaim Sheba Medical Center, Tel Hashomer and Sackler School of Medicine, Tel Aviv University, Israel
    Inflamm Bowel Dis 18:1628-33. 2012
    ....
  9. doi request reprint Prior varicella zoster virus exposure in IBD patients treated by anti-TNFs and other immunomodulators: implications for serological testing and vaccination guidelines
    U Kopylov
    Department of Gastroenterology, Sheba Medical Center, Tel Hashomer, Israel
    Aliment Pharmacol Ther 36:145-50. 2012
    ..Moreover, data on VZV immunity in adult IBD patients or accuracy of VZV serological testing under immunomodulator treatment is sparse...
  10. doi request reprint Clinical and radiographic presentation of superior mesenteric vein thrombosis in Crohn's disease: a single center experience
    Uri Kopylov
    Department of Gastroenterology, Chaim Sheba Medical Center, Israel
    J Crohns Colitis 6:543-9. 2012
    ..This study describes the clinical and radiological characteristics of CD /patients with superior mesenteric vein thrombosis (MVT) diagnosed by CT/MRI...
  11. doi request reprint Head or tail: the orientation of the small bowel capsule endoscope movement in the small bowel
    Uri Kopylov
    Department of Gastroenterology, Chaim Sheba Medical Center, Tel Hashomer, Israel
    Dig Dis Sci 57:694-8. 2012
    ..The aim of the study was to identify the orientation of the capsule along the migration through the small bowel...
  12. doi request reprint Expression of IL-2, IL-17 and TNF-alpha in patients with Crohn's disease treated with anti-TNF antibodies
    Lior H Katz
    Department of Gastroenterology, Sheba Medical Center, Ramat Gan, Israel
    Clin Res Hepatol Gastroenterol 38:491-8. 2014
    ..IL-2 is a potent stimulator of lymphocyte proliferation and IL2/IL21 receptor polymorphisms have recently been associated with susceptibility to IBD...
  13. doi request reprint Travel-associated health risks for patients with inflammatory bowel disease
    Shomron Ben-Horin
    Gastroenterology Department, Sheba Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Hashomer, Israel
    Clin Gastroenterol Hepatol 10:160-5, 165.e1. 2012
    ..There are few data on risk of travel for patients with inflammatory bowel disease (IBD). We assessed rates of illness while traveling among patients with IBD...
  14. doi request reprint Severe and morbid obesity in Crohn's disease patients: prevalence and disease associations
    Bella Ungar
    Department of Internal Medicine D, Sheba Medical Center, Tel Hashomer and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Digestion 88:26-32. 2013
    ..Crohn's disease (CD) is frequently associated with weight loss and malnutrition. However, as the prevalence of obesity increases worldwide, it may become a clinical problem even in CD...
  15. doi request reprint The temporal evolution of antidrug antibodies in patients with inflammatory bowel disease treated with infliximab
    Bella Ungar
    Department of Gastroenterology, Sheba Medical Center Tel Hashomer and Sackler School of Medicine, Tel Aviv University, Ramat Gan, Israel
    Gut 63:1258-64. 2014
    ..To characterise the temporal evolution of antibodies to infliximab (ATI)...
  16. doi request reprint Addition of an immunomodulator to infliximab therapy eliminates antidrug antibodies in serum and restores clinical response of patients with inflammatory bowel disease
    Shomron Ben-Horin
    Department of Gastroenterology, Sheba Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Clin Gastroenterol Hepatol 11:444-7. 2013
    ..The addition of immunomodulators to therapy might be helpful to patients who have lost response to anti-TNF agents owing to formation of antidrug antibodies...
  17. doi request reprint Detection of infliximab in breast milk of nursing mothers with inflammatory bowel disease
    Shomron Ben-Horin
    Dept of Gastroenterology, Sheba Medical Center and Sackler School of Medicine, Tel Aviv University, Israel
    J Crohns Colitis 5:555-8. 2011
    ..Limited data suggest the absence of infliximab in breast milk, thereby implying the safety of this drug during breast-feeding. We aimed to re-evaluate the presence of infliximab in breast milk of nursing IBD patients...
  18. doi request reprint The immunogenic part of infliximab is the F(ab')2, but measuring antibodies to the intact infliximab molecule is more clinically useful
    Shomron Ben-Horin
    Department of Gastroenterology, Chaim Sheba Medical Center, Tel Hashomer and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Gut 60:41-8. 2011
    ..To localise the immunogenic part of infliximab and evaluate the clinical usefulness of measuring antibodies against infliximab fragments...
  19. pmc Significance of low level infliximab in the absence of anti-infliximab antibodies
    Bella Ungar
    Bella Ungar, Adi Anafy, Miri Yavzori, Orit Picard, Ella Fudim, Uri Kopylov, Rami Eliakim, Shomron Ben Horin, Department of Gastroenterology, Sheba Medical Center Tel Hashomer and Sackler School of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel
    World J Gastroenterol 21:1907-14. 2015
    ..To evaluate the prevalence of double negative (DN) sera and the mechanisms responsible for DN status...
  20. doi request reprint Levels of drug and antidrug antibodies are associated with outcome of interventions after loss of response to infliximab or adalimumab
    Henit Yanai
    Inflammatory Bowel Disease Center, Department of Gastroenterology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Clin Gastroenterol Hepatol 13:522-530.e2. 2015
    ..We analyzed the association between trough levels of anti-TNF agents or ADAs and outcomes of interventions for patients with loss of response to infliximab or adalimumab...
  21. doi request reprint Optimizing anti-TNF treatments in inflammatory bowel disease
    Shomron Ben-Horin
    IBD Service, Department of Gastroenterology, Sheba Medical Center, Tel Aviv University, Tel Aviv, Israel Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel Electronic address
    Autoimmun Rev 13:24-30. 2014
    ..Failure of anti-TNF treatment in inflammatory bowel disease (IBD) patients can take on several forms, each posing distinct etio-pathogenic considerations and management dilemmas...
  22. doi request reprint Small bowel capsule endoscopy in the management of established Crohn's disease: clinical impact, safety, and correlation with inflammatory biomarkers
    Uri Kopylov
    Division of Gastroenterology, McGill University Health Center, Montreal, QC, Canada Department of Gastroenterology, Skane University Hospital, Malmo, Lund University, Lund, Sweden Endoscopy Unit, Centre for Liver and Digestive Disorders, The Royal Infirmary of Edinburgh, Edinburgh, United Kingdom Department of Gastroenterology, Gloucestershire Hospitals NHS Foundation Trust, Chetlenham, United Kingdom and Department of Gastroenterology, Chaim Sheba Medical Center, Tel Hashomer, Israel
    Inflamm Bowel Dis 21:93-100. 2015
    ..However, data on the clinical impact of VCE in patients with established CD are scarce. The aim of this study was to examine the impact and safety of VCE on the clinical management of patients with established CD...
  23. doi request reprint Magnetic resonance enterography in Crohn's disease: a guide to common imaging manifestations for the IBD physician
    Marianne M Amitai
    Department of Diagnostic Imaging, Chaim Sheba Medical Center, Tel Hashomer, Israel
    J Crohns Colitis 7:603-15. 2013
    ..This review is aimed to describe the indications for performing MRE in CD, essentials of MRE techniques and typical radiological findings in patients with CD to aid the IBD doctor in daily practice. ..
  24. doi request reprint Vitamin B12 deficiency in inflammatory bowel disease: prevalence, risk factors, evaluation, and management
    Robert Battat
    Department of Medicine, McGill University, Montreal, Quebec, Canada Department of Internal Medicine, Jewish General Hospital, Montreal, Quebec, Canada Division of Gastroenterology, McGill University Health Center, Montreal, Quebec, Canada Division of Gastroenterology, Jewish General Hospital, Montreal, Quebec, Canada Departments of Human Genetics, Pediatrics, and Biology, McGill University, Montreal, Quebec, Canada and Division of Hematology, McGill University Health Center, Montreal, Quebec, Canada
    Inflamm Bowel Dis 20:1120-8. 2014
    ..This systematic review examines whether IBD predisposes to Cbl deficiency. We provide an approach to the management of abnormal Cbl values in IBD based on current literature and consensus-based guidelines...
  25. pmc Cytomegalovirus positive ulcerative colitis: A single center experience and literature review
    Uri Kopylov
    Uri Kopylov, Gila Sasson, Rami Eliakim, Shomron Ben Horin, Department of Gastroenterology, Sheba Medical Center, Ramat Gan 52621, Israel
    World J Gastrointest Pathophysiol 4:18-23. 2013
    ..To compare the clinical outcome of cytomegalovirus (CMV)-positive ulcerative colitis (UC) patients with and without antiviral therapy...
  26. pmc Antiviral therapy in cytomegalovirus-positive ulcerative colitis: a systematic review and meta-analysis
    Uri Kopylov
    Uri Kopylov, Shomron Ben Horin, Lior Katz, Department of Gastroenterology, Sheba Medical Center, Tel Hashomer, Ramat Gan 5262, Israel
    World J Gastroenterol 20:2695-703. 2014
    ..To evaluate the impact of antiviral treatment on cytomegalovirus (CMV)-positive ulcerative colitis patients...
  27. doi request reprint Risk of infections with biological agents
    Uri Kopylov
    Division of Gastroenterology, McGill University Health Center, 687 Pine Avenue West, Ross 2 28, Montreal, Quebec H3A 1A1, Canada
    Gastroenterol Clin North Am 43:509-24. 2014
    ..A careful screening, surveillance, and immunization program, in accordance with available guidelines, is important to minimize any risk of infectious complications. ..
  28. doi request reprint Diagnostic modalities for the evaluation of small bowel disorders
    Uri Kopylov
    aDivision of Gastroenterology, Sheba Medical Center, Sackler School of Medicine, Tel Aviv, Israel bDivision of Gastroenterology, McGill University Health Center, McGill Faculty of Medicine, Montreal, Quebec, Canada
    Curr Opin Gastroenterol 31:111-7. 2015
    ..This review summarizes the recent developments in the evaluation of small bowel disorders using videocapsule endoscopy (VCE) and serological and breath-test biomarkers...
  29. pmc Role of capsule endoscopy in inflammatory bowel disease
    Uri Kopylov
    Uri Kopylov, Ernest G Seidman, Division of Gastroenterology, McGill University Health Center, Montreal, Quebec H3G A14, Canada
    World J Gastroenterol 20:1155-64. 2014
    ..This paper contains an overview of the current and future clinical applications of capsule endoscopy in inflammatory bowel disease...
  30. doi request reprint A patient with ulcerative colitis and central serous chorioretinopathy--a therapeutic dilemma
    Bella Geyshis
    Internal Medicine D, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel
    J Crohns Colitis 7:e66-8. 2013
    ..Awareness of this condition as a cause of visual disturbance in IBD patients and a close ophthalmological cooperation are required in order to provide the optimal care for these patients...
  31. doi request reprint Reciprocal regulation of CXCR4 and CXCR7 in intestinal mucosal homeostasis and inflammatory bowel disease
    Lael Werner
    Department of Gastroenterology and Liver Diseases, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    J Leukoc Biol 90:583-90. 2011
    ..Finally, T cells attracted by CXCL12 are mostly of a memory phenotype. In conclusion, the present study suggests that the interplay between CXCL12 and its receptors affects homeostasis and inflammation in the intestinal mucosa...