Richard D Kopke

Summary

Publications

  1. ncbi request reprint Noise protection with N-acetyl-l-cysteine (NAC) using a variety of noise exposures, NAC doses, and routes of administration
    Eric C Bielefeld
    Department of Communicative Disorders and Sciences, State University of New York at Buffalo, Buffalo, NY, USA
    Acta Otolaryngol 127:914-9. 2007
  2. ncbi request reprint NAC for noise: from the bench top to the clinic
    Richard D Kopke
    Hough Ear Institute, 3400 N W 56th Street, Oklahoma City, OK 73112, USA
    Hear Res 226:114-25. 2007
  3. doi request reprint Effectiveness of 4-hydroxy phenyl N-tert-butylnitrone (4-OHPBN) alone and in combination with other antioxidant drugs in the treatment of acute acoustic trauma in chinchilla
    Chul Hee Choi
    Hough Ear Institute, Oklahoma City, OK 73112, USA
    Free Radic Biol Med 44:1772-84. 2008
  4. ncbi request reprint Magnetic nanoparticles: inner ear targeted molecule delivery and middle ear implant
    Richard D Kopke
    Hough Ear Institute, Oklahoma City, OK 73112, USA
    Audiol Neurootol 11:123-33. 2006
  5. doi request reprint Selective degeneration of synapses in the dorsal cochlear nucleus of chinchilla following acoustic trauma and effects of antioxidant treatment
    Xiaoping Du
    Hough Ear Institute, Oklahoma, OK 73112, USA
    Hear Res 283:1-13. 2012
  6. pmc Magnetic targeted delivery of dexamethasone acetate across the round window membrane in guinea pigs
    Xiaoping Du
    Hough Ear Institute, Oklahoma City, USA
    Otol Neurotol 34:41-7. 2013
  7. doi request reprint Regeneration of mammalian cochlear and vestibular hair cells through Hes1/Hes5 modulation with siRNA
    Xiaoping Du
    Hough Ear Institute, P O Box 23206, Oklahoma City, OK 73112, USA
    Hear Res 304:91-110. 2013
  8. pmc Nitrones as therapeutics
    Robert A Floyd
    Experimental Therapeutics Research Program, Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Free Radic Biol Med 45:1361-74. 2008
  9. pmc Reduced formation of oxidative stress biomarkers and migration of mononuclear phagocytes in the cochleae of chinchilla after antioxidant treatment in acute acoustic trauma
    Xiaoping Du
    Hough Ear Institute, Oklahoma City, OK 73112, USA
    Int J Otolaryngol 2011:612690. 2011
  10. ncbi request reprint Distribution of PLGA nanoparticles in chinchilla cochleae
    Xianxi Ge
    Spatial Orientation Center, Department of Otolaryngology, Naval Medical Center San Diego, San Diego, CA 92134 5000, USA
    Otolaryngol Head Neck Surg 137:619-23. 2007

Research Grants

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Noise protection with N-acetyl-l-cysteine (NAC) using a variety of noise exposures, NAC doses, and routes of administration
    Eric C Bielefeld
    Department of Communicative Disorders and Sciences, State University of New York at Buffalo, Buffalo, NY, USA
    Acta Otolaryngol 127:914-9. 2007
    ..The studies further reveal the potential for the use of NAC in a clinical population exposed to noise...
  2. ncbi request reprint NAC for noise: from the bench top to the clinic
    Richard D Kopke
    Hough Ear Institute, 3400 N W 56th Street, Oklahoma City, OK 73112, USA
    Hear Res 226:114-25. 2007
    ..Early clinical trials with NAC are mentioned...
  3. doi request reprint Effectiveness of 4-hydroxy phenyl N-tert-butylnitrone (4-OHPBN) alone and in combination with other antioxidant drugs in the treatment of acute acoustic trauma in chinchilla
    Chul Hee Choi
    Hough Ear Institute, Oklahoma City, OK 73112, USA
    Free Radic Biol Med 44:1772-84. 2008
    ..These results demonstrate that 4-OHPBN and combinations of antioxidants can effectively treat acute acoustic trauma and drug combinations may increase the effectiveness of treatment and decrease the required individual medication dose...
  4. ncbi request reprint Magnetic nanoparticles: inner ear targeted molecule delivery and middle ear implant
    Richard D Kopke
    Hough Ear Institute, Oklahoma City, OK 73112, USA
    Audiol Neurootol 11:123-33. 2006
    ..A sinusoidal magnetic field applied to guinea pigs with SNP implanted in the middle ear resulted in displacements of the middle ear comparable to 90 dB SPL...
  5. doi request reprint Selective degeneration of synapses in the dorsal cochlear nucleus of chinchilla following acoustic trauma and effects of antioxidant treatment
    Xiaoping Du
    Hough Ear Institute, Oklahoma, OK 73112, USA
    Hear Res 283:1-13. 2012
    ..Results further suggest that early antioxidant treatment for acoustic trauma not only rescues cochlear hair cells, but also has impact on central auditory structures...
  6. pmc Magnetic targeted delivery of dexamethasone acetate across the round window membrane in guinea pigs
    Xiaoping Du
    Hough Ear Institute, Oklahoma City, USA
    Otol Neurotol 34:41-7. 2013
    ..Magnetically susceptible PLGA nanoparticles will effectively target the round window membrane (RWM) for delivery of dexamethasone-acetate (Dex-Ac) to the scala tympani...
  7. doi request reprint Regeneration of mammalian cochlear and vestibular hair cells through Hes1/Hes5 modulation with siRNA
    Xiaoping Du
    Hough Ear Institute, P O Box 23206, Oklahoma City, OK 73112, USA
    Hear Res 304:91-110. 2013
    ....
  8. pmc Nitrones as therapeutics
    Robert A Floyd
    Experimental Therapeutics Research Program, Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Free Radic Biol Med 45:1361-74. 2008
    ....
  9. pmc Reduced formation of oxidative stress biomarkers and migration of mononuclear phagocytes in the cochleae of chinchilla after antioxidant treatment in acute acoustic trauma
    Xiaoping Du
    Hough Ear Institute, Oklahoma City, OK 73112, USA
    Int J Otolaryngol 2011:612690. 2011
    ..The present study provides further evidence of effectiveness of antioxidant treatment in reducing permanent hearing loss...
  10. ncbi request reprint Distribution of PLGA nanoparticles in chinchilla cochleae
    Xianxi Ge
    Spatial Orientation Center, Department of Otolaryngology, Naval Medical Center San Diego, San Diego, CA 92134 5000, USA
    Otolaryngol Head Neck Surg 137:619-23. 2007
    ..To study the distribution of polylactic/glycolic acid-encapsulated iron oxide nanoparticles (PLGA-NPs) in chinchilla cochleae after application on the round window membrane (RWM)...
  11. ncbi request reprint The early kinetics of gentamicin uptake into the inner ear
    Michael E Hoffer
    Department of Defense Spatial Orientation Center, Department of Otolaryngology, Naval Medical Center San Diego, San Diego, CA 92134 2200, USA
    Int Tinnitus J 8:27-9. 2002
    ..The information gained from this study may increase our scientific understanding about the effects of gentamicin on the inner ear and may allow clinicians to treat patients more effectively for inner-ear disorders...
  12. ncbi request reprint Effect of trans-bullar gentamicin treatment on guinea pig angular and linear vestibulo-ocular reflexes
    Gavin E G Jones
    Department of Defense Spatial Orientation Center, Otolaryngology Department, Naval Medical Center, San Diego, 34800 Bob Wilson Dr Ste 200, CA 92134, San Diego, USA
    Exp Brain Res 152:293-306. 2003
    ..It is suggested that these effects indicate selective cytotoxic and/or physiologic effects of gentamicin intoxication in the inner ear or, possibly, the vestibular nerve and central nervous system...
  13. ncbi request reprint Candidate's thesis: enhancing intrinsic cochlear stress defenses to reduce noise-induced hearing loss
    Richard D Kopke
    Department of Defence Spatial Orientation Center, Naval Medical Center San Diego, California 92134, USA
    Laryngoscope 112:1515-32. 2002
    ..The objective of this study was to document the reduction in noise-induced hearing and hair cell loss, following application of ALCAR, carbamathione, and a GSH repletion drug D-methionine (MET), to a model of noise-induced hearing loss...

Research Grants1

  1. Preventing NIHL by enhancing glutathione pathways
    Richard Kopke; Fiscal Year: 2002
    ..These studies should lay the basis for clinical trials of oral agents to prevent NIHL. ..