Noise protection with N-acetyl-l-cysteine (NAC) using a variety of noise exposures, NAC doses, and routes of administrationEric C Bielefeld
Department of Communicative Disorders and Sciences, State University of New York at Buffalo, Buffalo, NY, USA
Acta Otolaryngol 127:914-9. 2007
..The studies further reveal the potential for the use of NAC in a clinical population exposed to noise...
- NAC for noise: from the bench top to the clinic
Richard D Kopke
Hough Ear Institute, 3400 N W 56th Street, Oklahoma City, OK 73112, USA
Hear Res 226:114-25. 2007
..Early clinical trials with NAC are mentioned...
Effectiveness of 4-hydroxy phenyl N-tert-butylnitrone (4-OHPBN) alone and in combination with other antioxidant drugs in the treatment of acute acoustic trauma in chinchillaChul Hee Choi
Hough Ear Institute, Oklahoma City, OK 73112, USA
Free Radic Biol Med 44:1772-84. 2008
..These results demonstrate that 4-OHPBN and combinations of antioxidants can effectively treat acute acoustic trauma and drug combinations may increase the effectiveness of treatment and decrease the required individual medication dose...
- Magnetic nanoparticles: inner ear targeted molecule delivery and middle ear implant
Richard D Kopke
Hough Ear Institute, Oklahoma City, OK 73112, USA
Audiol Neurootol 11:123-33. 2006
..A sinusoidal magnetic field applied to guinea pigs with SNP implanted in the middle ear resulted in displacements of the middle ear comparable to 90 dB SPL...
- Selective degeneration of synapses in the dorsal cochlear nucleus of chinchilla following acoustic trauma and effects of antioxidant treatment
Xiaoping Du
Hough Ear Institute, Oklahoma, OK 73112, USA
Hear Res 283:1-13. 2012
..Results further suggest that early antioxidant treatment for acoustic trauma not only rescues cochlear hair cells, but also has impact on central auditory structures...
Magnetic targeted delivery of dexamethasone acetate across the round window membrane in guinea pigsXiaoping Du
Hough Ear Institute, Oklahoma City, USA
Otol Neurotol 34:41-7. 2013
..Magnetically susceptible PLGA nanoparticles will effectively target the round window membrane (RWM) for delivery of dexamethasone-acetate (Dex-Ac) to the scala tympani...
- Nitrones as therapeutics
Robert A Floyd
Experimental Therapeutics Research Program, Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
Free Radic Biol Med 45:1361-74. 2008
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- Reduced formation of oxidative stress biomarkers and migration of mononuclear phagocytes in the cochleae of chinchilla after antioxidant treatment in acute acoustic trauma
Xiaoping Du
Hough Ear Institute, Oklahoma City, OK 73112, USA
Int J Otolaryngol 2011:612690. 2011
..The present study provides further evidence of effectiveness of antioxidant treatment in reducing permanent hearing loss...
- Distribution of PLGA nanoparticles in chinchilla cochleae
Xianxi Ge
Spatial Orientation Center, Department of Otolaryngology, Naval Medical Center San Diego, San Diego, CA 92134 5000, USA
Otolaryngol Head Neck Surg 137:619-23. 2007
..To study the distribution of polylactic/glycolic acid-encapsulated iron oxide nanoparticles (PLGA-NPs) in chinchilla cochleae after application on the round window membrane (RWM)...
- The early kinetics of gentamicin uptake into the inner ear
Michael E Hoffer
Department of Defense Spatial Orientation Center, Department of Otolaryngology, Naval Medical Center San Diego, San Diego, CA 92134 2200, USA
Int Tinnitus J 8:27-9. 2002
..The information gained from this study may increase our scientific understanding about the effects of gentamicin on the inner ear and may allow clinicians to treat patients more effectively for inner-ear disorders...
- Effect of trans-bullar gentamicin treatment on guinea pig angular and linear vestibulo-ocular reflexes
Gavin E G Jones
Department of Defense Spatial Orientation Center, Otolaryngology Department, Naval Medical Center, San Diego, 34800 Bob Wilson Dr. Ste 200, CA 92134, San Diego, USA
Exp Brain Res 152:293-306. 2003
..It is suggested that these effects indicate selective cytotoxic and/or physiologic effects of gentamicin intoxication in the inner ear or, possibly, the vestibular nerve and central nervous system...
- Candidate's thesis: enhancing intrinsic cochlear stress defenses to reduce noise-induced hearing loss
Richard D Kopke
Department of Defence Spatial Orientation Center, Naval Medical Center San Diego, California 92134, USA
Laryngoscope 112:1515-32. 2002
..The objective of this study was to document the reduction in noise-induced hearing and hair cell loss, following application of ALCAR, carbamathione, and a GSH repletion drug D-methionine (MET), to a model of noise-induced hearing loss...
