[Individualized integrated therapy on patients with vertigo]Weijia Kong
Department of Otorhinolaryngology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 22:145-9. 2008
..To explore the treatment of patients with vertigo by the integrated therapy including the drug, surgery and rehabilitation exercise and to investigate the establishment of individualized integrated therapy on patients with vertigo...
Prevalence of allergic rhinitis in 3-6-year-old children in Wuhan of ChinaW J Kong
Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
Clin Exp Allergy 39:869-74. 2009
..Only a few prevalence studies of allergic rhinitis (AR) have been reported in China. This study aimed to evaluate the prevalence of AR in a population of 3-6-year-old children in Wuhan, China...
- [The establishment of paired-standardized patients and its application in the PBL teaching of otorhinolaryngology]
Weijia Kong
Department of Otolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 22:764-5, 768. 2008
..The aim of the study is to explore the establishment of paired-standardized patients (PSPs), which can cover the deficiency of standardized patients...
- [Four-stage gradual expanding approach of problem based learning in otorhinolaryngology]
Weijia Kong
Department of Otolaryngology Head and Neck Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 22:715-7. 2008
..The aim of the study is to cover the shortages of PBL, such as time-consuming, abstract, lacking of the course of clinic practice, and to introduce PBL to the teaching of otorhinolaryngology...
- Sketches of otohistory Part 12: The history of otology in traditional Chinese medicine
Wei-Jia Kong
Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China
Audiol Neurootol 11:145-50. 2006
- [Combined flap of postauricular musculo-periosteal and ear canal skin flap with bone paté for mastoid obliteration and canal wall down mastoidectomy]
Wei Jia Kong
Department of Otorhinolaryngology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 42:487-90. 2007
..To investigate the long-term outcome and clinical value of modified radical mastoidectomy with mastoid obliteration using pedicled combined flap of postauricular musculo-periosteal and ear canal skin flap in conjunction with bone paté...
- [Postural characteristics of healthy subjects under different thickness of foam]
Wei Jia Kong
Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 42:721-5. 2007
..To investigate the effects of different thickness of foam on the postural control of standing in healthy subjects...
- The properties of ACh-induced BK currents in guinea pig type II vestibular hair cells
Wei Jia Kong
Department of Otolaryngology, Union Hospital of Tongji Medical College, Hua Zhong University of Science and Technology, Wuhan, Hubei, People s Republic of China
Hear Res 209:1-9. 2005
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- Fast cholinergic efferent inhibition in guinea pig outer hair cells
Wei Jia Kong
Department of Otolaryngology, Union Hospital of Tongji Medical College, Hua Zhong University of Science and Technology, Wu Han, People s Republic of China
Brain Res 1102:103-8. 2006
..This fast inhibition is both potently dependent on the permeability of Ca(2+) ions through the native nAChRs and modulated by Ca(2+) ions...
- Mitochondrial transcription factor A overexpression and base excision repair deficiency in the inner ear of rats with D-galactose-induced aging
Yi Zhong
Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
FEBS J 278:2500-10. 2011
..This study also provides new insights into the development of presbycusis...
- Methylation-associated silencing of death-associated protein kinase gene in laryngeal squamous cell cancer
Wei Jia Kong
Department of Otolaryngology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Dadao Avenue, Wuhan, Hubei 430 022, China
Laryngoscope 115:1395-401. 2005
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- The effect of the mtDNA4834 deletion on hearing
Wei Jia Kong
Department of Otorhinolaryngology, Union Hospital of Tongji Medical College, Huazhong Science and Technology University, Jiefang Avenue 1277, Wuhan, China
Biochem Biophys Res Commun 344:425-30. 2006
..Moreover, those suggest that mtDNA4834 deletion can not directly induce the hearing loss, but acting as a predisposing factor which can greatly enhance the sensitivity of the inner ear to the aminoglycoside antibiotic...
- Contribution of common deletion to total deletion burden in mitochondrial DNA from inner ear of d-galactose-induced aging rats
Yi Zhong
Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China
Mutat Res 712:11-9. 2011
..Taken together, these findings suggest that the common deletion may serve as an ideal molecular marker to assess the mtDNA damage in inner ear during aging...
- Effect of methylation-associated silencing of the death-associated protein kinase gene on nasopharyngeal carcinoma
Wei Jia Kong
Department of Otolaryngology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
Anticancer Drugs 17:251-9. 2006
..5-Aza-CdR may slow the growth of CNE cells in vitro and in vivo by reactivating the DAPK gene silenced by de novo methylation...
- Increased mitochondrial DNA damage and decreased base excision repair in the auditory cortex of D-galactose-induced aging rats
Bei Chen
Department of Otolaryngology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 430022, China
Mol Biol Rep 38:3635-42. 2011
..DNA repair enzymes such as pol γ and OGG1 may provide novel pharmacological targets to promote DNA repair and rescue the central auditory system in patients with degenerative diseases...
- The relation between D-galactose injection and mitochondrial DNA 4834 bp deletion mutation
Wei Jia Kong
Department of Otorhinolaryngology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue 1277, Wuhan 430022, China
Exp Gerontol 41:628-34. 2006
..A higher sensitive result could be gained using tissue biopsy to examine mtDNA 4834 bp deletion...
- The effect of overexpression of PGC-1α on the mtDNA4834 common deletion in a rat cochlear marginal cell senescence model
Xue Yan Zhao
Department of Otolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, PR China
Hear Res 296:13-24. 2013
..Our study may shed light on the pathogenesis of presbycusis and provide a new therapeutic target for presbycusis...
- Age-related changes in the central auditory system: comparison of D-galactose-induced aging rats and naturally aging rats
Bei Chen
Department of Otolaryngology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, China
Brain Res 1344:43-53. 2010
..Oxidative stress, large-scale mtDNA 4834 bp deletion, and apoptosis are likely to be involved in the progressive weakening of the central auditory system associated with the aging process...
- [Image examination of postoperative evaluation for the cochlear implanted electrode]
Wei Jia Kong
Department of Otorhinolaryngology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
Zhonghua Er Bi Yan Hou Ke Za Zhi 39:81-4. 2004
..To evaluate the image feature of the X-ray plain film, the spiral computed tomography (CT) scans and three dimension reconstruction of inner ear with implanted electrode...
- [Protective roles of vitamin E and coenzyme Q10 in the inner ear mitochondrial DNA 4834 bp deletion mutation of rats]
Wei Jia Kong
Department of Otorhinolaryngology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
Zhonghua Er Bi Yan Hou Ke Za Zhi 39:707-11. 2004
..To explore the protective roles of vitamin E and coenzyme Q10 in the inner ear mitochondrial DNA 4834 bp deletion mutation of rats...
- Evaluation of the implanted cochlear implant electrode by CT scanning with three-dimensional reconstruction
Wei Jia Kong
Department of Otorhinolaryngology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Hankou, Wuhan, Hubei, PR China
Acta Otolaryngol 132:116-22. 2012
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- [Sensitivity to the ototoxicity of kanamycin of the rat model for mimetic aging in the inner ear]
Yu juan Hu
Department of Otorhinolaryngology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 43:58-61. 2008
..To research the animal model with mimetic aging effect in the inner ear predispose to the ototoxicity of kanamycin...
- Two Distinct Channels Mediated by m2mAChR and α9nAChR Co-Exist in Type II Vestibular Hair Cells of Guinea Pig
Tao Zhou
Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China
Int J Mol Sci 14:8818-31. 2013
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- [Properties of cholinergic receptor-mediated ion channels on type I vestibular hair cells of guinea pigs]
Yun Zhu
Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
Sheng Li Xue Bao 60:375-81. 2008
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- PC cell-derived growth factor overexpression promotes proliferation and survival of laryngeal carcinoma
Wei Jia Kong
Department of Otolaryngology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PRC
Anticancer Drugs 18:29-40. 2007
..Our findings also indicate that PC cell-derived growth factor is a logical and potential target for early diagnosis, specific therapy and prognosis of laryngeal squamous cell carcinoma...
- [Oxidative stress experimental model of rat with stria vascularis marginal cells injury induced by hydrogen peroxide in vitro]
Jun Li
Department of Otorhinolaryngology, Wuhan Union Hospital, Tongji Medical College of Huazhong Universty of Science and Technology, China
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 43:835-9. 2008
..To set up the oxidative stress experimental model of rat cochlea with stria vascularis marginal cells injury induced by hydrogen peroxide in vitro...
- Reversible neurotoxicity of kanamycin on dorsal cochlear nucleus
Guo Run Fan
Department of Otorhinolaryngology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue 1277, Wuhan 430022, PR China
Brain Res 1502:30-46. 2013
..These data demonstrated that the neurons damage of the DCN caused by kanamycin was reversible and autophagy was upregulated in the neurotoxic course of kanamycin on DCN through JNK1-mediated phosphorylation of Bcl-2 pathway...
Increased p66Shc in the inner ear of D-galactose-induced aging mice with accumulation of mitochondrial DNA 3873-bp deletion: p66Shc and mtDNA damage in the inner ear during agingLisa Wu
Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People s Republic of China
PLoS ONE 7:e50483. 2012
..During aging, the oxidative stress-related increase of p66Shc and Ser36-P-p66Shc might be associated with the accumulation of the mtDNA 3873-bp deletion in the inner ear...
- M2 muscarinic ACh receptors sensitive BK channels mediate cholinergic inhibition of type II vestibular hair cells
Chang Kai Guo
Department of Otolaryngology, Union Hospital of Tongji Medical College, Hua Zhong University of Science and Technology, Wuhan 430022, People s Republic of China
Hear Res 285:13-9. 2012
..The activation of m2 mAChRs may stimulate Giβγ-mediated excitation of AC/cAMP activities and lead to the phosphorylation of Ca(2+) channels, resulting in the influx of Ca(2+) and opening of the BK channel...
- [Feature of ACh-sensitive potassium current in outer hair cells of guinea pig cochlea]
Chang Kai Guo
Department of Otorhinolaryngology, Union Hospital, Tongii Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 42:286-90. 2007
..To explore the feature of the ACh-sensitive potassium current in guinea pig cochlear outer hair cells...
- [Electrophysiological characteristics of muscarinic cholinergic receptor in rat medial vestibular nucleus neurons by visual patch clamp technique]
Yu Zhang
Department of Otorhinolaryngology, Union and Technology, Wuhan 430022, China
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 42:48-52. 2007
..To establish the visual patch clamp whole-cell recording technique and study the properties and functional significance of muscarinic receptor-mediated currents in rat medial vestibular nucleus neurons (MVNn)...
- Expression of nicotinic acetylcholine receptor subunit alpha9 in type II vestibular hair cells of rats
Wei Jia Kong
Department of Otorhinolaryngology, Union Hospital of Tongji Medical College, Huazhong Science and Technology University, Wuhan 430030, China
Acta Pharmacol Sin 27:1509-14. 2006
..To explore the cell specific existence of alpha 9 AChR in the vestibular type II hair cells (VHC II) of rats...
- [Protection of cochlear function from aminoglycosides ototoxicity by manganese superoxide dismutase gene in aging rat]
Yang Yang
Department of Otorhinolaryngology Head and Neck Surgery, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 44:657-63. 2009
..determine the feasibility of manganese superoxide dismutase (MnSOD) gene therapy for protecting the cochlear function against aminoglycoside-induced oxidative stress in aging rats...
- Multislice spiral computed tomography imaging in congenital inner ear malformations
Hui Ma
Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
J Comput Assist Tomogr 32:146-50. 2008
..The purpose of this study is to evaluate the usefulness of multislice spiral computed tomography (CT) in the diagnosis of congenital inner ear malformations...
- [Co-location of ACh-sensitive BK channels and L-type calcium channels in type II vestibular hair cells of guinea pig]
Chang Kai Guo
Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 43:208-12. 2008
..To explore the mechanisms of the influx of calcium ions during the activation of ACh-sensitive BK channel (big conductance, calcium-dependent potassium channel) in type II vestibular hair cells of guinea pigs...
- The coupling of acetylcholine-induced BK channel and calcium channel in guinea pig saccular type II vestibular hair cells
Wei Jia Kong
Department of Otolaryngology, Union Hospital of Tongji Medical College, Hua Zhong University of Science and Technology, Wu Han, 430022, People s Republic of China
Brain Res 1129:110-5. 2007
..The perfusion of ACh will drive the opening of calcium channels; the influx of calcium ions will then activate the BK current...
- [Intrinsic membrane properties of rat medial vestibular nucleus neurons and their responses to simulated vestibular input signals]
Jiao Xia
Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 43:767-72. 2008
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- [Comparation between modified coblation assisted uvulopalatopharyngoplasty and conventional uvulopalatopharyngoplasty in operative complication]
Xiong Chen
Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 47:101-6. 2012
..And to explore the more effective, safer and minimally invasive operative method in surgical therapy of OSAHS...
- High dose combination pertussis toxin induces autoimmune inner ear disease in Sprague-Dawley rats
Wei Jia Kong
Department of Otolaryngology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Acta Otolaryngol 131:692-700. 2011
..This study also indicated that inner ear-specific antigens can be involved in autoimmune reactions. Cell-mediated immune injury can play an important role in the induction of AIED, at least in the earlier stage...
- [Timed balance test and static posturography in the patients with unilateral vestibular hypofunction]
Bo Liu
Department of Otorhinolaryngology, Union Hospital, Tongii Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 42:165-8. 2007
..To investigate the balance function of the patients with unilateral vestibular hypofunction (UVH) by timed balance tests and static posturography (SPG)...
- [Electrophysiological findings for 106 cases with auditory neuropathy]
Ji Bao Wang
Department of Otorhinolaryngology, Union Hospital, Huazhong University of Science and Technology, Wuhan 430022, China
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 43:347-50. 2008
..To analyses the clinical characteristics and electrophysiological finding of 106 patients with auditory neuropathy (AN). Investigate the differential curve type of pure tone audiogram and the abnormal ABR...
- [Twenty four cases of cholesterol granuloma of the paranasal sinuses]
Li Xin Zhu
Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 40:517-20. 2005
..To investigate the etiology and pathogenesis of cholesterol granuloma of the paranasal sinuses and the treatment for the disease...
- Integrated profile to assess auditory nerve-auditory pathway integrity
Wei Jia Kong
Department of Otorhinolaryngology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
ORL J Otorhinolaryngol Relat Spec 71:196-208. 2009
..To evaluate the Integrated Cochlear Profile for Assessing Auditory Nerve-Auditory Pathway Integrity (ICP-API), as proposed by our group, in the selection of cochlear implant candidates...
- Trans-superior meatus endoscopic surgery of sphenoidal sinus and sellar area: a surgical technique for lesion of sellar area
Jian Xin Yue
Department of Otolaryngology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Hubei, China
Acta Otolaryngol 128:1233-7. 2008
..A trans-superior meatus endoscopic approach to treat diseases in the sphenoid sinus and sellar area is a safe, minimally traumatic, and effective method...
- [Revision of submucous resection of nasal septum]
Hong Jun Xiao
Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 41:184-6. 2006
..To explore the clinical significance and surgical technique for revisionary submucous resection of nasal septum...
- Comparison of three methods for isolation of nucleic acids from membranate inner ear tissue of rats
Wei Jia Kong
Department of Otorhinolaryngology, Union Hospital of Tongji Medicial College, Huazhong University of Science and Technology, Wuhan 430022, China
Chin Med J (Engl) 119:986-90. 2006
..Mitochondrial DNA mutations have been found in sensorineural deafness. The aim of this study was to compare three methods for extraction of nucleic acid from membranate inner ear tissue of rats...
- [Evaluation of the vestibular ocular reflex in patients with unilateral peripheral vestibular disorder by the head impulse test]
Bo Liu
Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 46:40-3. 2011
..To evaluate the function of vestibular ocular reflex (VOR) in patients with unilateral peripheral vestibular disorder (uPVD) by the head impulse test (HIT)...
- [Effect of early allergen immunization on the development of allergic rhinitis in mouse]
Yue Zhou
Department of Otorhinolaryngology, Union Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, China
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 45:52-5. 2010
..To investigate the effect of early allergen exposure on later development of allergic rhinitis in mouse...
