Receptive properties of mouse sensory neurons innervating hairy skinM Koltzenburg
Department of Neurology, University of Wurzburg, D 97080 Wurzburg, Germany
J Neurophysiol 78:1841-50. 1997
..This preparation has great potential for the study of transgenic mice with targeted mutations of genes that code factors that are involved in the specification of sensory neuron phenotypes...
- The low-affinity neurotrophin receptor p75 regulates the function but not the selective survival of specific subpopulations of sensory neurons
C L Stucky
Department of Neurology, University of Wurzburg, D 97080 Wurzburg, Germany
J Neurosci 17:4398-405. 1997
..Furthermore, the presence of p75 is required for normal mechanotransduction in C fibers and D-hair receptors and normal heat sensitivity in A-fiber nociceptors...
- Nerve growth factor evokes hyperalgesia in mice lacking the low-affinity neurotrophin receptor p75
I Bergmann
Department of Neurology, University of Wurzburg, Germany
Neurosci Lett 255:87-90. 1998
..This means that NGF-induced hyperalgesia can occur in the absence of the p75 receptor and suggests that the trkA receptor is sufficient to mediate the acute noxious action of NGF...
- Postnatal loss of Merkel cells, but not of slowly adapting mechanoreceptors in mice lacking the neurotrophin receptor p75
I Kinkelin
Department of Neurology, University of Wurzburg, Josef Schneider Str 11, D 97080 Wurzburg, Germany
Eur J Neurosci 11:3963-9. 1999
..We conclude that Merkel cells require p75 during the late postnatal development. However, neither the survival nor the mechanical sensitivity of slowly adapting mechanoreceptive Abeta-fibres depends on the presence of Merkel cells...
- Neutralization of endogenous NGF prevents the sensitization of nociceptors supplying inflamed skin
M Koltzenburg
Department of Neurology, University of Wurzburg, Germany
Eur J Neurosci 11:1698-704. 1999
..We therefore conclude that NGF is a crucial component for the sensitization of primary afferent nociceptors associated with tissue inflammation...
- Overexpression of nerve growth factor in skin selectively affects the survival and functional properties of nociceptors
C L Stucky
Department of Neurology, University of Wurzburg, D 97080 Wurzburg, Germany
J Neurosci 19:8509-16. 1999
..NGF also affects the response to noxious heat or mechanical stimuli in each group differently, implying specific regulations of transduction processes rather than general changes of excitability...
- Neurotrophin 4 is required for the survival of a subclass of hair follicle receptors
C L Stucky
Department of Neurology, University of Wurzburg, D 97080 Wurzburg, Germany
J Neurosci 18:7040-6. 1998
..Whereas NT4 is required for the survival of D-hair receptors, BDNF supports the mechanical function of SA fibers...
- The changing sensitivity in the life of the nociceptor
M Koltzenburg
Department of Neurology, University of Wurzburg, Germany
Pain . 1999
..Sensory neurons, including nociceptors, start to express adrenoceptors and become responsive for catecholamines and these changes appear to be responsible for the development of sympathetically maintained pain in some patients...
- Neural mechanisms of cutaneous nociceptive pain
M Koltzenburg
Department of Neurology, University of Wurzburg, Germany
Clin J Pain 16:S131-8. 2000
..Knowledge of the various types of hyperalgesia and their underlying mechanisms is required for better treatment of this challenging aspect of chronic pain...
- Painful neuropathies
M Koltzenburg
Department of Neurology, University of Wurzburg, Germany
Curr Opin Neurol 11:515-21. 1998
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- Analysis of cutaneous sensory neurons in transgenic mice lacking the low affinity neurotrophin receptor p75
I Bergmann
Department of Neurology, University of Wurzburg, Germany
Eur J Neurosci 9:18-28. 1997
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