Tobias R Kollmann

Summary

Publications

  1. pmc Ontogeny of Toll-like receptor mediated cytokine responses of human blood mononuclear cells
    Nathan P Corbett
    Division of Infectious and Immunological Diseases, Department of Pediatrics, University of British Columbia, Vancouver, Canada
    PLoS ONE 5:e15041. 2010
  2. pmc Ontogeny of Toll-like receptor mediated cytokine responses of South African infants throughout the first year of life
    Brian A Reikie
    Division of Infectious and Immunological Diseases, Department of Pediatrics, Centre for Understanding and Preventing Infections in Children, University of British Columbia, Vancouver, British Colombia, Canada
    PLoS ONE 7:e44763. 2012
  3. pmc Age-dependent differences in systemic and cell-autonomous immunity to L. monocytogenes
    Ashley M Sherrid
    Division of Infectious and Immunological Diseases, Department of Pediatrics, University of British Columbia, CFRI Rm A5 147, 938 West 28th Avenue, Vancouver, BC, Canada V5Z 4H4
    Clin Dev Immunol 2013:917198. 2013
  4. pmc Variation between Populations in the Innate Immune Response to Vaccine Adjuvants
    Tobias R Kollmann
    Division of Infectious and Immunological Diseases, Department of Paediatrics, University of British Columbia Vancouver, BC, Canada
    Front Immunol 4:81. 2013
  5. pmc Innate immune function by Toll-like receptors: distinct responses in newborns and the elderly
    Tobias R Kollmann
    Division of Infectious and Immunological Diseases, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada
    Immunity 37:771-83. 2012
  6. doi request reprint Neonatal innate TLR-mediated responses are distinct from those of adults
    Tobias R Kollmann
    Division of Infectious and Immunological Diseases, Department of Pediatrics, University of British Columbia, CFRI, 950 West 28th Avenue, Vancouver, BC, V5Z4H4, Canada
    J Immunol 183:7150-60. 2009
  7. doi request reprint Neonatal immunization with Listeria monocytogenes induces T cells with an adult-like avidity, sensitivity, and TCR-Vbeta repertoire, and does not adversely impact the response to boosting
    Kinga K Smolen
    Department of Experimental Medicine, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Vaccine 28:235-42. 2009
  8. pmc Antibody responses to vaccination among South African HIV-exposed and unexposed uninfected infants during the first 2 years of life
    Brian A Reikie
    Division of Infectious and Immunological Diseases and Centre for Understanding and Preventing Infections in Children, Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada
    Clin Vaccine Immunol 20:33-8. 2013
  9. doi request reprint A single immunization near birth elicits immediate and lifelong protective immunity
    Brian A Reikie
    Department of Medicine, University of British Columbia, Vancouver, British Columbia, V5Z 1M9, Canada
    Vaccine 29:83-90. 2010
  10. pmc Pattern recognition receptor-mediated cytokine response in infants across 4 continents
    Kinga K Smolen
    Department of Experimental Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    J Allergy Clin Immunol 133:818-26.e4. 2014

Collaborators

Detail Information

Publications21

  1. pmc Ontogeny of Toll-like receptor mediated cytokine responses of human blood mononuclear cells
    Nathan P Corbett
    Division of Infectious and Immunological Diseases, Department of Pediatrics, University of British Columbia, Vancouver, Canada
    PLoS ONE 5:e15041. 2010
    ....
  2. pmc Ontogeny of Toll-like receptor mediated cytokine responses of South African infants throughout the first year of life
    Brian A Reikie
    Division of Infectious and Immunological Diseases, Department of Pediatrics, Centre for Understanding and Preventing Infections in Children, University of British Columbia, Vancouver, British Colombia, Canada
    PLoS ONE 7:e44763. 2012
    ..This is the first report depicting dramatic differences in innate immune ontogeny between different populations in the world, with important implications for global vaccination strategies...
  3. pmc Age-dependent differences in systemic and cell-autonomous immunity to L. monocytogenes
    Ashley M Sherrid
    Division of Infectious and Immunological Diseases, Department of Pediatrics, University of British Columbia, CFRI Rm A5 147, 938 West 28th Avenue, Vancouver, BC, Canada V5Z 4H4
    Clin Dev Immunol 2013:917198. 2013
    ..monocytogenes. We here review what is known about age-dependent differences in systemic innate and adaptive as well as cell-autonomous immunity to infection with Listeria monocytogenes...
  4. pmc Variation between Populations in the Innate Immune Response to Vaccine Adjuvants
    Tobias R Kollmann
    Division of Infectious and Immunological Diseases, Department of Paediatrics, University of British Columbia Vancouver, BC, Canada
    Front Immunol 4:81. 2013
    ..This review summarizes what is currently known about differences between populations around the world in the innate immune response to existing as well as new and promising vaccine adjuvants...
  5. pmc Innate immune function by Toll-like receptors: distinct responses in newborns and the elderly
    Tobias R Kollmann
    Division of Infectious and Immunological Diseases, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada
    Immunity 37:771-83. 2012
    ..The near-mirror-image patterns that emerge in contrasts of early versus late innate immune ontogeny emphasize changes in host-environment interactions as the underlying molecular and teleologic drivers...
  6. doi request reprint Neonatal innate TLR-mediated responses are distinct from those of adults
    Tobias R Kollmann
    Division of Infectious and Immunological Diseases, Department of Pediatrics, University of British Columbia, CFRI, 950 West 28th Avenue, Vancouver, BC, V5Z4H4, Canada
    J Immunol 183:7150-60. 2009
    ....
  7. doi request reprint Neonatal immunization with Listeria monocytogenes induces T cells with an adult-like avidity, sensitivity, and TCR-Vbeta repertoire, and does not adversely impact the response to boosting
    Kinga K Smolen
    Department of Experimental Medicine, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Vaccine 28:235-42. 2009
    ..Overall, our data provide further evidence in support of immunization at birth as a feasible public health strategy to combat early life infections...
  8. pmc Antibody responses to vaccination among South African HIV-exposed and unexposed uninfected infants during the first 2 years of life
    Brian A Reikie
    Division of Infectious and Immunological Diseases and Centre for Understanding and Preventing Infections in Children, Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada
    Clin Vaccine Immunol 20:33-8. 2013
    ..However, our data also suggest that a large fraction of both HEU and HUU South African infants have antibody titers for several infectious threats that remain below the level of protection for much of their first 2 years of life...
  9. doi request reprint A single immunization near birth elicits immediate and lifelong protective immunity
    Brian A Reikie
    Department of Medicine, University of British Columbia, Vancouver, British Columbia, V5Z 1M9, Canada
    Vaccine 29:83-90. 2010
    ..This is the first direct evidence that vaccination--even in the absence of a booster dose--is capable of inducing immediate and lifelong protective immune memory regardless of age at the time of initial vaccination...
  10. pmc Pattern recognition receptor-mediated cytokine response in infants across 4 continents
    Kinga K Smolen
    Department of Experimental Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    J Allergy Clin Immunol 133:818-26.e4. 2014
    ..Because innate immunity instructs adaptive immunity, we hypothesized that differences between populations in innate immune responses may represent a mechanistic link to variation in susceptibility to infection or response to vaccination...
  11. pmc Variables to be controlled in the assessment of blood innate immune responses to Toll-like receptor stimulation
    Darren Blimkie
    Division of Infectious and Immunological Diseases, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada
    J Immunol Methods 366:89-99. 2011
    ..In summary, for innate immune analysis scrupulous adherence to standard operating procedures is paramount...
  12. pmc Elevated inflammatory mediators in adults with oculorespiratory syndrome following influenza immunization: a public health agency of Canada/Canadian Institutes of Health Research Influenza Research Network Study
    Mona Al-Dabbagh
    Vaccine Evaluation Center, BC Children s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    Clin Vaccine Immunol 20:1108-14. 2013
    ..Further investigations are warranted, as they might identify subjects who are at risk for ORS prior to vaccination. ..
  13. pmc Identification of B cells through negative gating-An example of the MIFlowCyt standard applied
    Darren Blimkie
    Department of Pediatrics, Division of Infectious and Immunological Diseases, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
    Cytometry A 77:546-51. 2010
    ..We demonstrate how a MIFlowCyt-compliant report can be prepared with minimal effort, and yet provide the reader with a much clearer picture of the portrayed FCM experiment and data...
  14. doi request reprint Immunogenicity of 2 doses of HPV vaccine in younger adolescents vs 3 doses in young women: a randomized clinical trial
    Simon R M Dobson
    Department of Pediatrics, University of British Columbia, Vancouver, Canada
    JAMA 309:1793-802. 2013
    ..Global use of human papillomavirus (HPV) vaccines to prevent cervical cancer is impeded by cost. A 2-dose schedule for girls may be possible...
  15. doi request reprint Age of recipient and number of doses differentially impact human B and T cell immune memory responses to HPV vaccination
    Kinga K Smolen
    Experimental Medicine Program, Department of Medicine, University of British Columbia, Vancouver, BC, Canada
    Vaccine 30:3572-9. 2012
    ..Our data indicate that rational design of vaccines has to be tailored according to the desired induction of B and/or T cell memory...
  16. pmc Correlation analysis of intracellular and secreted cytokines via the generalized integrated mean fluorescence intensity
    Parisa Shooshtari
    Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada
    Cytometry A 77:873-80. 2010
    ..We refer to this model as generalized iMFI...
  17. doi request reprint Fine-tuning the safety and immunogenicity of Listeria monocytogenes-based neonatal vaccine platforms
    Daniela I M Loeffler
    Department of Paediatrics, Child and Family Research Institute, Vancouver, BC, Canada
    Vaccine 27:919-27. 2009
    ..Our phagosomal driven Lm-based vaccine platform presents the broadest (cellular & humoral response) and most efficient (highly protective) vaccine platform for neonatal vaccination yet described...
  18. pmc GLA-SE, a synthetic toll-like receptor 4 agonist, enhances T-cell responses to influenza vaccine in older adults
    Hayedeh Behzad
    Vancouver Coastal Health Research Institute, Vancouver, Canada
    J Infect Dis 205:466-73. 2012
    ..The decline in influenza vaccine efficacy in older adults is associated with a limited ability of current split-virus vaccines (SVVs) to stimulate cytotoxic T lymphocyte (CTL) responses required for clinical protection against influenza...
  19. pmc Flow cytometry data standards
    Josef Spidlen
    Terry Fox Laboratory, BC Cancer Agency, Vancouver, BC, Canada
    BMC Res Notes 4:50. 2011
    ..abstract:..
  20. pmc Profound lack of interleukin (IL)-12/IL-23p40 in neonates born early in gestation is associated with an increased risk of sepsis
    Pascal M Lavoie
    Child and Family Research Institute, Vancouver, British Columbia, Canada
    J Infect Dis 202:1754-63. 2010
    ..Infants born prematurely are highly vulnerable to infections and also exhibit a high susceptibility to organ damage due to inflammation...
  21. doi request reprint Systems biology evaluation of immune responses induced by human host defence peptide LL-37 in mononuclear cells
    Neeloffer Mookherjee
    Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, BC, Canada
    Mol Biosyst 5:483-96. 2009
    ..These data are discussed as reflecting the integration of several responsive signalling pathways through the involvement of transcription factor complexes in gene expression activated by LL-37 in human mononuclear cells...