Angela N Koehler

Summary

Publications

  1. pmc Small-molecule microarrays as tools in ligand discovery
    Arturo J Vegas
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
    Chem Soc Rev 37:1385-94. 2008
  2. pmc A complex task? Direct modulation of transcription factors with small molecules
    Angela N Koehler
    Broad Institute of Harvard and MIT, Chemical Biology Program, 7 Cambridge Center, Cambridge, MA 02142, USA
    Curr Opin Chem Biol 14:331-40. 2010
  3. pmc Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles
    Paul A Clemons
    Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 107:18787-92. 2010
  4. ncbi request reprint A method for the covalent capture and screening of diverse small molecules in a microarray format
    James E Bradner
    Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Protoc 1:2344-52. 2006
  5. pmc Identifying the proteins to which small-molecule probes and drugs bind in cells
    Shao En Ong
    Proteomics Platform, The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 106:4617-22. 2009
  6. ncbi request reprint Discovery of an inhibitor of a transcription factor using small molecule microarrays and diversity-oriented synthesis
    Angela N Koehler
    Department of Chemistry and Chemical Biology, Harvard Biophysics Program, Howard Hughes Medical Institute, Harvard Institute of Chemistry and Cell Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA
    J Am Chem Soc 125:8420-1. 2003
  7. pmc Identification of the molecular target of small molecule inhibitors of HDL receptor SR-BI activity
    Thomas J F Nieland
    Department of Biology, Massachusetts Institute of Technology, Room 68 483, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Biochemistry 47:460-72. 2008

Collaborators

  • Shao En Ong
  • Paul A Clemons
  • Thomas J F Nieland
  • Arturo J Vegas
  • James E Bradner
  • Jay L Duffner
  • Jared T Shaw
  • Monty Krieger
  • Tomas Kirchhausen
  • Firoz A Jaipuri
  • Vassilis I Zannis
  • Jason H Fuller
  • Sotirios Banakos
  • Olivia M McPherson

Detail Information

Publications7

  1. pmc Small-molecule microarrays as tools in ligand discovery
    Arturo J Vegas
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
    Chem Soc Rev 37:1385-94. 2008
    ....
  2. pmc A complex task? Direct modulation of transcription factors with small molecules
    Angela N Koehler
    Broad Institute of Harvard and MIT, Chemical Biology Program, 7 Cambridge Center, Cambridge, MA 02142, USA
    Curr Opin Chem Biol 14:331-40. 2010
    ..This review will summarize recent progress in the development of small-molecule probes of transcription factors and provide evidence to challenge the notion that this important protein class is chemically intractable...
  3. pmc Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles
    Paul A Clemons
    Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 107:18787-92. 2010
    ..Because binding proteins selectively can be a key feature of high-value probes and drugs, synthesizing compounds having features identified in this study may result in improved performance of screening collections...
  4. ncbi request reprint A method for the covalent capture and screening of diverse small molecules in a microarray format
    James E Bradner
    Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Protoc 1:2344-52. 2006
    ..With the appropriate materials and experimental setup, the printing of SMMs can be completed in 14 hours over 3 days. Screening and data analysis requires 2 days. A detailed timeline is provided...
  5. pmc Identifying the proteins to which small-molecule probes and drugs bind in cells
    Shao En Ong
    Proteomics Platform, The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 106:4617-22. 2009
    ..Here, we describe in full detail the application of the method to identify targets of kinase inhibitors and immunophilin binders...
  6. ncbi request reprint Discovery of an inhibitor of a transcription factor using small molecule microarrays and diversity-oriented synthesis
    Angela N Koehler
    Department of Chemistry and Chemical Biology, Harvard Biophysics Program, Howard Hughes Medical Institute, Harvard Institute of Chemistry and Cell Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA
    J Am Chem Soc 125:8420-1. 2003
    ..These results demonstrate that a small molecule discovered using the small molecule microarray binding assay can permeate yeast cells and reach its target transcription factor protein in cells...
  7. pmc Identification of the molecular target of small molecule inhibitors of HDL receptor SR-BI activity
    Thomas J F Nieland
    Department of Biology, Massachusetts Institute of Technology, Room 68 483, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Biochemistry 47:460-72. 2008
    ..Consequently, BLTs may help determine the therapeutic potential of SR-BI-targeted pharmaceutical drugs...