Antimonial therapy induces circulating proinflammatory cytokines in patients with cutaneous leishmaniasisAbdurrahim Kocyigit
Department of Biochemistry, University of Harran Medical School, Sanliurfa 63200, Turkey
Infect Immun 70:6589-91. 2002
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Effects of pistachio nuts consumption on plasma lipid profile and oxidative status in healthy volunteersA Kocyigit
Department of Clinical Biochemistry, Medical Faculty, Harran University, Sanliurfa, Turkey
Nutr Metab Cardiovasc Dis 16:202-9. 2006
..Effects of pistachio nuts consumption on plasma lipid profile and oxidative status were investigated in healthy volunteers with normal lipid levels...
- Erythrocyte antioxidative enzyme activities and lipid peroxidation levels in patients with cutaneous leishmaniasis
A Kocyigit
Department of Biochemistry, Medical Faculty, Harran University, 63200 Sanliurfa, Turkey
Parasite 10:277-81. 2003
..However, these changes may not only cause the killing of parasite but also may cause oxidative damage in the other cells or tissues...
- Increased DNA damage and oxidative stress in patients with cutaneous leishmaniasis
Abdurrahim Kocyigit
Harran University, Medical Faculty, Department of Biochemistry, 63200 Sanliurfa, Turkey
Mutat Res 585:71-8. 2005
..However, these intermediates not only cause the killing of the parasite but also induce oxidative damage in non-infected cells. Therefore, these patients must be treated urgently to counteract the oxidative DNA damage...
- Effects of tobacco smoking on plasma selenium, zinc, copper and iron concentrations and related antioxidative enzyme activities
A Kocyigit
Department of Clinical Biochemistry, Faculty of Medicine, Harran University, 63200 Sanliurfa, Turkey
Clin Biochem 34:629-33. 2001
..The aim of the study was to investigate whether alterations in antioxidative enzyme activities are dependent on their cofactor concentrations in tobacco smokers...
- Effects of antimonial therapy on serum zinc, copper and iron concentrations in patients with cutaneous Leishmaniasis in Turkey
A Kocyigit
Department of Biochemistry, Faculty of Harran University, Sanliurfa, Turkey
J Egypt Soc Parasitol 28:133-42. 1998
..322, p < 0.05). The findings showed that CL affects the essential trace element content and these changes began to disappear during antimonial therapy...
- Oxidative stress and antioxidative status of plasma and erythrocytes in patients with vivax malaria
O Erel
Department of Clinical Biochemistry, Faculty of Medicine, Harran University, Sanliurfa Turkey
Clin Biochem 30:631-9. 1997
..To investigate the oxidative stress and antioxidative status of plasma and erythrocytes in patients with vivax malaria and healthy persons...
- DNA damage in metabolic syndrome and its association with antioxidative and oxidative measurements
R Demirbag
Department of Cardiology, Faculty of Medicine, Harran University, Sanliurfa, Turkey
Int J Clin Pract 60:1187-93. 2006
..05, for all). DNA damage is increased in patients with MetS. The increase in DNA damage might be occur because of the increase in the imbalance between the production of oxidants and antioxidant defences in subjects with MetS...
- Alterations in plasma essential trace elements selenium, manganese, zinc, copper, and iron concentrations and the possible role of these elements on oxidative status in patients with childhood asthma
A Kocyigit
Department of Biochemistry, Medical Faculty, Harran University, Sanliurfa, Turkey
Biol Trace Elem Res 97:31-41. 2004
..These observations suggest that increased Fe and decreased Se concentrations in patients with childhood asthma may be responsible for the oxidant/antioxidant imbalance...
- Reactive nitrogen and oxygen intermediates in patients with cutaneous leishmaniasis
O Erel
Department of Clinical Biochemistry, Harran University, Sanliurfa, Turkey
Mem Inst Oswaldo Cruz 94:179-83. 1999
..These alterations in ROI enable nitric oxide (NO) to amplify its leishmanicidal effect. The determination of ROI and RNI in patients with CL may be a useful tool to evaluate effector mechanisms of NO and clinical manifestations...
- Efficacy of cryotherapy and intralesional pentostam in treatment of cutaneous leishmaniasis
M S Gurei
Department of Dermatology, Medical School, Harran University, Sanliurfa, Turkey
J Egypt Soc Parasitol 30:169-76. 2000
..They showed no severe side effects and no significant changes in laboratory values. It is suggested that cryotherapy is an alternative to intralesional pentostam injection...
- Synovial fluid and plasma selenium, copper, zinc, and iron concentrations in patients with rheumatoid arthritis and osteoarthritis
M Yazar
Department of Orthopaedic Surgery, Harran University, Medical Faculty, 63200 Sanliurfa-Turkey
Biol Trace Elem Res 106:123-32. 2005
..These alterations in trace element concentrations in inflammatory RA might be a result of the changes of the immunoregulatory cytokines...
- Oxidative and antioxidative balance in patients of migraine
R Alp
Department of Neurology, Faculty of Medicine, University of Kafkas, Kars, Turkey
Eur Rev Med Pharmacol Sci 14:877-82. 2010
..To the best of our knowledge, this is the first study investigating oxidant and antioxidant status of patients having migraine without aura (MWoA) and comparing them with those of age and sex matched healthy controls (CG)...
- Evaluation of systemic oxidative status and mononuclear leukocytes DNA damage in children with caustic esophageal stricture
M Kaya
Department of Pediatric Surgery, Medical Faculty, Harran University, Sanliurfa, Turkey
Dis Esophagus 19:280-4. 2006
..On the other hand, these results support that patients with ES may benefit from antioxidant treatment...
- Relationship among manganese, arginase, and nitric oxide in childhood asthma
A Kocyigit
Department of Biochemistry, Medical Faculty, Harran University, 63200 Sanliurfa, Turkey
Biol Trace Elem Res 102:11-8. 2004
..These data indicate that the lower concentration of Mn could cause lower arginase activity and this could also upregulate NO production by increasing l-arginine content in patients with childhood asthma...
- The association of circulating leptin level with peripheral DNA damage in hemodialysis subjects
Mehmet Horoz
Harran University School of Medicine, Department of Internal Medicine, Sanliurfa, Turkey
Clin Biochem 39:918-22. 2006
..Thus, in the present study, we aimed at finding out if there is any relationship between serum leptin level and peripheral DNA damage in hemodialysis subjects...
- Is the arginine-nitric oxide pathway involved in the pathogenesis of schizophrenia?
Medaim Yanik
Department of Psychiatry, Faculty of Medicine, University of Harran, Sanliurfa, Turkey
Neuropsychobiology 47:61-5. 2003
..Our results suggest that the arginine-NO pathway is involved in the pathogenesis of schizophrenia...
- No increase in sperm DNA damage and seminal oxidative stress in patients with idiopathic infertility
Fatma Ferda Verit
Department of Obstetrics and Gynecology, Harran University Medical School, Arastirma ve Uygulama Hastanesi, Sanliurfa, 63100, Turkey
Arch Gynecol Obstet 274:339-44. 2006
..We think that the pathophysiology of idiopathic infertility cannot be explained by sperm DNA damage or seminal oxidative stress...
- Lymphocyte DNA damage and oxidative stress in patients with iron deficiency anemia
Mehmet Aslan
Harran University, School of Medicine, Department of Internal Medicine, Sanliurfa, Turkey
Mutat Res 601:144-9. 2006
..The relationships of oxidative stress and DNA damage with the severity of anemia suggest that both oxidative stress and DNA damage may, in part, have a role in the pathogenesis of IDA...
- Associations among plasma selenium, zinc, copper, and iron concentrations and immunoregulatory cytokine levels in patients with cutaneous leishmaniasis
Abdurrahim Kocyigit
Department of Biochemistry, Medical Faculty, Harran University, 63200 Sanliurfa, Turkey
Biol Trace Elem Res 90:47-55. 2002
..These changes may not be a result of a specific deficiency from dietary inadequacies or imbalances, but, probably, a result of a part of the defense strategies of an organism that is regulated by immunoregulatory cytokines...
- Increased DNA damage and oxidative stress in patients with rheumatoid arthritis
Ozlem Altindag
Harran University, Medical Faculty, Research Hospital, Department of Physical Medicine and Rehabilitation, Tr 63100 Sanliurfa, Turkey
Clin Biochem 40:167-71. 2007
..The aim of the study was to investigate the peripheral DNA damage, total antioxidant status (TAS), and total oxidative status (TOS) in patients with RA...
- Relationship between total oxidant status and severity of diabetic nephropathy in type 2 diabetic patients
Mehmet Aslan
Department of Endocrinology, Faculty of Medicine, Harran University, Sanliurfa, Turkey
Nutr Metab Cardiovasc Dis 17:734-40. 2007
..The objective of this study was to investigate possible associations between total oxidant status (TOS) and the severity of diabetic nephropathy in type 2 diabetic patients by using a novel automated measurement method...
- Lymphocyte DNA damage is associated with increased aortic intima-media thickness
Mustafa Gur
Harran University, Faculty of Medicine, Department of Cardiology, Sanliurfa, Turkey
Mutat Res 617:111-8. 2007
..To investigate whether there is an association between lymphocyte DNA damage and aortic intima-media thickness (IMT)...
- Plasma total antioxidant capacity, lipid peroxidation, and erythrocyte antioxidant enzyme activities in patients with rheumatoid arthritis and osteoarthritis
Sezgin Sarban
Department of Orthopaedic Surgery, Harran University, Medical Faculty, 63200 Sanliurfa, Turkey
Clin Biochem 38:981-6. 2005
..The aim of the present study was to investigate the total antioxidant capacity (TAC), levels of lipid peroxidation (LPO), and antioxidant enzyme activities in patients with rheumatoid arthritis (RA) and osteoarthritis (OA)...
- Effect of coronary angiography on oxidative DNA damage observed in circulating lymphocytes
Recep Demirbag
Department of Cardiology, Harran University, Faculty of Medicine, Sanliurfa, Turkey
Angiology 58:141-7. 2007
..Our findings demonstrate that increased oxidative DNA damage in undergoing coronary angiography might be dependent on the severity of coronary artery disease and age, rather than on contrast media and radiation exposure time...
- PON1 activity and total oxidant status in patients with active pulmonary tuberculosis
Sahbettin Selek
Department of Biochemistry, School of Medicine, Harran University, Sanliurfa, Turkey
Clin Biochem 41:140-4. 2008
..The aim of this study was to the investigate effect of tuberculosis infection on paraoxonase-1 (PON1) activity and oxidative status in patients with pulmonary tuberculosis (PTB)...
Phototherapy causes DNA damage in peripheral mononuclear leukocytes in term infantsAli Aycicek
Pediatrics Department, Medical Faculty, Harran University, Sanliurfa, Turkey
J Pediatr (Rio J) 84:141-6. 2008
..Our aim was to determine whether endogenous mononuclear leukocyte DNA strand is a target of phototherapy...
- Phototherapy increases DNA damage in lymphocytes of hyperbilirubinemic neonates
Mustafa Mansur Tatli
Division of Neonatology, Department of Pediatrics, Fatih University School of Medicine, Ankara, Turkey
Mutat Res 654:93-5. 2008
..It remains to be seen whether the genotoxic effect observed in the present study can cause any long-term health effect in phototherapy-treated infants in later life...
- Relationship between levels of DNA damage in lymphocytes and histopathological severity of chronic hepatitis C and various clinical forms of hepatitis B
Cengiz Bolukbas
Department of Internal Medicine, Gastroenterology Division, Harran University, Medical Faculty, Sanliurfa, Turkey
J Gastroenterol Hepatol 21:610-6. 2006
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- Breast milk provides better antioxidant power than does formula
Ali Aycicek
Department of Pediatrics, Children s Hospital at Sanliurfa, Sanliurfa, Turkey
Nutrition 22:616-9. 2006
..We examined the effect of breast milk on plasma total antioxidant capacity (TAC), total peroxide (TP), and oxidative stress index (OSI), which are biomarkers of oxidative status...
- High frequency of maternal vitamin B12 deficiency as an important cause of infantile vitamin B12 deficiency in Sanliurfa province of Turkey
Ahmet Koc
Research Hospital, Dept of Pediatric Hematology, Harran University Faculty of Medicine Research Hospital, 63 100 Sanliurfa, Turkey
Eur J Nutr 45:291-7. 2006
..It is well known that infants born with deficient vitamin B12 storage have increased the risk of vitamin B12 deficiency. Vitamin B12 deficiency is more prevalent in infancy in Sanliurfa province (at the southeast region of Turkey)...
- Intranasal 17beta-estradiol treatment and Vitamin B12, folate and homocysteine in menopause
Muge Harma
Department of Obstetrics and Gynecology, University of Harran, Medical School, Sanliurfa, Turkey
Maturitas 50:353-8. 2005
..This study assessed the effect of intranasal administration of 17beta-estradiol (Aerodiol) on plasma levels of homocysteine, Vitamin B12 and folate in postmenopausal women...
- Increased DNA damage in patients with complete hydatidiform mole
Mehmet Harma
Department of Obstetrics and Gynecology, University of Harran, Medical School, Sanliurfa, Turkey
Mutat Res 583:49-54. 2005
..However, the nature of this link, and whether it is direct or indirect, remains to be explored...
- Lymphocyte DNA damage in patients with acute coronary syndrome and its relationship with severity of acute coronary syndrome
Recep Demirbag
Harran University, Faculty of Medicine, Department of Cardiology, Sanliurfa, Turkey
Mutat Res 578:298-307. 2005
..The aim of this study was to investigate the association between lymphocyte DNA damage and acute coronary syndromes (ACS)...
- Comparison of protein carbonyl and total plasma thiol concentrations in patients with complete hydatidiform mole with those in healthy pregnant women
Mehmet Harma
Department of Obstetrics and Gynecology, University of Harran Medical School, Sanliurfa, Turkey
Acta Obstet Gynecol Scand 83:857-60. 2004
..Normal pregnant women are known to have increased oxidative stress and lipid peroxidation (which can be estimated by protein carbonyl concentration) but offsetting antioxidant protection (of which plasma thiols are an important component)...
- Increased oxidative stress in infants exposed to passive smoking
Ali Aycicek
Paediatrics Department, Children s Hospital of Sanliurfa, Turkey
Eur J Pediatr 164:775-8. 2005
..01). We conclude that passive smoking has a negative impact on numerous parts of the antioxidant defence system in infants, and exposes them to potent oxidative stress...
- Relationship between synovial fluid and plasma manganese, arginase, and nitric oxide in patients with rheumatoid arthritis
Sezgin Sarban
Department of Orthopaedic Surgery, Harran University, Medical Faculty, Sanliurfa, Turkey
Biol Trace Elem Res 115:97-106. 2007
..Our results indicate that the lower concentration of synovial fluid Mn could cause lower arginase activity and this could also upregulate NO production by increasing L-arginine content in patients with RA...
- Serum levels of folate, vitamin B12 and homocysteine in complete hydatidiform mole
Muge Harma
Department of Gynecology and Obstetrics, Faculty of Medicine, University of Harran, Sanliurfa, Turkey
J Reprod Med 49:285-8. 2004
..To investigate the association, if any, between serum concentrations of folate, vitamin B12 and homocysteine in complete hydatiform mole (CHM)...
- Plasma manganese, selenium, zinc, copper, and iron concentrations in patients with schizophrenia
Medaim Yanik
Department of Psychiatry, Faculty of Medicine, University of Harran, Sanliurfa, Turkey
Biol Trace Elem Res 98:109-17. 2004
..However, findings from trace element levels in schizophrenia show a variety of results that are difficult to interpret...
- Increased DNA damage in patients with chronic obstructive pulmonary disease who had once smoked or been exposed to biomass
Erkan Ceylan
Department of Chest Disease, Medical Faculty, Harran University, Sanliurfa, Turkey
Respir Med 100:1270-6. 2006
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- Decreased total antioxidant capacity and increased oxidative stress in passive smoker infants and their mothers
Ali Aycicek
Department of Pediatrics, Children s Hospital at Sanliurfa, Sanliurfa, Turkey
Pediatr Int 47:635-9. 2005
..The purpose of the study was to study the effect of passive cigarette smoking on oxidative and antioxidative status of plasma in passive smoker infants and their mothers and to compare with those of non-smokers...
- Assessment of peripheral DNA damage by alkaline comet assay in maintenance hemodialysis subjects with hepatitis C infection
Mehmet Horoz
Harran University, School of Medicine, Department of Internal Medicine, Sanliurfa, Turkey
Mutat Res 596:137-42. 2006
..However, in hemodialysis subjects, hepatitis C infection does not cause significant additional increase in DNA damage level, and it may be partly due to protective effect of hemodialysis on hepatitis C infection...
- Association of increased total antioxidant capacity and anovulation in nonobese infertile patients with clomiphene citrate-resistant polycystic ovary syndrome
Fatma Ferda Verit
Department of Obstetrics and Gynecology, Faculty of Medicine, Harran University, Sanliurfa, Turkey
Fertil Steril 88:418-24. 2007
..To investigate whether total antioxidant capacity (TAC) could predict the response to ovulation induction to clomiphene citrate (CC) in nonobese women with polycystic ovary syndrome...
- Serum levels of zinc and copper in hydatidiform mole
Mehmet Harma
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Harran, Sanliurfa, Turkey
Arch Gynecol Obstet 271:304-6. 2005
..The aim of this study was to identify any association between serum levels of trace elements zinc and copper and development of hydatidiform mole...
- Relationship between DNA damage, total antioxidant capacity and coronary artery disease
Recep Demirbag
Harran University, Faculty of Medicine, Department of Cardiology, PK 112, 63200 Sanliurfa, Turkey
Mutat Res 570:197-203. 2005
..However, little is known about association of DNA damage with total antioxidant capacity (TAC) and CAD. The aim of this study is to evaluate the relationship between DNA damage, TAC and CAD...
- Essential trace elements selenium, zinc, copper, and iron concentrations and their related acute-phase proteins in patients with vivax malaria
Adnan Seyrek
Department of Microbiology, Medical Faculty, Firat University, Elazig, Turkey
Biol Trace Elem Res 106:107-15. 2005
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