Jeffrey A Knipstein

Summary

Publications

  1. ncbi Polo-like kinase 1 (PLK1) inhibition suppresses cell growth and enhances radiation sensitivity in medulloblastoma cells
    Peter S Harris
    Department of Pediatrics and Children s Hospital Colorado, University of Colorado Denver, Anschutz Medical Campus, Aurora, USA
    BMC Cancer 12:80. 2012
  2. ncbi Histone deacetylase inhibition decreases proliferation and potentiates the effect of ionizing radiation in atypical teratoid/rhabdoid tumor cells
    Jeffrey A Knipstein
    Department of Pediatrics, Section of Pediatric Hematology Oncology BMT, University of Colorado Denver, Aurora, CO, USA
    Neuro Oncol 14:175-83. 2012
  3. ncbi Inhibition of EZH2 suppresses self-renewal and induces radiation sensitivity in atypical rhabdoid teratoid tumor cells
    Irina Alimova
    Department of Pediatrics and Section of Pediatric Hematology Oncology BMT, Children s Hospital Colorado, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado 80045, USA
    Neuro Oncol 15:149-60. 2013
  4. ncbi Targeting Aurora Kinase A enhances radiation sensitivity of atypical teratoid rhabdoid tumor cells
    Sujatha Venkataraman
    Department of Pediatrics, Children s Hospital Colorado, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, USA
    J Neurooncol 107:517-26. 2012
  5. ncbi Diffuse intrinsic pontine tumors: a study of primitive neuroectodermal tumors versus the more common diffuse intrinsic pontine gliomas
    Alexandra Sufit
    Division of Neuro Oncology, Department of Pediatrics, The Children s Hospital of Colorado, University of Colorado, Aurora, Colorado 80045, USA
    J Neurosurg Pediatr 10:81-8. 2012

Collaborators

Detail Information

Publications5

  1. ncbi Polo-like kinase 1 (PLK1) inhibition suppresses cell growth and enhances radiation sensitivity in medulloblastoma cells
    Peter S Harris
    Department of Pediatrics and Children s Hospital Colorado, University of Colorado Denver, Anschutz Medical Campus, Aurora, USA
    BMC Cancer 12:80. 2012
    ..Polo-like kinase 1 (PLK1) is highly expressed in many cancers and regulates critical steps in mitotic progression. Recent studies suggest that targeting PLK1 with small molecule inhibitors is a promising approach to tumor therapy...
  2. ncbi Histone deacetylase inhibition decreases proliferation and potentiates the effect of ionizing radiation in atypical teratoid/rhabdoid tumor cells
    Jeffrey A Knipstein
    Department of Pediatrics, Section of Pediatric Hematology Oncology BMT, University of Colorado Denver, Aurora, CO, USA
    Neuro Oncol 14:175-83. 2012
    ..Our findings suggest that the addition of HDIs to ATRT therapy may prove to be beneficial, especially when administered in combination with current treatment modalities, such as radiation...
  3. ncbi Inhibition of EZH2 suppresses self-renewal and induces radiation sensitivity in atypical rhabdoid teratoid tumor cells
    Irina Alimova
    Department of Pediatrics and Section of Pediatric Hematology Oncology BMT, Children s Hospital Colorado, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado 80045, USA
    Neuro Oncol 15:149-60. 2013
    ..ATRTs are characterized by absence of the chromatin remodeling protein SMARCB1. Given the role of EZH2 in regulating epigenetic changes, we investigated the role of EZH2 in ATRT...
  4. ncbi Targeting Aurora Kinase A enhances radiation sensitivity of atypical teratoid rhabdoid tumor cells
    Sujatha Venkataraman
    Department of Pediatrics, Children s Hospital Colorado, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, USA
    J Neurooncol 107:517-26. 2012
    ..Furthermore, inhibition of Aurora Kinase A resulted in decreased activity of pro-proliferative signaling pathways. These data indicate that inhibition of Aurora Kinase A is a promising small molecule target for ATRT therapy...
  5. ncbi Diffuse intrinsic pontine tumors: a study of primitive neuroectodermal tumors versus the more common diffuse intrinsic pontine gliomas
    Alexandra Sufit
    Division of Neuro Oncology, Department of Pediatrics, The Children s Hospital of Colorado, University of Colorado, Aurora, Colorado 80045, USA
    J Neurosurg Pediatr 10:81-8. 2012
    ..This study presents 2 cases of diffuse pontine PNETs with molecular evidence that these are indeed PNETs, distinct from DIPGs, thus supporting biopsy of diffuse pontine tumors as a standard of care...