Solar ultraviolet-B radiation and vitamin D: a cross-sectional population-based study using data from the 2007 to 2009 Canadian Health Measures SurveyJamie A Greenfield
Office of Biotechnology, Genomics and Population Health, Public Health Agency of Canada, 180 Queen Street West, Toronto, Canada
BMC Public Health 12:660. 2012
..The purpose of this study was to measure the association between ground-level solar UV-B and serum concentrations of 25-hydroxyvitamin D (25(OH)D) using a secondary analysis of the 2007 to 2009 Canadian Health Measures Survey (CHMS)...
- Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the breast cancer association consortium: a combined case-control study
Roger L Milne
Genetic and Molecular Epidemiology Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre CNIO, Madrid, 28029, Spain
Breast Cancer Res 12:R110. 2010
....
Vitamin D association with estradiol and progesterone in young womenJulia A Knight
Prosserman Centre for Health Research, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
Cancer Causes Control 21:479-83. 2010
..We conducted a study to determine whether there is an association between circulating 25-hydroxyvitamin D (25(OH)D) and estradiol and progesterone in young women...
Optical spectroscopy of the breast in premenopausal women reveals tissue variation with changes in age and parityJulia A Knight
Prosserman Centre for Health Research, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5T 3L9, Canada
Med Phys 37:419-26. 2010
..IGF-1 has been linked in particular to premenopausal breast cancer...
- Alcohol intake and cigarette smoking and risk of a contralateral breast cancer: The Women's Environmental Cancer and Radiation Epidemiology Study
Julia A Knight
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
Am J Epidemiol 169:962-8. 2009
..Smoking was not related to asynchronous contralateral breast cancer. In this, the largest study of asynchronous contralateral breast cancer to date, alcohol is a risk factor for the disease, as it is for a first primary breast cancer...
- Family-based association study of IGF1 microsatellites and height, weight, and body mass index
Gordon Fehringer
Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada
J Hum Genet 55:255-8. 2010
..This study does not support an association between IGF1 and these anthropometric measures. Study limitations, including sample size and capturing genetic variation at IGF1 with these markers, could mean associations were missed...
- Family-based genetic association study of insulin-like growth factor I microsatellite markers and premenopausal breast cancer risk
Gordon Fehringer
Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada
Breast Cancer Res Treat 118:415-24. 2009
..14; 5'CA 18-20, P = 0.25; 5'CA >20, P = 0.20). The associations we found could be due to chance as many comparisons were made. Our results do not strongly support an association between these IGF1 variants and breast cancer risk...
- MSH2 118T>C and MSH6 159C>T promoter polymorphisms and the risk of colorectal cancer
Miralem Mrkonjic
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario M5T 3L9, Canada
Carcinogenesis 28:2575-80. 2007
..003 and P = 0.0001, respectively). The MSH2 -118T>C polymorphism was associated with strong family history of CRC in Ontario patients...
- Prospective associations of vitamin D with β-cell function and glycemia: the PROspective Metabolism and ISlet cell Evaluation (PROMISE) cohort study
Sheena Kayaniyil
Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
Diabetes 60:2947-53. 2011
..To examine the prospective associations of baseline vitamin D [25-hydroxyvitamin D; 25(OH)D] with insulin resistance (IR), β-cell function, and glucose homeostasis in subjects at risk for type 2 diabetes...
- Association of 25(OH)D and PTH with metabolic syndrome and its traditional and nontraditional components
Sheena Kayaniyil
Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
J Clin Endocrinol Metab 96:168-75. 2011
..However, evidence to date is limited and inconsistent, and few studies have examined associations with nontraditional MetS components...
- Association of vitamin D related information from a telephone interview with 25-hydroxyvitamin D
Harleen Sahota
Prosserman Centre for Health Research, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 60 Murray Street, Toronto, Ontario, Canada
Cancer Epidemiol Biomarkers Prev 17:232-8. 2008
..0006). The R(2) was 0.29 for the summer model and was 0.21 for the winter model. Overall, there was evidence to suggest that questions designed to assess vitamin D exposure were in fact related to serum 25(OH)D...
- Polymorphisms cMyc-N11S and p27-V109G and breast cancer risk and prognosis
Jane C Figueiredo
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
BMC Cancer 7:99. 2007
..In this study, we focus on a rare non-synonymous polymorphism in cMyc (N11S) and a common polymorphism in p27 (V109G) and determine their role in risk and prognosis using data collected from the Ontario Breast Cancer Family Registry...
- Beliefs about optimal age and screening frequency predict breast screening adherence in a prospective study of female relatives from the Ontario site of the Breast Cancer Family Registry
Paul Ritvo
Research, Prevention and Cancer Control, Cancer Care Ontario, 620 University Ave, Toronto, ON M5G 2L7, Canada
BMC Public Health 12:518. 2012
..Although few studies have linked cognitive variables with adherence to mammography screening in women with family histories of breast and/or ovarian cancer, research studies suggest cognitive phenomena can be powerful adherence predictors...
- Adherence to breast and ovarian cancer screening recommendations for female relatives from the Ontario site of the Breast Cancer Family Registry
Michael A Campitelli
Prevention and Cancer Control, Cancer Care Ontario, Toronto, Canada
Eur J Cancer Prev 20:492-500. 2011
..76-4.05). Although the overall level of adherence among high-risk women is suboptimal in the community, women at a higher familial risk are adhering more often to cancer screening recommendations than women at a lower familial risk...
- Vitamin D from dietary intake and sunlight exposure and the risk of hormone-receptor-defined breast cancer
Kristina M Blackmore
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 60 Murray Street, Box 18, Toronto, Ontario, Canada M5T3L9
Am J Epidemiol 168:915-24. 2008
..51, 1.22) tumors. This study suggests that vitamin D is associated with a reduced risk of breast cancer regardless of ER/PR status of the tumor. Future studies with a larger number of receptor-negative and mixed tumors are required...
- Ultraviolet sunlight exposure during adolescence and adulthood and breast cancer risk: a population-based case-control study among Ontario women
Laura N Anderson
Prevention and Cancer Control, Cancer Care Ontario, Toronto, Canada
Am J Epidemiol 174:293-304. 2011
..This study suggests that factors suggestive of increased cutaneous production of vitamin D are associated with reduced breast cancer risk...
- Combined effect of CCND1 and COMT polymorphisms and increased breast cancer risk
Ummiye V Onay
Fred A, Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
BMC Cancer 8:6. 2008
..Several studies have also shown the relationship between estrogen and cell cycle progression through activation of CCND1 transcription...
- Ovarian cysts and breast cancer: results from the Women's Contraceptive and Reproductive Experiences Study
Julia A Knight
Prosserman Centre for Health Research, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 60 Murray Street, Box 18, Toronto, ON, Canada, M5T 3L9
Breast Cancer Res Treat 109:157-64. 2008
..Additional studies are required to determine the specific cyst type(s) responsible for the observed relationship...
- SNP-SNP interactions in breast cancer susceptibility
Venüs Ummiye Onay
Fred A Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
BMC Cancer 6:114. 2006
..However, polygenic models suggest that multiple commonly occurring low to modestly penetrant SNPs of cancer related genes might have a greater effect on a disease when considered in combination...
- No association between 25-hydroxyvitamin D and mammographic density
Julia A Knight
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 5th Floor, 60 Murray Street, Toronto, Ontario, Canada M5G 1X5
Cancer Epidemiol Biomarkers Prev 15:1988-92. 2006
..Unlike some previous reports, vitamin D does not seem to be related to mammographic density in this cohort...
- Vitamin D and reduced risk of breast cancer: a population-based case-control study
Julia A Knight
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 60 Murray Street, Box 18, Toronto, Ontario, Canada M5T 3L9
Cancer Epidemiol Biomarkers Prev 16:422-9. 2007
..We conducted a population-based case-control study to assess the evidence for a relationship between sources of vitamin D and breast cancer risk...
- Missense polymorphisms in the adenomatous polyposis coli gene and colorectal cancer risk
Sean P Cleary
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
Dis Colon Rectum 51:1467-73; discussion 1473-4. 2008
..Whereas truncating germline mutations of the adenomatous polyposis coli (APC) gene give rise to familial adenomatous polyposis, missense polymorphisms of APC may confer a weaker risk for colorectal cancer...
- Vitamin D and calcium intakes and breast cancer risk in pre- and postmenopausal women
Laura N Anderson
Cancer Care Ontario, Toronto, Canada
Am J Clin Nutr 91:1699-707. 2010
..Some evidence suggests that vitamin D may reduce breast cancer risk. Despite the biological interaction between vitamin D and calcium, few studies have evaluated their joint effects on breast cancer risk...
- Family history of hormonal cancers and colorectal cancer risk: a case-control study conducted in Ontario
Ji Hyun Jang
Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada
Int J Cancer 125:918-25. 2009
..In conclusion, individuals with a first-degree kin with breast cancer may have a modest increased risk for CRC compared to individuals without...
- Association between IGF1 CA microsatellites and mammographic density, anthropometric measures, and circulating IGF-I levels in premenopausal Caucasian women
Gordon Fehringer
Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada
Breast Cancer Res Treat 116:413-23. 2009
..Therefore, we examined the association of IGF1 polymorphisms with circulating IGF-I levels and mammographic density...
- MLH1 -93G>A promoter polymorphism and the risk of microsatellite-unstable colorectal cancer
Stavroula Raptis
Department of Pathology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada M5T 3L9
J Natl Cancer Inst 99:463-74. 2007
..We investigated whether polymorphisms in DNA mismatch repair genes are associated with the risk of colorectal cancer...
- Vitamin D intake is negatively associated with promoter methylation of the Wnt antagonist gene DKK1 in a large group of colorectal cancer patients
James B Rawson
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada
Nutr Cancer 64:919-28. 2012
..001) and a similar trend was observed in Ontario. These results suggest that vitamin D and other dietary/lifestyle factors may alter CRC risk by mediating extracellular Wnt inhibition...
- A cross-sectional study of different patterns of oral contraceptive use among premenopausal women and circulating IGF-1: implications for disease risk
Kristina M Blackmore
Prosserman Center for Health Research, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
BMC Womens Health 11:15. 2011
..Understanding the effects of different patterns of OC use on IGF-1 levels may offer insight into its influence on disease risk in young women...
- ADH3 genotype, alcohol intake and breast cancer risk
Mary Beth Terry
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA, and Prosserman Centre for Health Research, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
Carcinogenesis 27:840-7. 2006
..9, 95 % CI=1.2-7.1; postmenopausal women OR=1.8, 95% CI=0.9-3.8). These population-based data support the hypothesis that fast metabolizers of alcohol have a higher risk of breast cancer risk, from alcohol intake than slow metabolizers...
- Worry is good for breast cancer screening: a study of female relatives from the ontario site of the breast cancer family registry
Li Rita Zhang
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada M5T 3L9
J Cancer Epidemiol 2012:545062. 2012
..Conclusions. Medium levels of cancer worries predicted higher rates of screening mammography and CBE among high-risk women...
- Identification of germline alterations of the mad homology 2 domain of SMAD3 and SMAD4 from the Ontario site of the breast cancer family registry (CFR)
Eric Tram
Fred A, Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Department of Laboratory Medicine and Pathobiology, University of Toronto, 60 Murray St, Toronto, ON M5T 3L9, Canada
Breast Cancer Res 13:R77. 2011
..Thus, it is currently unknown whether germline SMAD3 and SMAD4 mutations are involved in breast cancer predisposition...
- Vitamin D-related genetic variants, interactions with vitamin D exposure, and breast cancer risk among Caucasian women in Ontario
Laura N Anderson
Prevention and Cancer Control, Cancer Care Ontario, Toronto, ON, Canada
Cancer Epidemiol Biomarkers Prev 20:1708-17. 2011
..This study investigated if candidate gene variants in vitamin D pathways are associated with breast cancer risk, or modify the associations between breast cancer and vitamin D exposure...
- Polymorphisms XRCC1-R399Q and XRCC3-T241M and the risk of breast cancer at the Ontario site of the Breast Cancer Family Registry
Jane C Figueiredo
Fred A Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
Cancer Epidemiol Biomarkers Prev 13:583-91. 2004
..Our results suggest that these polymorphisms may influence breast cancer risk by modifying the effect of risk factors such as FH. There is a need for further study into the role of these polymorphisms as effect modifiers...
- An inverse association between ovarian cysts and breast cancer in the breast cancer family registry
Julia A Knight
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
Int J Cancer 118:197-202. 2006
..Further study of ovarian cysts may increase our understanding of hormonal and other mechanisms of breast cancer etiology...
- Influence of young age at diagnosis and family history of breast or ovarian cancer on breast cancer outcomes in a population-based cohort study
Jane C Figueiredo
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 60 Murray Street, Box 18, Toronto, Ontario, Canada, M5T 3L9
Breast Cancer Res Treat 105:69-80. 2007
....
- Promoter methylation of Wnt antagonists DKK1 and SFRP1 is associated with opposing tumor subtypes in two large populations of colorectal cancer patients
James B Rawson
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
Carcinogenesis 32:741-7. 2011
..This is the first large study to identify associations between Wnt antagonist promoter hypermethylation and CRC MSI subtype. These events provide insight into subtype-specific epigenetic mediation of Wnt signaling in CRC...
- Influence of perceived breast cancer risk on screening behaviors of female relatives from the Ontario site of the Breast Cancer Family Registry
Li Rita Zhang
Prevention and Cancer Control, Cancer Care Ontario, 620 University Avenue, Toronto, Ontario M5G 2L7, Canada
Eur J Cancer Prev 20:255-62. 2011
..These findings may inform educational messages for improving risk communication of women at elevated familial breast cancer risk...
- Association between transillumination breast spectroscopy and quantitative mammographic features of the breast
Kristina M Blackmore
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 60 Murray Street, Box 18, Toronto, Ontario, Canada M5T 3L9
Cancer Epidemiol Biomarkers Prev 17:1043-50. 2008
..41 and rt4 = -0.36). Given the association with quantitative mammographic features and tissue changes related to age and menopause, TiBS scores may prove useful as intermediate markers in studies of breast cancer etiology and prevention...
- Light and exercise and melatonin production in women
Julia A Knight
Prosserman Centre for Health Research, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
Am J Epidemiol 162:1114-22. 2005
..It is possible that the protective effect of exercise with respect to breast cancer may operate in part through an effect on melatonin...
- Vitamin D intake from food and supplements among Ontario women based on the US block food frequency questionnaire with and without modification for Canadian food values
Laura N Anderson
Dalla Lana School of Public Health, University of Toronto, Toronto, ON
Can J Public Health 101:318-21. 2010
..To measure and compare dietary vitamin D intake among women in Ontario using a modified Block 1998 (US) food frequency questionnaire (FFQ) before and after modification for Canadian-specific vitamin D food fortification...
- Association of vitamin D with insulin resistance and beta-cell dysfunction in subjects at risk for type 2 diabetes
Sheena Kayaniyil
Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
Diabetes Care 33:1379-81. 2010
..To examine cross-sectional associations of serum vitamin D [25-hydroxyvitamin D, 25(OH)D] concentration with insulin resistance (IR) and beta-cell dysfunction in 712 subjects at risk for type 2 diabetes...
- Comparison of self-reported lifetime sun exposure with two methods of cutaneous microtopography
Lynn Weiler
Department of Public Health Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
Am J Epidemiol 165:222-30. 2007
..10). While the Beagley-Gibson method was associated with more variables than the skin line count method, both methods require further refinement before graded skin replicas can be recommended as a substitute for self-report measures...
- Genetic variants of GPX1 and SOD2 and breast cancer risk at the Ontario site of the Breast Cancer Family Registry
Julia A Knight
Division of Epidemiology and Biostatistics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
Cancer Epidemiol Biomarkers Prev 13:146-9. 2004
..30 for carriers versus noncarriers). There is a significant trend of increasing risk with increasing number of alleles with four GCG repeats (P = 0.03). This variant has not previously been reported to be associated with breast cancer...
- Accuracy of breast screening among women with and without a family history of breast and/or ovarian cancer
Erika Halapy
Division of Preventive Oncology, Cancer Care Ontario, 620 University Avenue, Toronto, Ontario M5G 2L7, Canada
Breast Cancer Res Treat 90:299-305. 2005
..To compare interval cancer rates, sensitivity and specificity of breast cancer screening between women with moderate or strong family history and women without a family history...
- HER-2/neu status and tumor morphology of invasive breast carcinomas in Ashkenazi women with known BRCA1 mutation status in the Ontario Familial Breast Cancer Registry
Louise A Quenneville
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
Cancer 95:2068-75. 2002
....
- Characteristics associated with participation at various stages at the Ontario site of the cooperative family registry for breast cancer studies
Julia A Knight
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
Ann Epidemiol 12:27-33. 2002
..The use of a cancer registry approach is likely more representative of the population than clinic-based recruitment of families for genetic studies...
