Pathological hypersexuality predominantly linked to adjuvant dopamine agonist therapy in Parkinson's disease and multiple system atrophyKevin J Klos
Department of Neurology, Division of Movement Disorders, Mayo Clinic, Rochester, MN 55905, USA
Parkinsonism Relat Disord 11:381-6. 2005
..A systematic literature review of pathological hypersexuality in PD revealed similar medication histories; combining these cases with our series, 26 of 29 patients (90%) were on adjuvant dopamine agonists...
- Brain metal concentrations in chronic liver failure patients with pallidal T1 MRI hyperintensity
K J Klos
Department of Neurology, Mayo Clinic, Rochester, MN, USA
Neurology 67:1984-9. 2006
..Manganese accumulation may be responsible for the imaging and clinical findings...
- Neuropsychological profiles of manganese neurotoxicity
K J Klos
Department of Neurology, Mayo Clinic, Rochester, MN, USA
Eur J Neurol 13:1139-41. 2006
..Across all three groups, the neuropsychological profiles suggest frontal and subcortical cognitive impairment, with more widespread abnormalities occurring in the non-welding groups...
- Neurologic manifestations in welders with pallidal MRI T1 hyperintensity
K A Josephs
Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
Neurology 64:2033-9. 2005
..Increased T1 MRI signal in the basal ganglia is a biologic marker of manganese accumulation. Recent studies have associated welding and parkinsonism, but generally without MRI corroboration...
- Alpha-synuclein pathology in the spinal cords of neurologically asymptomatic aged individuals
K J Klos
Department of Neurology, Mayo Clinic, Rochester, MN, USA
Neurology 66:1100-2. 2006
..Sparse alpha-synuclein pathology was also detected in the substantia nigra, basal forebrain, amygdala, or cortex in all but two cases...
- Pathological gambling caused by drugs used to treat Parkinson disease
M Leann Dodd
Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905, USA
Arch Neurol 62:1377-81. 2005
..Pathological gambling is a rare potential complication related to treatment of Parkinson disease (PD). However, the etiology of this behavior is poorly understood...
- Unusual compulsive behaviors primarily related to dopamine agonist therapy in Parkinson's disease and multiple system atrophy
Andrew McKeon
Department of Neurology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA
Parkinsonism Relat Disord 13:516-9. 2007
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Cardiac sympathetic denervation correlates with clinical and pathologic stages of Parkinson's diseaseHiroshige Fujishiro
Department of Pathology Neuropathology, Mayo Clinic, Jacksonville, Florida, USA
Mov Disord 23:1085-92. 2008
..42, P < 0.05). This study demonstrates that cardiac sympathetic degeneration and alpha-synuclein pathology is present in presymptomatic phase of PD, and that both increase with disease duration and severity...
- Evidence that incidental Lewy body disease is pre-symptomatic Parkinson's disease
Dennis W Dickson
Neuropathology Laboratory, Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
Acta Neuropathol 115:437-44. 2008
..The findings suggest that iLBD is preclinical PD and that the lack of symptoms is due to subthreshold pathology...
- Early-onset familial parkinsonism due to POLG mutations
Guido Davidzon
Department of Neurology, Columbia University Medical Center, New York, NY 10032, USA
Ann Neurol 59:859-62. 2006
..INTERPRETATION: POLG mutations can cause early-onset parkinsonism in the absence of progressive external ophthalmoplegia...
- Neurologic spectrum of chronic liver failure and basal ganglia T1 hyperintensity on magnetic resonance imaging: probable manganese neurotoxicity
Kevin J Klos
Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
Arch Neurol 62:1385-90. 2005
..We selected cases on the basis of evidence of brain manganese accumulation, and this may be a crucial component of these syndromes. Further studies are necessary to explore this issue...
- Alpha-synuclein immunohistochemistry in two cases of co-occurring idiopathic Parkinson's disease and motor neuron disease
Kevin J Klos
Department of Neurology, Movement Disorder Division, Mayo Clinic, Rochester, Minnesota, USA
Mov Disord 20:1515-20. 2005
..We compared our two cases to all previously published pathological cases of combined LBD and motor neuron degeneration...
- Incidental Lewy body disease and preclinical Parkinson disease
Anthony DelleDonne
Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA
Arch Neurol 65:1074-80. 2008
..The significance of Lewy bodies detected at autopsy in the brains of clinically normal individuals is uncertain but may represent preclinical Parkinson disease (PD)...
