A M Kleschevnikov

Summary

Publications

  1. pmc Traumatic brain injury enhances neuroinflammation and lesion volume in caveolin deficient mice
    Ingrid R Niesman
    Veterans Affairs San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    J Neuroinflammation 11:39. 2014
  2. pmc Deficits in cognition and synaptic plasticity in a mouse model of Down syndrome ameliorated by GABAB receptor antagonists
    Alexander M Kleschevnikov
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 32:9217-27. 2012
  3. pmc Increased efficiency of the GABAA and GABAB receptor-mediated neurotransmission in the Ts65Dn mouse model of Down syndrome
    Alexander M Kleschevnikov
    Department of Neurosciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Neurobiol Dis 45:683-91. 2012
  4. ncbi request reprint Discoveries in Down syndrome: moving basic science to clinical care
    A M Kleschevnikov
    Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA
    Prog Brain Res 197:199-221. 2012

Collaborators

  • Pavel V Belichenko
  • Ahmad Salehi
  • Ingrid R Niesman
  • Sameh S Ali
  • Jan M Schilling
  • Stan Krajewski
  • Hemal H Patel
  • Lee A Shapiro
  • Jacqueline A Bonds
  • Piyush M Patel
  • Sarah E Kellerhals
  • Brian P Head
  • Weihua Cui
  • David M Roth
  • April Voong

Detail Information

Publications4

  1. pmc Traumatic brain injury enhances neuroinflammation and lesion volume in caveolin deficient mice
    Ingrid R Niesman
    Veterans Affairs San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    J Neuroinflammation 11:39. 2014
    ..Previously we showed that astrocyte and microglial activation is increased in Cav-1 knock-out (KO) mice and that Cav-1 and Cav-3 modulate microglial morphology. We hypothesized that Cavs may regulate cytokine production after TBI...
  2. pmc Deficits in cognition and synaptic plasticity in a mouse model of Down syndrome ameliorated by GABAB receptor antagonists
    Alexander M Kleschevnikov
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 32:9217-27. 2012
    ..The ability to rescue cognitive performance through treatment with selective GABA(B) receptor antagonists motivates studies to further explore the therapeutic potential of these compounds in people with DS...
  3. pmc Increased efficiency of the GABAA and GABAB receptor-mediated neurotransmission in the Ts65Dn mouse model of Down syndrome
    Alexander M Kleschevnikov
    Department of Neurosciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Neurobiol Dis 45:683-91. 2012
    ..Thus, both GABAA and GABAB receptor-mediated synaptic efficiency is increased in the Ts65Dn DG, thus likely contributing to deficient synaptic plasticity and poor learning in DS...
  4. ncbi request reprint Discoveries in Down syndrome: moving basic science to clinical care
    A M Kleschevnikov
    Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA
    Prog Brain Res 197:199-221. 2012
    ..It is hoped that the identification of an increasing number of potential targets for pharmacotherapy of cognitive deficits in DS will add to the momentum for creating and completing clinical trials...