- Identifying differentially regulated subnetworks from phosphoproteomic dataMartin Klammer
Kinaxo Biotechnologies GmbH, Am Klopferspitz 19a, 82152 Martinsried, Germany
BMC Bioinformatics 11:351. 2010..In particular, processing mass spectrometry-based phosphoproteomic data in this manner may expose signal transduction pathways and, in the case of experiments with drug-treated cells, reveal the drug's mode of action...
- Comparison of SILAC and mTRAQ quantification for phosphoproteomics on a quadrupole orbitrap mass spectrometerFelix S Oppermann
Evotec München GmbH, Am Klopferspitz 19a, 82152 Martinsried, Germany
J Proteome Res 12:4089-100. 2013..In conclusion, our results demonstrate a strong analytical performance of the Q Exactive in global phosphoproteomics, and establish mTRAQ quantification as a useful alternative to metabolic isotope labeling. ..
- Phosphosignature predicts dasatinib response in non-small cell lung cancerMartin Klammer
Evotec München GmbH, 82152 Martinsried, Germany
Mol Cell Proteomics 11:651-68. 2012..Furthermore, our results show that identifying predictive phosphorylation signatures from global, quantitative phosphoproteomic data is possible and can open a new path to discovering molecular markers for response prediction...