Uday Kishore

Summary

Publications

  1. ncbi request reprint Biochemical and functional characterization of the interaction between pentraxin 3 and C1q
    Alma J Nauta
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Immunol 33:465-73. 2003
  2. ncbi request reprint Surfactant proteins SP-A and SP-D in human health and disease
    Uday Kishore
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
    Arch Immunol Ther Exp (Warsz) 53:399-417. 2005
  3. ncbi request reprint Complement C1q-target proteins recognition is inhibited by electric moment effectors
    Lubka Roumenina
    Department of Biochemistry, Sofia University, St Kliment Ohridski, 8 Dragan Tsankov St, Sofia 1164, Bulgaria
    J Mol Recognit 20:405-15. 2007
  4. ncbi request reprint Surfactant proteins SP-A and SP-D: structure, function and receptors
    Uday Kishore
    Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK
    Mol Immunol 43:1293-315. 2006
  5. pmc Structural and functional anatomy of the globular domain of complement protein C1q
    Uday Kishore
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
    Immunol Lett 95:113-28. 2004
  6. ncbi request reprint Lung surfactant proteins A and D as pattern recognition proteins
    Patrick Waters
    Department of Clinical Neurology, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, UK
    Adv Exp Med Biol 653:74-97. 2009
  7. doi request reprint Interactions of complement proteins C1q and factor H with lipid A and Escherichia coli: further evidence that factor H regulates the classical complement pathway
    Lee Aun Tan
    Medical Research Council Immunochemistry Unit, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX13QU, UK
    Protein Cell 2:320-32. 2011
  8. doi request reprint Human complement Factor H modulates C1q-mediated phagocytosis of apoptotic cells
    Yu Hoi Kang
    MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK
    Immunobiology 217:455-64. 2012
  9. ncbi request reprint C1q and tumor necrosis factor superfamily: modularity and versatility
    Uday Kishore
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, UK, OX3 9DS
    Trends Immunol 25:551-61. 2004
  10. ncbi request reprint A potential anti-coagulant role of complement factor H
    Janez Ferluga
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK Centre for Infection, Immunity and Disease Mechanisms, Biosciences, Heinz Wolff Building, Brunel University, London UB8 3PH, UK
    Mol Immunol 59:188-93. 2014

Collaborators

  • Britta C Urban
  • Taruna Madan
  • Wei Zhang
  • Anne Jäkel
  • Angela Vincent
  • Samson M Kinyanjui
  • Alok Agrawal
  • Uma Singh
  • Nick Willcox
  • David Beeson
  • Sue Kyes
  • Gerard J Arlaud
  • Mihaela Gadjeva
  • Alberto Mantovani
  • M R Daha
  • Jinhua Lu
  • A Roos
  • Alma J Nauta
  • Lubka T Roumenina
  • Robert B Sim
  • Mihaela S Kojouharova
  • Kenneth B M Reid
  • Lee Aun Tan
  • Patrick Waters
  • Janez Ferluga
  • Yu Hoi Kang
  • Alexander Kaplun
  • Ivanka Tsacheva
  • Lubka Roumenina
  • Damien V Cordery
  • Neli Olova
  • Alexandra S Zlatarova
  • Martin Kolev
  • Rohit Ghai
  • Ian Spreadbury
  • Boris P Atanasov
  • Ivanka G Tsacheva
  • Magdalena I Tchorbadjieva
  • Annette K Shrive
  • Mamta Singh
  • Andrew C Yang
  • Francis C J Sim
  • Bingbin Yu
  • Mudit Vaid
  • Krustyo T Popov
  • Shweta Rabheru
  • Roshni Thakrar
  • Mihaela Kojouharova
  • Svetlana V Bureeva
  • Kevin Marsh
  • Thomas N Williams
  • Mohammed J Shafi
  • Katherine R Watkins
  • Boris Atanasov
  • Robert Sim
  • Svetlana Bureeva
  • Michael Popov
  • Julian E Andia-Pravdivy
  • David Karlinsky
  • Trenka Argirova
  • Alexander Kantardjiev
  • Maria Radanova
  • Nadezhda Todorova
  • Alexandra Zlatarova
  • Ivan Dobrev
  • Jens Chr Jensenius
  • Marieta Rouseva
  • Barbara Bottazzi
  • Marieta M Ruseva
  • Alexandar A Kantardjiev
  • Liubka T Roumenina
  • Aleksandra Zlatarova
  • Peter Strong
  • Pierre J Rizkallah
  • Trevor J Greenhough
  • Shreemanta K Parida
  • P Usha Sarma
  • Ian Burns
  • Hazel A Tharia

Detail Information

Publications29

  1. ncbi request reprint Biochemical and functional characterization of the interaction between pentraxin 3 and C1q
    Alma J Nauta
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Immunol 33:465-73. 2003
    ..These results indicate that PTX3 can both inhibit and activate the classical complement pathway by binding C1q, depending on the way it is presented. PTX3 may therefore be involved in the regulation of the innate immune response...
  2. ncbi request reprint Surfactant proteins SP-A and SP-D in human health and disease
    Uday Kishore
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
    Arch Immunol Ther Exp (Warsz) 53:399-417. 2005
    ....
  3. ncbi request reprint Complement C1q-target proteins recognition is inhibited by electric moment effectors
    Lubka Roumenina
    Department of Biochemistry, Sofia University, St Kliment Ohridski, 8 Dragan Tsankov St, Sofia 1164, Bulgaria
    J Mol Recognit 20:405-15. 2007
    ..e. the complement activation signal transmission) will be impaired and the cascade initiation disrupted. These results could serve as a starting point for the exploration of a new form of 'electric moment inhibitors/effectors'...
  4. ncbi request reprint Surfactant proteins SP-A and SP-D: structure, function and receptors
    Uday Kishore
    Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK
    Mol Immunol 43:1293-315. 2006
    ..We also try to put in perspective the controversial subject of the candidate receptor molecules for SP-A and SP-D...
  5. pmc Structural and functional anatomy of the globular domain of complement protein C1q
    Uday Kishore
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
    Immunol Lett 95:113-28. 2004
    ..Although the biochemical and structural studies have provided novel insights into the structure-function relationships within the gC1q domain, they have also raised many unexpected issues for debate...
  6. ncbi request reprint Lung surfactant proteins A and D as pattern recognition proteins
    Patrick Waters
    Department of Clinical Neurology, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, UK
    Adv Exp Med Biol 653:74-97. 2009
    ..Recent data have also highlighted their involvement in clearance of apoptotic cells, hypersensitivity and a number of lung diseases...
  7. doi request reprint Interactions of complement proteins C1q and factor H with lipid A and Escherichia coli: further evidence that factor H regulates the classical complement pathway
    Lee Aun Tan
    Medical Research Council Immunochemistry Unit, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX13QU, UK
    Protein Cell 2:320-32. 2011
    ..We suggest that under physiological conditions, factor H may serve as a downregulator of bacterially-driven inflammatory responses, thereby fine-tuning and balancing the inflammatory response in infections with Gram-negative bacteria...
  8. doi request reprint Human complement Factor H modulates C1q-mediated phagocytosis of apoptotic cells
    Yu Hoi Kang
    MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK
    Immunobiology 217:455-64. 2012
    ..We conclude that under physiological conditions, Factor H may be important in controlling the inflammation which might arise from C1q deposition on apoptotic cells...
  9. ncbi request reprint C1q and tumor necrosis factor superfamily: modularity and versatility
    Uday Kishore
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, UK, OX3 9DS
    Trends Immunol 25:551-61. 2004
    ..This review is an attempt to draw structural and functional parallels between the members of the C1q and TNF superfamily...
  10. ncbi request reprint A potential anti-coagulant role of complement factor H
    Janez Ferluga
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK Centre for Infection, Immunity and Disease Mechanisms, Biosciences, Heinz Wolff Building, Brunel University, London UB8 3PH, UK
    Mol Immunol 59:188-93. 2014
    ..Here we examine whether FH could have similar anti-thrombotic properties. In vitro experiments with surface-bound phospholipids and human plasma, in the presence of FH, confirm this hitherto unreported property of FH. ..
  11. ncbi request reprint Use of peptide: HLA class II complexes to study specific T cells in autoimmune myasthenia gravis
    Uday Kishore
    Neurosciences Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, United Kingdom
    Ann N Y Acad Sci 998:339-42. 2003
  12. ncbi request reprint Immunological properties of human decidual macrophages--a possible role in intrauterine immunity
    Uma Singh
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK
    Reproduction 129:631-7. 2005
    ....
  13. doi request reprint Complement activation by phospholipids: the interplay of factor H and C1q
    Lee Aun Tan
    MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, South Parks Rd, Oxford OX13QU, UK
    Protein Cell 1:1033-49. 2010
    ..A factor H homologue, β2-glycoprotein-1, also strongly inhibits C1q binding to cardiolipin. Recombinant globular domains of C1q A, B and C chains bound aPL similarly to native C1q, confirming that C1q binds aPL via its globular heads...
  14. ncbi request reprint Ligands and receptors of lung surfactant proteins SP-A and SP-D
    Anne Jäkel
    Department of Pharmacology, University of Oxford, Oxford, UK
    Front Biosci (Landmark Ed) 18:1129-40. 2013
    ..The aim of this review is to provide an overview of the current knowledge of ligands and receptors that are known to interact with SP-A and SP-D...
  15. ncbi request reprint Recent progress in the understanding of the structure-function relationships of the globular head regions of C1q
    Uday Kishore
    Department of Biochemistry, and Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, United Kingdom
    Immunobiology 205:355-64. 2002
    ..The recognition of a C1q/TNF superfamily, which has wide-ranging functions, highlights the possibility that the globular regions of C1q may fulfill more binding functions than previously envisaged...
  16. ncbi request reprint Inhibition of acetylcholine receptor function by seronegative myasthenia gravis non-IgG factor correlates with desensitisation
    Ian Spreadbury
    Neurosciences Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom
    J Neuroimmunol 162:149-56. 2005
    ..The results suggest that, rather than acting indirectly as previously proposed, the SNMG factor may bind directly to an allosteric site that induces or enhances AChR desensitisation...
  17. pmc Characterization of a Plasmodium falciparum macrophage-migration inhibitory factor homologue
    Damien V Cordery
    Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, UK
    J Infect Dis 195:905-12. 2007
    ..The identification of a parasite homologue of MIF raised the question of whether it affects monocyte function in a manner similar to its human counterpart...
  18. ncbi request reprint Collectins and ficolins: sugar pattern recognition molecules of the mammalian innate immune system
    Jinhua Lu
    National University Medical Institutes, Blk MD11, 10 Medical Drive, 117597, Singapore, Singapore
    Biochim Biophys Acta 1572:387-400. 2002
    ....
  19. ncbi request reprint High-resolution structural insights into ligand binding and immune cell recognition by human lung surfactant protein D
    Annette K Shrive
    School of Life Sciences, Keele University, Staffordshire ST5 5BG, Keele, UK
    J Mol Biol 331:509-23. 2003
    ....
  20. ncbi request reprint Susceptibility of mice genetically deficient in the surfactant protein (SP)-A or SP-D gene to pulmonary hypersensitivity induced by antigens and allergens of Aspergillus fumigatus
    Taruna Madan
    Institute of Genomics and Integrative Biology, Council for Scientific and Industrial Research, Delhi, India
    J Immunol 174:6943-54. 2005
    ..These data reaffirm an important role for SP-A and SP-D in offering resistance to pulmonary allergenic challenge...
  21. ncbi request reprint Protective effects of a recombinant fragment of human surfactant protein D in a murine model of pulmonary hypersensitivity induced by dust mite allergens
    Mamta Singh
    Institute for Genomics and Integrative Biology, Council for Scientific and Industrial Research, Mall Road, Delhi 110007, India
    Immunol Lett 86:299-307. 2003
    ....
  22. ncbi request reprint Interaction of the globular domain of human C1q with Salmonella typhimurium lipopolysaccharide
    Lubka T Roumenina
    Department of Biochemistry, Sofia University, St Kliment Ohridski, 8 Dragan Tsankov St, Sofia 1164, Bulgaria
    Biochim Biophys Acta 1784:1271-6. 2008
    ..LPS and IgG-binding sites on the gC1q domain appear to be overlapping and this interaction can be inhibited by a synthetic C1q inhibitor, suggesting common interacting mechanisms...
  23. ncbi request reprint Detection of autoantibodies against the globular domain of human C1q in the sera of systemic lupus erythematosus patients
    Ivanka Tsacheva
    Department of Biochemistry, Faculty of Biology, Sofia University, 8 Dragan Tsankov Str, 1164 Sofia, Bulgaria
    Mol Immunol 44:2147-51. 2007
    ..Such antibodies can have severe pathophysiological consequences since these are likely to further impair the ability of C1q to clear immune complexes...
  24. ncbi request reprint Existence of different but overlapping IgG- and IgM-binding sites on the globular domain of human C1q
    Alexandra S Zlatarova
    Department of Biochemistry, Sofia University, St Kliment Ohridski, 8 Dragan Tzankov Strasse, Sofia 1164, Bulgaria
    Biochemistry 45:9979-88. 2006
    ..Given the location of Arg(B108), Arg (B109), and Tyr(B175) in the gC1q crystal structure, it is likely that C1q interacts with IgM via the top of the gC1q domain...
  25. pmc Interaction of C1q with IgG1, C-reactive protein and pentraxin 3: mutational studies using recombinant globular head modules of human C1q A, B, and C chains
    Lubka T Roumenina
    Department of Biochemistry, Sofia University, St Kliment Ohridski, 8 Dragan Tsankov Street, Sofia 1164, Bulgaria
    Biochemistry 45:4093-104. 2006
    ..Thus, a recently proposed model suggesting the rotation of the gC1q domain upon ligand recognition may be extended to C1q interaction with CRP and PTX3 in addition to IgG1...
  26. ncbi request reprint Modular organization of the carboxyl-terminal, globular head region of human C1q A, B, and C chains
    Uday Kishore
    Medical Research Council Immunochemistry Unit, Department of Biochemistry, University of Oxford, Oxford, United Kingdom
    J Immunol 171:812-20. 2003
    ..The heterotrimeric organization thus offers functional flexibility and versatility to the whole C1q molecule...
  27. ncbi request reprint Role of Ca2+ in the electrostatic stability and the functional activity of the globular domain of human C1q
    Lubka T Roumenina
    Department of Biochemistry, Sofia University, St Kliment Ohridski, 8 Dragan Tsankov Street, Sofia 1164, Bulgaria
    Biochemistry 44:14097-109. 2005
    ....
  28. ncbi request reprint Localization of ligand-binding sites on human C1q globular head region using recombinant globular head fragments and single-chain antibodies
    Mihaela S Kojouharova
    Department of Biochemistry, Sofia University, St Kliment Ohridski, 8 Dragan Tzankov Str, Sofia 1164, Bulgaria
    Biochim Biophys Acta 1652:64-74. 2003
    ....
  29. ncbi request reprint Mutational analyses of the recombinant globular regions of human C1q A, B, and C chains suggest an essential role for arginine and histidine residues in the C1q-IgG interaction
    Mihaela S Kojouharova
    Department of Biochemistry, Sofia University, St Kliment Ohridski, Sofia, Bulgaria
    J Immunol 172:4351-8. 2004
    ....