Brian Kirkpatrick

Summary

Publications

  1. ncbi Novel factor-based symptom scores in treatment resistant schizophrenia: implications for clinical trials
    Robert P McMahon
    Department of Psychiatry, Maryland Psychiatric Research Center, Spring Grove Hospital Grounds, Maple and Locust Avenues, PO Box 21247, Baltimore, MD 21228, USA
    Neuropsychopharmacology 26:537-45. 2002
  2. ncbi Three dimensions of clinical symptoms in elderly patients with schizophrenia: prediction of six-year cognitive and functional status
    Eran Chemerinski
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Schizophr Res 85:12-9. 2006
  3. pmc Neuropsychology of the deficit syndrome: new data and meta-analysis of findings to date
    Alex S Cohen
    Department of Psychology, University of Maryland, College Park, USA
    Schizophr Bull 33:1201-12. 2007
  4. pmc Progress in the study of negative symptoms
    Brian Kirkpatrick
    To whom correspondence should be addressed Department of Psychiatry and Behavioral Sciences, University of Nevada School of Medicine, 1664 North Virginia Street, Mail Stop 0354, Reno, NV 89557 0354, US tel 775 682 8449, fax 775 784 1428, E mail
    Schizophr Bull 40:S101-6. 2014
  5. ncbi Palate and dentition in schizophrenia
    Brian Kirkpatrick
    Department of Psychiatry and Health Behavior, Medical College of Georgia, FG 2227 1515 Pope Avenue Augusta, GA 30912, United States
    Schizophr Res 91:187-91. 2007
  6. doi Schizoid-like features and season of birth in a nonpatient sample
    Brian Kirkpatrick
    Department of Psychiatry and Health Behavior, Medical College of Georgia, 997 St Sebastian Way, 1515 Pope Av, Augusta, GA, USA
    Schizophr Res 103:151-5. 2008
  7. pmc Subdomains within the negative symptoms of schizophrenia: commentary
    Brian Kirkpatrick
    Department of Psychiatry and Health Behavior, Medical College of Georgia, USA
    Schizophr Bull 32:246-9. 2006
  8. pmc The NIMH-MATRICS consensus statement on negative symptoms
    Brian Kirkpatrick
    Department of Psychiatry and Health Behavior, Medical College of Georgia, USA
    Schizophr Bull 32:214-9. 2006
  9. pmc Differences in glucose tolerance between deficit and nondeficit schizophrenia
    Brian Kirkpatrick
    Department of Psychiatry and Health Behavior, Medical College of Georgia, Augusta, Georgia 30912, USA
    Schizophr Res 107:122-7. 2009
  10. doi Cholesterol and triglycerides in antipsychotic-naive patients with nonaffective psychosis
    Brian Kirkpatrick
    Department of Psychiatry, Texas A and M College of Medicine, Scott and White Healthcare, Temple, TX 76508, United States
    Psychiatry Res 178:559-61. 2010

Research Grants

  1. Diabetes in Neuropsychiatric Disorders
    Brian Kirkpatrick; Fiscal Year: 2005
  2. Diabetes in Neuropsychiatric Disorders
    Brian Kirkpatrick; Fiscal Year: 2006
  3. Diabetes in Neuropsychiatric Disorders
    Brian Kirkpatrick; Fiscal Year: 2007
  4. Diabetes in Neuropsychiatric Disorders
    Brian Kirkpatrick; Fiscal Year: 2009

Detail Information

Publications50

  1. ncbi Novel factor-based symptom scores in treatment resistant schizophrenia: implications for clinical trials
    Robert P McMahon
    Department of Psychiatry, Maryland Psychiatric Research Center, Spring Grove Hospital Grounds, Maple and Locust Avenues, PO Box 21247, Baltimore, MD 21228, USA
    Neuropsychopharmacology 26:537-45. 2002
    ..We recommend these four factor scores as clinical trial outcomes in patients with treatment resistant schizophrenia...
  2. ncbi Three dimensions of clinical symptoms in elderly patients with schizophrenia: prediction of six-year cognitive and functional status
    Eran Chemerinski
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Schizophr Res 85:12-9. 2006
    ..J., Gur, R.C., 1991. Relations among clinical scales in schizophrenia. Am. J. Psychiatry 148, 472-478. Brown, K.W., White, T., 1992. Syndromes of chronic schizophrenia and some clinical correlates. Br. J. Psychiatry 161, pp. 317-322]...
  3. pmc Neuropsychology of the deficit syndrome: new data and meta-analysis of findings to date
    Alex S Cohen
    Department of Psychology, University of Maryland, College Park, USA
    Schizophr Bull 33:1201-12. 2007
    ..The question of whether deficit patients exhibit a unique cognitive impairment profile will require a more sophisticated and rigorous examination of the neuropsychology of the deficit syndrome...
  4. pmc Progress in the study of negative symptoms
    Brian Kirkpatrick
    To whom correspondence should be addressed Department of Psychiatry and Behavioral Sciences, University of Nevada School of Medicine, 1664 North Virginia Street, Mail Stop 0354, Reno, NV 89557 0354, US tel 775 682 8449, fax 775 784 1428, E mail
    Schizophr Bull 40:S101-6. 2014
    ..This review assesses progress in 3 areas in which he has been an important investigator: the distinction between primary vs secondary negative symptoms; the appropriate design for treatment trials; and the nosology of negative symptoms. ..
  5. ncbi Palate and dentition in schizophrenia
    Brian Kirkpatrick
    Department of Psychiatry and Health Behavior, Medical College of Georgia, FG 2227 1515 Pope Avenue Augusta, GA 30912, United States
    Schizophr Res 91:187-91. 2007
    ..We decided to test the hypothesis that developmental abnormalities are present throughout the body by examining the oral cavity and in particular the teeth and dimensions of the palate of patients with schizophrenia...
  6. doi Schizoid-like features and season of birth in a nonpatient sample
    Brian Kirkpatrick
    Department of Psychiatry and Health Behavior, Medical College of Georgia, 997 St Sebastian Way, 1515 Pope Av, Augusta, GA, USA
    Schizophr Res 103:151-5. 2008
    ....
  7. pmc Subdomains within the negative symptoms of schizophrenia: commentary
    Brian Kirkpatrick
    Department of Psychiatry and Health Behavior, Medical College of Georgia, USA
    Schizophr Bull 32:246-9. 2006
  8. pmc The NIMH-MATRICS consensus statement on negative symptoms
    Brian Kirkpatrick
    Department of Psychiatry and Health Behavior, Medical College of Georgia, USA
    Schizophr Bull 32:214-9. 2006
  9. pmc Differences in glucose tolerance between deficit and nondeficit schizophrenia
    Brian Kirkpatrick
    Department of Psychiatry and Health Behavior, Medical College of Georgia, Augusta, Georgia 30912, USA
    Schizophr Res 107:122-7. 2009
    ..8 [21.9]); the deficit subjects also had significantly higher two-hour glucose concentrations than did the control subjects. These results provide further support that the deficit group has a distinctive etiopathophysiology...
  10. doi Cholesterol and triglycerides in antipsychotic-naive patients with nonaffective psychosis
    Brian Kirkpatrick
    Department of Psychiatry, Texas A and M College of Medicine, Scott and White Healthcare, Temple, TX 76508, United States
    Psychiatry Res 178:559-61. 2010
    ..After accounting for gender, age, smoking, socioeconomic status, and body mass index, there was no significant difference between the two groups in total cholesterol, high-density lipoproteins, low-density lipoproteins, or triglycerides...
  11. ncbi Sexual dimorphism and the NMDA receptor in alloparental behavior in juvenile prairie voles (Microtus ochrogaster)
    Brian Kirkpatrick
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD 21228, USA
    Behav Neurosci 118:584-9. 2004
    ..Both male and female voles exhibit alloparental behavior, but its neurobiological underpinnings are sexually dimorphic in juveniles...
  12. pmc Is schizophrenia a syndrome of accelerated aging?
    Brian Kirkpatrick
    Department of Psychiatry and Health Behavior, Medical College of Georgia, Augusta, GA, USA
    Schizophr Bull 34:1024-32. 2008
    ..We propose methods for testing the hypothesis...
  13. ncbi Interstitial cells of the white matter in the dorsolateral prefrontal cortex in deficit and nondeficit schizophrenia
    Brian Kirkpatrick
    Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland, USA
    J Nerv Ment Dis 191:563-7. 2003
    ..27 (.10),.53 (.39), and.76 (.20) cells per 10-6 cubic microns. These group differences provide further evidence that deficit and nondeficit schizophrenia differ in their pathophysiology...
  14. ncbi Summer birth and deficit schizophrenia in Dumfries and Galloway, southwestern Scotland
    Brian Kirkpatrick
    Maryland Psychiatric Research Center and the Department of Psychiatry, University of Maryland, Baltimore 21228, USA
    Am J Psychiatry 159:1382-7. 2002
    ..This analysis used data from an epidemiological study of incident cases of psychosis to test the hypothesis that deficit schizophrenia is associated with summer birth...
  15. pmc Next-generation negative symptom assessment for clinical trials: validation of the Brief Negative Symptom Scale
    Gregory P Strauss
    University of Maryland School of Medicine, Department of Psychiatry and Maryland Psychiatric Research Center, Baltimore, MD 21228, USA
    Schizophr Res 142:88-92. 2012
    ..Given its brevity (13-items, 15-minute interview) and good psychometric characteristics, the BNSS can be considered a promising new instrument for use in clinical trials...
  16. doi Advanced paternal age and parental history of schizophrenia
    Brian Miller
    Department of Psychiatry and Health Behavior, Medical College of Georgia Health Sciences University, Augusta, Georgia 30912, United States
    Schizophr Res 133:125-32. 2011
    ..The aim of this study was to examine whether later childbearing can be explained by parental schizophrenia, and in doing so, further evaluate the "de novo mutation" hypothesis for the association between APA and NAP...
  17. pmc Meta-analysis of paternal age and schizophrenia risk in male versus female offspring
    Brian Miller
    Department of Psychiatry, Medical College of Georgia, Augusta, GA 30912, USA
    Schizophr Bull 37:1039-47. 2011
    ..Advanced paternal age (APA) is a reported risk factor for schizophrenia in the offspring. We performed a meta-analysis of this association, considering the effect of gender and study design...
  18. pmc Deconstructing negative symptoms of schizophrenia: avolition-apathy and diminished expression clusters predict clinical presentation and functional outcome
    Gregory P Strauss
    Department of Psychiatry, University of Maryland School of Medicine, Maryland Psychiatric Research Center, P O Box 21247, Baltimore, MD 21228, USA
    J Psychiatr Res 47:783-90. 2013
    ..However, it is currently unclear whether negative symptoms themselves are multi-faceted, and whether sub-groups of patients who display unique negative symptom profiles can be identified...
  19. pmc Factor structure of the Brief Negative Symptom Scale
    Gregory P Strauss
    University of Maryland School of Medicine, Department of Psychiatry and Maryland Psychiatric Research Center, Baltimore, MD 21228, USA
    Schizophr Res 142:96-8. 2012
    ..These findings provide further support for the construct validity of the BNSS, and for the existence of these two negative symptom factors...
  20. pmc Differential patterns of premorbid social and academic deterioration in deficit and nondeficit schizophrenia
    Gregory P Strauss
    Department of Psychiatry, University of Maryland School of Medicine, Maryland Psychiatric Research Center, Baltimore, MD 21228, USA
    Schizophr Res 135:134-8. 2012
    ....
  21. ncbi Summer birth and deficit schizophrenia: a pooled analysis from 6 countries
    Erick Messias
    Department of Psychiatry, School of Medicine, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
    Arch Gen Psychiatry 61:985-9. 2004
    ..In some reports, summer birth has been associated with deficit schizophrenia. Deficit schizophrenia and nondeficit schizophrenia also differ in several other ways...
  22. pmc Is abnormal glucose tolerance in antipsychotic-naive patients with nonaffective psychosis confounded by poor health habits?
    Brian Kirkpatrick
    Department of Psychiatry, Texas A and M College of Medicine, Temple, TX, USA
    Schizophr Bull 38:280-4. 2012
    ..However, other factors merit consideration as potential confounders of this association...
  23. doi A multicenter, randomized, double-blind, placebo-controlled, 16-week study of adjunctive aripiprazole for schizophrenia or schizoaffective disorder inadequately treated with quetiapine or risperidone monotherapy
    John M Kane
    Department of Psychiatry, The Zucker Hillside Hospital, Glen Oaks, NY 11004 1150, USA
    J Clin Psychiatry 70:1348-57. 2009
    ..Combining antipsychotics is common practice in the treatment of schizophrenia. This study investigated aripiprazole adjunctive to risperidone or quetiapine for treating schizophrenia and schizoaffective disorder...
  24. pmc Cortical structural abnormalities in deficit versus nondeficit schizophrenia
    Bernard A Fischer
    Veterans Affairs Capital Network VISN 5 Mental Illness Research, Education, and Clinical Center, Baltimore, Maryland, USA
    Schizophr Res 136:51-4. 2012
    ..To examine the structural integrity of the dorsolateral prefrontal-basal ganglia-thalamocortical circuit in people with the deficit form of schizophrenia...
  25. ncbi Summer birth and deficit schizophrenia: Cantabria, Spain
    Brian Kirkpatrick
    Maryland Psychiatric Research Center, University of Maryland, Department of Psychiatry, P O Box 21247, Baltimore 21228, USA
    J Nerv Ment Dis 190:526-32. 2002
    ..The existence of a different risk factor for the two groups suggests a difference in etiology and pathophysiology...
  26. ncbi Olanzapine treatment of residual positive and negative symptoms
    Robert W Buchanan
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland, Baltimore 21228, USA
    Am J Psychiatry 162:124-9. 2005
    ..The authors examined the comparative efficacy and safety of olanzapine and haloperidol in outpatients with partially responsive schizophrenia...
  27. pmc The brief negative symptom scale: psychometric properties
    Brian Kirkpatrick
    Department of Psychiatry, Texas A and M College of Medicine, Temple, TX, USA
    Schizophr Bull 37:300-5. 2011
    ..93 for the BNSS total score and values of 0.89-0.95 for individual subscales. Comparisons with positive symptoms and other negative symptom instruments supported the discriminant and concurrent validity of the instrument...
  28. ncbi Schizophrenia: measurements of psychopathology
    J P Lindenmayer
    Department of Psychiatry, New York University, and Manhattan Psychiatric Center, New York, NY, USA
    Psychiatr Clin North Am 30:339-63. 2007
    ..The instruments discussed cover the broad range of psychopathology found in patients who have schizophrenia...
  29. ncbi Advanced paternal age, mortality, and suicide in the general population
    Brian Miller
    Department of Psychiatry and Health Behavior, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Nerv Ment Dis 198:404-11. 2010
    ..5% for suicides. Parental age at birth may affect suicide and all-causes mortality risk in the offspring in the general population. The causal pathways and specific disorders associated with this increased mortality are largely unknown...
  30. doi Understanding the physiology of schizophrenia
    Brian Kirkpatrick
    Department of Psychiatry and Behavioral Science, Texas A and M College of Medicine, College Station, USA
    J Clin Psychiatry 74:e05. 2013
    ..Clinicians who understand these additional problem areas can incorporate them into their assessment and treatment plans for patients with schizophrenia...
  31. ncbi DISC1 immunoreactivity at the light and ultrastructural level in the human neocortex
    Brian Kirkpatrick
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland 21228, USA
    J Comp Neurol 497:436-50. 2006
    ..These anatomical localization data suggest that DISC1 participates in synaptic activity and microtubule function, and are consistent with the limited data on its adult function...
  32. ncbi Recognizing primary vs secondary negative symptoms and apathy vs expression domains
    Brian Kirkpatrick
    From the Department of Psychiatry and Behavioral Sciences, University of Nevada School of Medicine, Reno
    J Clin Psychiatry 75:e09. 2014
    ..On most rating scales, negative symptoms have been found to load onto 1 of 2 domains-apathy or diminished expression. This distinction may facilitate the development of new treatments. ..
  33. pmc Deficit schizophrenia: association with serum antibodies to cytomegalovirus
    Faith Dickerson
    Stanley Research Center at Sheppard Pratt, 6501 North Charles St, Baltimore, MD 21204, USA
    Schizophr Bull 32:396-400. 2006
    ..Exposure to human herpesviruses is a possible risk factor for schizophrenia. We hypothesized that there would be deficit/nondeficit difference in the prevalence of serum antibodies to human herpesviruses...
  34. doi Developing concepts in negative symptoms: primary vs secondary and apathy vs expression
    Brian Kirkpatrick
    Psychiatry and Behavioral Science, University of Nevada School of Medicine, 1664 N Virginia St, Mail Stop 0354, Reno, NV 89557 0354
    J Clin Psychiatry 75:3-7. 2014
    ..This distinction may facilitate the development of new treatments. ..
  35. pmc Meta-analysis of cytokine alterations in schizophrenia: clinical status and antipsychotic effects
    Brian J Miller
    Department of Psychiatry and Health Behavior, Georgia Health Sciences University, Augusta, Georgia 30912, USA
    Biol Psychiatry 70:663-71. 2011
    ..We performed a meta-analysis of these associations, considering effects of clinical status and antipsychotic treatment following an acute illness exacerbation...
  36. ncbi Ultrastructural localization of reelin in the cortex in post-mortem human brain
    Rosalinda C Roberts
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland 21228, USA
    J Comp Neurol 482:294-308. 2005
    ..The presence of reelin in adult spines, PSD, and terminals suggests that in the adult human reelin has a role in synaptic remodeling, which is consistent with the evidence for its role in long-term potentiation in the adult brain...
  37. ncbi Glucocorticoid hormones and early brain development in schizophrenia
    James I Koenig
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Neuropsychopharmacology 27:309-18. 2002
    ..These clinical and preclinical studies could be used to develop hypotheses that could then be tested in patients with schizophrenia...
  38. pmc Impaired insight in patients with newly diagnosed nonaffective psychotic disorders with and without deficit features
    Hanan D Trotman
    Department of Psychiatry and Health Behavior, Medical College of Georgia, School of Medicine, Augusta, GA, United States
    Schizophr Res 126:252-6. 2011
    ..These results suggest that the treatment of deficit patients may be particularly complicated by poor insight...
  39. ncbi Paternal age and mortality in nonaffective psychosis
    Brian Miller
    Department of Psychiatry and Health Behavior, Medical College of Georgia, Augusta, Georgia 30912, United States
    Schizophr Res 121:218-26. 2010
    ..Advanced paternal age (APA) is associated with an increased mortality in the general population, and is a risk factor for schizophrenia. We aimed to test if APA is associated with increased mortality in people with nonaffective psychosis...
  40. doi Patterns of cranial, brain and sulcal CSF volumes in male and female deficit and nondeficit patients with schizophrenia
    Celso Arango
    Departamento de Psiquiatria, Hospital General Universitario Gregorio Maranon, Unidad de Adolescentes, Dpto de Psiquiatría, C Ibiza 43, Madrid, Spain
    Psychiatry Res 162:91-100. 2008
    ....
  41. pmc Parental history of type 2 diabetes in patients with nonaffective psychosis
    Emilio Fernandez-Egea
    Programa Esquizofrenia Clinic, Servel de Psiquiatria, Institut de Neurociencies, Hospital Clinic, Department de Psiquiatria, Universitat de Barcelona, Barcelona, Spain
    Schizophr Res 98:302-6. 2008
    ..We attempted to replicate two previous studies which found an increased risk of diabetes in the relatives of schizophrenia probands...
  42. ncbi Double dissociation of N1 and P3 abnormalities in deficit and nondeficit schizophrenia
    Armida Mucci
    Department of Psychiatry, University of Naples SUN, Largo Madonna delle Grazie, 80138 Naples, Italy
    Schizophr Res 92:252-61. 2007
    ..The N1 was affected in DS but not in NDS patients, whereas P3 was affected in NDS only. This double dissociation is consistent with the hypothesis that DS represents a separate disease entity within schizophrenia...
  43. ncbi Catechol-O-methyltransferase Val158Met polymorphism in schizophrenia: associations with cognitive and motor impairment
    Silvana Galderisi
    Department of Psychiatry, University of Naples SUN, Naples, Italy
    Neuropsychobiology 52:83-9. 2005
    ..These results support the hypothesis that the COMT Val(158)Met polymorphism influences executive functions in schizophrenia and the neuromotor performance in the deficit subtype only...
  44. doi Psychopathology and neuropsychological impairments in deficit and nondeficit schizophrenia of Chinese origin
    Xiang Wang
    The Medical Psychological Research Center, Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China
    Psychiatry Res 158:195-205. 2008
    ..Furthermore, this study suggested that deficit schizophrenia is associated with frontal and parietal lobe impairment, and that temporal lobe dysfunction may be a common basis for cognitive impairment in schizophrenia as a whole...
  45. ncbi No association between the deficit syndrome in psychosis and summer birth in a Southern hemisphere country
    Joy Welham
    Aust N Z J Psychiatry 40:935-6. 2006
  46. ncbi Season of birth and schizophrenia in Northeast Brazil: relationship to rainfall
    Erick Messias
    School of Medicine, Federal University of Ceara, Fortaleza CE, Brazil
    J Nerv Ment Dis 194:870-3. 2006
    ..03) and 4 months (p = 0.01) later. This study corroborates findings of a significant seasonality in schizophrenia births in northeast Brazil...
  47. ncbi COMT Val(158)Met and BDNF C(270)T polymorphisms in schizophrenia: a case-control study
    Silvana Galderisi
    Department of Psychiatry, University of Naples SUN, Largo Madonna delle Grazie 1, 80138 Naples, Italy
    Schizophr Res 73:27-30. 2005
    ..These results do not support the hypothesis that the COMT Val(158)Met or BDNF C(270)T gene polymorphisms are associated with liability to schizophrenia...
  48. pmc Glucose abnormalities in the siblings of people with schizophrenia
    Emilio Fernandez-Egea
    Hospital Clinic Schizophrenia Program, Department of Psychiatry, Neuroscience Institute, Hospital Clinic, Barcelona, Spain
    Schizophr Res 103:110-3. 2008
    ..Previous studies have also suggested that there is an increased prevalence of diabetes in the relatives of schizophrenia probands...
  49. ncbi The deficit syndrome in schizophrenia: implications for the treatment of negative symptoms
    Celso Arango
    Servicio de Psiquiatria, Hospital General Gregorio Maranon, C Ibiza 43, 280079 Madrid, Spain
    Eur Psychiatry 19:21-6. 2004
    ..The loss of precious human experiences and the association with poor long-term functional outcome justifies a focused and dedicated effort to discover the causes and treatments of this distinctive aspect of schizophrenia...
  50. ncbi Substance abuse and the heterogeneity of schizophrenia a population-based study
    Brian Kirkpatrick
    Schizophr Res 62:293-4. 2003

Research Grants5

  1. Diabetes in Neuropsychiatric Disorders
    Brian Kirkpatrick; Fiscal Year: 2005
    ..These studies will assess whether schizophrenia is associated with impaired glucose tolerance, and whether this abnormality predicts the subsequent risk of impaired fasting glucose with olanzapine administration. ..
  2. Diabetes in Neuropsychiatric Disorders
    Brian Kirkpatrick; Fiscal Year: 2006
    ..These studies will assess whether schizophrenia is associated with impaired glucose tolerance, and whether this abnormality predicts the subsequent risk of impaired fasting glucose with olanzapine administration. ..
  3. Diabetes in Neuropsychiatric Disorders
    Brian Kirkpatrick; Fiscal Year: 2007
    ..These studies will assess whether schizophrenia is associated with impaired glucose tolerance, and whether this abnormality predicts the subsequent risk of impaired fasting glucose with olanzapine administration. ..
  4. Diabetes in Neuropsychiatric Disorders
    Brian Kirkpatrick; Fiscal Year: 2009
    ..These studies will assess whether schizophrenia is associated with impaired glucose tolerance, and whether this abnormality predicts the subsequent risk of impaired fasting glucose with olanzapine administration. ..