Family characteristics of deficit and nondeficit schizophrenia in the Roscommon Family StudyB Kirkpatrick
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland, Baltimore, MD 21228, USA
Schizophr Res 45:57-64. 2000
..The deficit syndrome may be a useful phenotype in genetic linkage studies...
- A separate disease within the syndrome of schizophrenia
B Kirkpatrick
Maryland Psychiatric Research Center, PO Box 21247, Baltimore, MD 21228, USA
Arch Gen Psychiatry 58:165-71. 2001
..We suggest a series of studies designed to falsify one of these hypotheses, ie, multiple diseases vs a single disease...
- Risk factors for the deficit syndrome of schizophrenia
B Kirkpatrick
Maryland Psychiatric Research Center, University of Maryland, Baltimore 21228, USA
Schizophr Bull 26:233-42. 2000
..The deficit/nondeficit differences could not be attributed to confounding by demographic features or the severity of hallucinations, delusions, or formal thought disorder...
- At issue: a default analysis for schizophrenia research
B Kirkpatrick
Maryland Psychiatric Research Center, Baltimore 21228, USA
Schizophr Bull 26:157-61; discussion 163-5. 2000
..The yield of research studies could be increased by the application of a "default" data analysis, in which the differential association--if any--of the three syndromes with the dependent variable(s) of a study is determined...
- Interstitial cells of the white matter in the inferior parietal cortex in schizophrenia: An unbiased cell-counting study
B Kirkpatrick
Maryland Psychiatric Research Center, Dept of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland 21228, USA
Synapse 34:95-102. 1999
....
- Diazepam treatment of early signs of exacerbation in schizophrenia
W T Carpenter
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland, Baltimore 21228, USA
Am J Psychiatry 156:299-303. 1999
..This study examined diazepam efficacy for this phase of treatment...
- Sibling correlation of deficit syndrome in the Irish study of high-density schizophrenia families
D E Ross
Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 0710, USA
Am J Psychiatry 157:1071-6. 2000
..Little is known about the familial or genetic aspects of the deficit syndrome. The purpose of this study was to determine whether deficit versus nondeficit subtypes are correlated in sibling pairs affected with schizophrenia...
- A five-year followup study of deficit and nondeficit schizophrenia
C Tek
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland, Baltimore, MD 21246, USA
Schizophr Res 49:253-60. 2001
..These findings confirm that patients with the deficit schizophrenia have a set of relatively stable clinical features that are associated with poor outcome...
- [The deficit syndrome: a domain of schizophrenia]
C Arango
Maryland Psychiatric Research Center, Medical School, University of Maryland, Baltimore, USA
Actas Luso Esp Neurol Psiquiatr Cienc Afines 26:180-6. 1998
..The data obtained in the recent years and summarized in this review show that negative symptoms broadly defined are less effective for subgrouping schizophrenia and that the deficit syndrome is a different domain within schizophrenia...
- Suspiciousness as a specific risk factor for major depressive episodes in schizophrenia
E Messias
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland, Baltimore, MD, USA
Schizophr Res 47:159-65. 2001
..Interventions that decrease suspiciousness, or mitigate its isolating effects, might decrease the risk of serious depression and suicide...
- Comparative effectiveness of fluphenazine decanoate injections every 2 weeks versus every 6 weeks
W T Carpenter
Maryland Psychiatric Research Center and the Department of Psychiatry, University of Maryland School of Medicine, Baltimore 21228, USA
Am J Psychiatry 156:412-8. 1999
..The authors tested a new dose reduction approach: increasing the interval between injections during intramuscular decanoate antipsychotic treatment...
- Summer birth and deficit schizophrenia in Nithsdale, Scotland
C Tek
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland, Baltimore 21228, USA
J Nerv Ment Dis 189:613-7. 2001
..03). The association with summer birth is consistent with other evidence that patients with deficit schizophrenia have a pathophysiology that differs in some ways from that of other patients with schizophrenia...
- Summer birth and deficit schizophrenia in the epidemiological catchment area study
E Messias
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland, Baltimore 21228, USA
J Nerv Ment Dis 189:608-12. 2001
..These findings add to the evidence suggesting the etiopathophysiology of the deficit group differs from that found in other patients with schizophrenia...
- Limbic system abnormalities identified in schizophrenia using positron emission tomography with fluorodeoxyglucose and neocortical alterations with deficit syndrome
C A Tamminga
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore 21228
Arch Gen Psychiatry 49:522-30. 1992
..These results suggest that the limbic system, especially the hippocampus, is functionally involved in schizophrenic psychosis and that different manifestations of schizophrenia may involve different neuronal circuits...
- Subclinical suspiciousness as a risk factor for depressive episodes
E Messias
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland, Baltimore, Maryland 21228, USA
Acta Psychiatr Scand 103:262-6. 2001
..CONCLUSION: Subclinical suspiciousness appears to increase the risk of depression in the general population. Some other delusion-like experiences may do the same...
- Schizophrenia and season of birth in a tropical region: relationship to rainfall
E L de Messias
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland, Baltimore, MD, USA
Schizophr Res 48:227-34. 2001
..The relationship of birth to rainfall, rather than winter birth, may be associated with risk of schizophrenia in tropical regions; exposure to influenza during gestation may be the basis for such a relationship...
- At issue: stress, hippocampal neuronal turnover, and neuropsychiatric disorders
C Arango
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland, Baltimore, USA
Schizophr Bull 27:477-80. 2001
..New therapeutic possibilities arise if such a process is proven to occur...
