Bernd Kirchhof

Summary

Publications

  1. ncbi request reprint Use of perfluorohexyloctane as a long-term internal tamponade agent in complicated retinal detachment surgery
    Bernd Kirchhof
    University of Aachen, Department of Ophthalmology, Aachen, Germany
    Am J Ophthalmol 133:95-101. 2002
  2. doi request reprint Heavy silicone oil versus standard silicone oil in as vitreous tamponade in inferior PVR (HSO Study): interim analysis
    Antonia M Joussen
    Department of Ophthalmology, Charite, University Medicine, Berlin, Germany
    Acta Ophthalmol 89:e483-9. 2011
  3. ncbi request reprint Autologous translocation of the choroid and retinal pigment epithelium in patients with geographic atrophy
    Antonia M Joussen
    Department of Ophthalmology, University of Duesseldorf, Duesseldorf, Germany
    Ophthalmology 114:551-60. 2007
  4. ncbi request reprint Heavy silicone oil versus standard silicone oil as vitreous tamponade in inferior PVR (HSO Study): design issues and implications
    Antonia M Joussen
    Department of Ophthalmology, University of Dusseldorf, Moorenstrasse 5, Dusseldorf, Germany
    Acta Ophthalmol Scand 85:623-30. 2007
  5. doi request reprint Long-term stability of vascular endothelial growth factor suppression time under ranibizumab treatment in age-related macular degeneration
    Philipp S Muether
    Department of Ophthalmology, University of Cologne, Cologne, Germany
    Am J Ophthalmol 156:989-993.e2. 2013
  6. doi request reprint Relationship between Visual Acuity and Spectral Domain Optical Coherence Tomography Retinal Parameters in Neovascular Age-Related Macular Degeneration
    Tina Ristau
    Cologne Image Reading Center, Department of Ophthalmology, University Hospital of Cologne, Cologne, Germany
    Ophthalmologica 231:37-44. 2014
  7. ncbi request reprint A central role for inflammation in the pathogenesis of diabetic retinopathy
    Antonia M Joussen
    Department of Vitreoretinal Surgery and Angiogenesis Laboratory, Center of Ophthalmology, University of Cologne, Koln, Germany
    FASEB J 18:1450-2. 2004
  8. ncbi request reprint Strategies to influence PVR development
    Bernd Kirchhof
    Department of Vitreo retinal Surgery, Centre of Ophthalmology, University of Cologne, Joseph Stelzmann Strasse 9, 50931 Cologne, Germany
    Graefes Arch Clin Exp Ophthalmol 242:699-703. 2004
  9. ncbi request reprint Suppression of Fas-FasL-induced endothelial cell apoptosis prevents diabetic blood-retinal barrier breakdown in a model of streptozotocin-induced diabetes
    Antonia M Joussen
    Retina Research Institute, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    FASEB J 17:76-8. 2003
  10. ncbi request reprint Is significant relevant? Validity and patient benefit of randomized controlled clinical trials on age-related macular degeneration
    Antonia M Joussen
    Department of Ophthalmology, University of Dusseldorf, Dusseldorf, Germany
    Surv Ophthalmol 52:266-78. 2007

Detail Information

Publications46

  1. ncbi request reprint Use of perfluorohexyloctane as a long-term internal tamponade agent in complicated retinal detachment surgery
    Bernd Kirchhof
    University of Aachen, Department of Ophthalmology, Aachen, Germany
    Am J Ophthalmol 133:95-101. 2002
    ..To report the use of perfluorohexyloctane, a liquid semifluorinated alkane that is heavier than water, as an internal tamponade agent in surgery for complicated retinal detachments...
  2. doi request reprint Heavy silicone oil versus standard silicone oil in as vitreous tamponade in inferior PVR (HSO Study): interim analysis
    Antonia M Joussen
    Department of Ophthalmology, Charite, University Medicine, Berlin, Germany
    Acta Ophthalmol 89:e483-9. 2011
    ..The Heavy Silicone Oil versus Standard Silicone Oil Study (HSO study) is designed to answer the question whether a heavier-than-water tamponade improves the prognosis of eyes with proliferative vitreoretinopathy (PVR) of the lower retina...
  3. ncbi request reprint Autologous translocation of the choroid and retinal pigment epithelium in patients with geographic atrophy
    Antonia M Joussen
    Department of Ophthalmology, University of Duesseldorf, Duesseldorf, Germany
    Ophthalmology 114:551-60. 2007
    ..To evaluate the functional and anatomical outcomes of autologous translocation of peripheral choroid and retinal pigment epithelium (RPE) in patients with geographic atrophy...
  4. ncbi request reprint Heavy silicone oil versus standard silicone oil as vitreous tamponade in inferior PVR (HSO Study): design issues and implications
    Antonia M Joussen
    Department of Ophthalmology, University of Dusseldorf, Moorenstrasse 5, Dusseldorf, Germany
    Acta Ophthalmol Scand 85:623-30. 2007
    ..The Heavy Silicone Oil versus Standard Silicone Oil Study (HSO Study) is designed to answer the question of whether a heavier-than-water tamponade improves the prognosis of eyes with PVR of the lower retina...
  5. doi request reprint Long-term stability of vascular endothelial growth factor suppression time under ranibizumab treatment in age-related macular degeneration
    Philipp S Muether
    Department of Ophthalmology, University of Cologne, Cologne, Germany
    Am J Ophthalmol 156:989-993.e2. 2013
    ..To determine intra-individual long-term stability of vascular endothelial growth factor (VEGF) suppression time in eyes with neovascular age-related macular degeneration (AMD) treated with ranibizumab...
  6. doi request reprint Relationship between Visual Acuity and Spectral Domain Optical Coherence Tomography Retinal Parameters in Neovascular Age-Related Macular Degeneration
    Tina Ristau
    Cologne Image Reading Center, Department of Ophthalmology, University Hospital of Cologne, Cologne, Germany
    Ophthalmologica 231:37-44. 2014
    ..Message: Atrophy of the outer retina is an important correlate for lower VA in NVAMD. © 2013 S. Karger AG, Basel. ..
  7. ncbi request reprint A central role for inflammation in the pathogenesis of diabetic retinopathy
    Antonia M Joussen
    Department of Vitreoretinal Surgery and Angiogenesis Laboratory, Center of Ophthalmology, University of Cologne, Koln, Germany
    FASEB J 18:1450-2. 2004
    ..These data highlight the central and causal role of adherent leukocytes in the pathogenesis of diabetic retinopathy. They also underscore the potential utility of anti-inflammatory treatment in diabetic retinopathy...
  8. ncbi request reprint Strategies to influence PVR development
    Bernd Kirchhof
    Department of Vitreo retinal Surgery, Centre of Ophthalmology, University of Cologne, Joseph Stelzmann Strasse 9, 50931 Cologne, Germany
    Graefes Arch Clin Exp Ophthalmol 242:699-703. 2004
    ..As for the treatment of existent PVR despite some progress in the past, there should be better ways of treatment ahead of us...
  9. ncbi request reprint Suppression of Fas-FasL-induced endothelial cell apoptosis prevents diabetic blood-retinal barrier breakdown in a model of streptozotocin-induced diabetes
    Antonia M Joussen
    Retina Research Institute, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    FASEB J 17:76-8. 2003
    ..These data imply that the targeting of the Fas-FasL pathway may prove beneficial in the treatment of diabetic retinopathy...
  10. ncbi request reprint Is significant relevant? Validity and patient benefit of randomized controlled clinical trials on age-related macular degeneration
    Antonia M Joussen
    Department of Ophthalmology, University of Dusseldorf, Dusseldorf, Germany
    Surv Ophthalmol 52:266-78. 2007
    ..This review aims to analyze problems with external validity in the randomized controlled trials on ARMD and surveys the endpoints of clinical studies with respect to the patient benefit...
  11. doi request reprint Aqueous flare is increased in patients with clinically significant cystoid macular oedema after cataract surgery
    Lebriz Ersoy
    Department of Ophthalmology, University Hospital of Cologne, Cologne, Germany
    Br J Ophthalmol 97:862-5. 2013
    ....
  12. pmc SDOCT thickness measurements of various retinal layers in patients with autosomal dominant optic atrophy due to OPA1 mutations
    Andrea M Schild
    Department of Ophthalmology, University Hospital of Cologne, 50924 Cologne, Germany
    Biomed Res Int 2013:121398. 2013
    ..To specify thickness values of various retinal layers on macular spectral domain Optical Coherence Tomography (SDOCT) scans in patients with autosomal dominant optic atrophy (ADOA) compared to healthy controls...
  13. doi request reprint Surgical management of subfoveal choroidal neovascular membranes in age-related macular degeneration by macular relocation: experiences of an early-stopped randomised clinical trial (MARAN Study)
    A M Joussen
    Department of Ophthalmology, University of Duesseldorf, Duesseldorf, Germany
    Eye (Lond) 24:284-9. 2010
    ..The MARAN (Macular Relocation in Age-related Neovascular disease) trial was planned to assess the effectiveness of full macular relocation (MR) in patients with neovascular age-related macular degeneration (AMD)...
  14. ncbi request reprint Neodymium:YAG laser capsulotomy in vitrectomized pseudophakic eyes with persistent endotamponade
    Thomas S Dietlein
    Department of Ophthalmology, University Cologne, Cologne, Germany
    J Cataract Refract Surg 29:2385-9. 2003
    ..To evaluate the feasibility and limits of neodymium:YAG (Nd:YAG) laser capsulotomy in eyes with persistent endotamponade...
  15. pmc Grading of Age-Related Macular Degeneration: Comparison between Color Fundus Photography, Fluorescein Angiography, and Spectral Domain Optical Coherence Tomography
    Nils F Mokwa
    Cologne Image Reading Center and Laboratory, Department of Ophthalmology, University of Cologne, 50924 Cologne, Germany
    J Ophthalmol 2013:385915. 2013
    ..Conclusions. CNV lesions and activity may be missed by FP alone, but FP may help identifying drusen and pigmentary changes. SDOCT is highly sensitive for the detection of AMD, CNV, and CNV activity; however, it cannot fully replace FA...
  16. ncbi request reprint Translocation of iris pigment epithelium in patients with exudative age-related macular degeneration: long-term results
    Alexandra Lappas
    Department of Ophthalmology, University of Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany
    Graefes Arch Clin Exp Ophthalmol 242:638-47. 2004
    ..To report the practicability and efficacy of autologous iris pigment epithelium (IPE) translocation in exudative age-related macular degeneration (ARMD) over 1 year...
  17. pmc Cost-effectiveness of autologous retinal pigment epithelium and choroid translocation in neovascular AMD
    Aljoscha S Neubauer
    Department of Ophthalmology, Ludwig Maximilians University Munich, Mathildenstr 8, 80336 Muenchen, Germany
    Int J Ophthalmol 3:228-33. 2010
    ..To assess the cost-effectiveness of autologous retinal pigment epithelium and choroid translocation (PATCH) in neovascular age-related macular degeneration (AMD)...
  18. pmc Histological evidence for revascularisation of an autologous retinal pigment epithelium--choroid graft in the pig
    Kristel J M Maaijwee
    Department of Vitreoretinal Surgery, Center of Ophthalmology, University of Cologne, Germany
    Br J Ophthalmol 91:546-50. 2007
    ..Angiographic studies in these patients suggest that their grafts become revascularised...
  19. ncbi request reprint Influence on membrane-mediated cell activation by vesicles of silicone oil or perfluorohexyloctane
    Norbert Kociok
    Department of Vitreoretinal Surgery, Center for Ophthalmology, University Hospital of Cologne and Center for Molecular Medicine ZMMK, University of Cologne, Koln, Germany
    Graefes Arch Clin Exp Ophthalmol 243:345-58. 2005
    ..It has been hypothesized that emulsification of vitreous tamponades might stimulate retinal membrane formation...
  20. ncbi request reprint Combined penetrating keratoplasty and vitreoretinal surgery with silicone oil: a 1-year follow-up
    Sigrid Roters
    Center of Ophthalmology, University of Cologne, Joseph Stelzmann Strasse 9, 50924 Cologne, Germany
    Graefes Arch Clin Exp Ophthalmol 241:24-33. 2003
    ....
  21. ncbi request reprint A 7-year follow-up of severe ocular trauma following a bomb explosion
    Kan Koizumi
    Acta Ophthalmol Scand 81:667-9. 2003
  22. ncbi request reprint Nonsteroidal anti-inflammatory drugs prevent early diabetic retinopathy via TNF-alpha suppression
    Antonia M Joussen
    Retina Research Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    FASEB J 16:438-40. 2002
    ..Taken together, these data identify COX-2 and TNF-alpha as operative in the early signature pathologies of diabetic retinopathy, a newly recognized inflammatory disease...
  23. pmc Retinal vascular endothelial growth factor induces intercellular adhesion molecule-1 and endothelial nitric oxide synthase expression and initiates early diabetic retinal leukocyte adhesion in vivo
    Antonia M Joussen
    Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA
    Am J Pathol 160:501-9. 2002
    ..The inhibition of VEGF bioactivity may prove useful in the treatment of the early diabetic retinopathy...
  24. ncbi request reprint Role of syndecan-1 in leukocyte-endothelial interactions in the ocular vasculature
    Martin Götte
    Division of Newborn Medicine, Children s Hospital, Boston, Massachusetts 02115, USA
    Invest Ophthalmol Vis Sci 43:1135-41. 2002
    ..In this study, the role of the HS proteoglycan syndecan-1 in mediating leukocyte-endothelial interactions in the ocular vasculature was investigated...
  25. ncbi request reprint Indocyanine-green-assisted internal limiting membrane peeling in macular hole surgery--a follow-up study
    Andreas W A Weinberger
    Augenklinik des Universitätsklinikums Aachen, Pauwelsstr 30, 52057 Aachen, Germany
    Graefes Arch Clin Exp Ophthalmol 240:913-7. 2002
    ..Poor visualization of the ILM is an obstacle for successful surgery. Recently, indocyanine green (ICG) has been reported to be a helpful intraocular substance in identifying these membranes...
  26. ncbi request reprint Outcome of combined penetrating keratoplasty with vitreoretinal surgery for management of severe ocular injuries
    Sigrid Roters
    Center of Ophthalmology, University of Cologne, Germany
    Retina 23:48-56. 2003
    ..To assess the effectiveness of a combined procedure (pars plana vitrectomy with temporary keratoprosthesis, vitreoretinal surgery, and penetrating keratoplasty) and to determine which factors influence corneal transplant success rates...
  27. ncbi request reprint Contribution of TNF-alpha to leukocyte adhesion, vascular leakage, and apoptotic cell death in endotoxin-induced uveitis in vivo
    Kan Koizumi
    Department of Vitreoretinal Surgery, Center for Ophthalmology, and Center for Molecular Medicine, University of Cologne, Cologne, Germany
    Invest Ophthalmol Vis Sci 44:2184-91. 2003
    ..To investigate the effect of TNF-alpha on leukocyte adhesion, vascular leakage, and apoptotic cell death in endotoxin-induced uveitis (EIU) in the rat...
  28. ncbi request reprint [Diabetic maculopathy - classification and therapy]
    Sascha Fauser
    Abteilung für Netzhaut und Glaskörperchirurgie des Zentrums für Augenheilkunde und Zentrum für Molekulare Medizin, Universitat zu Koln
    Klin Monbl Augenheilkd 220:526-31. 2003
    ..This review discusses the value of standard therapeutical options as well as the recent surgical and pharmacological approaches...
  29. ncbi request reprint [Pathogenesis of diabetic macular oedema]
    Tim U Krohne
    Abteilung für Netzhaut und Glaskörperchirurgie des Zentrums für Augenheilkunde und Zentrum für Molekulare Medizin, Universitat zu Koln, Germany
    Klin Monbl Augenheilkd 220:521-5. 2003
    ..This review focuses on the molecular basis of these mechanisms and discusses the role of cytokines and cellular interactions in blood retina barrier breakdown...
  30. ncbi request reprint Fixation stability and macular light sensitivity in patients with diabetic maculopathy: a microperimetric study with a scanning laser ophthalmoscope
    Thomas Kube
    Augenklinik, Universitätsklinikum der RWTH Aachen, Aachen, Deutschland
    Ophthalmologica 219:16-20. 2005
    ..The aim of the study was to assess localized light sensitivity in the central visual field and to determine fixation stability in patients with diabetic maculopathy with moderate visual loss in comparison to healthy controls...
  31. ncbi request reprint Internal limiting membrane staining with various concentrations of indocyanine green dye
    Andreas W A Weinberger
    Am J Ophthalmol 137:589; author reply 589-90. 2004
  32. ncbi request reprint Comment on papers by Ashikari, Ozeki, Tomida, Sakurai, Tamai, Ogura: retention of dye after indocyanine-green assisted internal limiting membrane peeling, and by Ciardella, Schiff, Barile, Vidne, Sparrow, Langton, Chang: persistent indocyanine green fluor
    Andreas W A Weinberger
    Am J Ophthalmol 137:590-1; author reply 591. 2004
  33. ncbi request reprint [Macular translocation. Improved prognosis for age-related macular degeneration]
    Bernd Kirchhof
    Ophthalmologe 99:143. 2002
  34. ncbi request reprint Visual outcome of patients with macular edema after pars plana vitrectomy and indocyanine green-assisted peeling of the internal limiting membrane
    Sven Radetzky
    Department of Vitreoretinal Surgery, Center for Ophthalmology, Joseph Stelzmann Strasse 9, 50931, Cologne, Germany
    Graefes Arch Clin Exp Ophthalmol 242:273-8. 2004
    ..To evaluate the efficacy of inner limiting membrane (ILM) peeling in persistent macular edema...
  35. ncbi request reprint [Treatment of Acute Central Retinal Artery Occlusion (CRAO) by Hyperbaric Oxygenation Therapy (HBO)--Pilot study with 21 patients]
    Andreas W A Weinberger
    Augenklinik der Medizinischen Fakultät der RWTH Aachen, Germany
    Klin Monbl Augenheilkd 219:728-34. 2002
    ..In this study we applied hyperbaric oxygenation treatment additionally to haemodilution to overcome retinal ischaemia until spontaneous recanalisation of the central retinal artery occurs...
  36. ncbi request reprint VEGF-dependent conjunctivalization of the corneal surface
    Antonia M Joussen
    Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA
    Invest Ophthalmol Vis Sci 44:117-23. 2003
    ..To investigate the mechanisms governing corneal neovascularization and the appearance of goblet cells in a murine model of limbal insufficiency...
  37. ncbi request reprint Apoptosis-mediating receptor-ligand systems in human retinal pigment epithelial cells
    Arno Hueber
    Department of Vitreo retinal Surgery, Center of Ophthalmology, University of Cologne, Joseph Stelzmann Strasse 9, Germany
    Graefes Arch Clin Exp Ophthalmol 240:551-6. 2002
    ..TRAIL (Apo2-L) and Apo3-L are capable of inducing cell death via their receptors Trail-R1 to Trail-R4 and TRAMP. The goal of this study was to prove the existence of these new apoptosis-inducing receptors and ligands in RPE cells...
  38. ncbi request reprint [Macular hole surgery: experience with autologous platelet concentrate and indocyanine green-assisted internal limiting membrane peeling]
    Thomas Kube
    Augenklinik der Albert Ludwigs Universität Freiburg, Freiburg
    Klin Monbl Augenheilkd 219:883-8. 2002
    ..To report on our clinical experience with autologous platelet concentrate and indocyanine green(ICG)-assisted internal limiting membrane (ILM) peeling in macular hole surgery...
  39. ncbi request reprint Electro-oculographic findings after 360 degrees retinotomy and macular translocation for subfoveal choroidal neovascularisation in age-related macular degeneration
    Christoph Lüke
    Center of Ophthalmology, Department of Vitreoretinal Surgery, University of Cologne, Joseph Stelzmann Strasse 9, 50924 Cologne, Germany
    Graefes Arch Clin Exp Ophthalmol 241:710-5. 2003
    ....
  40. ncbi request reprint The effect of membrane differential filtration on the colloid osmotic pressure in patients with age-related macular degeneration: significance to visual function?
    Christoph Lüke
    Center of Ophthalmology, Department of Vitreoretinal Surgery, University of Koln, Koln, Germany
    Ther Apher Dial 7:263-8. 2003
    ..Based on the observation that visual field and COP are correlated, one may hope for a means to improve decreased central retinal function in eyes with geographic AMD by modulation of COP plasma level...
  41. ncbi request reprint Autologous translocation of the choroid and retinal pigment epithelium in age-related macular degeneration
    Antonia M Joussen
    Department of Vitreoretinal Surgery, Center for Ophthalmology, University of Cologne, Cologne, Germany
    Am J Ophthalmol 142:17-30. 2006
    ..To evaluate the autologous translocation of peripheral choroid and retinal pigment epithelium (RPE) in 45 eyes of 43 patients with age-related macular degeneration (AMD)...
  42. ncbi request reprint Overexpression of FasL in retinal pigment epithelial cells reduces choroidal neovascularization
    Irina Semkova
    Department of Vitreoretinal Surgery, Center for Ophthalmology, University of Cologne, Cologne, Germany
    FASEB J 20:1689-91. 2006
    ..The specific overexpression of FasL in RPE layer reduced CNV formation in our laser model. Our results strongly point to the FasL-Fas pathway as a potential therapeutic target in controlling pathological choroidal neovascularization...
  43. ncbi request reprint Characteristics of iris and retinal pigment epithelial cells cultured on collagen type I membranes
    Gabriele Thumann
    Department of Ophthalmology and IZKF BIOMAT, RHWTH Aachen University, Germany
    Curr Eye Res 31:241-9. 2006
    ..For this purpose, it is necessary to establish cell culture techniques that allow acquisition of proper functional and morphological characteristics by the cells to be transplanted...
  44. ncbi request reprint Characterization of daunorubicin-induced apoptosis in retinal pigment epithelial cells: modulation by CD95L
    Arno Hueber
    Department of Vitreo retinal Surgery, Center of Ophthalmology, University of Cologne, Germany
    Invest Ophthalmol Vis Sci 44:2851-7. 2003
    ..To characterize daunorubicin-induced cell death in cultured human retinal pigment epithelial (RPE) cells and its modulation by CD95 ligand (CD95L)...
  45. ncbi request reprint Effects of daunorubicin and CD95L on retinal function in superfused vertebrate retina
    Arno Hueber
    Center of Ophthalmology, University of Cologne, Koln, Germany
    J Ocul Pharmacol Ther 21:133-8. 2005
    ..The combination with CD95L did not increase retinal toxicity. It is, therefore, concluded that daunorubicin may be applied intraocularly, combined with CD95L, without interfering with retinal function...
  46. ncbi request reprint In vivo retinal tolerance of various heavy silicone oils
    Jerzy Mackiewicz
    Department of Vitreoretinal Surgery, Center for Ophthalmology, University of Cologne, Cologne, Germany
    Invest Ophthalmol Vis Sci 48:1873-83. 2007
    ....