Use of perfluorohexyloctane as a long-term internal tamponade agent in complicated retinal detachment surgeryBernd Kirchhof
University of Aachen, Department of Ophthalmology, Aachen, Germany
Am J Ophthalmol 133:95-101. 2002
..To report the use of perfluorohexyloctane, a liquid semifluorinated alkane that is heavier than water, as an internal tamponade agent in surgery for complicated retinal detachments...
Heavy silicone oil versus standard silicone oil in as vitreous tamponade in inferior PVR (HSO Study): interim analysisAntonia M Joussen
Department of Ophthalmology, Charite, University Medicine, Berlin, Germany
Acta Ophthalmol 89:e483-9. 2011
..The Heavy Silicone Oil versus Standard Silicone Oil Study (HSO study) is designed to answer the question whether a heavier-than-water tamponade improves the prognosis of eyes with proliferative vitreoretinopathy (PVR) of the lower retina...
- Autologous translocation of the choroid and retinal pigment epithelium in patients with geographic atrophy
Antonia M Joussen
Department of Ophthalmology, University of Duesseldorf, Duesseldorf, Germany
Ophthalmology 114:551-60. 2007
..To evaluate the functional and anatomical outcomes of autologous translocation of peripheral choroid and retinal pigment epithelium (RPE) in patients with geographic atrophy...
- Heavy silicone oil versus standard silicone oil as vitreous tamponade in inferior PVR (HSO Study): design issues and implications
Antonia M Joussen
Department of Ophthalmology, University of Dusseldorf, Moorenstrasse 5, Dusseldorf, Germany
Acta Ophthalmol Scand 85:623-30. 2007
..The Heavy Silicone Oil versus Standard Silicone Oil Study (HSO Study) is designed to answer the question of whether a heavier-than-water tamponade improves the prognosis of eyes with PVR of the lower retina...
- Is significant relevant? Validity and patient benefit of randomized controlled clinical trials on age-related macular degeneration
Antonia M Joussen
Department of Ophthalmology, University of Dusseldorf, Dusseldorf, Germany
Surv Ophthalmol 52:266-78. 2007
..This review aims to analyze problems with external validity in the randomized controlled trials on ARMD and surveys the endpoints of clinical studies with respect to the patient benefit...
- Suppression of Fas-FasL-induced endothelial cell apoptosis prevents diabetic blood-retinal barrier breakdown in a model of streptozotocin-induced diabetes
Antonia M Joussen
Retina Research Institute, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
FASEB J 17:76-8. 2003
..These data imply that the targeting of the Fas-FasL pathway may prove beneficial in the treatment of diabetic retinopathy...
- Strategies to influence PVR development
Bernd Kirchhof
Department of Vitreo retinal Surgery, Centre of Ophthalmology, University of Cologne, Joseph Stelzmann Strasse 9, 50931 Cologne, Germany
Graefes Arch Clin Exp Ophthalmol 242:699-703. 2004
..As for the treatment of existent PVR despite some progress in the past, there should be better ways of treatment ahead of us...
- A central role for inflammation in the pathogenesis of diabetic retinopathy
Antonia M Joussen
Department of Vitreoretinal Surgery and Angiogenesis Laboratory, Center of Ophthalmology, University of Cologne, Koln, Germany
FASEB J 18:1450-2. 2004
..These data highlight the central and causal role of adherent leukocytes in the pathogenesis of diabetic retinopathy. They also underscore the potential utility of anti-inflammatory treatment in diabetic retinopathy...
- Surgical management of subfoveal choroidal neovascular membranes in age-related macular degeneration by macular relocation: experiences of an early-stopped randomised clinical trial (MARAN Study)
A M Joussen
Department of Ophthalmology, University of Duesseldorf, Duesseldorf, Germany
Eye (Lond) 24:284-9. 2010
..The MARAN (Macular Relocation in Age-related Neovascular disease) trial was planned to assess the effectiveness of full macular relocation (MR) in patients with neovascular age-related macular degeneration (AMD)...
- Neodymium:YAG laser capsulotomy in vitrectomized pseudophakic eyes with persistent endotamponade
Thomas S Dietlein
Department of Ophthalmology, University Cologne, Cologne, Germany
J Cataract Refract Surg 29:2385-9. 2003
..To evaluate the feasibility and limits of neodymium:YAG (Nd:YAG) laser capsulotomy in eyes with persistent endotamponade...
- Translocation of iris pigment epithelium in patients with exudative age-related macular degeneration: long-term results
Alexandra Lappas
Department of Ophthalmology, University of Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany
Graefes Arch Clin Exp Ophthalmol 242:638-47. 2004
..To report the practicability and efficacy of autologous iris pigment epithelium (IPE) translocation in exudative age-related macular degeneration (ARMD) over 1 year...
Cost-effectiveness of autologous retinal pigment epithelium and choroid translocation in neovascular AMDAljoscha S Neubauer
Department of Ophthalmology, Ludwig Maximilians University Munich, Mathildenstr 8, 80336 Muenchen, Germany
Int J Ophthalmol 3:228-33. 2010
..To assess the cost-effectiveness of autologous retinal pigment epithelium and choroid translocation (PATCH) in neovascular age-related macular degeneration (AMD)...
- A 7-year follow-up of severe ocular trauma following a bomb explosion
Kan Koizumi
Acta Ophthalmol Scand 81:667-9. 2003
- Combined penetrating keratoplasty and vitreoretinal surgery with silicone oil: a 1-year follow-up
Sigrid Roters
Center of Ophthalmology, University of Cologne, Joseph Stelzmann Strasse 9, 50924 Cologne, Germany
Graefes Arch Clin Exp Ophthalmol 241:24-33. 2003
....
- Influence on membrane-mediated cell activation by vesicles of silicone oil or perfluorohexyloctane
Norbert Kociok
Department of Vitreoretinal Surgery, Center for Ophthalmology, University Hospital of Cologne and Center for Molecular Medicine ZMMK, University of Cologne, Koln, Germany
Graefes Arch Clin Exp Ophthalmol 243:345-58. 2005
..It has been hypothesized that emulsification of vitreous tamponades might stimulate retinal membrane formation...
- Histological evidence for revascularisation of an autologous retinal pigment epithelium--choroid graft in the pig
Kristel J M Maaijwee
Department of Vitreoretinal Surgery, Center of Ophthalmology, University of Cologne, Germany
Br J Ophthalmol 91:546-50. 2007
..Angiographic studies in these patients suggest that their grafts become revascularised...
- [Diabetic maculopathy - classification and therapy]
Sascha Fauser
,
Klin Monatsbl Augenheilkd 220:526-31. 2003
..This review discusses the value of standard therapeutical options as well as the recent surgical and pharmacological approaches...
- [Pathogenesis of diabetic macular oedema]
Tim U Krohne
, , Germany
Klin Monatsbl Augenheilkd 220:521-5. 2003
..This review focuses on the molecular basis of these mechanisms and discusses the role of cytokines and cellular interactions in blood retina barrier breakdown...
- Outcome of combined penetrating keratoplasty with vitreoretinal surgery for management of severe ocular injuries
Sigrid Roters
Center of Ophthalmology, University of Cologne, Germany
Retina 23:48-56. 2003
....
- Nonsteroidal anti-inflammatory drugs prevent early diabetic retinopathy via TNF-alpha suppression
Antonia M Joussen
Retina Research Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
FASEB J 16:438-40. 2002
..Taken together, these data identify COX-2 and TNF-alpha as operative in the early signature pathologies of diabetic retinopathy, a newly recognized inflammatory disease...
- Contribution of TNF-alpha to leukocyte adhesion, vascular leakage, and apoptotic cell death in endotoxin-induced uveitis in vivo
Kan Koizumi
Department of Vitreoretinal Surgery, Center for Ophthalmology, and Center for Molecular Medicine, University of Cologne, Cologne, Germany
Invest Ophthalmol Vis Sci 44:2184-91. 2003
..These results suggest the involvement of TNF-alpha in inflammatory uveitis and its potential use as a therapeutic agent in the reduction of ocular inflammation...
- Retinal vascular endothelial growth factor induces intercellular adhesion molecule-1 and endothelial nitric oxide synthase expression and initiates early diabetic retinal leukocyte adhesion in vivo
Antonia M Joussen
Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA
Am J Pathol 160:501-9. 2002
..The inhibition of VEGF bioactivity may prove useful in the treatment of the early diabetic retinopathy...
- Role of syndecan-1 in leukocyte-endothelial interactions in the ocular vasculature
Martin Götte
Division of Newborn Medicine, Children s Hospital, Boston, Massachusetts 02115, USA
Invest Ophthalmol Vis Sci 43:1135-41. 2002
..In this study, the role of the HS proteoglycan syndecan-1 in mediating leukocyte-endothelial interactions in the ocular vasculature was investigated...
- Indocyanine-green-assisted internal limiting membrane peeling in macular hole surgery--a follow-up study
Andreas W A Weinberger
Augenklinik des Universitätsklinikums Aachen, Pauwelsstr 30, 52057 Aachen, Germany
Graefes Arch Clin Exp Ophthalmol 240:913-7. 2002
..Poor visualization of the ILM is an obstacle for successful surgery. Recently, indocyanine green (ICG) has been reported to be a helpful intraocular substance in identifying these membranes...
- Autologous translocation of the choroid and retinal pigment epithelium in age-related macular degeneration
Antonia M Joussen
Department of Vitreoretinal Surgery, Center for Ophthalmology, University of Cologne, Cologne, Germany
Am J Ophthalmol 142:17-30. 2006
..To evaluate the autologous translocation of peripheral choroid and retinal pigment epithelium (RPE) in 45 eyes of 43 patients with age-related macular degeneration (AMD)...
- [Treatment of Acute Central Retinal Artery Occlusion (CRAO) by Hyperbaric Oxygenation Therapy (HBO)--Pilot study with 21 patients]
Andreas W A Weinberger
Augenklinik der Medizinischen Fakultät der RWTH Aachen, Germany
Klin Monbl Augenheilkd 219:728-34. 2002
..In this study we applied hyperbaric oxygenation treatment additionally to haemodilution to overcome retinal ischaemia until spontaneous recanalisation of the central retinal artery occurs...
- In vivo retinal tolerance of various heavy silicone oils
Jerzy Mackiewicz
Department of Vitreoretinal Surgery, Center for Ophthalmology, University of Cologne, Cologne, Germany
Invest Ophthalmol Vis Sci 48:1873-83. 2007
....
- Electro-oculographic findings after 360 degrees retinotomy and macular translocation for subfoveal choroidal neovascularisation in age-related macular degeneration
Christoph Lüke
Center of Ophthalmology, Department of Vitreoretinal Surgery, University of Cologne, Joseph Stelzmann Strasse 9, 50924 Cologne, Germany
Graefes Arch Clin Exp Ophthalmol 241:710-5. 2003
....
- [Macular translocation. Improved prognosis for age-related macular degeneration]
Bernd Kirchhof
Ophthalmologe 99:143. 2002
- Overexpression of FasL in retinal pigment epithelial cells reduces choroidal neovascularization
Irina Semkova
Department of Vitreoretinal Surgery, Center for Ophthalmology, University of Cologne, Cologne, Germany
FASEB J 20:1689-91. 2006
..The specific overexpression of FasL in RPE layer reduced CNV formation in our laser model. Our results strongly point to the FasL-Fas pathway as a potential therapeutic target in controlling pathological choroidal neovascularization...
- VEGF-dependent conjunctivalization of the corneal surface
Antonia M Joussen
Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA
Invest Ophthalmol Vis Sci 44:117-23. 2003
..Both processes are probably mediated, in part, through the Flt-1 receptor. Taken together, these data indicate that an anti-VEGF therapeutic approach may limit the visual loss associated with conjunctivalization of the corneal surface...
- Apoptosis-mediating receptor-ligand systems in human retinal pigment epithelial cells
Arno Hueber
Department of Vitreo retinal Surgery, Center of Ophthalmology, University of Cologne, Joseph Stelzmann Strasse 9, Germany
Graefes Arch Clin Exp Ophthalmol 240:551-6. 2002
..TRAIL (Apo2-L) and Apo3-L are capable of inducing cell death via their receptors Trail-R1 to Trail-R4 and TRAMP. The goal of this study was to prove the existence of these new apoptosis-inducing receptors and ligands in RPE cells...
- Characterization of daunorubicin-induced apoptosis in retinal pigment epithelial cells: modulation by CD95L
Arno Hueber
Department of Vitreo retinal Surgery, Center of Ophthalmology, University of Cologne, Germany
Invest Ophthalmol Vis Sci 44:2851-7. 2003
..To characterize daunorubicin-induced cell death in cultured human retinal pigment epithelial (RPE) cells and its modulation by CD95 ligand (CD95L)...
- Internal limiting membrane staining with various concentrations of indocyanine green dye
Andreas W A Weinberger
Am J Ophthalmol 137:589; author reply 589-90. 2004
- Comment on papers by Ashikari, Ozeki, Tomida, Sakurai, Tamai, Ogura: retention of dye after indocyanine-green assisted internal limiting membrane peeling, and by Ciardella, Schiff, Barile, Vidne, Sparrow, Langton, Chang: persistent indocyanine green fluor
Andreas W A Weinberger
Am J Ophthalmol 137:590-1; author reply 591. 2004
- Visual outcome of patients with macular edema after pars plana vitrectomy and indocyanine green-assisted peeling of the internal limiting membrane
Sven Radetzky
Department of Vitreoretinal Surgery, Center for Ophthalmology, Joseph Stelzmann-Strasse 9, 50931, Cologne, Germany
Graefes Arch Clin Exp Ophthalmol 242:273-8. 2004
..Large-scale investigations are needed to evaluate the efficacy in certain diagnosis groups...
- The effect of membrane differential filtration on the colloid osmotic pressure in patients with age-related macular degeneration: significance to visual function?
Christoph Lüke
Center of Ophthalmology, Department of Vitreoretinal Surgery, University of Koln, Koln, Germany
Ther Apher Dial 7:263-8. 2003
..Based on the observation that visual field and COP are correlated, one may hope for a means to improve decreased central retinal function in eyes with geographic AMD by modulation of COP plasma level...
- [Macular hole surgery: experience with autologous platelet concentrate and indocyanine green-assisted internal limiting membrane peeling]
Thomas Kube
Augenklinik der Albert Ludwigs Universität Freiburg, Freiburg
Klin Monbl Augenheilkd 219:883-8. 2002
..To report on our clinical experience with autologous platelet concentrate and indocyanine green(ICG)-assisted internal limiting membrane (ILM) peeling in macular hole surgery...
- Fixation stability and macular light sensitivity in patients with diabetic maculopathy: a microperimetric study with a scanning laser ophthalmoscope
Thomas Kube
Augenklinik, Universitätsklinikum der RWTH Aachen, Aachen, Deutschland
Ophthalmologica 219:16-20. 2005
..The aim of the study was to assess localized light sensitivity in the central visual field and to determine fixation stability in patients with diabetic maculopathy with moderate visual loss in comparison to healthy controls...
- Effects of daunorubicin and CD95L on retinal function in superfused vertebrate retina
Arno Hueber
Center of Ophthalmology, University of Cologne, Koln, Germany
J Ocul Pharmacol Ther 21:133-8. 2005
..The combination with CD95L did not increase retinal toxicity. It is, therefore, concluded that daunorubicin may be applied intraocularly, combined with CD95L, without interfering with retinal function...
- Characteristics of iris and retinal pigment epithelial cells cultured on collagen type I membranes
Gabriele Thumann
Department of Ophthalmology and IZKF BIOMAT, RHWTH Aachen University, Germany
Curr Eye Res 31:241-9. 2006
..For this purpose, it is necessary to establish cell culture techniques that allow acquisition of proper functional and morphological characteristics by the cells to be transplanted...
