Research Topics

Genomes and Genes


G S Kirshenbaum



  1. Kirshenbaum G, Saltzman K, Rose B, Petersen J, Vilsen B, Roder J. Decreased neuronal Na+, K+ -ATPase activity in Atp1a3 heterozygous mice increases susceptibility to depression-like endophenotypes by chronic variable stress. Genes Brain Behav. 2011;10:542-50 pubmed publisher
    ..Pharmaceuticals that increase Na(+) ,K(+) -ATPase activity or block endogenous Na(+) , K(+) -ATPase inhibition may provide effective treatment for depressive disorders and preclude depression in susceptible individuals. ..
  2. Kirshenbaum G, Clapcote S, Petersen J, Vilsen B, Ralph M, Roder J. Genetic suppression of agrin reduces mania-like behavior in Na+ , K+ -ATPase ?3 mutant mice. Genes Brain Behav. 2012;11:436-43 pubmed publisher
    ..These results introduce agrin as a potential therapeutic target for the treatment of mania and other neurological disorders associated with reduced Na(+) ,K(+) -ATPase activity and neuronal hyperexcitability. ..
  3. Kirshenbaum G, Burgess C, Déry N, Fahnestock M, Peever J, Roder J. Attenuation of mania-like behavior in Na(+),K(+)-ATPase ?3 mutant mice by prospective therapies for bipolar disorder: melatonin and exercise. Neuroscience. 2014;260:195-204 pubmed publisher
    ..Their effects on mood regulation should be further examined in randomized clinical trials. Our results also suggest that hippocampal BDNF may not mediate the effects of exercise on mania-related behavior in the Myk/+ model of mania. ..