Rhonda C Kines

Summary

Publications

  1. doi Optical imaging of HPV infection in a murine model
    Rhonda C Kines
    Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Methods Mol Biol 961:141-50. 2013
  2. pmc In vivo mechanisms of vaccine-induced protection against HPV infection
    Patricia M Day
    Laboratory of Cellular Oncology, National Cancer Institute National Institutes of Health, Bethesda, MD 20892, USA
    Cell Host Microbe 8:260-70. 2010
  3. pmc Intravaginal immunization with HPV vectors induces tissue-resident CD8+ T cell responses
    Nicolas Cuburu
    Laboratory of Cellular Oncology, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 122:4606-20. 2012
  4. pmc In vivo longitudinal imaging of experimental human papillomavirus infection in mice with a multicolor fluorescence mini-endoscopy system
    Makoto Mitsunaga
    Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Cancer Prev Res (Phila) 4:767-73. 2011
  5. pmc A human papillomavirus (HPV) in vitro neutralization assay that recapitulates the in vitro process of infection provides a sensitive measure of HPV L2 infection-inhibiting antibodies
    Patricia M Day
    Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Clin Vaccine Immunol 19:1075-82. 2012
  6. pmc Effect of Pap smear collection and carrageenan on cervicovaginal human papillomavirus-16 infection in a rhesus macaque model
    Jeffrey N Roberts
    Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Natl Cancer Inst 103:737-43. 2011
  7. pmc The initial steps leading to papillomavirus infection occur on the basement membrane prior to cell surface binding
    Rhonda C Kines
    Laboratory of Cellular Oncology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:20458-63. 2009
  8. pmc Targeting the vaginal mucosa with human papillomavirus pseudovirion vaccines delivering simian immunodeficiency virus DNA
    Shari N Gordon
    Animal Models and Retroviral Vaccines Section, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 188:714-23. 2012
  9. pmc Current understanding of the mechanism of HPV infection
    John T Schiller
    Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, MD 20892, USA
    Gynecol Oncol 118:S12-7. 2010
  10. pmc Role of heparan sulfate in attachment to and infection of the murine female genital tract by human papillomavirus
    Katherine M Johnson
    Laboratory of Cellular Oncology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 83:2067-74. 2009

Collaborators

Detail Information

Publications10

  1. doi Optical imaging of HPV infection in a murine model
    Rhonda C Kines
    Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Methods Mol Biol 961:141-50. 2013
    ..Herein we provide details for a murine model of cervicovaginal HPV infection in conjunction with several methods for imaging and quantitating the transduced genes, both ex vivo and in vivo...
  2. pmc In vivo mechanisms of vaccine-induced protection against HPV infection
    Patricia M Day
    Laboratory of Cellular Oncology, National Cancer Institute National Institutes of Health, Bethesda, MD 20892, USA
    Cell Host Microbe 8:260-70. 2010
    ..Regardless of the concentration, L2 vaccine-induced antibodies allow BM association but prevent association with the cell surface. Thus, we have revealed distinct mechanisms of vaccine-induced inhibition of virus infection in vivo...
  3. pmc Intravaginal immunization with HPV vectors induces tissue-resident CD8+ T cell responses
    Nicolas Cuburu
    Laboratory of Cellular Oncology, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 122:4606-20. 2012
    ..Thus, HPV vectors are attractive gene-delivery platforms for inducing durable intraepithelial cervicovaginal CD8+ T cell responses by promoting local proliferation and retention of primed antigen-specific CD8+ T cells...
  4. pmc In vivo longitudinal imaging of experimental human papillomavirus infection in mice with a multicolor fluorescence mini-endoscopy system
    Makoto Mitsunaga
    Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Cancer Prev Res (Phila) 4:767-73. 2011
    ..This method offers the ability to monitor experimental virus infections before and after intervention, thereby accelerating the development of appropriate prevention and therapy...
  5. pmc A human papillomavirus (HPV) in vitro neutralization assay that recapitulates the in vitro process of infection provides a sensitive measure of HPV L2 infection-inhibiting antibodies
    Patricia M Day
    Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Clin Vaccine Immunol 19:1075-82. 2012
    ..This "L2-based" in vitro neutralization assay should prove useful in critically evaluating the immunogenicity of L2 vaccine candidates in preclinical studies and future clinical trials...
  6. pmc Effect of Pap smear collection and carrageenan on cervicovaginal human papillomavirus-16 infection in a rhesus macaque model
    Jeffrey N Roberts
    Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Natl Cancer Inst 103:737-43. 2011
    ..Therefore, we determined whether a cytology specimen collection procedure (Pap smear), which disrupts the epithelium by design, renders the cervix more susceptible to HPV infection in a primate model...
  7. pmc The initial steps leading to papillomavirus infection occur on the basement membrane prior to cell surface binding
    Rhonda C Kines
    Laboratory of Cellular Oncology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:20458-63. 2009
    ....
  8. pmc Targeting the vaginal mucosa with human papillomavirus pseudovirion vaccines delivering simian immunodeficiency virus DNA
    Shari N Gordon
    Animal Models and Retroviral Vaccines Section, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 188:714-23. 2012
    ....
  9. pmc Current understanding of the mechanism of HPV infection
    John T Schiller
    Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, MD 20892, USA
    Gynecol Oncol 118:S12-7. 2010
    ....
  10. pmc Role of heparan sulfate in attachment to and infection of the murine female genital tract by human papillomavirus
    Katherine M Johnson
    Laboratory of Cellular Oncology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 83:2067-74. 2009
    ..We speculate that cutaneous HPVs, such as HPV5, and genital mucosal HPVs, such as HPV16 and -31, may have evolved to recognize different forms of HSPGs to enable them to preferentially infect keratinocytes at different anatomical sites...