Paul E Kinahan

Summary

Publications

  1. pmc Challenges and opportunities in patient-specific, motion-managed and PET/CT-guided radiation therapy of lung cancer: review and perspective
    Stephen R Bowen
    University of Washington Medical Center, Department of Radiation Oncology, 1959 NE Pacific St, Box 356043, Seattle, WA 98195, USA
    Clin Transl Med 1:18. 2012
  2. pmc Positron emission tomography-computed tomography standardized uptake values in clinical practice and assessing response to therapy
    Paul E Kinahan
    Department of Radiology, University of Washington, Seattle, WA, USA
    Semin Ultrasound CT MR 31:496-505. 2010
  3. ncbi request reprint Improved quantitation for PET/CT image reconstruction with system modeling and anatomical priors
    Adam M Alessio
    Department of Radiology, University of Washington Medical Center, 200 Old Fisheries Center Box 357987, Seattle, Washington 98195 7987, USA
    Med Phys 33:4095-103. 2006
  4. pmc Quantitative assessment of dynamic PET imaging data in cancer imaging
    Mark Muzi
    Department of Radiology, University of Washington, Seattle, WA 98195 6004, USA
    Magn Reson Imaging 30:1203-15. 2012
  5. pmc Application and evaluation of a measured spatially variant system model for PET image reconstruction
    Adam M Alessio
    Department of Radiology, University of Washington Medical Center, Seattle, WA 98195, USA
    IEEE Trans Med Imaging 29:938-49. 2010
  6. pmc Attenuation-emission alignment in cardiac PET/CT based on consistency conditions
    Adam M Alessio
    Department of Radiology, University of Washington Medical Center, 4000 15th Avenue NE, Box 357987, Seattle, Washington 98195 7987, USA
    Med Phys 37:1191-200. 2010
  7. pmc The impact of respiratory motion on tumor quantification and delineation in static PET/CT imaging
    Chi Liu
    Department of Radiology, University of Washington, Seattle, WA, USA
    Phys Med Biol 54:7345-62. 2009
  8. doi request reprint Statistical LOR estimation for a high-resolution dMiCE PET detector
    Kyle M Champley
    Department of Radiology, University of Washington, Seattle, WA, USA
    Phys Med Biol 54:6369-82. 2009
  9. pmc Planogram rebinning with the frequency-distance relationship
    Kyle Champley
    Department of Radiology, University of Washington, Seattle, WA 98195, USA
    IEEE Trans Med Imaging 27:925-33. 2008
  10. pmc Applying a patient-specific bio-mathematical model of glioma growth to develop virtual [18F]-FMISO-PET images
    Stanley Gu
    Department of Bioengineering and Pathology, University of Washington, Seattle, WA 98195, USA
    Math Med Biol 29:31-48. 2012

Collaborators

Detail Information

Publications31

  1. pmc Challenges and opportunities in patient-specific, motion-managed and PET/CT-guided radiation therapy of lung cancer: review and perspective
    Stephen R Bowen
    University of Washington Medical Center, Department of Radiation Oncology, 1959 NE Pacific St, Box 356043, Seattle, WA 98195, USA
    Clin Transl Med 1:18. 2012
    ..These two concepts are then integrated into proposed patient-specific workflows that span classification schemes, PET/CT image formation, treatment planning, and adaptive image-guided radiotherapy delivery techniques...
  2. pmc Positron emission tomography-computed tomography standardized uptake values in clinical practice and assessing response to therapy
    Paul E Kinahan
    Department of Radiology, University of Washington, Seattle, WA, USA
    Semin Ultrasound CT MR 31:496-505. 2010
    ..In this article the overall imaging process is reviewed and estimates of the magnitude of errors, where known, are given. Recommendations are provided for best practices in improving SUV accuracy...
  3. ncbi request reprint Improved quantitation for PET/CT image reconstruction with system modeling and anatomical priors
    Adam M Alessio
    Department of Radiology, University of Washington Medical Center, 200 Old Fisheries Center Box 357987, Seattle, Washington 98195 7987, USA
    Med Phys 33:4095-103. 2006
    ..At common clinical image noise levels for the detection task, the proposed method reduces the error in maximum tumor values by 11% compared to filtered back-projection and 5% compared to conventional iterative methods...
  4. pmc Quantitative assessment of dynamic PET imaging data in cancer imaging
    Mark Muzi
    Department of Radiology, University of Washington, Seattle, WA 98195 6004, USA
    Magn Reson Imaging 30:1203-15. 2012
    ....
  5. pmc Application and evaluation of a measured spatially variant system model for PET image reconstruction
    Adam M Alessio
    Department of Radiology, University of Washington Medical Center, Seattle, WA 98195, USA
    IEEE Trans Med Imaging 29:938-49. 2010
    ..With the proposed and other resolution-modeled reconstruction methods, edge artifacts need to be studied in more detail to determine the optimal tradeoff of resolution/contrast enhancement and edge fidelity...
  6. pmc Attenuation-emission alignment in cardiac PET/CT based on consistency conditions
    Adam M Alessio
    Department of Radiology, University of Washington Medical Center, 4000 15th Avenue NE, Box 357987, Seattle, Washington 98195 7987, USA
    Med Phys 37:1191-200. 2010
    ..This misalignment leads to erroneous attenuation correction and can cause errors in perfusion mapping and quantification. This study develops and tests a method for automated alignment of attenuation and emission data...
  7. pmc The impact of respiratory motion on tumor quantification and delineation in static PET/CT imaging
    Chi Liu
    Department of Radiology, University of Washington, Seattle, WA, USA
    Phys Med Biol 54:7345-62. 2009
    ..To overcome the motion effect, motion compensation techniques may be necessary in clinical practice to improve the tumor quantification for determining the response to therapy or for radiation treatment planning...
  8. doi request reprint Statistical LOR estimation for a high-resolution dMiCE PET detector
    Kyle M Champley
    Department of Radiology, University of Washington, Seattle, WA, USA
    Phys Med Biol 54:6369-82. 2009
    ..Monte Carlo experiments are performed using our LOR estimation algorithm and compared with Anger logic. We show that our LOR estimation algorithm provides a significant improvement over Anger logic under a variety of parameters...
  9. pmc Planogram rebinning with the frequency-distance relationship
    Kyle Champley
    Department of Radiology, University of Washington, Seattle, WA 98195, USA
    IEEE Trans Med Imaging 27:925-33. 2008
    ..Theoretical error bounds and numerical results are included...
  10. pmc Applying a patient-specific bio-mathematical model of glioma growth to develop virtual [18F]-FMISO-PET images
    Stanley Gu
    Department of Bioengineering and Pathology, University of Washington, Seattle, WA 98195, USA
    Math Med Biol 29:31-48. 2012
    ....
  11. pmc Quantification of radiotracer uptake with a dedicated breast PET imaging system
    Raymond R Raylmana
    Center for Advanced Imaging, Department of Radiology, West Virginia University, Morgantown, West Virginia 26506 9236, USA
    Med Phys 35:4989-97. 2008
    ..Results from these preliminary studies indicate that the PEM-PET scanner will be useful for the quantification of radiotracer uptake in breast tumors, possibly facilitating early assessment of cancer treatments...
  12. doi request reprint Quantifying and reducing the effect of calibration error on variability of PET/CT standardized uptake value measurements
    Catherine M Lockhart
    Department of Radiology, University of Washington, Seattle, Washington 98195, USA
    J Nucl Med 52:218-24. 2011
    ..The purpose of this study was to measure the errors introduced by regular calibration of PET/CT scanners and to minimize the effect of calibration error on standardized uptake value measurements...
  13. ncbi request reprint Dual energy CT attenuation correction methods for quantitative assessment of response to cancer therapy with PET/CT imaging
    Paul E Kinahan
    Department of Radiology, University of Washington, 200 Old Fisheries Center, Box 35 7987, Seattle, WA 98195, USA
    Technol Cancer Res Treat 5:319-27. 2006
    ....
  14. doi request reprint Model-based iterative reconstruction versus adaptive statistical iterative reconstruction and filtered back projection in liver 64-MDCT: focal lesion detection, lesion conspicuity, and image noise
    William P Shuman
    Department of Radiology, University of Washington School of Medicine, Seattle, WA 98195, USA
    AJR Am J Roentgenol 200:1071-6. 2013
    ..The purpose of this study is to compare three CT image reconstruction algorithms for liver lesion detection and appearance, subjective lesion conspicuity, and measured noise...
  15. pmc Early experiences in establishing a regional quantitative imaging network for PET/CT clinical trials
    Robert K Doot
    Department of Radiology, University of Washington, Seattle, WA, USA Seattle Cancer Care Alliance, Seattle, WA, USA
    Magn Reson Imaging 30:1291-300. 2012
    ..These methods should be developed and implemented in multicenter clinical trials employing quantitative PET imaging of patients...
  16. pmc Design considerations for using PET as a response measure in single site and multicenter clinical trials
    Robert K Doot
    Department of Radiology, University of Washington, Seattle, 98109 1023, USA
    Acad Radiol 19:184-90. 2012
    ..Here we demonstrate impacts of PET measurement error and choice of quantification method on clinical trial design...
  17. pmc Optimization of noise equivalent count rate performance for a partially collimated PET scanner by varying the number of septa
    Ruth E Schmitz
    Department of Radiology, University of Washington, Seattle, WA 98195, USA
    IEEE Trans Med Imaging 26:935-44. 2007
    ..However, the significant increase in statistical data quality warrants further investigation of the impact of partial collimation on clinical whole-body PET imaging...
  18. pmc Effects of MR surface coils on PET quantification
    Lawrence R MacDonald
    Department of Radiology, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Med Phys 38:2948-56. 2011
    ..In this case, conventional PET CT-AC methods could be used. A challenge here is that high atomic number materials within MR coils cause artifacts in CT images and CT based AC is typically not validated for coil materials...
  19. pmc Multicenter trials using ¹⁸F-fluorodeoxyglucose (FDG) PET to predict chemotherapy response: effects of differential measurement error and bias on power calculations for unselected and enrichment designs
    Brenda F Kurland
    aFred Hutchinson Cancer Research Center, Seattle, WA, USA
    Clin Trials 10:886-95. 2013
    ..However, it is often unknown how measurement error and bias in a multicenter trial will differ from that in single-institution studies...
  20. pmc Dynamic and static approaches to quantifying 18F-FDG uptake for measuring cancer response to therapy, including the effect of granulocyte CSF
    Robert K Doot
    Department of Bioengineering, University of Washington, Seattle, Washington, USA
    J Nucl Med 48:920-5. 2007
    ..We tested whether chemotherapy and treatment with granulocyte colony-stimulating factor (CSF) changed the blood clearance curves and therefore affected the relationship between MRFDG and SUV...
  21. doi request reprint Weight-based, low-dose pediatric whole-body PET/CT protocols
    Adam M Alessio
    Department of Radiology, University of Washington, Old Fisheries Center, Seattle, Washington 98195 7987, USA
    J Nucl Med 50:1570-7. 2009
    ..We developed pediatric PET/CT acquisition protocols customized to patient weight and estimated the dosimetry and cancer risk of these low-dose protocols to communicate basic imaging risks...
  22. pmc DOI-based reconstruction algorithms for a compact breast PET scanner
    Kyle M Champley
    GE Global Research, Niskayuna, New York 12309, USA
    Med Phys 38:1660-71. 2011
    ..This design allows a unique combination of event estimation and fast projection methods...
  23. ncbi request reprint Tumor delineation using PET in head and neck cancers: threshold contouring and lesion volumes
    Eric C Ford
    University of Washington, Department of Radiation Oncology, 1959 N E Pacific Street, Seattle, Washington 98195, USA
    Med Phys 33:4280-8. 2006
    ..The appropriate threshold level depends on lesion size and image reconstruction parameters. These effects should be carefully considered when using PET contour and/or volume information for radiotherapy applications...
  24. doi request reprint The positron emission mammography/tomography breast imaging and biopsy system (PEM/PET): design, construction and phantom-based measurements
    Raymond R Raylman
    Center for Advanced Imaging, Department of Radiology, West Virginia University, Morgantown, WV, USA
    Phys Med Biol 53:637-53. 2008
    ..08 mm (axial). Maximum system detection sensitivity of the scanner is 488.9 kcps microCi(-1) ml(-1) (6.88%). These promising findings indicate that PEM/PET may be an effective system for the detection and diagnosis of breast cancer...
  25. pmc Variability in PET quantitation within a multicenter consortium
    Frederic H Fahey
    Department of Radiology, Division of Nuclear Medicine, Children s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Med Phys 37:3660-6. 2010
    ..The purpose of this study was to evaluate the variability in quantitation of positron emission tomography (PET) data acquired within the context of a multicenter consortium...
  26. pmc Dual energy CT for attenuation correction with PET/CT
    Ting Xia
    Department of Bioengineering, University of Washington, Seattle, Washington 98105
    Med Phys 41:012501. 2014
    ..This is becoming more relevant with the increased use of quantitative imaging by PET/CT and SPECT/CT scanners. There are, however, potential variations in the noise and bias of synthesized monoenergetic images as a function of energy...
  27. pmc Ultra-low dose CT attenuation correction for PET/CT
    Ting Xia
    Department of Bioengineering, University of Washington, Seattle, WA, USA
    Phys Med Biol 57:309-28. 2012
    ..The significant dose reduction strategies proposed here could enable respiratory motion compensation methods that require extended duration CT scans and reduce radiation exposure in general for all PET/CT imaging...
  28. doi request reprint Gas bubble motion artifact in MDCT
    Franklin Liu
    Department of Radiology, University of Washington Medical Center, Box 357115, Seattle, WA 98195, USA
    AJR Am J Roentgenol 190:294-9. 2008
    ..The purpose of our study was to characterize the imaging features of an MDCT artifact caused by gas bubble motion...
  29. pmc PET/CT Assessment of Response to Therapy: Tumor Change Measurement, Truth Data, and Error
    Paul E Kinahan
    Department of Radiology, University of Washington, Seattle, WA, USA
    Transl Oncol 2:223-30. 2009
    ..We conclude with a discussion of moving from assessing measurement variation to the steps necessary to establish the efficacy of PET/CT imaging as a biomarker for response...
  30. ncbi request reprint Modeling and incorporation of system response functions in 3-D whole body PET
    Adam M Alessio
    Department of Radiology, University of Washington Medical Center, Seattle, WA 98195 6004, USA
    IEEE Trans Med Imaging 25:828-37. 2006
    ..Furthermore, simulation and measured studies show the proposed method improves quantitative accuracy with a reduction in tumor bias compared to conventional OSEM on the order of 10%-30% depending on tumor size and smoothing parameter...
  31. ncbi request reprint [11C]metahydroxyephedrine and [18F]fluorodeoxyglucose positron emission tomography improve clinical decision making in suspected pheochromocytoma
    Gary N Mann
    Department of Surgery, University of Washington, Box 356410, 1959 N E Pacific Street, Seattle, Washington 98195, USA
    Ann Surg Oncol 13:187-97. 2006
    ..We evaluated whether positron emission tomography (PET) scanning with the combination of [18F]fluorodeoxyglucose (FDG) and the norepinephrine analogue [11C]metahydroxyephedrine (mHED) would allow more exact diagnosis and localization...