Positron emission tomography-computed tomography standardized uptake values in clinical practice and assessing response to therapyPaul E Kinahan
Department of Radiology, University of Washington, Seattle, WA, USA
Semin Ultrasound CT MR 31:496-505. 2010
..In this article the overall imaging process is reviewed and estimates of the magnitude of errors, where known, are given. Recommendations are provided for best practices in improving SUV accuracy...
Improved quantitation for PET/CT image reconstruction with system modeling and anatomical priorsAdam M Alessio
Department of Radiology, University of Washington Medical Center, 200 Old Fisheries Center Box 357987, Seattle, Washington 98195 7987, USA
Med Phys 33:4095-103. 2006
..At common clinical image noise levels for the detection task, the proposed method reduces the error in maximum tumor values by 11% compared to filtered back-projection and 5% compared to conventional iterative methods...
- Quantitative assessment of dynamic PET imaging data in cancer imaging
Mark Muzi
Department of Radiology, University of Washington, Seattle, WA 98195 6004, USA
Magn Reson Imaging 30:1203-15. 2012
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- Attenuation-emission alignment in cardiac PET/CT based on consistency conditions
Adam M Alessio
Department of Radiology, University of Washington Medical Center, 4000 15th Avenue NE, Box 357987, Seattle, Washington 98195 7987, USA
Med Phys 37:1191-200. 2010
..This misalignment leads to erroneous attenuation correction and can cause errors in perfusion mapping and quantification. This study develops and tests a method for automated alignment of attenuation and emission data...
- Application and evaluation of a measured spatially variant system model for PET image reconstruction
Adam M Alessio
Department of Radiology, University of Washington Medical Center, Seattle, WA 98195, USA
IEEE Trans Med Imaging 29:938-49. 2010
..With the proposed and other resolution-modeled reconstruction methods, edge artifacts need to be studied in more detail to determine the optimal tradeoff of resolution/contrast enhancement and edge fidelity...
- The impact of respiratory motion on tumor quantification and delineation in static PET/CT imaging
Chi Liu
Department of Radiology, University of Washington, Seattle, WA, USA
Phys Med Biol 54:7345-62. 2009
..To overcome the motion effect, motion compensation techniques may be necessary in clinical practice to improve the tumor quantification for determining the response to therapy or for radiation treatment planning...
- Planogram rebinning with the frequency-distance relationship
Kyle Champley
Department of Radiology, University of Washington, Seattle, WA 98195, USA
IEEE Trans Med Imaging 27:925-33. 2008
..Theoretical error bounds and numerical results are included...
Statistical LOR estimation for a high-resolution dMiCE PET detectorKyle M Champley
Department of Radiology, University of Washington, Seattle, WA, USA
Phys Med Biol 54:6369-82. 2009
..Monte Carlo experiments are performed using our LOR estimation algorithm and compared with Anger logic. We show that our LOR estimation algorithm provides a significant improvement over Anger logic under a variety of parameters...
- Applying a patient-specific bio-mathematical model of glioma growth to develop virtual [18F]-FMISO-PET images
Stanley Gu
Department of Bioengineering and Pathology, University of Washington, Seattle, WA 98195, USA
Math Med Biol 29:31-48. 2012
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- Dual energy CT attenuation correction methods for quantitative assessment of response to cancer therapy with PET/CT imaging
Paul E Kinahan
Department of Radiology, University of Washington, 200 Old Fisheries Center, Box 35 7987, Seattle, WA 98195, USA
Technol Cancer Res Treat 5:319-27. 2006
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- Quantification of radiotracer uptake with a dedicated breast PET imaging system
Raymond R Raylmana
Center for Advanced Imaging, Department of Radiology, West Virginia University, Morgantown, West Virginia 26506 9236, USA
Med Phys 35:4989-97. 2008
..Results from these preliminary studies indicate that the PEM-PET scanner will be useful for the quantification of radiotracer uptake in breast tumors, possibly facilitating early assessment of cancer treatments...
- Quantifying and reducing the effect of calibration error on variability of PET/CT standardized uptake value measurements
Catherine M Lockhart
Department of Radiology, University of Washington, Seattle, Washington 98195, USA
J Nucl Med 52:218-24. 2011
..The purpose of this study was to measure the errors introduced by regular calibration of PET/CT scanners and to minimize the effect of calibration error on standardized uptake value measurements...
- Early experiences in establishing a regional quantitative imaging network for PET/CT clinical trials
Robert K Doot
Department of Radiology, University of Washington, Seattle, WA, USA Seattle Cancer Care Alliance, Seattle, WA, USA
Magn Reson Imaging 30:1291-300. 2012
..These methods should be developed and implemented in multicenter clinical trials employing quantitative PET imaging of patients...
- Design considerations for using PET as a response measure in single site and multicenter clinical trials
Robert K Doot
Department of Radiology, University of Washington, Seattle, 98109 1023, USA
Acad Radiol 19:184-90. 2012
..Here we demonstrate impacts of PET measurement error and choice of quantification method on clinical trial design...
- Effects of MR surface coils on PET quantification
Lawrence R MacDonald
Department of Radiology, University of Washington School of Medicine, Seattle, Washington 98195, USA
Med Phys 38:2948-56. 2011
..In this case, conventional PET CT-AC methods could be used. A challenge here is that high atomic number materials within MR coils cause artifacts in CT images and CT based AC is typically not validated for coil materials...
- Optimization of noise equivalent count rate performance for a partially collimated PET scanner by varying the number of septa
Ruth E Schmitz
Department of Radiology, University of Washington, Seattle, WA 98195, USA
IEEE Trans Med Imaging 26:935-44. 2007
..However, the significant increase in statistical data quality warrants further investigation of the impact of partial collimation on clinical whole-body PET imaging...
- Dynamic and static approaches to quantifying 18F-FDG uptake for measuring cancer response to therapy, including the effect of granulocyte CSF
Robert K Doot
Department of Bioengineering, University of Washington, Seattle, Washington, USA
J Nucl Med 48:920-5. 2007
..We tested whether chemotherapy and treatment with granulocyte colony-stimulating factor (CSF) changed the blood clearance curves and therefore affected the relationship between MRFDG and SUV...
- Weight-based, low-dose pediatric whole-body PET/CT protocols
Adam M Alessio
Department of Radiology, University of Washington, Old Fisheries Center, Seattle, Washington 98195 7987, USA
J Nucl Med 50:1570-7. 2009
..We developed pediatric PET/CT acquisition protocols customized to patient weight and estimated the dosimetry and cancer risk of these low-dose protocols to communicate basic imaging risks...
- DOI-based reconstruction algorithms for a compact breast PET scanner
Kyle M Champley
GE Global Research, Niskayuna, New York 12309, USA
Med Phys 38:1660-71. 2011
..This design allows a unique combination of event estimation and fast projection methods...
- The positron emission mammography/tomography breast imaging and biopsy system (PEM/PET): design, construction and phantom-based measurements
Raymond R Raylman
Center for Advanced Imaging, Department of Radiology, West Virginia University, Morgantown, WV, USA
Phys Med Biol 53:637-53. 2008
..08 mm (axial). Maximum system detection sensitivity of the scanner is 488.9 kcps microCi(-1) ml(-1) (6.88%). These promising findings indicate that PEM/PET may be an effective system for the detection and diagnosis of breast cancer...
- Tumor delineation using PET in head and neck cancers: threshold contouring and lesion volumes
Eric C Ford
University of Washington, Department of Radiation Oncology, 1959 N. E. Pacific Street, Seattle, Washington 98195, USA
Med Phys 33:4280-8. 2006
..The appropriate threshold level depends on lesion size and image reconstruction parameters. These effects should be carefully considered when using PET contour and/or volume information for radiotherapy applications...
- Variability in PET quantitation within a multicenter consortium
Frederic H Fahey
Department of Radiology, Division of Nuclear Medicine, Children s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
Med Phys 37:3660-6. 2010
..The purpose of this study was to evaluate the variability in quantitation of positron emission tomography (PET) data acquired within the context of a multicenter consortium...
- Ultra-low dose CT attenuation correction for PET/CT
Ting Xia
Department of Bioengineering, University of Washington, Seattle, WA, USA
Phys Med Biol 57:309-28. 2012
..The significant dose reduction strategies proposed here could enable respiratory motion compensation methods that require extended duration CT scans and reduce radiation exposure in general for all PET/CT imaging...
- Gas bubble motion artifact in MDCT
Franklin Liu
Department of Radiology, University of Washington Medical Center, Box 357115, Seattle, WA 98195, USA
AJR Am J Roentgenol 190:294-9. 2008
..The purpose of our study was to characterize the imaging features of an MDCT artifact caused by gas bubble motion...
- PET/CT Assessment of Response to Therapy: Tumor Change Measurement, Truth Data, and Error
Paul E Kinahan
Department of Radiology, University of Washington, Seattle, WA, USA
Transl Oncol 2:223-30. 2009
..We conclude with a discussion of moving from assessing measurement variation to the steps necessary to establish the efficacy of PET/CT imaging as a biomarker for response...
- Modeling and incorporation of system response functions in 3-D whole body PET
Adam M Alessio
Department of Radiology, University of Washington Medical Center, Seattle, WA 98195 6004, USA
IEEE Trans Med Imaging 25:828-37. 2006
..Furthermore, simulation and measured studies show the proposed method improves quantitative accuracy with a reduction in tumor bias compared to conventional OSEM on the order of 10%-30% depending on tumor size and smoothing parameter...
- [11C]metahydroxyephedrine and [18F]fluorodeoxyglucose positron emission tomography improve clinical decision making in suspected pheochromocytoma
Gary N Mann
Department of Surgery, University of Washington, Box 356410, 1959 N E Pacific Street, Seattle, Washington 98195, USA
Ann Surg Oncol 13:187-97. 2006
..We evaluated whether positron emission tomography (PET) scanning with the combination of [18F]fluorodeoxyglucose (FDG) and the norepinephrine analogue [11C]metahydroxyephedrine (mHED) would allow more exact diagnosis and localization...
