Susan S Kim

Summary

Publications

  1. pmc Neurabin in the anterior cingulate cortex regulates anxiety-like behavior in adult mice
    Susan S Kim
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, ON, Canada
    Mol Brain 4:6. 2011
  2. doi request reprint Identification of an adenylyl cyclase inhibitor for treating neuropathic and inflammatory pain
    Hansen Wang
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, Medical Sciences Building, 1 King s College Circle, Toronto, Ontario M5S1A8, Canada
    Sci Transl Med 3:65ra3. 2011
  3. doi request reprint Alleviating neuropathic pain hypersensitivity by inhibiting PKMzeta in the anterior cingulate cortex
    Xiang yao Li
    Department of Physiology, Faculty of Medicine, Center for the Study of Pain, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Science 330:1400-4. 2010
  4. pmc Roles of fragile X mental retardation protein in dopaminergic stimulation-induced synapse-associated protein synthesis and subsequent alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-4-propionate (AMPA) receptor internalization
    Hansen Wang
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 285:21888-901. 2010
  5. pmc Enhancement of presynaptic glutamate release and persistent inflammatory pain by increasing neuronal cAMP in the anterior cingulate cortex
    Long Jun Wu
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for Study of Pain, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Pain 4:40. 2008
  6. pmc DREAM (downstream regulatory element antagonist modulator) contributes to synaptic depression and contextual fear memory
    Long Jun Wu
    Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada
    Mol Brain 3:3. 2010
  7. pmc Presynaptic and postsynaptic amplifications of neuropathic pain in the anterior cingulate cortex
    Hui Xu
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, Toronto, Ontario, Canada
    J Neurosci 28:7445-53. 2008
  8. doi request reprint FMRP acts as a key messenger for dopamine modulation in the forebrain
    Hansen Wang
    Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, ON M5S1A8, Canada
    Neuron 59:634-47. 2008
  9. pmc Sexual attraction enhances glutamate transmission in mammalian anterior cingulate cortex
    Long Jun Wu
    Department of Physiology, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Brain 2:9. 2009
  10. pmc Neurabin contributes to hippocampal long-term potentiation and contextual fear memory
    Long Jun Wu
    Department of Physiology, University of Toronto, Toronto, Onatrio, Canada
    PLoS ONE 3:e1407. 2008

Detail Information

Publications14

  1. pmc Neurabin in the anterior cingulate cortex regulates anxiety-like behavior in adult mice
    Susan S Kim
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, ON, Canada
    Mol Brain 4:6. 2011
    ..These findings reveal novel roles of the ACC in anxiety disorders, and provide a new therapeutic target for the treatment of anxiety disorders...
  2. doi request reprint Identification of an adenylyl cyclase inhibitor for treating neuropathic and inflammatory pain
    Hansen Wang
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, Medical Sciences Building, 1 King s College Circle, Toronto, Ontario M5S1A8, Canada
    Sci Transl Med 3:65ra3. 2011
    ..Our study thus shows that AC1 could be a productive therapeutic target for neuropathic pain and describes a new agent for the possible treatment of neuropathic pain...
  3. doi request reprint Alleviating neuropathic pain hypersensitivity by inhibiting PKMzeta in the anterior cingulate cortex
    Xiang yao Li
    Department of Physiology, Faculty of Medicine, Center for the Study of Pain, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Science 330:1400-4. 2010
    ..Microinjection of ZIP into the ACC blocked behavioral sensitization. These results suggest that PKMζ in the ACC acts to maintain neuropathic pain. PKMζ could thus be a new therapeutic target for treating chronic pain...
  4. pmc Roles of fragile X mental retardation protein in dopaminergic stimulation-induced synapse-associated protein synthesis and subsequent alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-4-propionate (AMPA) receptor internalization
    Hansen Wang
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 285:21888-901. 2010
    ..Our study thus provides further insights into FMRP involvement in DA modulation and may help to reveal the molecular mechanisms underlying impaired learning and memory in fragile X syndrome...
  5. pmc Enhancement of presynaptic glutamate release and persistent inflammatory pain by increasing neuronal cAMP in the anterior cingulate cortex
    Long Jun Wu
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for Study of Pain, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Pain 4:40. 2008
    ..The present study provides the first evidence linking enhanced presynaptic glutamate release in the ACC to behavioral sensitization caused by peripheral inflammation...
  6. pmc DREAM (downstream regulatory element antagonist modulator) contributes to synaptic depression and contextual fear memory
    Long Jun Wu
    Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada
    Mol Brain 3:3. 2010
    ..By contrast, sensory responses to noxious stimuli were not affected. Our results demonstrate that DREAM plays a novel role in postsynaptic modulation of the NMDA receptor, and contributes to synaptic plasticity and behavioral memory...
  7. pmc Presynaptic and postsynaptic amplifications of neuropathic pain in the anterior cingulate cortex
    Hui Xu
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, Toronto, Ontario, Canada
    J Neurosci 28:7445-53. 2008
    ..AC1 thus may serve as a potential therapeutic target for treating neuropathic pain...
  8. doi request reprint FMRP acts as a key messenger for dopamine modulation in the forebrain
    Hansen Wang
    Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, ON M5S1A8, Canada
    Neuron 59:634-47. 2008
    ..Our study has identified FMRP as a key messenger for DA modulation in the forebrain and may provide insights into the cellular and molecular mechanisms underlying fragile X syndrome...
  9. pmc Sexual attraction enhances glutamate transmission in mammalian anterior cingulate cortex
    Long Jun Wu
    Department of Physiology, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Brain 2:9. 2009
    ..Our results present direct evidence of the critical role of the ACC in sexual attraction, and long-term increases in glutamate mediated excitatory transmission may contribute to sexual attraction between male and female mice...
  10. pmc Neurabin contributes to hippocampal long-term potentiation and contextual fear memory
    Long Jun Wu
    Department of Physiology, University of Toronto, Toronto, Onatrio, Canada
    PLoS ONE 3:e1407. 2008
    ..Our results indicate that neurabin regulates contextual fear memory and LTP in hippocampal CA1 pyramidal neurons...
  11. doi request reprint Molecular targets of anxiety: from membrane to nucleus
    Long Jun Wu
    Department of Physiology, University of Toronto, 1 King s College Circle, Toronto, ON, Canada
    Neurochem Res 33:1925-32. 2008
    ..Studies on the interactions between these molecules will help elucidate the cellular mechanisms of anxiety, and will provide molecular targets for treating the disorders...
  12. pmc Selective activation of microglia in spinal cord but not higher cortical regions following nerve injury in adult mouse
    Fuxing Zhang
    Department of Physiology, Faculty of Medicine, University of Toronto, University of Toronto Centre for Study of Pain, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Pain 4:15. 2008
    ..Our results provide strong evidence that nerve injury primarily activates microglia in the spinal cord of adult mice, and pain-related cortical plasticity is likely mediated by neurons...
  13. pmc Investigation of molecular mechanism of chronic pain in the anterior cingulate cortex using genetically engineered mice
    Susan S Kim
    Department of Physiology, Faculty of Medicine, University of Toronto, Centre for the Study of Pain, 1 King s College Circle, Toronto, ON, Canada
    Curr Genomics 11:70-6. 2010
    ..In this review, we will examine the genetic models that are currently in use to study chronic pain in the anterior cingulate cortex: knockout mice; transgenic mice; and the strength of combining pharmacology with these genetic models...
  14. doi request reprint GluR3 subunit regulates sleep, breathing and seizure generation
    Hendrik W Steenland
    Department of Physiology, Faculty of Medicine, University of Toronto, Medical Sciences Building, 1 King s College Circle, Toronto, Ontario, Canada M5S 1A8
    Eur J Neurosci 27:1166-73. 2008
    ..Finally, this is the first study to demonstrate the feasibility of direct diaphragm electromyogram recordings in freely behaving mice...