Phosphorylation of mitogen-activated protein kinase in the medial prefrontal cortex and the amygdala following memory retrieval or forgetting in developing ratsJee Hyun Kim
School of Psychology, University of New South Wales, Sydney, NSW 2052, Australia
Neurobiol Learn Mem 97:59-68. 2012
..These findings provide initial evidence suggesting that while the mPFC is involved in memory retrieval, MAPK phosphorylation in the amygdala may be a persisting neural signature of fear memory...
- Immunohistochemical analyses of long-term extinction of conditioned fear in adolescent rats
Jee Hyun Kim
School of Psychology, University of New South Wales, Sydney, New South Wales 2052, Australia
Cereb Cortex 21:530-8. 2011
..These findings suggest that adolescents are less efficient in utilizing prefrontal areas, which may lead to an impairment in the maintenance of extinguished behavior...
- Extinction in preweanling rats does not involve NMDA receptors
Jee Hyun Kim
School of Psychology, University of New South Wales, Anzac Parade, Kensington, Sydney, New South Wales 2052, Australia
Neurobiol Learn Mem 94:176-82. 2010
..e., these rats still exhibited an impairment in extinction retention if given MK-801 prior to re-extinction). Taken together, these findings demonstrate that a qualitatively different system mediates extinction early in life...
- New findings on extinction of conditioned fear early in development: theoretical and clinical implications
Jee Hyun Kim
University of New South Wales, Sydney, Australia
Biol Psychiatry 67:297-303. 2010
..These findings showing that distinct processes mediate extinction at different stages of development may have significant clinical implications, which are discussed in this review...
The effect of the NMDA receptor antagonist MK-801 on the acquisition and extinction of learned fear in the developing ratJulia M Langton
School of Psychology, The University of New South Wales, Sydney 2052, Australia
Learn Mem 14:665-8. 2007
..These results illustrate another fundamental developmental difference in extinction as well as a dissociation in the role of NMDA in the acquisition and extinction of fear early in development...
- Expression of renewal is dependent on the extinction-test interval rather than the acquisition-extinction interval
Jee Hyun Kim
School of Psychology, The University of New South Wales, Sydney, Australia
Behav Neurosci 123:641-9. 2009
..Finally, the expression of extinction appears to be GABA dependent regardless of the extinction-test interval or the test context...
- A developmental dissociation of context and GABA effects on extinguished fear in rats
Jee Hyun Kim
School of Psychology, The University of New South Wales, Sydney, NSW, Australia
Behav Neurosci 121:131-9. 2007
..Taken together, it appears that there are fundamental differences in the processes involved in extinction across development...
- The effect of the mu-opioid receptor antagonist naloxone on extinction of conditioned fear in the developing rat
Jee Hyun Kim
School of Psychology, University of New South Wales, Sydney 2052, Australia
Learn Mem 16:161-6. 2009
..Taken together, these findings indicate that opioid neurotransmission, in contrast to GABA and NMDA activity, is critical for extinction acquisition across development...
- Differential involvement of the medial prefrontal cortex in the expression of learned fear across development
Stella Li
School of Psychology, The University of New South Wales, Sydney, NSW 2052, Australia
Behav Neurosci 126:217-25. 2012
..Taken together, these experiments suggest that a different neural circuitry underlies fear regulation early in life and that the lack of mPFC involvement may reflect a less flexible emotional regulation system in infant animals...
- Fear extinction across development: the involvement of the medial prefrontal cortex as assessed by temporary inactivation and immunohistochemistry
Jee Hyun Kim
School of Psychology, The University of New South Wales, Kensington, Sydney, New South Wales 2052, Australia
J Neurosci 29:10802-8. 2009
..Together, these findings show that extinction in P17 rats does not involve the mPFC, which has important theoretical and clinical implications for the treatment of anxiety disorders in humans...
- A developmental dissociation in reinstatement of an extinguished fear response in rats
Jee Hyun Kim
School of Psychology, The University of New South Wales, Sydney 2052, Australia
Neurobiol Learn Mem 88:48-57. 2007
..Taken together, the results suggest that fundamentally different processes may mediate extinction early in development compared to later in development...
- The effect of temporary amygdala inactivation on extinction and reextinction of fear in the developing rat: unlearning as a potential mechanism for extinction early in development
Jee Hyun Kim
School of Psychology, The University of New South Wales, Sydney 2052, Australia
J Neurosci 28:1282-90. 2008
..Consistent with previous findings, these results show that there are fundamental differences in the neural mechanisms of fear extinction across development...
- Immediate post-reminder injection of gamma-amino butyric acid (GABA) agonist midazolam attenuates reactivation of forgotten fear in the infant rat
Jee Hyun Kim
School of Psychology, University of New South Wales, Sydney, Australia
Behav Neurosci 121:1328-32. 2007
..From this, it appears that alterations in GABAergic neurotransmission may be an underlying process mediating memory reactivation in the infant rat...
Impaired extinction retention in adolescent rats: effects of D-cycloserineJessica McCallum
University of New South Wales, Anzac Parade, Kensington, New South Wales, Australia
Neuropsychopharmacology 35:2134-42. 2010
..These novel findings have potential implications for clinical treatments of fear and anxiety disorders in adolescent patients...
- Recovery of fear memories in rats: role of gamma-amino butyric acid (GABA) in infantile amnesia
Jee Hyun Kim
School of PsychologyUniversity of New South Wales, Sydney, NSW, Australia
Behav Neurosci 120:40-8. 2006
..It appears that GABA may be involved in infantile amnesia regardless of the emotional content of the memory...
