Genomes and Genes


Ulkan Kilic



  1. Kilic U, Elibol B, Uysal O, Kilic E, Yulug B, Sayin Sakul A, et al. Specific alterations in the circulating levels of the SIRT1, TLR4, and IL7 proteins in patients with dementia. Exp Gerontol. 2018;111:203-209 pubmed publisher
    ..Furthermore, it highlights the importance of epigenetics in several age-related diseases and suggests that developing novel therapies to prevent or slow down the progression of dementia may support healthy aging. ..
  2. Kilic U, Kilic E, Tuzcu Z, Tuzcu M, Ozercan I, Yilmaz O, et al. Melatonin suppresses cisplatin-induced nephrotoxicity via activation of Nrf-2/HO-1 pathway. Nutr Metab (Lond). 2013;10:7 pubmed publisher
    ..Our present data suggest that melatonin attenuates cisplatin-induced nephrotoxicity possibly by modulating Nrf2/HO-1 signaling. ..
  3. Kilic U, Gok O, Elibol Can B, Ozgen I, Erenberk U, Uysal O, et al. SIRT1 gene variants are related to risk of childhood obesity. Eur J Pediatr. 2015;174:473-9 pubmed publisher
    ..There was no significant difference for rs7069102 C > G gene polymorphism between groups. This is the first study reporting an association between SIRT1 gene polymorphisms and obesity in children. ..
  4. Ä°zmirli M, Göktekin Ã, Bacaksız A, Uysal Ã, Kılıç Ã. The effect of the SIRT1 2827 A>G polymorphism, resveratrol, exercise, age and occupation in Turkish population with cardiovascular disease. Anatol J Cardiol. 2015;15:103-6 pubmed publisher
    ..17; CI 95%, 0.1-0.2; p ≤ 0.001). This is the first study demonstrating the correlation between the SIRT1 rs144124002 polymorphism and CVD in Turkish population. ..
  5. Yamac A, Kucukbuzcu S, Ozansoy M, Gok O, Oz K, Erturk M, et al. Altered expression of micro-RNA 199a and increased levels of cardiac SIRT1 protein are associated with the occurrence of atrial fibrillation after coronary artery bypass graft surgery. Cardiovasc Pathol. 2016;25:232-6 pubmed publisher
    ..001). Altered expression of the SIRT1 protein regulating miR-199a in human atrial tissue was found to be related to the occurrence of POAF, indicating its usefulness as a biomarker for cardiac surgery management. ..