Naveed Ahmed Khan

Summary

Publications

  1. pmc Acanthamoeba and bacteria produce antimicrobials to target their counterpart
    Junaid Iqbal
    Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan
    Parasit Vectors 7:56. 2014
  2. pmc Is semen a useful diagnostic tool for rare infections of the central nervous system?
    Ruqaiyyah Siddiqui
    Department of Biological and Biomedical Sciences, Aga Khan University, Stadium Road, Karachi, Pakistan
    Parasit Vectors 5:297. 2012
  3. pmc Photochemotherapeutic strategies against Acanthamoeba keratitis
    Ruqaiyyah Siddiqui
    Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan
    AMB Express 2:47. 2012
  4. doi request reprint Escherichia coli K1-induced cytopathogenicity of human brain microvascular endothelial cells
    Naveed Ahmed Khan
    Department of Biological and Biomedical Sciences, Aga Khan University, Stadium Road, Karachi, Pakistan
    Microb Pathog 53:269-75. 2012
  5. pmc A simple assay to screen antimicrobial compounds potentiating the activity of current antibiotics
    Junaid Iqbal
    Department of Biological and Biomedical Sciences, Aga Khan University, Stadium Road, Karachi 74800, Pakistan
    Biomed Res Int 2013:927323. 2013
  6. doi request reprint The effect of different environmental conditions on the encystation of Acanthamoeba castellanii belonging to the T4 genotype
    Yousuf Aqeel
    Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan
    Exp Parasitol 135:30-5. 2013
  7. pmc Acanthamoeba castellanii of the T4 genotype is a potential environmental host for Enterobacter aerogenes and Aeromonas hydrophila
    Farzana Abubakar Yousuf
    Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan
    Parasit Vectors 6:169. 2013
  8. pmc In vitro efficacies of clinically available drugs against growth and viability of an Acanthamoeba castellanii keratitis isolate belonging to the T4 genotype
    Abdul Mannan Baig
    Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan
    Antimicrob Agents Chemother 57:3561-7. 2013
  9. pmc The role of Src kinase in the biology and pathogenesis of Acanthamoeba castellanii
    Ruqaiyyah Siddiqui
    Department of Biological and Biomedical Sciences, The Aga Khan University, Karachi, Pakistan
    Parasit Vectors 5:112. 2012
  10. doi request reprint Prevalence of Acanthamoeba and superbugs in a clinical setting: coincidence or hyperparasitism?
    Ruqaiyyah Siddiqui
    Department of Biological and Biomedical Sciences, Aga Khan University, Stadium Road, Karachi, Pakistan
    Parasitol Res 112:1349-51. 2013

Collaborators

Detail Information

Publications38

  1. pmc Acanthamoeba and bacteria produce antimicrobials to target their counterpart
    Junaid Iqbal
    Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan
    Parasit Vectors 7:56. 2014
    ..Many currently used antibiotics were developed by exploiting this potential of certain microbes...
  2. pmc Is semen a useful diagnostic tool for rare infections of the central nervous system?
    Ruqaiyyah Siddiqui
    Department of Biological and Biomedical Sciences, Aga Khan University, Stadium Road, Karachi, Pakistan
    Parasit Vectors 5:297. 2012
    ..ABSTRACT: Given that the blood-testis barrier is more permeable than the blood-brain barrier, the use of semen to detect rare parasitic antigens/infections of the CNS in males is hypothesized...
  3. pmc Photochemotherapeutic strategies against Acanthamoeba keratitis
    Ruqaiyyah Siddiqui
    Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan
    AMB Express 2:47. 2012
    ....
  4. doi request reprint Escherichia coli K1-induced cytopathogenicity of human brain microvascular endothelial cells
    Naveed Ahmed Khan
    Department of Biological and Biomedical Sciences, Aga Khan University, Stadium Road, Karachi, Pakistan
    Microb Pathog 53:269-75. 2012
    ..coli K1. E. coli K1-mediated HBMEC death was independent of phosphatidylinositol 3-kinase (PI3K) but dependent partially on focal adhesion kinase (FAK) using HBMEC expressing dominant negative FAK and PI3K...
  5. pmc A simple assay to screen antimicrobial compounds potentiating the activity of current antibiotics
    Junaid Iqbal
    Department of Biological and Biomedical Sciences, Aga Khan University, Stadium Road, Karachi 74800, Pakistan
    Biomed Res Int 2013:927323. 2013
    ..In conclusion, our assay is able to detect either synergistic or additive action of J. regia extract against multiple drug-resistant bacteria when tested with a range of antibiotics. ..
  6. doi request reprint The effect of different environmental conditions on the encystation of Acanthamoeba castellanii belonging to the T4 genotype
    Yousuf Aqeel
    Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan
    Exp Parasitol 135:30-5. 2013
    ..castellanii, as determined by Trypan blue exclusion assay. A complete knowledge of encystation in A. castellanii is crucial to our understanding of the biology of these ecologically and medically important organisms...
  7. pmc Acanthamoeba castellanii of the T4 genotype is a potential environmental host for Enterobacter aerogenes and Aeromonas hydrophila
    Farzana Abubakar Yousuf
    Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan
    Parasit Vectors 6:169. 2013
    ..and Escherichia coli. In this capacity, Acanthamoeba has been suggested as a vector in the transmission of bacterial pathogens to the susceptible hosts...
  8. pmc In vitro efficacies of clinically available drugs against growth and viability of an Acanthamoeba castellanii keratitis isolate belonging to the T4 genotype
    Abdul Mannan Baig
    Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan
    Antimicrob Agents Chemother 57:3561-7. 2013
    ..and possibly against other meningoencephalitis-causing amoebae, such as Balamuthia mandrillaris and Naegleria fowleri. ..
  9. pmc The role of Src kinase in the biology and pathogenesis of Acanthamoeba castellanii
    Ruqaiyyah Siddiqui
    Department of Biological and Biomedical Sciences, The Aga Khan University, Karachi, Pakistan
    Parasit Vectors 5:112. 2012
    ..Here, we evaluated the role of Src, a non-receptor protein tyrosine kinase in the biology and pathogenesis of Acanthamoeba...
  10. doi request reprint Prevalence of Acanthamoeba and superbugs in a clinical setting: coincidence or hyperparasitism?
    Ruqaiyyah Siddiqui
    Department of Biological and Biomedical Sciences, Aga Khan University, Stadium Road, Karachi, Pakistan
    Parasitol Res 112:1349-51. 2013
    ..Given that Acanthamoeba can harbor bacteria, anti-amoebic approaches may represent a strategy in eradicating "superbugs" from the clinical setting in addition to the current measures...
  11. doi request reprint Inefficacy of marketed contact lens disinfection solutions against keratitis-causing Acanthamoeba castellanii belonging to the T4 genotype
    Sahreena Lakhundi
    Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan
    Exp Parasitol 141:122-8. 2014
    ..aeruginosa which is in accordance with the ISO Stand-Alone Primary acceptance criteria. These findings are of great concern for contact lens users. ..
  12. pmc Neuropathogenic Escherichia coli K1 does not exhibit proteolytic activities to exert its pathogenicity
    Junaid Iqbal
    Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan
    J Negat Results Biomed 12:8. 2013
    ..Because proteases are frequently associated with vascular permeability by targeting junctional proteins, here it is hypothesized that neuropathogenic Escherichia coli K1 exhibit proteolytic activities to exert its pathogenicity...
  13. doi request reprint Acanthamoeba can propagate on thermophilic Sulfolobus spp
    Junaid Iqbal
    Department of Biological and Biomedical Sciences, Aga Khan University, Stadium Road, Karachi, Pakistan
    Parasitol Res 112:879-81. 2013
    ..This feeding behavior is important as extremophilic/mesophilic Archaea are known to play a role in biogeochemical cycling of different elements in their natural habitat impacting different ecosystems...
  14. doi request reprint Anti-Acanthamoebic properties of resveratrol and demethoxycurcumin
    Yousuf Aqeel
    Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan
    Exp Parasitol 132:519-23. 2012
    ..Of both compounds, resveratrol is of most interest for further investigation, because of the selective toxicity of resveratrol on A. castellanii but not the human brain microvascular endothelial cells...
  15. doi request reprint Atomic force microscopic imaging of Acanthamoeba castellanii and Balamuthia mandrillaris trophozoites and cysts
    Yousuf Aqeel
    Department of Biological and Biomedical Sciences, Aga Khan University, Stadium Road, Karachi, Pakistan
    J Eukaryot Microbiol 62:85-94. 2015
    ....
  16. pmc Interactions of neuropathogenic Escherichia coli K1 (RS218) and its derivatives lacking genomic islands with phagocytic Acanthamoeba castellanii and nonphagocytic brain endothelial cells
    Farzana Abubakar Yousuf
    Department of Biological and Biomedical Sciences, Aga Khan University, Stadium Road, Karachi 74800, Pakistan
    Biomed Res Int 2014:265424. 2014
    ..coli K1-mediated HBMEC cytotoxicity in a CNF1-independent manner. Therefore, the characterization of these genomic islands should reveal mechanisms of evolutionary gain for E. coli K1 pathogenicity. ..
  17. doi request reprint Killing the dead: chemotherapeutic strategies against free-living cyst-forming protists (Acanthamoeba sp. and Balamuthia mandrillaris)
    Ruqaiyyah Siddiqui
    Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan
    J Eukaryot Microbiol 60:291-7. 2013
    ....
  18. doi request reprint Silencing of xylose isomerase and cellulose synthase by siRNA inhibits encystation in Acanthamoeba castellanii
    Yousuf Aqeel
    Department of Biological and Biomedical Sciences, Aga Khan University, Stadium Road, Karachi, Pakistan
    Parasitol Res 112:1221-7. 2013
    ..castellanii metamorphosis, as demonstrated by the arrest of encystation of A. castellanii. Neither inhibitor nor siRNA probes had any effect on the viability and extracellular proteolytic activities of A. castellanii...
  19. doi request reprint War of the microbial worlds: who is the beneficiary in Acanthamoeba-bacterial interactions?
    Ruqaiyyah Siddiqui
    Department of Biological and Biomedical Sciences, Aga Khan University, Stadium Road, Karachi, Pakistan
    Exp Parasitol 130:311-3. 2012
    ..Here, we discuss the nature of these convoluted interactions and the benefit they represent for the symbionts...
  20. doi request reprint Status of the effectiveness of contact lens solutions against keratitis-causing pathogens
    Ruqaiyyah Siddiqui
    Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan
    Cont Lens Anterior Eye 38:34-8. 2015
    ..The aim of this study was to assess the antimicrobial effects of marketed contact lens disinfecting solutions...
  21. doi request reprint Laboratory testing of clinically approved drugs against Balamuthia mandrillaris
    Huma Kalsoom
    Department of Biological and Biomedical Sciences, Aga Khan University, Stadium Road, Karachi, Pakistan
    World J Microbiol Biotechnol 30:2337-42. 2014
    ..mandrillaris, and other free-living amoebae, such as Acanthamoeba spp., and Naegleria fowleri...
  22. pmc Cellulose degradation: a therapeutic strategy in the improved treatment of Acanthamoeba infections
    Sahreena Lakhundi
    Department of Biological and Biomedical Sciences, Aga Khan University, Stadium Road, Karachi, Pakistan
    Parasit Vectors 8:23. 2015
    ....
  23. pmc Stress management in cyst-forming free-living protists: programmed cell death and/or encystment
    Naveed Ahmed Khan
    Department of Biological and Biomedical Sciences, Aga Khan University, Karachi 74800, Pakistan
    Biomed Res Int 2015:437534. 2015
    ....
  24. doi request reprint The effect of environmental and physiological conditions on excystation of Acanthamoeba castellanii belonging to the T4 genotype
    Sahreena Lakhundi
    Department of Biological and Biomedical Sciences, Aga Khan University, Stadium Road, Karachi, Pakistan
    Parasitol Res 113:2809-16. 2014
    ..None of the aforementioned conditions had any effect on the viability of A. castellanii. A complete understanding of excystation in A. castellanii will be of value to counter infection recurrence...
  25. doi request reprint Partial characterization of Acanthamoeba castellanii (T4 genotype) DNase activity
    Junaid Iqbal
    Department of Biological and Biomedical Sciences, Aga Khan University, Stadium Road, Karachi, Pakistan
    Parasitol Res 114:457-63. 2015
    ....
  26. doi request reprint Combined drug therapy in the management of granulomatous amoebic encephalitis due to Acanthamoeba spp., and Balamuthia mandrillaris
    Huma Kulsoom
    Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan
    Exp Parasitol 145:S115-20. 2014
    ..As these drugs are used clinically against non-communicable diseases, the findings reported here have the potential to be tested in a clinical setting against amoebic encephalitis caused by A. castellanii and B. mandrillaris. ..
  27. doi request reprint In vitro inhibition of protease-activated receptors 1, 2 and 4 demonstrates that these receptors are not involved in an Acanthamoeba castellanii keratitis isolate-mediated disruption of the human brain microvascular endothelial cells
    Junaid Iqbal
    Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan
    Exp Parasitol 145:S78-83. 2014
    ..castellanii-mediated dysfunction of HBMEC, which constitute the blood-brain barrier. The role of additional protease-activated receptors in amoebic invasion of the central nervous system is discussed further...
  28. doi request reprint The role of G protein coupled receptor-mediated signaling in the biological properties of Acanthamoeba castellanii of the T4 genotype
    Yousuf Aqeel
    Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan
    Microb Pathog 81:22-7. 2015
    ..The aforementioned findings suggest that G-protein coupled receptor, β adrenergic receptor-mediated signaling in A. castellanii biology and pathogenesis may offer new pharmacological targets. ..
  29. doi request reprint Acanthamoeba differentiation: a two-faced drama of Dr Jekyll and Mr Hyde
    Ruqaiyyah Siddiqui
    Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan
    Parasitology 139:826-34. 2012
    ..Acanthamoeba can elude inhospitable conditions by forming cysts. Here we unravel the processes involved in the phenotypic switching of Acanthamoeba, which are critical in our efforts to find potential targets for chemotherapy...
  30. pmc Biology and pathogenesis of Acanthamoeba
    Ruqaiyyah Siddiqui
    The Aga Khan University, Karachi, Pakistan
    Parasit Vectors 5:6. 2012
    ..There is a significant emphasis on Acanthamoeba as a Trojan horse of other microbes including viral, bacterial, protists and yeast pathogens...
  31. doi request reprint Status of free-living amoebae (Acanthamoeba spp., Naegleria fowleri, Balamuthia mandrillaris) in drinking water supplies in Karachi, Pakistan
    Farzana Abubakar Yousuf
    Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan
    J Water Health 11:371-5. 2013
    ..mandrillaris antibody prevalence rate was 5.5% in males only (females were negative). Our findings suggest that free-living amoebae are a potential health hazard in domestic water supplies in Karachi, Pakistan...
  32. pmc Primary amoebic meningoencephalitis caused by Naegleria fowleri: an old enemy presenting new challenges
    Ruqaiyyah Siddiqui
    Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan
    PLoS Negl Trop Dis 8:e3017. 2014
    ..With increasing water scarcity and public reliance on water storage, here we debate the need for increased awareness of primary amoebic meningoencephalitis and the associated risk factors, particularly in developing countries. ..
  33. doi request reprint Pharmacological basis for the medicinal use of Linum usitatissimum (Flaxseed) in infectious and non-infectious diarrhea
    Amber Hanif Palla
    Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74800, Pakistan
    J Ethnopharmacol 160:61-8. 2015
    ..This study was planned to assess pharmacological basis for the medicinal use of Flaxseed in infectious and non-infectious diarrhea...
  34. doi request reprint Tackling infection owing to brain-eating amoeba
    Abdul Mannan Baig
    Department of Biological and Biomedical Sciences, Aga Khan University, Stadium Road, Karachi, Pakistan
    Acta Trop 142:86-8. 2015
    ..The proposed rationale should stimulate interest in this emerging infection that almost always proves fatal. ..
  35. doi request reprint Acanthamoeba is an evolutionary ancestor of macrophages: a myth or reality?
    Ruqaiyyah Siddiqui
    Aga Khan University, Stadium Road, Karachi, Pakistan
    Exp Parasitol 130:95-7. 2012
    ..Further debate and studies will determine if Acanthamoeba is an evolutionary ancestor of macrophages. Is this a myth or reality?..
  36. pmc Next generation of non-mammalian blood-brain barrier models to study parasitic infections of the central nervous system
    Ruqaiyyah Siddiqui
    Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan
    Virulence 3:159-63. 2012
    ..The availability of models of the blood-brain barrier that closely mimic the situation in vivo offers unprecedented opportunities for the development of novel therapeutics...
  37. doi request reprint Predator vs aliens: bacteria interactions with Acanthamoeba
    Naveed Ahmed Khan
    Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan
    Parasitology 141:869-74. 2014
    ..The microbial survival of amoebae in harsh environments, ability to interact with bacteria, and their ability to aid transmission to susceptible hosts is of great concern to human, animal and ecosystem health...
  38. doi request reprint The type III secretion system is involved in Escherichia coli K1 interactions with Acanthamoeba
    Ruqaiyyah Siddiqui
    Aga Khan University, Stadium Road, Karachi, Pakistan
    Exp Parasitol 128:409-13. 2011
    ..coli interactions with Acanthamoeba. A complete understanding of how amoebae harbor bacterial pathogens will help design strategies against E. coli transmission to the susceptible hosts...