M A Khamashta

Summary

Publications

  1. ncbi Management of thrombosis and pregnancy loss in the antiphospholipid syndrome
    M A Khamashta
    Lupus Research Unit, The Rayne Institute, St Thomas Hospital, London, UK
    Lupus 7:S162-5. 1998
  2. ncbi Primary prevention of thrombosis in subjects with positive antiphospholipid antibodies
    M A Khamashta
    Lupus Research Unit, The Rayne Institute, St Thomas Hospital, London, UK
    J Autoimmun 15:249-53. 2000
  3. ncbi Atherosclerosis and autoimmunity
    P A Gordon
    Lupus Research Unit, Rayne Institute, St Thomas Hospital, London, UK
    Lupus 10:249-52. 2001
  4. ncbi Bleeding and recurrent thrombosis in definite antiphospholipid syndrome: analysis of a series of 66 patients treated with oral anticoagulation to a target international normalized ratio of 3.5
    Guillermo Ruiz-Irastorza
    Lupus Research Unit, The Rayne Institute, St Thomas Hospital, London SE1 7EH, England
    Arch Intern Med 162:1164-9. 2002
  5. ncbi Therapy of systemic lupus erythematosus: new agents and new evidence
    G Ruiz-Irastorza
    Lupus Research Unit, The Rayne Institute, St Thomas Hospital, London SE1 7EH, UK
    Expert Opin Investig Drugs 9:1581-93. 2000
  6. ncbi A candidate gene analysis of three related photosensitivity disorders: cutaneous lupus erythematosus, polymorphic light eruption and actinic prurigo
    T P Millard
    Department of Photobiology, St John s Institute of Dermatology, St Thomas Hospital, London SE1 7EH, UK
    Br J Dermatol 145:229-36. 2001
  7. ncbi Renal artery stenosis in hypertensive patients with antiphospholipid (Hughes) syndrome: outcome following anticoagulation
    S R Sangle
    St Thomas Hospital, Lupus Research Unit, London, UK
    Rheumatology (Oxford) 44:372-7. 2005
  8. pmc Characteristics of patients with antiphospholipid syndrome with major bleeding after oral anticoagulant treatment
    G Castellino
    Lupus Research Unit, The Rayne Institute, St Thomas's Hospital, London, UK
    Ann Rheum Dis 60:527-30. 2001
  9. ncbi The value of IgA antiphospholipid testing for diagnosis of antiphospholipid (Hughes) syndrome in systemic lupus erythematosus
    M L Bertolaccini
    Lupus Research Unit, The Rayne Institute, St. Thomas' Hospital, London, UK
    J Rheumatol 28:2637-43. 2001
  10. pmc Association of HLA-DM polymorphism with the production of antiphospholipid antibodies
    M L Sanchez
    Lupus Research Unit, The Rayne Institute, St Thomas Hospital, London, SE1 7EH, UK
    Ann Rheum Dis 63:1645-8. 2004

Collaborators

Detail Information

Publications64

  1. ncbi Management of thrombosis and pregnancy loss in the antiphospholipid syndrome
    M A Khamashta
    Lupus Research Unit, The Rayne Institute, St Thomas Hospital, London, UK
    Lupus 7:S162-5. 1998
    ....
  2. ncbi Primary prevention of thrombosis in subjects with positive antiphospholipid antibodies
    M A Khamashta
    Lupus Research Unit, The Rayne Institute, St Thomas Hospital, London, UK
    J Autoimmun 15:249-53. 2000
    ..However, very little is known about the risk of thrombosis in individuals positive for aPL but still free of thrombosis. Should these individuals receive any treatment? If so, which one?..
  3. ncbi Atherosclerosis and autoimmunity
    P A Gordon
    Lupus Research Unit, Rayne Institute, St Thomas Hospital, London, UK
    Lupus 10:249-52. 2001
    ..In particular we will focus on several autoantigens, review the evidence for their role in the process of atherosclerosis and the nature of the immune responses...
  4. ncbi Bleeding and recurrent thrombosis in definite antiphospholipid syndrome: analysis of a series of 66 patients treated with oral anticoagulation to a target international normalized ratio of 3.5
    Guillermo Ruiz-Irastorza
    Lupus Research Unit, The Rayne Institute, St Thomas Hospital, London SE1 7EH, England
    Arch Intern Med 162:1164-9. 2002
    ..Prolonged anticoagulation is the treatment of choice for patients with thrombosis and the antiphospholipid syndrome. However, there is still debate about the optimum intensity of anticoagulation...
  5. ncbi Therapy of systemic lupus erythematosus: new agents and new evidence
    G Ruiz-Irastorza
    Lupus Research Unit, The Rayne Institute, St Thomas Hospital, London SE1 7EH, UK
    Expert Opin Investig Drugs 9:1581-93. 2000
    ..Other recently developed molecules, including anti-CD40L monoclonal antibodies (mAbs), are still under investigation...
  6. ncbi A candidate gene analysis of three related photosensitivity disorders: cutaneous lupus erythematosus, polymorphic light eruption and actinic prurigo
    T P Millard
    Department of Photobiology, St John s Institute of Dermatology, St Thomas Hospital, London SE1 7EH, UK
    Br J Dermatol 145:229-36. 2001
    ....
  7. ncbi Renal artery stenosis in hypertensive patients with antiphospholipid (Hughes) syndrome: outcome following anticoagulation
    S R Sangle
    St Thomas Hospital, Lupus Research Unit, London, UK
    Rheumatology (Oxford) 44:372-7. 2005
    ..We have demonstrated a point prevalence of 26% renal artery stenosis in patients with antiphospholipid syndrome (APS) and uncontrolled hypertension. We describe the effect of anticoagulation on blood pressure control and renal function...
  8. pmc Characteristics of patients with antiphospholipid syndrome with major bleeding after oral anticoagulant treatment
    G Castellino
    Lupus Research Unit, The Rayne Institute, St Thomas's Hospital, London, UK
    Ann Rheum Dis 60:527-30. 2001
    ..CONCLUSION: No relation was established between age, duration of oral anticoagulant treatment, and bleeding. Concomitant drugs, mainly aspirin, and high blood pressure were present at the time of bleeding in a large number of patients...
  9. ncbi The value of IgA antiphospholipid testing for diagnosis of antiphospholipid (Hughes) syndrome in systemic lupus erythematosus
    M L Bertolaccini
    Lupus Research Unit, The Rayne Institute, St. Thomas' Hospital, London, UK
    J Rheumatol 28:2637-43. 2001
    ..IgA aPT and aPS/PT are not present in patients with SLE, therefore there is no need to test for these antibodies...
  10. pmc Association of HLA-DM polymorphism with the production of antiphospholipid antibodies
    M L Sanchez
    Lupus Research Unit, The Rayne Institute, St Thomas Hospital, London, SE1 7EH, UK
    Ann Rheum Dis 63:1645-8. 2004
    ....
  11. pmc Antiphospholipid antibody tests: spreading the net
    M L Bertolaccini
    Lupus Research Unit, The Rayne Institute, St Thomas Hospital, London SE1 7EH, UK
    Ann Rheum Dis 64:1639-43. 2005
    ....
  12. ncbi Reduction of proteinuria with mycophenolate mofetil in predominantly membranous lupus nephropathy
    M Y Karim
    Lupus Research Unit, The Rayne Institute, Guy s and St Thomas NHS Foundation Trust, Lambeth Palace Road, London SE1 7EH, UK
    Rheumatology (Oxford) 44:1317-21. 2005
    ..Studies have shown good results with mycophenolate mofetil (MMF) in proliferative lupus nephropathy (LN) (WHO class III and IV disease)...
  13. ncbi Plasma tumor necrosis factor alpha levels and the -238*A promoter polymorphism in patients with antiphospholipid syndrome
    M L Bertolaccini
    Lupus Research Unit, The Rayne Institute, St Thomas Hospital, London, UK
    Thromb Haemost 85:198-203. 2001
    ....
  14. ncbi Lack of association between antiphospholipid antibody and WHO classification in lupus nephritis
    C Fofi
    Lupus Research Unit, Rayne Institute, St Thomas' Hospital, London
    Clin Exp Rheumatol 19:75-7. 2001
    ..The presence of these antibodies does not seem to be related to histological activity or the chronicity of lupus nephritis nor proteinuria...
  15. pmc Anti-dsDNA, anti-Sm antibodies, and the lupus anticoagulant: significant factors associated with lupus nephritis
    P Alba
    Lupus Research Unit, The Rayne Institute, UK
    Ann Rheum Dis 62:556-60. 2003
    ..Lupus nephritis (LN) is a common manifestation in patients with systemic lupus erythematosus (SLE). Autoantibodies and ethnicity have been associated with LN, but the results are controversial...
  16. pmc Prevalence of an abnormal ankle-brachial index in patients with primary antiphospholipid syndrome: preliminary data
    M A Baron
    Research Unit, The Rayne Institute, St Thomas Hospital, London SE1 7EH, UK
    Ann Rheum Dis 64:144-6. 2005
    ....
  17. ncbi Familial clustering of polymorphic light eruption in relatives of patients with lupus erythematosus: evidence of a shared pathogenesis
    T P Millard
    Department of Photobiology, St John s Institute of Dermatology, London SE1 7EH, UK
    Br J Dermatol 144:334-8. 2001
    ..Abnormal photosensitivity is a common feature of many forms of lupus erythematosus (LE)...
  18. pmc Anti-C1q antibodies in nephritis: correlation between titres and renal disease activity and positive predictive value in systemic lupus erythematosus
    N Marto
    Lupus Research Unit, The Rayne Institute, St Thomas Hospital, London SE1 7EH, UK
    Ann Rheum Dis 64:444-8. 2005
    ..To investigate antibodies to complement 1q (anti-C1q) and investigate the correlation between anti-C1q titres and renal disease in systemic lupus erythematosus (SLE)...
  19. ncbi Lupus pregnancy: is heparin a risk factor for osteoporosis?
    G Ruiz-Irastorza
    Lupus Research Unit, The Rayne Institute, St Thomas Hospital, London, UK
    Lupus 10:597-600. 2001
    ..Corticosteroids must be reduced as much as possible in these women, and calcium plus vitamin D are recommended. Finally, indications for heparin use must be clearly justified and advice regarding breastfeeding must be offered...
  20. ncbi Moderate dose oral anticoagulant therapy in patients with the antiphospholipid syndrome? No
    M A Khamashta
    Lupus Unit, King s College London School of Medicine, Guy s and St Thomas NHS Foundation Trust, London, UK
    J Thromb Haemost 3:844-5. 2005
  21. ncbi Mycophenolate mofetil treatment in resistant myositis
    C N Pisoni
    Lupus Research Unit, The Rayne Institute, King s College London School of Medicine at Guy s, King s and St Thomas Hospitals, St Thomas Hospital, London, UK
    Rheumatology (Oxford) 46:516-8. 2007
    ..To assess the efficacy and tolerability of mycophenolate mofetil (MMF) in six patients with myositis refractory to conventional immunosuppressive therapy...
  22. doi Failure of intravenous immunoglobulin to prevent congenital heart block: Findings of a multicenter, prospective, observational study
    C N Pisoni
    St Thomas Hospital, and King s College London, London, UK
    Arthritis Rheum 62:1147-52. 2010
    ..The purpose of this study was to determine whether intravenous immunoglobulin (IVIG) therapy could prevent the development of CHB in the fetuses of high-risk pregnant women...
  23. ncbi Chromium-51 ethylenediamine tetraacetic acid glomerular filtration rate: a better predictor than glomerular filtration rate calculated by the Cockcroft-Gault formula for renal involvement in systemic lupus erythematosus patients
    T Godfrey
    Lupus Research Unit, The Rayne Institute, St Thomas' Hospital, London SE1 7EH, UK
    Rheumatology (Oxford) 40:324-8. 2001
    ..Significant numbers of patients with WHO class III, IV or V lupus nephritis may be missed if biochemical creatinine clearance or serum creatinine concentration alone is used to assess renal disease...
  24. doi The clinical value of testing for antibodies to phosphatidylethanolamine (aPE) in patients with systemic lupus erythematosus (SLE)
    M L Bertolaccini
    Lupus Research Unit, The Rayne Institute, Division of Women s Health, King s College London, UK
    Thromb Res 130:914-8. 2012
    ..The value of testing for aPE in venous thrombosis and fetal death is in constant debate. We evaluated if testing for aPE has a diagnostic value in patients with SLE...
  25. ncbi Mycophenolate mofetil for systemic lupus erythematosus refractory to other immunosuppressive agents
    M Y Karim
    Lupus Research Unit, The Rayne Institute, Immunology Department, St Thomas Hospital, London, UK
    Rheumatology (Oxford) 41:876-82. 2002
    ..MMF has been introduced as a novel immunosuppressive agent in systemic lupus erythematosus (SLE), often in patients intolerant of or resistant to conventional immunosuppressive regimens...
  26. ncbi Primary antiphospholipid syndrome in pregnancy: an analysis of outcome in a cohort of 33 women treated with a rigorous protocol
    S Stone
    Maternal and Fetal Research Unit, Division of Reproductive Health, Endocrinology and Development, Guy s, King s and St Thomas School of Medicine, King s College, London, UK
    J Thromb Haemost 3:243-5. 2005
  27. ncbi Systemic lupus erythematosus
    G Ruiz-Irastorza
    Lupus Research Unit, Rayne Institute, St Thomas' Hospital, London, UK
    Lancet 357:1027-32. 2001
    ..New data also refer to management of thrombosis in APS and high-risk pregnancies in women with SLE or APS...
  28. ncbi Treatment of menorrhagia associated with oral anticoagulation: efficacy and safety of the levonorgestrel releasing intrauterine device (Mirena coil)
    C N Pisoni
    Lupus Research Unit, The Rayne Institute, King s College London School of Medicine at Guy s, King s and St Thomas Hospital, UK
    Lupus 15:877-80. 2006
    ..We feel the use of LNG-IUS is a major advance in reducing menorrhagia in women on oral anticoagulation as the previous alternative--hysterectomy--is associated with an increased risk of thrombosis and bleeding...
  29. pmc Renal artery stenosis in the antiphospholipid (Hughes) syndrome and hypertension
    S R Sangle
    The Lupus Research Unit, The Rayne Institute, Lambeth Wing, St Thomas Hospital, London SE1 7EH, UK
    Ann Rheum Dis 62:999-1002. 2003
    ..Hypertension is common in the antiphospholipid (Hughes) syndrome (APS) and its cause is poorly understood. Anecdotal evidence suggests that renal artery stenosis (RAS) may be a relevant and treatable cause of hypertension...
  30. ncbi Water intoxication induced by low-dose cyclophosphamide in two patients with systemic lupus erythematosus
    M Salido
    Lupus Research Unit, Rayne Institute, St Thomas Hospital, London, UK
    Lupus 12:636-9. 2003
    ..v. CY may induce hyponatremia related to inappropriate antidiuretic hormone secretion. This potentially life-threatening complication of i.v. CY could be minimized by avoidance of overhydration following pulse i.v. CY...
  31. doi Clinical accuracy for diagnosis of antiphospholipid syndrome in systemic lupus erythematosus: evaluation of 23 possible combinations of antiphospholipid antibody specificities
    S Sciascia
    Lupus Research Unit, The Rayne Institute, Division of Women s Health, King s College London, London, UK
    J Thromb Haemost 10:2512-8. 2012
    ....
  32. pmc Anti-endothelial cell antibodies in systemic vasculitis and systemic lupus erythematosus (SLE): effects of heat inactivation on binding and specificity
    D P D'Cruz
    Lupus Research Unit, Rayne Institute, St Thomas Hospital, London, UK
    Clin Exp Immunol 115:567-70. 1999
    ..Heating sera increases AECA binding in both patient and control sera. The mechanism is probably non-specific damage to the immunoglobulin molecule, and heating sera should thus be avoided...
  33. doi Proteomics in antiphospholipid syndrome: a review
    M J Cuadrado
    Lupus Research Unit, St Thomas Hospital, London, UK
    Lupus 19:385-8. 2010
    ....
  34. doi Migraine and antiphospholipid antibodies: no association found in migraine-discordant monozygotic twins
    F M K Williams
    Twin Research and Genetic Epidemiology Unit, King s College London, London, UK
    Cephalalgia 28:1048-52. 2008
    ..Despite 95% power to detect a difference of 0.59 IgG units per litre in anticardiolipin antibody IgG titres, no difference in prevalence of aPL could be detected in migraine-discordant MZ twins...
  35. ncbi Laboratory diagnosis and management challenges in the antiphospholipid syndrome
    M L Bertolaccini
    Lupus Research Unit, The Rayne Institute, King s College London School of Medicine at Guy s Hospital, London, UK
    Lupus 15:172-8. 2006
    ..Correct identification of patients with APS is important, because prophylactic anticoagulant therapy can prevent thrombosis from recurring, and treatment of affected women during pregnancy can improve fetal and maternal outcome...
  36. ncbi Skin manifestations of systemic lupus erythematosus refractory to multiple treatment modalities: poor results with mycophenolate mofetil
    C N Pisoni
    Lupus Research Unit, The Rayne Institute, St Thomas Hospital, Lambeth Palace Road, London, United Kingdom
    Clin Exp Rheumatol 23:393-6. 2005
    ..However in difficult cases a variety of other drugs have been tried. Here we describe our clinical experience with mycophenolate mofetil (MMF) in patients with cutaneous manifestations of SLE...
  37. ncbi Antiphospholipid antibodies and the endothelium
    B J Hunt
    Departments of Hematology and Lupus Unit, Guy s and St Thomas Trust, London SE1 7EH, England
    Curr Rheumatol Rep 2:252-5. 2000
    ..In vitro antiphospholipid antibodies produce endothelial cell activation. Clinical data in this area are scanty and worthy of future research, which could lead to new therapies in the management of antiphospholipid syndrome...
  38. pmc Value of IgA anticardiolipin and anti-beta2-glycoprotein I antibody testing in patients with pregnancy morbidity
    S Carmo-Pereira
    Lupus Research Unit, The Rayne Institute, UK
    Ann Rheum Dis 62:540-3. 2003
    ..To study the prevalence of IgA antiphospholipid antibodies, particularly anticardiolipin antibodies (aCL) and anti-beta(2)-glycoprotein I (abeta(2)GPI), in a cohort of patients with pregnancy morbidity...
  39. ncbi Update on therapy--thalidomide in the treatment of lupus
    M Y Karim
    Lupus Research Unit, Rayne Institute, St Thomas Hospital, London, UK
    Lupus 10:188-92. 2001
    ..Reliable contraceptive measures should be strictly observed by patients taking thalidomide. Close clinical and neurophysiological supervision using nerve conduction studies should be undertaken...
  40. ncbi Polymorphic light eruption and the HLA DRB1*0301 extended haplotype are independent risk factors for cutaneous lupus erythematosus
    T P Millard
    Department of Photobiology, St John s Institute of Dermatology, London, UK
    Lupus 10:473-9. 2001
    ..They form a basis for examining the genetic architecture of photosensitivity, some aspects of which may be common to both cutaneous LE and PLE...
  41. ncbi Human Ro60 (SSA2) genomic organization and sequence alterations, examined in cutaneous lupus erythematosus
    T P Millard
    Department of Photobiology, Guy s, King s and St Thomas School of Medicine, St Thomas Hospital, London SE1 7EH, UK
    Br J Dermatol 146:210-5. 2002
    ..The genomic organization and any sequence variation within the DNA encoding Ro60 are unknown...
  42. pmc Prevalence of the antiphospholipid syndrome in primary systemic vasculitis
    J D Rees
    The Lupus Research Unit, The Rayne Institute, St Thomas Hospital, London, UK
    Ann Rheum Dis 65:109-11. 2006
    ..It has been described in patients with primary systemic vasculitis (PSV)...
  43. pmc Prevalence and associations of an abnormal ankle-brachial index in systemic lupus erythematosus: a pilot study
    A Theodoridou
    Lupus Research Unit, The Rayne Institute, St Thomas Hospital, London, UK
    Ann Rheum Dis 62:1199-203. 2003
    ..Accelerated atheroma is a well recognised complication of systemic lupus erythematosus (SLE). Its aetiology is multifactorial and several methods may be used to detect early signs of atheroma...
  44. pmc Antiphospholipid antibodies, systemic lupus erythematosus, and non-traumatic metatarsal fractures
    S Sangle
    The Lupus Research Unit, The Rayne Institute, St Thomas Hospital, London SE1 7EH, UK
    Ann Rheum Dis 63:1241-3. 2004
    ..Stress fractures are common in military recruits and athletes and are thought to be secondary to stress and overuse. Less often they are associated with metabolic disorders such as osteoporosis, hypophosphataemia, and diabetes mellitus...
  45. pmc Antibodies to endothelial cells in systemic lupus erythematosus: a potential marker for nephritis and vasculitis
    D P D'Cruz
    Lupus Arthritis Research Unit, Rayne Institute, Department of Immunology, St Thomas Hospital, London, England
    Clin Exp Immunol 85:254-61. 1991
    ..No correlation was seen with serum immunoglobulin levels and immune complexes did not bind significantly to the endothelial surface. The possible role of these antibodies as a marker in lupus nephritis is discussed...
  46. ncbi Antiphospholipid antibodies do not a syndrome make
    S Stone
    Lupus Pregnancy Clinic, Guy s and St Thomas Hospitals Trust, London, UK
    Lupus 11:130-3. 2002
    ..Pregnancy outcomes in these women were not improved with antithrombotic therapy alone. Successful outcomes were achieved only when other causes of recurrent miscarriage were considered and treated...
  47. ncbi Management of hypogammaglobulinaemia occurring in patients with systemic lupus erythematosus
    P F K Yong
    Louise Coote Lupus Unit, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, UK
    Rheumatology (Oxford) 47:1400-5. 2008
    ..The purpose of this article is to describe various cases of SLE and hypogammaglobulinaemia, review the literature and present management strategies for hypogammaglobulinaemia in SLE...
  48. ncbi Anticardiolipin antibodies in a patient with Crohn's disease and thrombosis
    J L Vianna
    Lupus and Arthritis Unit, Rayne Institute, St Thomas Hospital, London, UK
    Clin Exp Rheumatol 10:165-8. 1992
    ..To our knowledge, this is the first report of an association between these two clinical conditions and, in this particular case, aCL may be implicated in the thrombotic events...
  49. ncbi The placental bed in pregnancies complicated by primary antiphospholipid syndrome
    S Stone
    Maternal and Fetal Research Unit, Division of Reproductive Health, Endocrinology and Development, Guy s, King s and St Thomas School of Medicine, London, UK
    Placenta 27:457-67. 2006
    ..The aim of this study was to investigate the placental bed in APS pregnancies for evidence of impaired trophoblast invasion, endothelial cell activation (ECA) and macrophage infiltration...
  50. ncbi Antiaggregant and anticoagulant therapy in systemic lupus erythematosus and Hughes' syndrome
    G Ruiz-Irastorza
    Lupus Research Unit, St Thomas' Hospital, London, UK
    Lupus 10:241-5. 2001
    ..There is still debate regarding the optimal intensity of oral anticoagulation, the best drug combination for pregnancy failure in APS and the management of asymptomatic patients with antiphospholipid antibodies...
  51. doi Update on immunotherapy for systemic lupus erythematosus--what's hot and what's not!
    M Y Karim
    Lupus Research Unit, The Rayne Institute, Lambeth Wing, St Thomas Hospital, London, UK
    Rheumatology (Oxford) 48:332-41. 2009
    ..Data are presented on more generalized immune strategies, such as the use of stem cell transplantation and intravenous immunoglobulin...
  52. ncbi Central nervous system involvement in the antiphospholipid (Hughes) syndrome
    G Sanna
    Lupus Research Unit, The Rayne Institute, St Thomas Hospital, London, UK
    Rheumatology (Oxford) 42:200-13. 2003
    ..In this review we focus on the common and some of the less common CNS manifestations that have been reported in association with antiphospholipid antibodies...
  53. ncbi Measuring systemic lupus erythematosus activity during pregnancy: validation of the lupus activity index in pregnancy scale
    G Ruiz-Irastorza
    St Thomas Hospital, London, United Kingdom
    Arthritis Rheum 51:78-82. 2004
    ..To validate the Lupus Activity Index in Pregnancy (LAI-P) scale as a diagnostic tool for lupus flares during pregnancy and the puerperium...
  54. ncbi Absence of conduction defects in the electrocardiograms [correction of echocardiograms] of mothers with children with congenital complete heart block
    P A Gordon
    Lupus Unit, The Rayne Institute, St Thomas Hospital, London, England
    J Rheumatol 28:366-9. 2001
    ..To investigate the association between complete congenital heart block (CCHB) in the fetus and adult disease...
  55. ncbi Placentation, antiphospholipid syndrome and pregnancy outcome
    S Stone
    Lupus Pregnancy Clinic, St Thomas' Hospitals, London, UK
    Lupus 10:67-74. 2001
    ..The evidence for defective placentation in APS pregnancies and involvement of aPLs in this process is summarized. Finally hypotheses based on the interpretation of these studies are discussed...
  56. ncbi Hypertension as the presenting feature of the antiphospholipid syndrome
    M Y Karim
    Lupus Research Unit, The Rayne Institute, London, UK
    Lupus 11:253-6. 2002
    ..Thrombotic microangiopathy (TMA) affecting the kidney has been reported as a manifestation in both primary and secondary APS. This report describes hypertension related to underlying renal TMA as a presenting symptom of APS...
  57. ncbi Fibrinogen in systemic lupus erythematosus: more than an acute phase reactant?
    P R Ames
    Department of Haematology, Guy s and St Thomas Hospital Trust, London, UK
    J Rheumatol 27:1190-5. 2000
    ....
  58. pmc Seronegative antiphospholipid syndrome
    G R V Hughes
    Lupus Research Unit, The Rayne Institute, St Thomas Hospital, London, UK
    Ann Rheum Dis 62:1127. 2003
  59. ncbi Treatment of systemic lupus erythematosus
    M Mosca
    Lupus Research Unit, Rayne Institute, St. Thomas' Hospital, London SE1 7EH, UK
    Int Immunopharmacol 1:1065-75. 2001
    ..If the promising results already available are confirmed, the use of these drugs might represent the keystone in the future management of SLE and other autoimmune diseases...
  60. ncbi The challenge of pregnancy for patients with SLE
    O Ateka-Barrutia
    Lupus Research Unit, Women s Health Division, King s College London, UK
    Lupus 22:1295-308. 2013
    ..Planned pregnancies lead to better outcomes for both mothers and babies. Close surveillance throughout pregnancy and the puerperium, and tailored management approach guarantee the highest rates of successful pregnancies in these women. ..
  61. doi The cost of care of systemic lupus erythematosus (SLE) in the UK: annual direct costs for adult SLE patients with active autoantibody-positive disease
    M A Khamashta
    1Lupus Research Unit, The Rayne Institute, St Thomas Hospital, London, UK
    Lupus 23:273-83. 2014
    ..This paper presents the UK analyses only...
  62. ncbi HLA class II gene polymorphisms in antiphospholipid syndrome: haplotype analysis in 83 Caucasoid patients
    R Caliz
    Lupus Research Unit, The Rayne Institute, St Thomas Hospital, London, UK
    Rheumatology (Oxford) 40:31-6. 2001
    ..We investigated the association between HLA class II haplotypes and antiphospholipid syndrome (APS)...
  63. pmc Thin-layer chromatography immunostaining in detecting anti-phospholipid antibodies in seronegative anti-phospholipid syndrome
    F Conti
    Reumatologia, Dipartimento di Medicina Interna e Specialita Mediche, Universita di Roma, Viale del Policlinico 155, Rome, Italy
    Clin Exp Immunol 167:429-37. 2012
    ..TLC immunostaining could identify the presence of aPL in patients with SN-APS. Moreover, the results suggest the proinflammatory and procoagulant effects in vitro of these antibodies...
  64. ncbi Effects of an aromatase inhibitor on thymus and kidney and on oestrogen receptors in female MRL/MP-lpr/lpr mice
    B D Greenstein
    Lupus and Arthritis Research Unit, Rayne Institute, St Thomas Hospital, London, UK
    Lupus 2:221-5. 1993
    ..These results support the hypothesis that oestrogens may be involved in the aetiology of murine SLE and provide data suggesting that substances which block oestrogen production in vivo may be useful to treat certain forms of SLE...