Muhammad Rashid Khan

Summary

Publications

  1. Sajid M, Yan C, Li D, Merugu S, Negi H, Khan M. Potent anti-cancer activity of Alnus nitida against lung cancer cells; in vitro and in vivo studies. Biomed Pharmacother. 2019;110:254-264 pubmed publisher
    ..01) decreased the number of nodules per lung and the level of various proteins reciprocating the in vitro studies. These results suggest that ANL and ANB be explored further for therapeutic use in lung cancer. ..
  2. Batool R, Rashid Khan M, Ahmed Zai J, Ali S, Maryam S, Naz I, et al. Brachychiton populneus (Schott & Endl.) R.Br. ameliorate carbon tetrachloride induced oxidative stress through regulation of endoplasmic reticulum stress markers and inflammatory mediators in Sprague-Dawley male rats. Biomed Pharmacother. 2018;107:1601-1610 pubmed publisher
    ..These results suggested the presence of antioxidant and anti-inflammatory constituents in methanol extract of B. populneus. ..
  3. Ali S, Khan M, Shah S, Batool R, Maryam S, Majid M, et al. Protective aptitude of Periploca hydaspidis Falc against CCl4 induced hepatotoxicity in experimental rats. Biomed Pharmacother. 2018;105:1117-1132 pubmed publisher
    ..hydaspidis in a dose dependent manner. These results suggested the presence of antioxidant and anti-inflammatory phyto-constituents in methanol extract of P. hydaspidis. ..
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    Khan M, Younus T. Prevention of CCl(4)-induced oxidative damage in adrenal gland by Digera muricata extract in rat. Pak J Pharm Sci. 2011;24:469-73 pubmed
    ..These results indicate that Digera muricata extract is able to ameliorate oxidative stress in adrenal gland induced by CCl(4) in rat. ..
  5. Kazmi S, Majid M, Maryam S, Rahat A, Ahmed M, Khan M, et al. Quercus dilatata Lindl. ex Royle ameliorates BPA induced hepatotoxicity in Sprague Dawley rats. Biomed Pharmacother. 2018;102:728-738 pubmed publisher
    ..dilatata with known polyphenolics content and validates the traditional use of this plant in natural medicine to manage disorders like hepatotoxicity. ..
  6. Khan M, Ahmed D. Protective effects of Digera muricata (L.) Mart. on testis against oxidative stress of carbon tetrachloride in rat. Food Chem Toxicol. 2009;47:1393-9 pubmed publisher
    ..muricata treatment augments the antioxidants defense mechanism against carbon tetrachloride induced toxicity and provides evidence that it may have a therapeutic role in free radical mediated diseases. ..
  7. Ullah S, Rashid Khan M, Ali Shah N, Afzal Shah S, Majid M, Asad Farooq M. Ethnomedicinal plant use value in the Lakki Marwat District of Pakistan. J Ethnopharmacol. 2014;158 Pt A:412-22 pubmed publisher
    ..In addition, species with high use values (UV) might provide valuable leads for further pharmacological investigations. ..
  8. Khan M, Zehra H. Amelioration of CCl(4)-induced nephrotoxicity by Oxalis corniculata in rat. Exp Toxicol Pathol. 2013;65:327-34 pubmed publisher
    ..Treatment with OCME caused significant recovery in changed parameters. It could be concluded that OCME has a protective role against CCl(4)-induced oxidative stress in rat, due to antioxidant effects of phenolics. ..
  9. Jan S, Khan M. Antipyretic, analgesic and anti-inflammatory effects of Kickxia ramosissima. J Ethnopharmacol. 2016;182:90-100 pubmed publisher
    ..The results suggested the anti-inflammatory effects of KRM in inflammation related disorders, might be attributed by the presence of active phytoconstituents; flavonoids, saponins and terpenoids. ..

More Information

Publications38

  1. Afsar T, Khan M, Razak S, Ullah S, Mirza B. Antipyretic, anti-inflammatory and analgesic activity of Acacia hydaspica R. Parker and its phytochemical analysis. BMC Complement Altern Med. 2015;15:136 pubmed publisher
    ..hydaspica. These results revealed that the presence of bioactive compounds in A. hydaspica might be responsible for the pharmacological activities, confirming the indigenous utility of A. hydaspica against inflammatory disorders. ..
  2. Sahreen S, Khan M, Khan R, Hadda T. Evaluation of phytochemical content, antimicrobial, cytotoxic and antitumor activities of extract from Rumex hastatus D. Don roots. BMC Complement Altern Med. 2015;15:211 pubmed publisher
    ..These results showed that R. hastatus appeared as an important source for the discovery of new antimicrobial drugs and antitumor agents; verify its traditional uses and its exploitation as therapeutic agent. ..
  3. Majid M, Khan M, Shah N, ul Haq I, Farooq M, Ullah S, et al. Studies on phytochemical, antioxidant, anti-inflammatory and analgesic activities of Euphorbia dracunculoides. BMC Complement Altern Med. 2015;15:349 pubmed publisher
    ..Our results suggest that presence of various polyphenolics, terpenoids and steroids render E. dracunculoides with therapeutic potential for oxidative stress and inflammation related disorders. ..
  4. Ahmad B, Khan M, Shah N. Amelioration of carbon tetrachloride-induced pulmonary toxicity with Oxalis corniculata. Toxicol Ind Health. 2015;31:1243-51 pubmed publisher
    ..OCME, dose dependently, prevented the alterations in these parameters. These results suggest that OCME protected the lungs due to its intrinsic properties by scavenging of free radicals generated by CCl4. ..
  5. Sajid M, Khan M, Shah S, Majid M, Ismail H, Maryam S, et al. Investigations on anti-inflammatory and analgesic activities of Alnus nitida Spach (Endl). stem bark in Sprague Dawley rats. J Ethnopharmacol. 2017;198:407-416 pubmed publisher
    ..nitida bark and its derived fractions. This study endorsed the folklore use of A. nitida bark for inflammation related disorders. ..
  6. Tahir I, Khan M, Shah N, Aftab M. Evaluation of phytochemicals, antioxidant activity and amelioration of pulmonary fibrosis with Phyllanthus emblica leaves. BMC Complement Altern Med. 2016;16:406 pubmed
    ..The findings of this study demonstrate that presence of polyphenolics and other active constituents in PELE might play a significant role in repairing the pulmonary damages instigated with CCl4. ..
  7. Younis T, Khan M, Sajid M, Majid M, Zahra Z, Shah N. Fraxinus xanthoxyloides leaves reduced the level of inflammatory mediators during in vitro and in vivo studies. BMC Complement Altern Med. 2016;16:230 pubmed publisher
    ..The study demonstrates the therapeutic potential of F. xanthoxyloides leaves against the inflammatory disorders suggesting the presence of active constituents in chloroform fraction. ..
  8. Bokhari J, Khan M. Evaluation of anti-asthmatic and antioxidant potential of Boerhavia procumbens in toluene diisocyanate (TDI) treated rats. J Ethnopharmacol. 2015;172:377-85 pubmed publisher
    ..The BPM has the anti-inflammatory properties that may be used to treat the asthma and inflammatory related ailments. ..
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    Bokhari J, Khan M, Haq I. Assessment of phytochemicals, antioxidant, and anti-inflammatory potential of Boerhavia procumbens Banks ex Roxb. Toxicol Ind Health. 2016;32:1456-1466 pubmed
    ..Results revealed that various fractions of B. procumbens manifested the antioxidant and anti-inflammatory potential and accredit the local use of B. procumbens in various disorders. ..
  10. Sajid M, Khan M, Shah N, Shah S, Ismail H, Younis T, et al. Phytochemical, antioxidant and hepatoprotective effects of Alnus nitida bark in carbon tetrachloride challenged Sprague Dawley rats. BMC Complement Altern Med. 2016;16:268 pubmed publisher
    ..Based on the results of antioxidants, restoration of various antioxidant enzymes and histopathological studies, the recent study concludes that antioxidant potential of A. nitida bark might protect the liver damages. ..
  11. Younis T, Khan M, Sajid M. Protective effects of Fraxinus xanthoxyloides (Wall.) leaves against CCl4 induced hepatic toxicity in rat. BMC Complement Altern Med. 2016;16:407 pubmed
    ..Results of present investigation revealed that F. xanthoxyloides leaves possibly protect the liver against CCl4 induced injuries like silymarin by its antioxidant constituents. ..
  12. Shah N, Khan M, Nigussie D. Phytochemical investigation and nephroprotective potential of Sida cordata in rat. BMC Complement Altern Med. 2017;17:388 pubmed publisher
    ..These results are an evidence of the renal protective role of S.cordat ethyl acetate fraction against CCl4 induced nephrotoxicity in rats which may be due to its antioxidant compounds. ..
  13. Afsar T, Razak S, Almajwal A, Rashid Khan M. Modulatory influence of Acacia hydaspica R. Parker ethyl acetate extract against cisplatin inveigled hepatic injury and dyslipidemia in rats. BMC Complement Altern Med. 2017;17:307 pubmed publisher
    ..These results reveal that treatment of AHE may be useful in the prevention of CP induced hepatotoxicity due to its antioxidant potential and polyphenolic constituents. ..
  14. Afsar T, Razak S, Khan M, Almajwal A. Anti-depressant and anxiolytic potential of Acacia hydaspica R. Parker aerial parts extract: Modulation of brain antioxidant enzyme status. BMC Complement Altern Med. 2017;17:228 pubmed publisher
    ..hydaspica. The present study revealed that A. hydaspica exerts an antidepressant and anxiolytic effect by improving brain antioxidant status. The observed activities might be due to the presence of diverse phytochemicals. ..
  15. Rashid U, Khan M, Jan S, Bokhari J, Shah N. Assessment of phytochemicals, antimicrobial and cytotoxic activities of extract and fractions from Fagonia olivieri (Zygophyllaceae). BMC Complement Altern Med. 2013;13:167 pubmed publisher
    ..This study evaluated the crude methanol extract of F. olivieri (FOM) and its derived fractions for their antimicrobial and cytotoxic activities as well as the classes of phytochemical...
  16. Shabbir M, Khan M, Saeed N. Assessment of phytochemicals, antioxidant, anti-lipid peroxidation and anti-hemolytic activity of extract and various fractions of Maytenus royleanus leaves. BMC Complement Altern Med. 2013;13:143 pubmed publisher
    ..The aim of this study was to evaluate the methanol extract of leaves and its derived fractions for various antioxidant assays and for its potential against lipid peroxidation and hemolytic activity...
  17. Khan R, Khan M, Ahmed M, Sahreen S, Shah N, Shah M, et al. Hepatoprotection with a chloroform extract of Launaea procumbens against CCl4-induced injuries in rats. BMC Complement Altern Med. 2012;12:114 pubmed publisher
    ..These results indicated that Launaea procumbens efficiently protected against the hepatotoxicity induced by CCl4 in rats, possibly through the antioxidant effects of flavonoids present in LPCE. ..
  18. Khan R, Khan M, Sahreen S, Shah N. Hepatoprotective activity of Sonchus asper against carbon tetrachloride-induced injuries in male rats: a randomized controlled trial. BMC Complement Altern Med. 2012;12:90 pubmed
    ..Liver histopathology showed that SAME reduced the incidence of hepatic lesions induced by CCl4 in rats. SAME may protect the liver against CCl4-induced oxidative damage in rats. ..
  19. Saeed N, Khan M, Shabbir M. Antioxidant activity, total phenolic and total flavonoid contents of whole plant extracts Torilis leptophylla L. BMC Complement Altern Med. 2012;12:221 pubmed publisher
    ..Data from present results revealed that Torilis leptophylla act as an antioxidant agent due to its free radical scavenging and cytoprotective activity. ..
  20. Rashid U, Khan M, Sajid M. Hepatoprotective potential of Fagonia olivieri DC. against acetaminophen induced toxicity in rat. BMC Complement Altern Med. 2016;16:449 pubmed
    ..Our results showed that F. olivieri is a potential source of natural antioxidants, which justifies its use in folklore medicine. ..
  21. Ali S, Khan M, Sajid M. Protective potential of Parrotiopsis jacquemontiana (Decne) Rehder on carbon tetrachloride induced hepatotoxicity in experimental rats. Biomed Pharmacother. 2017;95:1853-1867 pubmed publisher
  22. Noureen F, Khan M, Shah N, Khan R, Naz K, Sattar S. Pistacia chinensis: Strong antioxidant and potent testicular toxicity amelioration agent. Asian Pac J Trop Med. 2017;10:380-389 pubmed publisher
    ..chinensis against CCl4 induced toxicity. It is concluded that some bioactive antioxidants of P. chinensis bark might be a good source to isolate the potent antioxidant components. ..
  23. Batool R, Khan M, Majid M. Euphorbia dracunculoides L. abrogates carbon tetrachloride induced liver and DNA damage in rats. BMC Complement Altern Med. 2017;17:223 pubmed publisher
    ..These results suggested that the phyto-constituents of EDME were able to ameliorate the oxidative stress induced with CCl4 and can be a useful therapeutic agent for oxidative stress related disorders. ..
  24. Shah M, Parveen Z, Khan M. Evaluation of antioxidant, anti-inflammatory, analgesic and antipyretic activities of the stem bark of Sapindus mukorossi. BMC Complement Altern Med. 2017;17:526 pubmed publisher
    ..The resulted obtained in this study suggested the therapeutic importance of stem bark of S. mukorossi in inflammatory related disorders. ..
  25. Ali S, Khan M, Irfanullah -, Sajid M, Zahra Z. Phytochemical investigation and antimicrobial appraisal of Parrotiopsis jacquemontiana (Decne) Rehder. BMC Complement Altern Med. 2018;18:43 pubmed publisher
    ..The remarkable inhibition of various bacterial and fungal strains at low doses of the extract/fractions suggested the strong antibacterial, antifungal and anti-candidal potential of P. jacquemontiana leaves. ..
  26. Shah N, Khan M. Increase of glutathione, testosterone and antioxidant effects of Jurenia dolomiaea on CCl4 induced testicular toxicity in rat. BMC Complement Altern Med. 2017;17:206 pubmed publisher
    ..Enhanced level of GSH, thickness of germinal layers in testes and testosterone in serum with JDEE (400 mg/kg) treatment alone to rats demanded the evaluation of JDEE for sexual behavior. ..
  27. Rashid U, Khan M. Fagonia olivieri prevented hepatorenal injuries induced with gentamicin in rat. Biomed Pharmacother. 2017;88:469-479 pubmed publisher
    ..Results of the present investigation suggested the protective potential of FOM against the oxidative injuries of gentamicin that could be attributed by phytochemicals having antioxidant and free radical scavenging abilities. ..
  28. Khan M, Badar I, Siddiquah A. Prevention of hepatorenal toxicity with Sonchus asper in gentamicin treated rats. BMC Complement Altern Med. 2011;11:113 pubmed publisher
    ..These results suggested the preventive role of SAME for gentamicin induced toxicity that could be attributed by phytochemicals having antioxidant and free radical scavenging properties. ..
  29. Khan M, Rizvi W, Khan G, Khan R, Shaheen S. Carbon tetrachloride-induced nephrotoxicity in rats: protective role of Digera muricata. J Ethnopharmacol. 2009;122:91-9 pubmed publisher