Marleen Keyaerts

Summary

Publications

  1. doi request reprint Bioluminescence imaging: looking beyond the light
    Marleen Keyaerts
    In Vivo Cellular and Molecular Imaging ICMI Laboratory, Vrije Universiteit Brussel VUB, Laarbeeklaan 103, 1090 Brussels, Belgium
    Trends Mol Med 18:164-72. 2012
  2. pmc Inhibition of firefly luciferase by general anesthetics: effect on in vitro and in vivo bioluminescence imaging
    Marleen Keyaerts
    In Vivo Cellular and Molecular Imaging ICMI Laboratory, Vrije Universiteit Brussel VUB, Brussels, Belgium
    PLoS ONE 7:e30061. 2012
  3. doi request reprint Plasma protein binding of luciferase substrates influences sensitivity and accuracy of bioluminescence imaging
    Marleen Keyaerts
    In Vivo Cellular and Molecular Imaging Laboratory, Vrije Universiteit Brussel, Brussels, Belgium
    Mol Imaging Biol 13:59-66. 2011
  4. doi request reprint Comparison of the biodistribution and tumor targeting of two 99mTc-labeled anti-EGFR nanobodies in mice, using pinhole SPECT/micro-CT
    Lea Olive Tchouate Gainkam
    In Vivo Cellular and Molecular Imaging Laboratory, Vrije Universiteit Brussel, Brussels, Belgium
    J Nucl Med 49:788-95. 2008
  5. ncbi request reprint Intra-individual comparison of the human biodistribution and dosimetry of the D and L isomers of 2-[123I]iodo-phenylalanine
    Matthias Bauwens
    BEFY, Radiopharmaceutical Chemistry, Vrije Universiteit Brussels, Laarbeeklaan 103, 1090 Brussels, Belgium
    Nucl Med Commun 28:823-8. 2007
  6. doi request reprint Synthesis, preclinical validation, dosimetry, and toxicity of 68Ga-NOTA-anti-HER2 Nanobodies for iPET imaging of HER2 receptor expression in cancer
    Catarina Xavier
    In Vivo Cellular and Molecular Imaging Laboratory, Vrije Universiteit Brussel, Brussels, Belgium
    J Nucl Med 54:776-84. 2013
  7. doi request reprint Dynamic bioluminescence imaging for quantitative tumour burden assessment using IV or IP administration of D: -luciferin: effect on intensity, time kinetics and repeatability of photon emission
    Marleen Keyaerts
    In Vivo Cellular and Molecular Imaging ICMI Laboratory, Vrije Universiteit Brussel VUB, Brussels, Belgium
    Eur J Nucl Med Mol Imaging 35:999-1007. 2008
  8. doi request reprint SPECT imaging with 99mTc-labeled EGFR-specific nanobody for in vivo monitoring of EGFR expression
    Lieven Huang
    Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium
    Mol Imaging Biol 10:167-75. 2008
  9. doi request reprint Correlation between epidermal growth factor receptor-specific nanobody uptake and tumor burden: a tool for noninvasive monitoring of tumor response to therapy
    Lea Olive Tchouate Gainkam
    ICMI, In Vivo Cellular and Molecular Imaging Laboratory, Vrije Universiteit Brussel VUB, Brussels, Belgium
    Mol Imaging Biol 13:940-8. 2011
  10. doi request reprint Regional quantitative analysis of small animal myocardial sympathetic innervation and initial application in streptozotocin induced diabetes
    Lode R Goethals
    Radiology Department, University Hospital Brussels, Brussels, Belgium
    Contrast Media Mol Imaging 4:174-82. 2009

Collaborators

Detail Information

Publications12

  1. doi request reprint Bioluminescence imaging: looking beyond the light
    Marleen Keyaerts
    In Vivo Cellular and Molecular Imaging ICMI Laboratory, Vrije Universiteit Brussel VUB, Laarbeeklaan 103, 1090 Brussels, Belgium
    Trends Mol Med 18:164-72. 2012
    ..The knowledge and detection of such factors, together with the development of new strategies and better BLI compounds, will improve the accuracy of the technique in the future...
  2. pmc Inhibition of firefly luciferase by general anesthetics: effect on in vitro and in vivo bioluminescence imaging
    Marleen Keyaerts
    In Vivo Cellular and Molecular Imaging ICMI Laboratory, Vrije Universiteit Brussel VUB, Brussels, Belgium
    PLoS ONE 7:e30061. 2012
    ..Often isoflurane anesthesia is used because of its ease of use and fast induction/recovery. However, general anesthetics have been described as important inhibitors of the luciferase enzyme reaction...
  3. doi request reprint Plasma protein binding of luciferase substrates influences sensitivity and accuracy of bioluminescence imaging
    Marleen Keyaerts
    In Vivo Cellular and Molecular Imaging Laboratory, Vrije Universiteit Brussel, Brussels, Belgium
    Mol Imaging Biol 13:59-66. 2011
    ..Potential confounding factors in bioluminescence imaging (BLI)-quantification need to be identified to improve its accuracy and repeatability...
  4. doi request reprint Comparison of the biodistribution and tumor targeting of two 99mTc-labeled anti-EGFR nanobodies in mice, using pinhole SPECT/micro-CT
    Lea Olive Tchouate Gainkam
    In Vivo Cellular and Molecular Imaging Laboratory, Vrije Universiteit Brussel, Brussels, Belgium
    J Nucl Med 49:788-95. 2008
    ..We compared the in vivo tumor uptake and biodistribution of 2 anti-epidermal growth factor receptor (anti-EGFR) Nanobodies, (99m)Tc-7C12 and (99m)Tc-7D12...
  5. ncbi request reprint Intra-individual comparison of the human biodistribution and dosimetry of the D and L isomers of 2-[123I]iodo-phenylalanine
    Matthias Bauwens
    BEFY, Radiopharmaceutical Chemistry, Vrije Universiteit Brussels, Laarbeeklaan 103, 1090 Brussels, Belgium
    Nucl Med Commun 28:823-8. 2007
    ..Here we compare, intra-individually, the normal biodistribution and dosimetry of both tracers in healthy human subjects...
  6. doi request reprint Synthesis, preclinical validation, dosimetry, and toxicity of 68Ga-NOTA-anti-HER2 Nanobodies for iPET imaging of HER2 receptor expression in cancer
    Catarina Xavier
    In Vivo Cellular and Molecular Imaging Laboratory, Vrije Universiteit Brussel, Brussels, Belgium
    J Nucl Med 54:776-84. 2013
    ..In this study we labeled the anti-human epidermal growth factor receptor type 2 (HER2) Nanobody with (68)Ga via a 1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA) derivative and assessed its use for HER2 iPET imaging...
  7. doi request reprint Dynamic bioluminescence imaging for quantitative tumour burden assessment using IV or IP administration of D: -luciferin: effect on intensity, time kinetics and repeatability of photon emission
    Marleen Keyaerts
    In Vivo Cellular and Molecular Imaging ICMI Laboratory, Vrije Universiteit Brussel VUB, Brussels, Belgium
    Eur J Nucl Med Mol Imaging 35:999-1007. 2008
    ..The aim of this study is to compare the repeatability of BLI measurement after IV versus IP administration of D: -luciferin and assess the correlation between photon emission and histological cell count both in vitro and in vivo...
  8. doi request reprint SPECT imaging with 99mTc-labeled EGFR-specific nanobody for in vivo monitoring of EGFR expression
    Lieven Huang
    Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium
    Mol Imaging Biol 10:167-75. 2008
    ..We describe the use of a llama single-domain antibody fragment, termed Nanobody, for the in vivo radioimmunodetection of EGFR overexpressing tumors using single photon emission computed tomography (SPECT) in mice...
  9. doi request reprint Correlation between epidermal growth factor receptor-specific nanobody uptake and tumor burden: a tool for noninvasive monitoring of tumor response to therapy
    Lea Olive Tchouate Gainkam
    ICMI, In Vivo Cellular and Molecular Imaging Laboratory, Vrije Universiteit Brussel VUB, Brussels, Belgium
    Mol Imaging Biol 13:940-8. 2011
    ..We studied the relationship between tumor uptake of the epidermal growth factor receptor (EGFR)-specific nanobody (99m)Tc-7C12 and tumor burden and evaluated the possibility of using this probe to monitor tumor response to erlotinib...
  10. doi request reprint Regional quantitative analysis of small animal myocardial sympathetic innervation and initial application in streptozotocin induced diabetes
    Lode R Goethals
    Radiology Department, University Hospital Brussels, Brussels, Belgium
    Contrast Media Mol Imaging 4:174-82. 2009
    ..After evaluation of the image procedure in normal animals, we then applied our imaging protocol to visualize the regional dysinnervation in cardiac autonomic neuropathy occurring in streptozotocin-induced diabetes...
  11. ncbi request reprint 123I-2-iodo-tyrosine, a new tumour imaging agent: human biodistribution, dosimetry and initial clinical evaluation in glioma patients
    Marleen Keyaerts
    Department of Nuclear Medicine, Academic Hospital, Vrije Universiteit Brussel AZ VUB, Laarbeeklaan 101, 1090 Brussels, Belgium
    Eur J Nucl Med Mol Imaging 34:994-1002. 2007
    ..Uptake is mediated by LAT1 transport, which is increased in tumour cells. In this study we present the human biodistribution and first clinical results in glioma patients...
  12. doi request reprint Air leaks localized with lung ventilation SPECT
    Gaetane Ceulemans
    Departments of Nuclear Medicine, UZ Brussel, Laarbeeklaan, Brussels, Belgium
    Clin Nucl Med 37:1182-3. 2012
    ..Fused high-resolution CT/Tc Technegas images localized leakage not only to a bleb in the right upper lobe but also to the subcutaneous emphysema in the thoracic wall. The air leak resolved after conservative treatment...